MX169605B - Procedimiento para la preparacion de hidroxialquil-1 nitroimidazoles - Google Patents

Procedimiento para la preparacion de hidroxialquil-1 nitroimidazoles

Info

Publication number
MX169605B
MX169605B MX014535A MX1453589A MX169605B MX 169605 B MX169605 B MX 169605B MX 014535 A MX014535 A MX 014535A MX 1453589 A MX1453589 A MX 1453589A MX 169605 B MX169605 B MX 169605B
Authority
MX
Mexico
Prior art keywords
formula
nitroimidazoles
iii
hydroxialkyl
procedure
Prior art date
Application number
MX014535A
Other languages
English (en)
Inventor
Viviane Massonneau
Michel Mulhauser
Albert Buforn
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of MX169605B publication Critical patent/MX169605B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Detergent Compositions (AREA)

Abstract

La presente invención se refiere a procedimiento para la preparación de un hidroxialquil-1 nitroimidazol, caracterizado en que se hace reaccionar un ácido fuerte en presencia del sulfito o del diacetato de un alquilendiol puede estar substituído por un radical metilo, sobre un derivado del imidazol, la parte alcohílo contiene de 1 a 4 átomos de carbono o aciloximetilo donde la parte acilo contiene de 1 a 4 átomos de carbono en cadena recta o ramificada o un radical etilenico alílico o un radical arilmetilo, a una temperatura comprendida entre 80 y 140 grados C, despues se hidroliza o alcoholiza el producto de condensación obtenido y se aisla el hidroxialquil-1 nitroimidazol.
MX014535A 1988-01-15 1989-01-13 Procedimiento para la preparacion de hidroxialquil-1 nitroimidazoles MX169605B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR888800417A FR2625999B1 (fr) 1988-01-15 1988-01-15 Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles

Publications (1)

Publication Number Publication Date
MX169605B true MX169605B (es) 1993-07-14

Family

ID=9362338

Family Applications (1)

Application Number Title Priority Date Filing Date
MX014535A MX169605B (es) 1988-01-15 1989-01-13 Procedimiento para la preparacion de hidroxialquil-1 nitroimidazoles

Country Status (23)

Country Link
US (1) US4925951A (es)
EP (1) EP0325513B1 (es)
JP (1) JPH01216977A (es)
KR (1) KR890011857A (es)
CN (1) CN1023220C (es)
AT (1) ATE87913T1 (es)
AU (1) AU608934B2 (es)
CA (1) CA1310328C (es)
DE (1) DE68905830T2 (es)
DK (1) DK14689A (es)
ES (1) ES2054036T3 (es)
FI (1) FI890188A (es)
FR (1) FR2625999B1 (es)
GR (1) GR3007573T3 (es)
HU (1) HU200448B (es)
IE (1) IE890093L (es)
IL (1) IL88946A (es)
MX (1) MX169605B (es)
NO (1) NO171911C (es)
PT (1) PT89445B (es)
SU (1) SU1657059A3 (es)
YU (1) YU7489A (es)
ZA (1) ZA89309B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1023221C (zh) * 1988-01-15 1993-12-22 罗纳·布朗克制药公司 1-烷基-5-硝基咪唑的制备方法
FR2625998B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles
CN100376559C (zh) * 2006-05-22 2008-03-26 浙江苏泊尔制药有限公司 塞克硝唑的制备方法
CN102321028B (zh) * 2011-06-30 2013-12-25 湖北省宏源药业有限公司 一种合成2-甲基-5-硝基咪唑-1-乙醇的方法
KR20190026962A (ko) 2014-09-05 2019-03-13 심바이오믹스 세러퓨틱스 엘엘씨 세균질증 치료에 사용하기 위한 세크니다졸
CA2988082C (en) 2015-06-01 2020-09-29 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1212028A (fr) * 1957-09-20 1960-03-21 Rhone Poulenc Sa Nouveaux dérivés du nitro-5' imidazole et leur préparation
US3178446A (en) * 1961-07-27 1965-04-13 Luso Farmaco Inst Oxyethylation of imidazole compounds
FR3270M (fr) * 1963-10-10 1965-04-26 Rhone Poulenc Sa Nouveaux dérivés de l'imidazole et compositions les contenant.
FR1379787A (fr) * 1963-10-18 1964-11-27 Rhone Poulenc Sa Procédé de préparation de dérivés de l'imidazole
FR1545317A (fr) * 1966-11-26 1968-11-08 Richter Gedeon Vegyeszet Procédé de préparation de dérivés d'imidazoles
GB1277666A (en) * 1969-12-17 1972-06-14 Pfizer Ltd Improvements in the n-alkylation of nitroimidazoles
CN1023221C (zh) * 1988-01-15 1993-12-22 罗纳·布朗克制药公司 1-烷基-5-硝基咪唑的制备方法
FR2625998B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles

Also Published As

Publication number Publication date
FR2625999B1 (fr) 1990-06-08
HUT49587A (en) 1989-10-30
YU7489A (en) 1990-12-31
EP0325513A1 (fr) 1989-07-26
ES2054036T3 (es) 1994-08-01
FR2625999A1 (fr) 1989-07-21
DE68905830D1 (de) 1993-05-13
DK14689D0 (da) 1989-01-13
HU200448B (en) 1990-06-28
GR3007573T3 (es) 1993-08-31
JPH01216977A (ja) 1989-08-30
US4925951A (en) 1990-05-15
NO890160D0 (no) 1989-01-13
DK14689A (da) 1989-07-16
NO890160L (no) 1989-07-17
PT89445B (pt) 1993-09-30
ATE87913T1 (de) 1993-04-15
KR890011857A (ko) 1989-08-23
CA1310328C (fr) 1992-11-17
AU608934B2 (en) 1991-04-18
FI890188A (fi) 1989-07-16
SU1657059A3 (ru) 1991-06-15
CN1035289A (zh) 1989-09-06
ZA89309B (en) 1989-10-25
DE68905830T2 (de) 1993-09-23
CN1023220C (zh) 1993-12-22
EP0325513B1 (fr) 1993-04-07
NO171911B (no) 1993-02-08
IE890093L (en) 1989-07-15
FI890188A0 (fi) 1989-01-13
IL88946A0 (en) 1989-08-15
NO171911C (no) 1993-05-19
IL88946A (en) 1993-03-15
AU2845389A (en) 1989-07-20
PT89445A (pt) 1990-02-08

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