JPS6475485A - Bisnitrourea derivative and antitumor agent - Google Patents

Bisnitrourea derivative and antitumor agent

Info

Publication number
JPS6475485A
JPS6475485A JP23246087A JP23246087A JPS6475485A JP S6475485 A JPS6475485 A JP S6475485A JP 23246087 A JP23246087 A JP 23246087A JP 23246087 A JP23246087 A JP 23246087A JP S6475485 A JPS6475485 A JP S6475485A
Authority
JP
Japan
Prior art keywords
formula
derivative
give
antitumor agent
bisnitrourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP23246087A
Other languages
Japanese (ja)
Inventor
Hiroyuki Sasamori
Chiyuki Hori
Kaoru Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokko Chemical Industry Co Ltd
Original Assignee
Hokko Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokko Chemical Industry Co Ltd filed Critical Hokko Chemical Industry Co Ltd
Priority to JP23246087A priority Critical patent/JPS6475485A/en
Publication of JPS6475485A publication Critical patent/JPS6475485A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I (R is group shown by formula II or formula III). EXAMPLE:1-[beta-D-2',4'-Di(3-(2-chloroethyl)-3-nitrosoureido)-2',3',4',6 '-tetradeoxyara binohexopyranosyl]-imidazole. USE:An antitumor agent. PREPARATION:For example, triacetylkasugamine shown by formula IV (Ac is acetyl) is reacted with imidazole in the presence of Lewis acid, hydrolyzed and the acetyl group is removed to give a diamino derivative shown by formula V. Then this compound is condensed with 2-chloroethyl isocyanate to give a bis-chloroethylurea derivative, which is nitrosated with sodium nitrite to give a compound shown by formula I.
JP23246087A 1987-09-18 1987-09-18 Bisnitrourea derivative and antitumor agent Pending JPS6475485A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23246087A JPS6475485A (en) 1987-09-18 1987-09-18 Bisnitrourea derivative and antitumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23246087A JPS6475485A (en) 1987-09-18 1987-09-18 Bisnitrourea derivative and antitumor agent

Publications (1)

Publication Number Publication Date
JPS6475485A true JPS6475485A (en) 1989-03-22

Family

ID=16939632

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23246087A Pending JPS6475485A (en) 1987-09-18 1987-09-18 Bisnitrourea derivative and antitumor agent

Country Status (1)

Country Link
JP (1) JPS6475485A (en)

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