ES2054036T3 - Procedimiento para la preparacion de hidroxi-alquil-1-metil-2-nitro-5 imidazoles. - Google Patents

Procedimiento para la preparacion de hidroxi-alquil-1-metil-2-nitro-5 imidazoles.

Info

Publication number
ES2054036T3
ES2054036T3 ES89400097T ES89400097T ES2054036T3 ES 2054036 T3 ES2054036 T3 ES 2054036T3 ES 89400097 T ES89400097 T ES 89400097T ES 89400097 T ES89400097 T ES 89400097T ES 2054036 T3 ES2054036 T3 ES 2054036T3
Authority
ES
Spain
Prior art keywords
formula
imidazoles
nitro
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89400097T
Other languages
English (en)
Inventor
Albert Buforn
Viviane Massonneau
Michel Mulhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of ES2054036T3 publication Critical patent/ES2054036T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Detergent Compositions (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE HIDROXI - ALQUIL - 1 NITROIMIDAZOLES DE FORMULA(I) POR ACCION DE UN ACIDO FUERTE (ACIDO SULFONICO) EN PRESENCIA DE UN SULFITO O DE DIACETATO DE UN ALQUILENO DIOL DE FORMULA(II) SOBRE UN DERIVADO DFE IMIDAZOL DE FORMULA(III) SEGUIDO DE LA HIDROLISIS O DE LA ALCOHOLISIS DEL PRODUCTO OBTENIDO. EN LAS FORMULAS (I) Y (III) R ES UN ATOMO DE H O UN RADICAL HIDROCARBONADO. EN LAS FORMULAS (I) Y (II), N ES IGUAL A 2 O 3. EN LAS FORMULA(III), X ES UN ATOMO DE H O UN RADICAL ELIMINABLE POR HIDROLISIS O ALCOHOLISIS.
ES89400097T 1988-01-15 1989-01-12 Procedimiento para la preparacion de hidroxi-alquil-1-metil-2-nitro-5 imidazoles. Expired - Lifetime ES2054036T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR888800417A FR2625999B1 (fr) 1988-01-15 1988-01-15 Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles

Publications (1)

Publication Number Publication Date
ES2054036T3 true ES2054036T3 (es) 1994-08-01

Family

ID=9362338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89400097T Expired - Lifetime ES2054036T3 (es) 1988-01-15 1989-01-12 Procedimiento para la preparacion de hidroxi-alquil-1-metil-2-nitro-5 imidazoles.

Country Status (23)

Country Link
US (1) US4925951A (es)
EP (1) EP0325513B1 (es)
JP (1) JPH01216977A (es)
KR (1) KR890011857A (es)
CN (1) CN1023220C (es)
AT (1) ATE87913T1 (es)
AU (1) AU608934B2 (es)
CA (1) CA1310328C (es)
DE (1) DE68905830T2 (es)
DK (1) DK14689A (es)
ES (1) ES2054036T3 (es)
FI (1) FI890188A (es)
FR (1) FR2625999B1 (es)
GR (1) GR3007573T3 (es)
HU (1) HU200448B (es)
IE (1) IE890093L (es)
IL (1) IL88946A (es)
MX (1) MX169605B (es)
NO (1) NO171911C (es)
PT (1) PT89445B (es)
SU (1) SU1657059A3 (es)
YU (1) YU7489A (es)
ZA (1) ZA89309B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2625998B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles
CN1023221C (zh) * 1988-01-15 1993-12-22 罗纳·布朗克制药公司 1-烷基-5-硝基咪唑的制备方法
CN100376559C (zh) * 2006-05-22 2008-03-26 浙江苏泊尔制药有限公司 塞克硝唑的制备方法
CN102321028B (zh) * 2011-06-30 2013-12-25 湖北省宏源药业有限公司 一种合成2-甲基-5-硝基咪唑-1-乙醇的方法
WO2016037131A1 (en) 2014-09-05 2016-03-10 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
US11253501B2 (en) 2015-06-01 2022-02-22 Lupin Inc. Secnidazole formulations and use in treating bacterial vaginosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1212028A (fr) * 1957-09-20 1960-03-21 Rhone Poulenc Sa Nouveaux dérivés du nitro-5' imidazole et leur préparation
US3178446A (en) * 1961-07-27 1965-04-13 Luso Farmaco Inst Oxyethylation of imidazole compounds
FR3270M (fr) * 1963-10-10 1965-04-26 Rhone Poulenc Sa Nouveaux dérivés de l'imidazole et compositions les contenant.
FR1379787A (fr) * 1963-10-18 1964-11-27 Rhone Poulenc Sa Procédé de préparation de dérivés de l'imidazole
FR1545317A (fr) * 1966-11-26 1968-11-08 Richter Gedeon Vegyeszet Procédé de préparation de dérivés d'imidazoles
GB1277666A (en) * 1969-12-17 1972-06-14 Pfizer Ltd Improvements in the n-alkylation of nitroimidazoles
FR2625998B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles
CN1023221C (zh) * 1988-01-15 1993-12-22 罗纳·布朗克制药公司 1-烷基-5-硝基咪唑的制备方法

Also Published As

Publication number Publication date
CN1035289A (zh) 1989-09-06
MX169605B (es) 1993-07-14
IE890093L (en) 1989-07-15
NO171911C (no) 1993-05-19
CA1310328C (fr) 1992-11-17
FI890188A0 (fi) 1989-01-13
DE68905830D1 (de) 1993-05-13
FR2625999B1 (fr) 1990-06-08
JPH01216977A (ja) 1989-08-30
AU608934B2 (en) 1991-04-18
NO171911B (no) 1993-02-08
DK14689D0 (da) 1989-01-13
DE68905830T2 (de) 1993-09-23
EP0325513A1 (fr) 1989-07-26
FR2625999A1 (fr) 1989-07-21
ZA89309B (en) 1989-10-25
KR890011857A (ko) 1989-08-23
FI890188A (fi) 1989-07-16
PT89445B (pt) 1993-09-30
DK14689A (da) 1989-07-16
NO890160L (no) 1989-07-17
AU2845389A (en) 1989-07-20
HU200448B (en) 1990-06-28
US4925951A (en) 1990-05-15
ATE87913T1 (de) 1993-04-15
YU7489A (en) 1990-12-31
CN1023220C (zh) 1993-12-22
IL88946A (en) 1993-03-15
IL88946A0 (en) 1989-08-15
PT89445A (pt) 1990-02-08
HUT49587A (en) 1989-10-30
NO890160D0 (no) 1989-01-13
SU1657059A3 (ru) 1991-06-15
GR3007573T3 (es) 1993-08-31
EP0325513B1 (fr) 1993-04-07

Similar Documents

Publication Publication Date Title
ATE271546T1 (de) Herstellung von 1,3-disubstituierter imidazolsalzen
MX5769A (es) Procedimiento para la preparacion de derivados de eter de 1-triazoliletilo y producto obtenido
ES2028444T3 (es) Procedimiento para la preparacion de hidroxialquil-1 nitro-5 imidazoles.
ES2038623T3 (es) Procedimiento para preparar soluciones de oxazafosforinas con estabilidad mejorada.
ES2054036T3 (es) Procedimiento para la preparacion de hidroxi-alquil-1-metil-2-nitro-5 imidazoles.
YU217181A (en) Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles
ES2054035T3 (es) Procedimiento para la preparacion de alquil-1 nitro-5 imidazoles.
TW344741B (en) Process for the preparation of alkylimidazolidone (meth)acrylates
EP0358484A3 (en) Process for preparation of 1-benzylimidazole compound, and its compound
JPS6475485A (en) Bisnitrourea derivative and antitumor agent
RO95699A2 (ro) Derivati de 1,1' -oxibis-2n-benzamido-benzen si procedeu de prepararea acestora

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 325513

Country of ref document: ES