MEP15808A - Pirimidini supstituisani sulfoksaminima kao cdk-i/ili vegf-inhibitori, njihovo dobijanje i primjena kao lijeka - Google Patents

Pirimidini supstituisani sulfoksaminima kao cdk-i/ili vegf-inhibitori, njihovo dobijanje i primjena kao lijeka

Info

Publication number
MEP15808A
MEP15808A MEP-158/08A MEP15808A MEP15808A ME P15808 A MEP15808 A ME P15808A ME P15808 A MEP15808 A ME P15808A ME P15808 A MEP15808 A ME P15808A
Authority
ME
Montenegro
Prior art keywords
sulfoximine
cdk
drugs
production
substituted pyrimidines
Prior art date
Application number
MEP-158/08A
Other languages
English (en)
Inventor
Ulrich Luecking
Martin Krueger
Rolf Jautelat
Gerhard Siemeister
Original Assignee
Bayer Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Ag filed Critical Bayer Schering Ag
Publication of MEP15808A publication Critical patent/MEP15808A/bs
Publication of ME00158B publication Critical patent/ME00158B/me

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Virology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
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Abstract

Predloženi pronalazak se odnosi na pirimidin-derivate opšte formule (I), u kojoj Q, R1, R2, R3, R4, R5, X i m imaju ono u opisu sadržano značenje, kao inhibitore ciklin-zavisnih kinaza i VEGF-receptortirozinkinaza, njihovo dobijanje kao i njihovu primjenu kao lijeka za liječenje različitih oboljenja
MEP-2008-158A 2003-10-16 2004-10-12 Pirimidini supstituisani sulfoksiiminima kao cdk-i/ili vegf-inhibitori, njihovo dobijanje i primjena kao lijeka ME00158B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349423A DE10349423A1 (de) 2003-10-16 2003-10-16 Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
PCT/EP2004/011661 WO2005037800A1 (de) 2003-10-16 2004-10-12 Sulfoximinsubstituierte pyrimidine als cdk- und/oder vegf-inhibitoren, deren herstellung und verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
MEP15808A true MEP15808A (bs) 2010-06-10
ME00158B ME00158B (me) 2010-10-10

Family

ID=34442222

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-158A ME00158B (me) 2003-10-16 2004-10-12 Pirimidini supstituisani sulfoksiiminima kao cdk-i/ili vegf-inhibitori, njihovo dobijanje i primjena kao lijeka

Country Status (35)

Country Link
US (2) US8507510B2 (bs)
EP (1) EP1673352B1 (bs)
JP (1) JP4700006B2 (bs)
KR (1) KR101117387B1 (bs)
CN (1) CN1867553B (bs)
AR (1) AR046119A1 (bs)
AT (1) ATE427939T1 (bs)
AU (1) AU2004281960B2 (bs)
BR (1) BRPI0415421A (bs)
CA (1) CA2542492C (bs)
CR (1) CR8363A (bs)
CY (1) CY1110058T1 (bs)
DE (2) DE10349423A1 (bs)
DK (1) DK1673352T3 (bs)
EC (1) ECSP066568A (bs)
ES (1) ES2324475T3 (bs)
GT (1) GT200400206A (bs)
HR (1) HRP20090348T1 (bs)
IL (1) IL174952A (bs)
JO (1) JO2534B1 (bs)
ME (1) ME00158B (bs)
MX (1) MXPA06004091A (bs)
MY (1) MY140291A (bs)
NO (1) NO337290B1 (bs)
NZ (1) NZ546510A (bs)
PE (1) PE20050907A1 (bs)
PL (1) PL1673352T3 (bs)
PT (1) PT1673352E (bs)
RS (1) RS51657B (bs)
RU (1) RU2410378C2 (bs)
SI (1) SI1673352T1 (bs)
TW (1) TWI347844B (bs)
UA (1) UA86041C2 (bs)
WO (1) WO2005037800A1 (bs)
ZA (1) ZA200603885B (bs)

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