MEP8509A - Combination treatment for diabetes mellitus - Google Patents

Combination treatment for diabetes mellitus

Info

Publication number
MEP8509A
MEP8509A MEP-85/09A MEP8509A MEP8509A ME P8509 A MEP8509 A ME P8509A ME P8509 A MEP8509 A ME P8509A ME P8509 A MEP8509 A ME P8509A
Authority
ME
Montenegro
Prior art keywords
diabetes mellitus
combination treatment
treatment
hexahydrophenanthridine
pyridin
Prior art date
Application number
MEP-85/09A
Other languages
English (en)
Croatian (hr)
Inventor
Thomas Klein
Anja Blaser
Betna Rudolph
Ulrich Kautz
Jens Selige
Wolfgang Kromer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of MEP8509A publication Critical patent/MEP8509A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
MEP-85/09A 2006-09-07 2007-09-04 Combination treatment for diabetes mellitus MEP8509A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120305 2006-09-07
PCT/EP2007/059253 WO2008028914A1 (en) 2006-09-07 2007-09-04 Combination treatment for diabetes mellitus

Publications (1)

Publication Number Publication Date
MEP8509A true MEP8509A (en) 2011-12-20

Family

ID=38441474

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-85/09A MEP8509A (en) 2006-09-07 2007-09-04 Combination treatment for diabetes mellitus

Country Status (17)

Country Link
US (2) US20100179131A1 (pt)
EP (2) EP2063890A1 (pt)
JP (1) JP2010502670A (pt)
KR (1) KR20090047546A (pt)
CN (1) CN101511364B (pt)
AU (1) AU2007293885A1 (pt)
BR (1) BRPI0716134A2 (pt)
CA (1) CA2662084A1 (pt)
EA (1) EA200900392A1 (pt)
IL (1) IL196869A0 (pt)
ME (1) MEP8509A (pt)
MX (1) MX2009002282A (pt)
NO (1) NO20091260L (pt)
NZ (1) NZ574710A (pt)
UA (1) UA100497C2 (pt)
WO (1) WO2008028914A1 (pt)
ZA (1) ZA200900501B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2349324T1 (en) 2008-10-17 2018-01-31 Sanofi-Aventis Deutschland Gmbh The combination of insulin and agonist GLP-1
JP5980466B2 (ja) * 2009-11-13 2016-08-31 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン及びメトホルミンへの付加療法を含む2型糖尿病の治療方法
AU2009238271B8 (en) * 2009-11-13 2014-05-15 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin
AR078973A1 (es) 2009-11-13 2011-12-14 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
KR101836070B1 (ko) 2009-11-13 2018-03-09 사노피-아벤티스 도이칠란트 게엠베하 Glp-1 작용제, 인슐린 및 메티오닌을 포함하는 약제학적 조성물
AU2009238272B2 (en) * 2009-11-13 2014-05-08 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to metformin
CN101747426B (zh) * 2009-12-18 2013-01-16 深圳翰宇药业股份有限公司 一种合成普兰林肽的方法
CN101798301A (zh) * 2010-04-13 2010-08-11 漆又毛 吡咯烷基嘧啶甲磺酰胺衍生物及制备方法
SI2611458T1 (sl) 2010-08-30 2017-01-31 Sanofi-Aventis Deutschland Gmbh Uporaba AVE0010 za izdelavo zdravila za zdravljenje sladkorne bolezni tipa 2
TWI462739B (zh) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途
EP2468268B1 (en) * 2010-12-21 2017-12-13 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Combination composition of vildagliptin and gliclazide
TR201101809A1 (tr) * 2010-12-21 2012-07-23 Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Vildagliptin ve glimepirid kombinasyonları.
TR201107482A1 (tr) * 2010-12-21 2012-07-23 Sanovel İlaç San.Ve Ti̇c.A.Ş. Vildagliptin ve gliklazidin iki tabakalı kombinasyon kompozisyonu.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
MX370264B (es) 2011-08-29 2019-12-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2.
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
WO2014124860A1 (en) 2013-02-14 2014-08-21 Boehringer Ingelheim International Gmbh Specific pde4b-inhibitors for the treatment of diabetes mellitus
US10132302B2 (en) * 2013-07-22 2018-11-20 Baxter International Inc. Infusion pump including reverse loading protection
US10105442B2 (en) 2014-05-07 2018-10-23 Novo Nordisk A/S Treatment of diabetes type 1 using GLP-1 and anti-IL-21
CN108025060A (zh) * 2014-06-08 2018-05-11 瑞美德生物医药科技有限公司 使用胰高血糖素受体拮抗性抗体治疗1型糖尿病的方法
HUE062573T2 (hu) 2014-12-12 2023-11-28 Sanofi Aventis Deutschland Glargin inzulin/lixiszenatid rögzített arányú készítmény
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
JP7048863B2 (ja) * 2016-08-26 2022-04-06 武田薬品工業株式会社 非アルコール性脂肪肝疾患の治療法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
DE3856378T2 (de) 1987-09-04 2000-05-11 Beecham Group Plc Substituierte Thiazolidindionderivate
IE61928B1 (en) 1988-11-29 1994-11-30 Boots Co Plc Treatment of obesity
EP0567626B1 (en) 1991-11-19 2001-09-19 Amylin Pharmaceuticals, Inc. Amylin agonist peptides and uses therefor
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
JP2845743B2 (ja) 1992-12-28 1999-01-13 三菱化学株式会社 新規なナフタレン誘導体
DE4439947A1 (de) 1994-11-09 1996-05-15 Boehringer Mannheim Gmbh 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CZ293016B6 (cs) 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
ATE205477T1 (de) 1995-06-06 2001-09-15 Pfizer Substituierte n-(indol-2-carbonyl)-amide und derivate als glycogen phosphorylase inhibitoren
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
CZ300837B6 (cs) 1996-08-30 2009-08-26 Novo Nordisk A/S Deriváty GLP-1(7-37) nebo jeho analogy, farmaceutický prostredek je obsahující a jejich použití
JP2001512307A (ja) 1997-02-05 2001-08-21 1149336 オンタリオ インコーポレーテッド プロエキセンジンをコードするポリヌクレオチドならびにその作製方法および使用
JP2001516765A (ja) * 1997-09-12 2001-10-02 ヴォルフ ゲオルグ フォースマン 真性糖尿病及び肥満の治療のための組成物
DE19823831A1 (de) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
US6428852B1 (en) 1998-07-02 2002-08-06 Mykrolis Corporation Process for coating a solid surface with a liquid composition
FR2783246B1 (fr) 1998-09-11 2000-11-17 Aventis Pharma Sa Derives d'azetidine, leur preparation et les medicaments les contenant
DE19844547C2 (de) 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR100353014B1 (ko) 1998-11-11 2002-09-18 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
JP3702181B2 (ja) 1998-12-07 2005-10-05 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Glp−1の類似体
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
GB9900416D0 (en) 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US6417208B1 (en) 1999-02-05 2002-07-09 Albert Einstein College Of Medicine Of Yeshiva University Method of identification of inhibitors of PDE1C
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
AU767558B2 (en) 1999-09-16 2003-11-13 Mitsubishi Tanabe Pharma Corporation Aromatic nitrogenous six-membered ring compounds
TWI302149B (en) 1999-09-22 2008-10-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
WO2001035979A2 (en) * 1999-11-13 2001-05-25 Icos Corporation Combined pde3 and pde4 inhibitor therapy for the treatment of obesity
SE9904413D0 (sv) 1999-12-03 1999-12-03 Astra Ab Comminuted form
US6965033B2 (en) 1999-12-22 2005-11-15 Metabasis Therapeutics, Inc. Bisamidate phosphonate prodrugs
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US20020165237A1 (en) * 2000-08-11 2002-11-07 Fryburg David Albert Treatment of the insulin resistance syndrome
KR20030023747A (ko) 2000-08-11 2003-03-19 화이자 인코포레이티드 인슐린 저항성 증후군의 치료
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
WO2002060422A2 (en) 2001-02-02 2002-08-08 Pfizer Limited Treatment of diabetes mellitus using vardenafil
BR0210190A (pt) 2001-06-07 2004-04-06 Lilly Co Eli Moduladores de receptores ativados de proliferador de peroxissomo
DE60222667T2 (de) 2001-06-27 2008-07-17 Smithkline Beecham Corp. Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
DE10150517A1 (de) 2001-10-12 2003-04-17 Merck Patent Gmbh Verwendung von Phosphodiesterase IV-Inhibitoren
HUP0401998A2 (hu) 2001-11-02 2005-01-28 Pfizer Products Inc., PDE9 inhibitorok alkalmazása olyan gyógyszer előállítására, amellyel inzulin-rezisztencia szindróma és 2-es típusú diabétesz kezelhető
EP1463752A4 (en) 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
WO2003077949A2 (en) 2002-03-14 2003-09-25 Bayer Pharmaceuticals Corporation Methods of treating diabetes using pde 11a inhibitors
JP2006520777A (ja) 2003-03-17 2006-09-14 ファイザー・プロダクツ・インク Pde5阻害剤を用いる1型糖尿病の治療
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
DE10327439A1 (de) * 2003-06-18 2005-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazopyridazinon- und Imidazopyridonderivate, deren Herstellung und deren Verwendung als Arzneimittel
EP1641794A1 (en) 2003-06-30 2006-04-05 ALTANA Pharma AG Novel pyrrolodihydroisoquinolines useful in the treatment of cancer
AU2004257645A1 (en) * 2003-07-07 2005-01-27 David H. Wagner Methods for predicting development of auto-immune diseases and treatment of same
US20070032404A1 (en) 2003-07-31 2007-02-08 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
JP2007504201A (ja) 2003-09-05 2007-03-01 アルタナ ファルマ アクチエンゲゼルシャフト 真性糖尿病の治療のためのpde4阻害剤の使用
WO2005085225A1 (en) * 2004-03-03 2005-09-15 Altana Pharma Ag Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors
NZ549716A (en) 2004-03-15 2010-04-30 Takeda Pharmaceutical Pyrimidin-dione derivatives as dipeptidyl peptidase inhibitors
CA2568929A1 (en) 2004-06-07 2005-12-22 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
WO2006087481A1 (fr) * 2005-02-21 2006-08-24 Sanofi-Aventis Utilisation du rimonabant pour la preparation de medicaments utiles dans la prevention et le traitement du diabete du type 2
KR101421914B1 (ko) 2005-03-02 2014-07-22 다케다 게엠베하 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염
NZ560269A (en) * 2005-03-08 2010-12-24 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus

Also Published As

Publication number Publication date
AU2007293885A1 (en) 2008-03-13
CA2662084A1 (en) 2008-03-13
US20120129817A1 (en) 2012-05-24
NZ574710A (en) 2012-02-24
IL196869A0 (en) 2009-11-18
UA100497C2 (ru) 2013-01-10
EP2063890A1 (en) 2009-06-03
ZA200900501B (en) 2010-02-24
NO20091260L (no) 2009-03-26
CN101511364A (zh) 2009-08-19
JP2010502670A (ja) 2010-01-28
CN101511364B (zh) 2012-08-15
KR20090047546A (ko) 2009-05-12
WO2008028914A1 (en) 2008-03-13
BRPI0716134A2 (pt) 2013-09-17
US20100179131A1 (en) 2010-07-15
MX2009002282A (es) 2009-03-20
EP2213289A1 (en) 2010-08-04
EA200900392A1 (ru) 2010-06-30

Similar Documents

Publication Publication Date Title
MEP8509A (en) Combination treatment for diabetes mellitus
MX2007010560A (es) Roflumilast para el tratamiento de diabetes mellitus.
UY30364A1 (es) Arilimidazolonas y ariltriazolonas sustituidas asi como su uso
EA201000089A1 (ru) Применение гомо- и сополимеров для стабилизации составов активных ингредиентов
HN2009000784A (es) Dihidropirazolonas sustituidas
CL2008000592A1 (es) Compuestos derivados de pirrol sustituido, supresores de la secrecion de acidos; composicion farmaceutica; y uso en el tratamiento o profilaxis en enfermedades tales como ulcera peptica, gastritis, esofagitis, entre otras.
GB0625648D0 (en) Compounds
ZA200807274B (en) Novel pyridine derivatives
TW200639173A (en) Substituted pyrazolopyridines, compositions containing same, manufacturing process therefor and use thereof
EA200802428A1 (ru) Комбинации агентов для биологической борьбы и нематоцидов, входящих в покрытие семян
DOP2009000205A (es) 4-aril-1,4-dihidro-1,6-naftiridinamidas sustituidas y su uso
CR10838A (es) Derivados de 2,3-dihidroimidazol [1,2-c] quinazolina sustituidos, de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis
PA8671301A1 (es) Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricación y utilización
HRP20090511T1 (en) Compositions for vaginal use
CL2007002346A1 (es) Compuestos no nucleosidicos derivados de fenoxi-fenil sustituidos, inhibidores de la transcriptasa inversa del vih; composicion farmaceutica; y su uso para tratar prevenir una infeccion vih o para tratar el sida o crs.
EA200701820A1 (ru) Применение диосметиновых соединений при лечении и профилактике тромботических патологий
UA98658C2 (uk) Циклічні депсипептиди
ECSP088745A (es) Derivados sustituidos de cromanol y su uso
CL2007002671A1 (es) Compuestos derivados de octahidro-pirrolo[3,4-c]pirrol; composicion farmaceutica que la comprende; y uso del compuesto en el tratamiento del vih, sida o arc.
TR201901390T4 (tr) Demodikoza karşı madde.
CL2008003546A1 (es) Compuestos derivados de piridina; procedimiento de preparacion; composicion farmaceutica de dichos compuestos; y uso en el tratamiento y/o profilaxis de la diabetes mellitus tipo i y/o tipo ii.
EA200901406A1 (ru) Чистящий блок для туалета
GT200600106A (es) Agentes endoparasiticidas
CL2008003602A1 (es) Compuestos derivados de triazolotriazinas y triazolopirazinas sustituidas; composicion farmaceutica; y su uso en el tratamiento y/o profilaxis de trastornos hematologicos.
DK1838716T3 (da) Olanzapinpamota-dihydrat