MD960271A - Derivati ai 2-amino-1,2,3,4-tetrahidronaftalinei cu actiune asupra sistemului cardiovascular, procedeu de obtinere a acestora si compozitii farmaceutice care ii contin - Google Patents

Derivati ai 2-amino-1,2,3,4-tetrahidronaftalinei cu actiune asupra sistemului cardiovascular, procedeu de obtinere a acestora si compozitii farmaceutice care ii contin

Info

Publication number
MD960271A
MD960271A MD96-0271A MD960271A MD960271A MD 960271 A MD960271 A MD 960271A MD 960271 A MD960271 A MD 960271A MD 960271 A MD960271 A MD 960271A
Authority
MD
Moldova
Prior art keywords
amino
compozitions
pharmaceutical
processes
preparation
Prior art date
Application number
MD96-0271A
Other languages
English (en)
Other versions
MD1449F1 (ro
MD1449G2 (ro
Inventor
Francesco Santangelo
Giorgio Bertolini
Cesare Casagrande
Francesco Marchini
Stefania Montanari
Claudio Semeraro
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of MD960271A publication Critical patent/MD960271A/ro
Publication of MD1449F1 publication Critical patent/MD1449F1/ro
Publication of MD1449G2 publication Critical patent/MD1449G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
MD96-0271A 1992-03-17 1993-03-13 Derivaţi ai 2-amino-1,2,3,4-tetrahidronaftalinei cu acţiune asupra sistemului cardiovascular, procedeu de obţinere a acestora şi compoziţii farmaceutice care îi conţin MD1449G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920608A IT1254521B (it) 1992-03-17 1992-03-17 Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
PCT/EP1993/000577 WO1993019036A1 (en) 1992-03-17 1993-03-13 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
MD960271A true MD960271A (ro) 1997-09-30
MD1449F1 MD1449F1 (ro) 2000-04-30
MD1449G2 MD1449G2 (ro) 2000-12-31

Family

ID=11362451

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0271A MD1449G2 (ro) 1992-03-17 1993-03-13 Derivaţi ai 2-amino-1,2,3,4-tetrahidronaftalinei cu acţiune asupra sistemului cardiovascular, procedeu de obţinere a acestora şi compoziţii farmaceutice care îi conţin

Country Status (20)

Country Link
US (2) US5407956A (ro)
EP (1) EP0585440B1 (ro)
JP (1) JP3231775B2 (ro)
KR (1) KR100283945B1 (ro)
AT (1) ATE137737T1 (ro)
CA (1) CA2102490C (ro)
DE (1) DE69302544T2 (ro)
DK (1) DK0585440T3 (ro)
ES (1) ES2087729T3 (ro)
FI (1) FI935066A7 (ro)
GR (1) GR3020419T3 (ro)
HU (2) HUT68936A (ro)
IT (1) IT1254521B (ro)
MD (1) MD1449G2 (ro)
NO (1) NO180230C (ro)
NZ (1) NZ249845A (ro)
OA (1) OA09843A (ro)
PL (2) PL172056B1 (ro)
RU (1) RU2120435C1 (ro)
WO (1) WO1993019036A1 (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
IT1271008B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271007B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
IT1271009B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
IT1289980B1 (it) * 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
KR101774598B1 (ko) 2008-12-09 2017-09-04 인터퀴임, 에스.에이. （6ｓ）­（­）­５，６，７，８­테트라하이드로-６-［프로필­（２­티에닐）에틸］아미노­１­나프톨（로티고틴）의 제조를 위한 공정

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072061B1 (en) * 1981-08-05 1985-05-15 FISONS plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0142283B1 (en) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
PL171844B1 (pl) 1997-06-30
IT1254521B (it) 1995-09-25
HUT68936A (en) 1995-08-28
US5451608A (en) 1995-09-19
RU2120435C1 (ru) 1998-10-20
PL172056B1 (pl) 1997-07-31
GR3020419T3 (en) 1996-10-31
AU650201B2 (en) 1994-06-09
JPH06507920A (ja) 1994-09-08
NO934160D0 (no) 1993-11-17
DE69302544D1 (de) 1996-06-13
ITMI920608A0 (it) 1992-03-17
KR100283945B1 (ko) 2001-03-02
HU211517A9 (en) 1995-11-28
NZ249845A (en) 1996-03-26
OA09843A (en) 1994-08-15
US5407956A (en) 1995-04-18
CA2102490C (en) 2004-06-08
AU3747893A (en) 1993-10-21
FI935066L (fi) 1993-11-16
EP0585440B1 (en) 1996-05-08
DE69302544T2 (de) 1996-09-19
NO180230B (no) 1996-12-02
CA2102490A1 (en) 1993-09-18
ATE137737T1 (de) 1996-05-15
JP3231775B2 (ja) 2001-11-26
EP0585440A1 (en) 1994-03-09
FI935066A0 (fi) 1993-11-16
FI935066A7 (fi) 1993-11-16
NO934160L (no) 1993-11-17
ES2087729T3 (es) 1996-07-16
ITMI920608A1 (it) 1993-09-17
MD1449F1 (ro) 2000-04-30
WO1993019036A1 (en) 1993-09-30
NO180230C (no) 1997-03-12
MD1449G2 (ro) 2000-12-31
DK0585440T3 (da) 1996-06-10

Similar Documents

Publication Publication Date Title
TW250435B (ro)
HU913776D0 (en) Process for the production of heparosane-n,o-sulphates, and medical preparations containing them as active agents
CA2125662A1 (en) Transdermally administered system containing acetylsalicylic acid for thrombosis therapy and cancer prophylaxis
OA09843A (en) 2-Amino-1, 2, 3, 4-tetahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
NO891293D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazol - og triazol-derivater.
GB9103764D0 (en) Compositions
HU904007D0 (en) Medical preparations providing regulated active agent discharge and processes for the preparation thereof
NO893909L (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.
CA2051369A1 (en) Thyroid hormone cardiac treatment
MY117006A (en) 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them
NO884176D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive amidinoderivater.
NO891114D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater.
WO1998022099A3 (en) New use of creatine
NZ303993A (en) Pharmaceutical compositions containing aminotetralin derivatives for treating cardiac disorders
HU9201358D0 (en) 2-amino-pirimidine-4-carboxamide derivatives, process for their production and for the production of medical preparations containing them as active agents
NO891046D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,2,4-triazol-derivater.
IT8519907A0 (it) Prodotto farmaceutico cosmetico, in particolare per la cura di acne e seborrea.
DE68905076D1 (de) Pharmazeutische zusammensetzung fuer die behandlung von hautwunden.
NO913644D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
HU910109D0 (en) Process for the production of medical preparations for preventing proline-and lysine-hydroxylase and process for the production of some of the active agents
NO892871D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
CA2151561A1 (en) Hydrazino and hydroxyamino-14.beta.-hydroxyandrostane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
NO882282D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive pyrazin-amider.
NO904470D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater.
IL84012A0 (en) Pharmaceutical composition for the treatment of high blood pressure

Legal Events

Date Code Title Description
PD99 Pending application