ME03802B - Rezim doziranja agonista s1p receptora - Google Patents
Rezim doziranja agonista s1p receptoraInfo
- Publication number
- ME03802B ME03802B MEP-2020-156A MEP2020156A ME03802B ME 03802 B ME03802 B ME 03802B ME P2020156 A MEP2020156 A ME P2020156A ME 03802 B ME03802 B ME 03802B
- Authority
- ME
- Montenegro
- Prior art keywords
- dose
- receptor
- agonist
- product
- use according
- Prior art date
Links
- 229940044601 receptor agonist Drugs 0.000 title claims 9
- 239000000018 receptor agonist Substances 0.000 title 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims 14
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims 14
- 239000000556 agonist Substances 0.000 claims 9
- 229940075993 receptor modulator Drugs 0.000 claims 8
- 238000011287 therapeutic dose Methods 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 6
- 238000011283 initial treatment period Methods 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- 238000000159 protein binding assay Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (11)
1. Upotreba modulatora ili agonista S1P receptora u proizvodnji leka za lečenje autoimunske bolesti, pri čemu je autoimunska bolest izabrana sa liste koja se sastoji od multiple skleroze, polimiozitisa, lupus nefritisa, reumatoidnog artritisa, zapaljenske bolesti creva i psorijaze, pri čemu se, pre otpočinjanja primene modulatora ili agonista SIP receptora u standardnoj dnevnoj terapijskoj dozi, navedeni modulator ili agonist S1P receptora primenjuje u dnevnoj dozi koja je niža od standardne dnevne terapijske doze tokom početnog perioda lečenja i pri čemu je najviša početna doza izmedu 0,01 mg i 0,30 mg.
2. Modulator ili agonist S1P receptora za upotrebu u lečenju autoimunske bolesti, pri čemu je autoimunska bolest izabrana sa liste koja se sastoji od multiple skleroze, polimiozitisa, lupus nefritisa, reumatoidnog artritisa, zapaljenske bolesti creva i psorijaze, pri čemu se, pre otpočinjanja primene modulatora ili agonista S1P receptora u standardnoj dnevnoj terapijskoj dozi, navedeni modulator ili agonist S1P receptora primenjuje u dnevnoj dozi koja je niža od standardne dnevne terapijske doze tokom početnog perioda lečenja i pri čemu je najviša početna doza izmedu 0,01 mg i 0,30 mg.
3. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što početni period lečenja je izabran iz grupe koja se sastoji od:do 10 dana i 5 do 14 dana.
4. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što se ista doza daje u toku prvih 2 do 4 dana lečenja pre povećanja doze.
5. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što se ista doza daje u toku prvih 4 dana lečenja pre povećanja doze.
6. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što u poetnom periodu lečenja dnevna doza je povećavana postepeno do 6 puta do standardne dnevne terapijske doze i zatim se lečenje nastavlja sa standardnom terapijskomdnevnom dozom.
7. Upotreba ili proizvod za upotrebu prema bilo kom od patentnih zahteva 1-8, naznačeni time što se tokom početnog perioda lečenja javlja samo jedno povećanje doze pre davanja standardne dnevne terapijske doze.
8. Upotreba ili proizvod za upotrebu prema bilo kom od patentnih zahteva 1-8, naznačeni time to je u toku početnog perioda lečenja doza povećana samo jednom da bi se dostigla standardna dnevna terapijska doza.
9. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što je modulator ili agonist S1P receptora selektivan za S1P1receptor.
10. Upotreba ili proizvod za upotrebu prema patentnom zahtevu 9, naznačeni time što modulator ili agonist S1P receptora poseduje selektivnost za S1P1 receptor u odnosu na S1P3 receptor od najmanje 20, 100, 500, 1000 ili 2000 puta više, kao to je mereno preko odnosa EC50 za S1P1receptor prema EC50 za S1P3 receptor kao to je mereno preko analize vezivanja 35S-GTPγS i pri čemu navedeni modulator ili agonist S1P receptora ima EC50 za vezivanje za S1P1 receptor od 100 nM ili manje kao to je procenjivano preko analize vezivanja 35S-GTPγS.
11. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time, bolest je multipla skleroza.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13967208P | 2008-12-22 | 2008-12-22 | |
| US21853009P | 2009-06-19 | 2009-06-19 | |
| US24671509P | 2009-09-29 | 2009-09-29 | |
| EP18201062.9A EP3453387B1 (en) | 2008-12-22 | 2009-12-21 | Dosage regimen for a s1p receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03802B true ME03802B (me) | 2021-04-20 |
Family
ID=41667217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2020-156A ME03802B (me) | 2008-12-22 | 2009-12-21 | Rezim doziranja agonista s1p receptora |
| MEP-2019-339A ME03594B (me) | 2008-12-22 | 2009-12-21 | Režim doziranja agonista s1p receptora |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-339A ME03594B (me) | 2008-12-22 | 2009-12-21 | Režim doziranja agonista s1p receptora |
Country Status (43)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2716448A1 (en) | 2008-03-17 | 2009-09-24 | Patrick Brossard | Dosing regimen for a selective s1p1 receptor agonist |
| US20100160259A1 (en) | 2008-12-22 | 2010-06-24 | Robert Schmouder | Dosage regimen for a s1p receptor agonist |
| EP3831371A1 (en) | 2009-09-29 | 2021-06-09 | Novartis AG | Dosage regimen of an s1p receptor modulator |
| US20110124605A1 (en) * | 2009-11-20 | 2011-05-26 | Shreeram Aradhye | Use of an S1P Receptor Agonist |
| EP2528894A1 (en) | 2010-01-27 | 2012-12-05 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| WO2011138398A1 (en) * | 2010-05-06 | 2011-11-10 | Novartis Ag | Dosage regimen of diaryl sulfide derivatives |
| EP2455080A1 (en) * | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
| FR2968556B1 (fr) | 2010-12-13 | 2013-12-27 | Centre Nat Rech Scient | Inhibiteurs des infections a vih et leurs utilisations |
| SG191286A1 (en) | 2011-01-07 | 2013-07-31 | Novartis Ag | Immunosuppressant formulations |
| ES2716865T3 (es) | 2011-02-18 | 2019-06-17 | Scripps Research Inst | Diferenciación dirigida de células precursoras de oligodendrocitos a un destino celular mielinizante |
| AR085749A1 (es) | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| US9592268B2 (en) | 2011-05-23 | 2017-03-14 | Cornell University | Endothelium protective materials and methods of use |
| TW201320994A (zh) | 2011-10-11 | 2013-06-01 | Novartis Ag | 投藥療程 |
| HUE050733T2 (hu) | 2012-08-17 | 2021-01-28 | Actelion Pharmaceuticals Ltd | Eljárás (2Z,5Z)-5-(3-klór-4-((R)-2,3-dihidroxipropoxi)benzilidén)-2-(pro-pilimino)-3-(O-tolil)tiazolidin-4-on elõállítására és ezen eljárásban alkalmazott köztitermék |
| US20160129084A1 (en) * | 2013-03-06 | 2016-05-12 | Acorda Therapeutics, Inc. | Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure |
| EP3054933A4 (en) | 2013-10-11 | 2017-03-15 | Teikoku Pharma USA, Inc. | Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same |
| WO2015053879A1 (en) | 2013-10-11 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same |
| CN106456552A (zh) * | 2014-04-10 | 2017-02-22 | 诺华股份有限公司 | S1p调节剂的立即释放剂量方案 |
| MA41139B1 (fr) | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| HUE057865T2 (hu) | 2014-12-11 | 2022-06-28 | Actelion Pharmaceuticals Ltd | A poneszimodra, egy szelektív S1P1 receptor agonistára vonatkozó adagolási rend |
| CA3002540C (en) * | 2015-01-06 | 2023-11-07 | Arena Pharmaceuticals, Inc. | Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor |
| WO2016135644A1 (en) | 2015-02-26 | 2016-09-01 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩 |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| KR20190113955A (ko) | 2017-02-16 | 2019-10-08 | 아레나 파마슈티칼스, 인크. | 장-외 증상을 갖는 염증성 장질환의 치료를 위한 화합물 및 방법 |
| JP7397011B2 (ja) | 2018-06-06 | 2023-12-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
| CA3156298A1 (en) | 2019-10-31 | 2021-05-06 | Laetitia POUZOL | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| US11135197B2 (en) | 2020-02-07 | 2021-10-05 | Argentum Pharmaceuticals Llc | Dosage regimen of an S1P receptor modulator |
| WO2021158848A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Dosage regimen of an s1p receptor agonist |
| AU2021228371A1 (en) * | 2020-02-28 | 2022-10-13 | Akaal Pharma Pty Ltd | S1P receptor modulators |
| CN113332435B (zh) * | 2021-06-18 | 2022-10-18 | 广州中医药大学(广州中医药研究院) | 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0155015B1 (ko) | 1992-10-21 | 1998-12-01 | 고우야 마사시 | 2-아미노-1,3-프로판디올 화합물 및 면역 억제제 |
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| JP5227492B2 (ja) | 2002-05-16 | 2013-07-03 | ノバルティス アーゲー | 癌におけるｅｄｇレセプター結合剤の使用 |
| WO2005025553A2 (en) * | 2003-09-12 | 2005-03-24 | Neuronova Ab | Treatment of disorders of nervous systemsystem with fty720 |
| US20060002999A1 (en) * | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| EP2384749A1 (en) * | 2004-11-29 | 2011-11-09 | Novartis AG | Dosage regimen of an S1P receptor agonist |
| EP1688141A1 (en) * | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
| CN101541227B (zh) * | 2005-02-10 | 2013-06-05 | G.I.视频有限公司 | 用于带导向元件的胃肠工具的前进技术 |
| WO2009048993A2 (en) * | 2007-10-12 | 2009-04-16 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
| CA2716448A1 (en) * | 2008-03-17 | 2009-09-24 | Patrick Brossard | Dosing regimen for a selective s1p1 receptor agonist |
| WO2009155475A1 (en) * | 2008-06-20 | 2009-12-23 | Novartis Ag | Paediatric compositions for treating1 multiple sclerosis |
| US20100160259A1 (en) | 2008-12-22 | 2010-06-24 | Robert Schmouder | Dosage regimen for a s1p receptor agonist |
| MX367667B (es) * | 2008-12-22 | 2019-08-30 | Novartis Ag | Régimen de dosificación de un agonista de los receptores de s1p. |
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2009
- 2009-12-21 US US12/642,892 patent/US20100160259A1/en not_active Abandoned
- 2009-12-21 SI SI200931311T patent/SI2379067T1/sl unknown
- 2009-12-21 HU HUE09797234A patent/HUE026869T2/en unknown
- 2009-12-21 CA CA2747802A patent/CA2747802C/en active Active
- 2009-12-21 CN CN2009801518640A patent/CN102264359A/zh active Pending
- 2009-12-21 PL PL22187007.4T patent/PL4098256T3/pl unknown
- 2009-12-21 LT LTEP18201062.9T patent/LT3453387T/lt unknown
- 2009-12-21 US US13/141,552 patent/US20110257133A1/en not_active Abandoned
- 2009-12-21 HU HUE18179301A patent/HUE048717T4/hu unknown
- 2009-12-21 EP EP22187007.4A patent/EP4098256B9/en active Active
- 2009-12-21 SG SG2011037629A patent/SG171404A1/en unknown
- 2009-12-21 JP JP2011542521A patent/JP2012513401A/ja not_active Withdrawn
- 2009-12-21 RS RS20250452A patent/RS66784B9/sr unknown
- 2009-12-21 LT LTEP22187007.4T patent/LT4098256T/lt unknown
- 2009-12-21 RS RS20200900A patent/RS60666B1/sr unknown
- 2009-12-21 PL PL09797234T patent/PL2379067T3/pl unknown
- 2009-12-21 HU HUE22187007A patent/HUE071189T2/hu unknown
- 2009-12-21 DK DK18179301.9T patent/DK3409274T3/da active
- 2009-12-21 WO PCT/US2009/068888 patent/WO2010075239A1/en not_active Ceased
- 2009-12-21 DK DK18201062.9T patent/DK3453387T3/da active
- 2009-12-21 EP EP16182876.9A patent/EP3120844A1/en not_active Withdrawn
- 2009-12-21 ME MEP-2020-156A patent/ME03802B/me unknown
- 2009-12-21 PT PT181793019T patent/PT3409274T/pt unknown
- 2009-12-21 BR BRPI0923500-0A patent/BRPI0923500A2/pt not_active Application Discontinuation
- 2009-12-21 LT LTEP18179301.9T patent/LT3409274T/lt unknown
- 2009-12-21 PT PT97972343T patent/PT2379067E/pt unknown
- 2009-12-21 PL PL18201062T patent/PL3453387T3/pl unknown
- 2009-12-21 EP EP09797234.3A patent/EP2379067B1/en not_active Revoked
- 2009-12-21 UY UY0001032352A patent/UY32352A/es not_active Application Discontinuation
- 2009-12-21 PT PT221870074T patent/PT4098256T/pt unknown
- 2009-12-21 PT PT182010629T patent/PT3453387T/pt unknown
- 2009-12-21 KR KR1020117017073A patent/KR101347919B1/ko active Active
- 2009-12-21 EP EP15158251.7A patent/EP2907511A1/en not_active Withdrawn
- 2009-12-21 SM SM20200441T patent/SMT202000441T1/it unknown
- 2009-12-21 NZ NZ593065A patent/NZ593065A/xx not_active IP Right Cessation
- 2009-12-21 AU AU2009330176A patent/AU2009330176C9/en not_active Withdrawn - After Issue
- 2009-12-21 SI SI200932211T patent/SI4098256T1/sl unknown
- 2009-12-21 ES ES18179301T patent/ES2760607T3/es active Active
- 2009-12-21 MX MX2011006623A patent/MX2011006623A/es unknown
- 2009-12-21 DK DK09797234.3T patent/DK2379067T3/en active
- 2009-12-21 EP EP20160225.7A patent/EP3677260A1/en active Pending
- 2009-12-21 FI FIEP22187007.4T patent/FI4098256T3/fi active
- 2009-12-21 HR HRP20250568TT patent/HRP20250568T1/hr unknown
- 2009-12-21 SI SI200932080T patent/SI3453387T1/sl unknown
- 2009-12-21 RS RS20191546A patent/RS59857B1/sr unknown
- 2009-12-21 SM SM20200054T patent/SMT202000054T1/it unknown
- 2009-12-21 HR HRP20151190TT patent/HRP20151190T1/hr unknown
- 2009-12-21 MA MA34034A patent/MA32981B1/fr unknown
- 2009-12-21 HU HUE18201062A patent/HUE052048T2/hu unknown
- 2009-12-21 PL PL18179301T patent/PL3409274T3/pl unknown
- 2009-12-21 ES ES22187007T patent/ES3017254T3/es active Active
- 2009-12-21 ME MEP-2019-339A patent/ME03594B/me unknown
- 2009-12-21 EP EP18201062.9A patent/EP3453387B1/en not_active Revoked
- 2009-12-21 PE PE2011001265A patent/PE20120337A1/es not_active Application Discontinuation
- 2009-12-21 DK DK22187007.4T patent/DK4098256T5/da active
- 2009-12-21 SI SI200932015T patent/SI3409274T1/sl unknown
- 2009-12-21 ES ES09797234.3T patent/ES2552823T3/es active Active
- 2009-12-21 EP EP18179301.9A patent/EP3409274B1/en not_active Revoked
- 2009-12-21 MX MX2018006099A patent/MX385959B/es unknown
- 2009-12-21 AR ARP090105010A patent/AR074826A1/es not_active Application Discontinuation
- 2009-12-21 EA EA201100978A patent/EA201100978A1/ru unknown
- 2009-12-21 TW TW098143960A patent/TW201028143A/zh unknown
- 2009-12-21 ES ES18201062T patent/ES2810823T3/es active Active
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2011
- 2011-05-25 CR CR20110274A patent/CR20110274A/es not_active Application Discontinuation
- 2011-05-25 ZA ZA2011/03863A patent/ZA201103863B/en unknown
- 2011-05-26 TN TN2011000272A patent/TN2011000272A1/fr unknown
- 2011-05-26 IL IL213170A patent/IL213170A0/en unknown
- 2011-06-17 MX MX2021010759A patent/MX2021010759A/es unknown
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