MX2008013668A - Agentes antivirales que activan la arnasa l. - Google Patents

Agentes antivirales que activan la arnasa l.

Info

Publication number
MX2008013668A
MX2008013668A MX2008013668A MX2008013668A MX2008013668A MX 2008013668 A MX2008013668 A MX 2008013668A MX 2008013668 A MX2008013668 A MX 2008013668A MX 2008013668 A MX2008013668 A MX 2008013668A MX 2008013668 A MX2008013668 A MX 2008013668A
Authority
MX
Mexico
Prior art keywords
alkyl
ring
compound
independently
haloalkyl
Prior art date
Application number
MX2008013668A
Other languages
English (en)
Spanish (es)
Inventor
Robert Silverman
Paul Torrence
Babal Kant Jha
Paula Francom
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Publication of MX2008013668A publication Critical patent/MX2008013668A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2008013668A 2006-04-25 2007-04-25 Agentes antivirales que activan la arnasa l. MX2008013668A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79506906P 2006-04-25 2006-04-25
PCT/US2007/009959 WO2007127212A2 (en) 2006-04-25 2007-04-25 Anti-viral agents that activate rnase l

Publications (1)

Publication Number Publication Date
MX2008013668A true MX2008013668A (es) 2009-01-27

Family

ID=38374152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013668A MX2008013668A (es) 2006-04-25 2007-04-25 Agentes antivirales que activan la arnasa l.

Country Status (10)

Country Link
EP (1) EP2016062A2 (zh)
JP (1) JP2009536622A (zh)
KR (1) KR20090007609A (zh)
CN (1) CN101460471A (zh)
AU (1) AU2007243403A1 (zh)
CA (1) CA2650028A1 (zh)
IL (1) IL194890A0 (zh)
MX (1) MX2008013668A (zh)
RU (1) RU2008146422A (zh)
WO (1) WO2007127212A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009123588A1 (en) * 2008-04-01 2009-10-08 The Cleveland Clinic Foundation Amides of 3, 5-substituted-is0xaz0le-4-carb0xylic acids for the treatment of viral infections, cancer and restenosis
EP2411001B1 (en) * 2009-03-23 2018-01-17 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
WO2013020164A1 (en) 2011-08-05 2013-02-14 Biota Scientific Management Pty Ltd Compounds for treating respiratory syncytial virus infections
RU2487708C1 (ru) * 2012-03-12 2013-07-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздравсоцразвития России) Способ лечения парвовирусной инфекции в19 у детей раннего возраста
TWI472518B (zh) * 2014-01-02 2015-02-11 Univ China Medical 苯胺衍生物於抗病毒之用途
US20200055848A1 (en) * 2016-11-04 2020-02-20 Carna Biosciences, Inc. Furanone derivates and methods of use thereof
CN109745311B (zh) * 2019-02-22 2021-12-17 北京大学深圳研究生院 RNase L酶抑制剂的应用
CN112088903A (zh) * 2020-09-28 2020-12-18 武汉愔紫生物科技有限公司 一种大分子蛋白在抗菌抗病毒消毒剂中的应用
CN112107679A (zh) * 2020-09-28 2020-12-22 武汉愔紫生物科技有限公司 一种大分子蛋白在抗rna病毒消毒剂中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80572C2 (en) * 2002-11-22 2007-10-10 Smithkline Beecham Corp THIAZOLIDINE DERIVATIVES AS hYAK3 INHIBITORS
WO2005051974A2 (en) * 2003-06-09 2005-06-09 The Regents Of The University Of California Novel molecules for regulating cell death
WO2005016227A2 (en) * 2003-08-14 2005-02-24 Insight Biopharmaceuticals Ltd. Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof
US20070269420A1 (en) * 2003-11-24 2007-11-22 Chunduru Srinivas K Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases
WO2005082363A1 (en) * 2004-02-20 2005-09-09 Board Of Regents, The University Of Texas System Thiazolone compounds for treatment of cancer
JP2007523957A (ja) * 2004-02-25 2007-08-23 スミスクライン・ビーチャム・コーポレイション 新規化学化合物

Also Published As

Publication number Publication date
RU2008146422A (ru) 2010-05-27
WO2007127212A2 (en) 2007-11-08
IL194890A0 (en) 2009-08-03
JP2009536622A (ja) 2009-10-15
AU2007243403A1 (en) 2007-11-08
EP2016062A2 (en) 2009-01-21
WO2007127212A3 (en) 2008-03-27
KR20090007609A (ko) 2009-01-19
CA2650028A1 (en) 2007-11-08
CN101460471A (zh) 2009-06-17

Similar Documents

Publication Publication Date Title
MX2008013668A (es) Agentes antivirales que activan la arnasa l.
AU2005203740B2 (en) Diamidine compounds as DNA minor groove binders
AU2017344178B2 (en) Microtubule protein inhibitor
EP1627635B1 (en) Benzothiazolium compounds for use in methods of inhibiting NO production and TNF alpha and treating coronaviral infection
JP2007084494A (ja) Ｐｉｍ−１活性阻害剤
WO2007139150A1 (ja) ＴＮＦα阻害物質を含有してなる抗インフルエンザウイルス剤
KR20110137941A (ko) 신규한 티오우레아 또는 우레아 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 ａｉｄｓ 예방 또는 치료용 약학 조성물
Zhan et al. Arylazolyl (azinyl) thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents
JPH11507375A (ja) 低分子によるｒｎａ／リガンド結合の阻害
KR20060129396A (ko) 신규한 ｈｉｖ 프로테아제 억제제
CN108283631B (zh) 一种肠道病毒的抑制剂及其应用
CN113912594A (zh) 硝基噻吩甲胺类光学异构体及其医药用途
KR20110006083A (ko) 디히드록시크로몬 유도체를 유효성분으로 함유하는 코로나바이러스로 인해 유발되는 질환의 치료 및 예방을 위한 약학 조성물
WO2009124184A2 (en) Methods of activating rnase l
US9447047B2 (en) Inhibitors of protein phosphatase-1 and uses thereof
US20240082235A1 (en) Method for treating or inhibiting cytomegalovirus infection using small molecules targeting protein phosphatase 1
US20120226031A1 (en) Palmarumycin based inhibitors of thioredoxin and methods of using same
EP4173621A1 (en) Pharmaceutical composition, its use as a drug and new compounds, especially for treating sars-cov-2 infection
US11389455B2 (en) Inhibitors of HIV-1 integrase multimerization
CN108774161B (zh) 六种parp1抑制剂的制备及其应用
EP1844776B1 (en) Agent for prevention/treatment of disease caused by acyclovir-resistant herpesvirus
Takada et al. Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity
CN117924242A (zh) 一种吡啶-2（1h）-酮类hiv-1非核苷类逆转录酶抑制剂及其制备方法与应用
GR1010570B (el) 4-(2-(4-((2,4-διοξοθειαζολιδιν-5-υλ)μεθυλ)φαινοξυ) παραγωγα με δραση αναστολης της αυτοταξινης
CZ2004162A3 (cs) Nové inhibitory HIV proteasy

Legal Events

Date Code Title Description
FA Abandonment or withdrawal