MX2007005377A - Particulas de ramiprilo estabilizadas, individualmente recubiertas, composiciones y metodos. - Google Patents

Particulas de ramiprilo estabilizadas, individualmente recubiertas, composiciones y metodos.

Info

Publication number
MX2007005377A
MX2007005377A MX2007005377A MX2007005377A MX2007005377A MX 2007005377 A MX2007005377 A MX 2007005377A MX 2007005377 A MX2007005377 A MX 2007005377A MX 2007005377 A MX2007005377 A MX 2007005377A MX 2007005377 A MX2007005377 A MX 2007005377A
Authority
MX
Mexico
Prior art keywords
ramipril
methods
bioavailability
compositions
novel
Prior art date
Application number
MX2007005377A
Other languages
English (en)
Inventor
Martin W Beasley
Edward Wilson
Original Assignee
King Pharmaceuticals Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King Pharmaceuticals Res & Dev filed Critical King Pharmaceuticals Res & Dev
Publication of MX2007005377A publication Critical patent/MX2007005377A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

La presente invencion se relaciona con particulas cristalinas de ramipril novedosas con estabilidad y biodisponibilidad mejoradas. Mas particularmente, la presente invencion se dirige a particulas cristalinas de ramipril unitarias, individualmente recubiertas para aplicaciones farmaceuticas y biofarmaceuticas en terapias orales que se estabilizan contra la descomposicion en productos de degradacion, principalmente, ramipril-DKP y ramipril-diacido, durante la formulacion y condiciones de almacenamiento. La presente invencion tambien se relaciona con composiciones farmaceuticas de ramipril estabilizadas, polvos de ramipril de grado farmaceutico anhidro novedoso, metodos para mejorar la biodisponibilidad de ramipril y metodos de fabricacion y estabilizacion de formulaciones de ramipril. Los polvos de ramipril de grado farmaceutico anhidro novedoso, y composiciones de ramipril y formas de dosificacion formadas con las mismas son utiles en el tratamiento de trastornos cardiovasculares y que tienen la ventaja de que proporcionan mayor estabilidad contra la descomposicion en los ramiprilDKP y ramipril-diacidos bajo la formulacion y condiciones de almacenamiento. Ademas mantienen potencia de ramipril de etiquetado consistente sobre la vida de anaquel prolongada y proporcionan variabilidad in vivo reducida en la biodisponibilidad de ramipril entre sujetos cuamndo se administra oralmente.
MX2007005377A 2004-11-05 2005-11-07 Particulas de ramiprilo estabilizadas, individualmente recubiertas, composiciones y metodos. MX2007005377A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62527004P 2004-11-05 2004-11-05
PCT/US2005/040429 WO2006050533A2 (en) 2004-11-05 2005-11-07 Stabilized individually coated ramipril particles, compositions and methods

Publications (1)

Publication Number Publication Date
MX2007005377A true MX2007005377A (es) 2008-01-11

Family

ID=36319833

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2007005377A MX2007005377A (es) 2004-11-05 2005-11-07 Particulas de ramiprilo estabilizadas, individualmente recubiertas, composiciones y metodos.
MX2007005373A MX2007005373A (es) 2004-11-05 2005-11-07 Composiciones estabilizadas de ramipril y metodos para elaborarlas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2007005373A MX2007005373A (es) 2004-11-05 2005-11-07 Composiciones estabilizadas de ramipril y metodos para elaborarlas.

Country Status (14)

Country Link
US (2) US20060134213A1 (es)
EP (2) EP1817007A2 (es)
JP (2) JP2008519062A (es)
KR (2) KR20070085759A (es)
CN (2) CN101098681A (es)
AU (2) AU2005304664A1 (es)
BR (2) BRPI0517662A (es)
CA (2) CA2586760A1 (es)
IL (2) IL183017A0 (es)
MX (2) MX2007005377A (es)
NO (2) NO20072741L (es)
RU (2) RU2007120821A (es)
WO (2) WO2006052968A2 (es)
ZA (2) ZA200704767B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1635792E (pt) * 2003-06-26 2009-05-15 Teva Pharma Composições farmacêuticas estáveis de derivados do ácido 2-aza-biciclo[3.3.0]octano-3-carboxílico
US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
EP1734931A2 (en) * 2004-03-24 2006-12-27 Actavis Group Formulations of ramipril
WO2006052968A2 (en) * 2004-11-05 2006-05-18 King Pharmaceuticals Research & Development, Inc. Stabilized ramipril compositions and methods of making
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
EP1948136A1 (en) * 2005-11-07 2008-07-30 King Pharmaceuticals Research and Development, Inc. Compositions of stabilized ramipril in combination with another active agent
WO2007120930A2 (en) * 2006-04-19 2007-10-25 Teva Pharmaceutical Industries Ltd. Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
WO2008134047A1 (en) * 2007-04-27 2008-11-06 King Pharmaceuticals Research And Development, Inc. Methods of treating hypertension
WO2008132756A1 (en) * 2007-05-01 2008-11-06 Lupin Limited Stable pharmaceutical compositions of ramipril
ITMI20072427A1 (it) * 2007-12-24 2009-06-25 I P S Internat Products & Ser Matrce polimerica polivalente a immediata disgregazione per prodotti solidi per uso orale a rilascio modificato e metodo per la sua preparazione
WO2010030735A2 (en) * 2008-09-11 2010-03-18 Aethos Pharmaceuticals, Inc. Stabilized coating for pharmaceutical formulations
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
SG183449A1 (en) * 2010-02-24 2012-09-27 Sanofi Aventis Deutschland Solid pharmaceutical formulations of ramipril and amlodipine besylate, and their preparation
RU2479310C2 (ru) * 2011-02-09 2013-04-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения артериальной гипертензии и застойной сердечной недостаточности и способ ее получения
CN102139109A (zh) * 2011-03-30 2011-08-03 上海蓝药实业有限公司 一种质量稳定的血管紧张素转化酶抑制剂的制剂组合物
JP5648124B2 (ja) * 2011-08-31 2015-01-07 株式会社奈良機械製作所 固体粒子の表面改質装置および固体粒子の表面改質方法
WO2013121233A1 (en) * 2012-02-17 2013-08-22 Egis Gyógyszergyár Nyilvánosan Működö Részvénytársaság Pharmaceutical formulation having improved stability
US10835495B2 (en) 2012-11-14 2020-11-17 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide material and methods of making and using the same
HUP1300496A2 (hu) * 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
JP6323846B2 (ja) * 2016-04-07 2018-05-16 塩野義製薬株式会社 オピオイドを含有する乱用防止製剤
CA3061479A1 (en) * 2017-04-25 2018-11-01 Proteus Digital Health, Inc. Lisinopril compositions with an ingestible event marker
WO2021162562A2 (en) * 2020-02-10 2021-08-19 Adamed Pharma S.A. Stable ramipril composition and fixed dose composition comprising thereof
KR20240046661A (ko) 2022-10-01 2024-04-09 김성현 높이 조절 노트북

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5256687A (en) * 1985-09-09 1993-10-26 Hoechst Aktiengesellschaft Pharmaceutical composition for the treatment of high blood pressure
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
DE3739690A1 (de) * 1987-11-24 1989-06-08 Hoechst Ag Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
DE3926606A1 (de) * 1989-08-11 1991-02-14 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
TW197945B (es) * 1990-11-27 1993-01-11 Hoechst Ag
US5562921A (en) * 1994-07-15 1996-10-08 Sherman; Bernard C. Stable solid pharmaceutical compositions containing enalapril maleate
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
DE19737224A1 (de) * 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
ATE313319T1 (de) * 1999-03-31 2006-01-15 Janssen Pharmaceutica Nv Vorgelatinierte stärke in einer formulierung mit gesteuerter freigabe
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
TR200200515T2 (tr) * 1999-08-30 2002-11-21 Aventis Pharma Deutschland Gmbh Renin-anjiyotensin sistem önleyicilerinin kardiyovasküler vakaların engellenmesinde kullanılması.
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2824477B1 (fr) * 2001-05-09 2005-09-09 Ethypharm Lab Prod Ethiques Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes
ATE361758T1 (de) * 2001-06-22 2007-06-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend eine feste dispersion eines im wasser schwerlöslichen arzneimittels und ein löslichkeitsteigerndes polymer
PT1404300E (pt) * 2001-06-22 2009-11-09 Bend Res Inc Composições farmacêuticas de dispersões de fármacos e polímeros neutros
WO2003000226A2 (en) * 2001-06-22 2003-01-03 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
WO2003013609A1 (en) * 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Sustained-release medicines
EP1428022A1 (en) * 2001-09-12 2004-06-16 National Research Council of Canada A method for the simultaneous and direct determination of serum cholesterol in high-and low-density lipoproteins using infrared spectroscopy
US20050065203A1 (en) * 2001-10-17 2005-03-24 Salim Yusuf Method of reducing type 2 diabetes in high risk patients
WO2003037301A2 (en) * 2001-10-29 2003-05-08 King Pharmaceuticals Research And Development, Inc Oral dosage forms for improving the bioavailability of therapeutic agents
WO2004064809A1 (en) * 2003-01-22 2004-08-05 Sandoz Ag Solid pharmaceutical composition comprising ramipril
PT1635792E (pt) * 2003-06-26 2009-05-15 Teva Pharma Composições farmacêuticas estáveis de derivados do ácido 2-aza-biciclo[3.3.0]octano-3-carboxílico
WO2006052968A2 (en) * 2004-11-05 2006-05-18 King Pharmaceuticals Research & Development, Inc. Stabilized ramipril compositions and methods of making
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation

Also Published As

Publication number Publication date
WO2006052968A3 (en) 2006-10-12
CN101098681A (zh) 2008-01-02
AU2005304664A1 (en) 2006-05-18
JP2008519063A (ja) 2008-06-05
NO20072739L (no) 2007-07-24
CA2586547A1 (en) 2006-05-11
WO2006050533A3 (en) 2006-09-14
IL183017A0 (en) 2007-09-20
KR20070085754A (ko) 2007-08-27
US20060134213A1 (en) 2006-06-22
NO20072741L (no) 2007-08-03
ZA200704768B (en) 2008-08-27
MX2007005373A (es) 2007-08-14
BRPI0517663A (pt) 2008-10-14
RU2007120821A (ru) 2008-12-10
KR20070085759A (ko) 2007-08-27
CA2586760A1 (en) 2006-05-18
WO2006050533A2 (en) 2006-05-11
AU2005301989A1 (en) 2006-05-11
JP2008519062A (ja) 2008-06-05
US20060159742A1 (en) 2006-07-20
BRPI0517662A (pt) 2008-10-14
EP1824451A2 (en) 2007-08-29
EP1817007A2 (en) 2007-08-15
CN101098679A (zh) 2008-01-02
IL183018A0 (en) 2007-09-20
WO2006052968A2 (en) 2006-05-18
RU2007120817A (ru) 2008-12-10
ZA200704767B (en) 2008-08-27

Similar Documents

Publication Publication Date Title
MX2007005377A (es) Particulas de ramiprilo estabilizadas, individualmente recubiertas, composiciones y metodos.
ES2331991T3 (es) (+)-2-(1-(3-etoxi-4-metoxifenil)-2-metilsulfoniletil)-4-acetilaminoisoindolin-1,3-diona para usar en el tratamiento de la psoriasis mediante administracion oral.
EP2201947A3 (en) Use of SAHA for treating mesothelioma
WO2012035559A3 (en) Sustained release pharmaceutical compositions comprising pregabalin
WO2005039498A3 (en) Methods of treating cancer with hdac inhibitors
HK1096034A1 (en) A solid dosage form comprising a fibrate
US20060222703A1 (en) Pharmaceutical composition and preparation method thereof
GB0814302D0 (en) Compounds and methods
MY143549A (en) Compositions for external application, containing adenosyl cobalamin for improvement of skin diseases
WO2004108162A3 (en) Controlled release pharmaceutical composition
MXPA05008138A (es) Composiciones orales de fenretinida que tienen biodisponibilidad incrementada y metodos de uso de las mismas.
WO2008146016A3 (en) Cyclodextrins for administering fatty acids in tablets
MX2010004556A (es) Formulacion farmaceutica de acido clavulanico.
JP2022107687A (ja) ペメトレキセドまたはその薬剤学的に許容可能な塩を含有する安定化された薬学組成物
NZ594669A (en) Oral composition of Vorinostat
EP1778209B8 (en) Methods and compositions for oral delivery of fts
MXPA06000332A (es) Nueva composicion farmaceutica solida que comprende amisulprida.
MX2011007771A (es) Composiciones farmaceuticas que comprenden un profarmaco inhibidor de la polimerasa del virus de la hepatitis c (hcv).
WO2010098482A1 (ja) 安定なカプセル製剤及びその製造方法
JP4890657B1 (ja) リマプロストとβ−シクロデキストリンを含有する錠剤
TNSN06072A1 (en) Use of oxcarbazepine for the treatment of diabetic neuropathic pain and the improvement of sleep
JP2008162955A (ja) バリン含有高密度顆粒剤
WO2003070153A3 (en) Stabilized pharmaceutical compositions of halofuginone and other quinazolinone derivatives
WO2011108882A3 (ko) 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물
MX2023001572A (es) Formas farmaceuticas sólidas de palbociclib.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal