MD59C2 - Process for obtaining the 5-piperidino-7-N-(N-pentyl)-N-(b-oxyethyl)-amino)-S-triazolo (1,5-a) pyrimidine - Google Patents

Process for obtaining the 5-piperidino-7-N-(N-pentyl)-N-(b-oxyethyl)-amino)-S-triazolo (1,5-a) pyrimidine

Info

Publication number
MD59C2
MD59C2 MD94-0068A MD940068A MD59C2 MD 59 C2 MD59 C2 MD 59C2 MD 940068 A MD940068 A MD 940068A MD 59 C2 MD59 C2 MD 59C2
Authority
MD
Moldova
Prior art keywords
pyrimidine
triazolo
oxyethyl
piperidino
pentyl
Prior art date
Application number
MD94-0068A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD59B1 (en
Inventor
Ballnus Martina
Tenor Ernst
Thomas Eckehard
Pasche Rudi
Jurgen Mest Hans
Block Hans-Ulrich
Mentz Peter
Heinroth-Hoffman Ingrid
Original Assignee
Rodleben Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rodleben Pharma Gmbh filed Critical Rodleben Pharma Gmbh
Publication of MD59B1 publication Critical patent/MD59B1/en
Publication of MD59C2 publication Critical patent/MD59C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The invention relates to the heterocyclic substances, particularly to the obtaining of the 5-piperidino-7-N-(N-pentyl)-N-(β-oxyethyl)-amino)-S-triazolo (1,5)-pyrimidine possessing vasodilating properties, inotropic and antiarhythmic action that can be used in the medicine.the purpose of the invention consists in the creation of a more active compound of the said class. Its synthesis is realized by means of 5,7-dichlor-S-triazol-(1,5)-pyrimidine reaction with n-pentylethanol-amine at 10-15°C with the subsequent addition of piperidine at 40-50°C, realization of the process in the inferior alcohol medium-ethanol and the product escape with the ratio of 80% and t°C of melting of 117-118°C. The new substance in comparison with the trapidule provides blocking of thrombocytes aggregation and a higher influence on the contracting power of the heart at the toxicity of LD50=230 mg/g againts 150 mg/kg.
MD94-0068A 1984-04-17 1994-02-15 Process for obtaining the 5-piperidino-7-N-(N-pentyl)-N-(b-oxyethyl)-amino)-S-triazolo (1,5-a) pyrimidine MD59C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD84262043A DD228811A1 (en) 1984-04-17 1984-04-17 PROCESS FOR THE PREPARATION OF NEW TRIAZOLOPYRIMIDINES

Publications (2)

Publication Number Publication Date
MD59B1 MD59B1 (en) 1994-08-31
MD59C2 true MD59C2 (en) 1995-01-31

Family

ID=5556238

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0068A MD59C2 (en) 1984-04-17 1994-02-15 Process for obtaining the 5-piperidino-7-N-(N-pentyl)-N-(b-oxyethyl)-amino)-S-triazolo (1,5-a) pyrimidine

Country Status (15)

Country Link
JP (1) JPS60224692A (en)
AT (1) AT391866B (en)
BE (2) BE902218A (en)
CH (1) CH669196A5 (en)
DD (1) DD228811A1 (en)
DE (1) DE3512629C2 (en)
ES (1) ES8706682A1 (en)
FR (1) FR2562895B1 (en)
GB (1) GB2157684B (en)
LT (1) LT2594B (en)
MD (1) MD59C2 (en)
NL (1) NL8501111A (en)
SE (1) SE466104B (en)
SU (1) SU1468423A3 (en)
YU (1) YU47167B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4246C1 (en) * 2012-03-12 2014-03-31 Иван ПРИДА Barrel for aging alcoholic products

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
ATE226936T1 (en) * 1995-08-08 2002-11-15 Ono Pharmaceutical Co HYDROXAMIC ACID DERIVATIVES USABLE FOR INHIBITING GELATINASE
JP2001322933A (en) 2000-05-15 2001-11-20 Ucb Sa Cd40 signal blocker
US8186931B2 (en) 2006-08-17 2012-05-29 Steven Borntrager Powered hand truck

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE61269C (en) * 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Washing machine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD61269A (en) *
CH569734A5 (en) * 1967-07-01 1975-11-28 Hydrierwerk Rodleben Veb 5-and 7-basically subst s-triazolo 1 5-a pyrimidines
DE1720004A1 (en) * 1968-03-08 1971-05-19 Hydrierwerk Rodleben Veb Process for the preparation of s-triazolo (1.5-a) pyrimidines which are substituted in the 5- and 7-positions by basic groups

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE61269C (en) * 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Washing machine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Brevet nr. 70885, DE, Int. cl. C 07 D 57/18, publ. 1970. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4246C1 (en) * 2012-03-12 2014-03-31 Иван ПРИДА Barrel for aging alcoholic products

Also Published As

Publication number Publication date
GB8509561D0 (en) 1985-05-22
SE8501835D0 (en) 1985-04-15
ATA105085A (en) 1990-06-15
NL8501111A (en) 1985-11-18
DE3512629A1 (en) 1986-10-09
GB2157684B (en) 1987-11-11
JPS60224692A (en) 1985-11-09
JPH0455193B2 (en) 1992-09-02
FR2562895B1 (en) 1988-10-07
AT391866B (en) 1990-12-10
FR2562895A1 (en) 1985-10-18
CH669196A5 (en) 1989-02-28
LT2594B (en) 1994-03-25
YU64185A (en) 1992-09-07
DE3512629C2 (en) 1995-07-06
ES542269A0 (en) 1987-07-01
ES8706682A1 (en) 1987-07-01
GB2157684A (en) 1985-10-30
BE903828R (en) 1986-04-01
SE466104B (en) 1991-12-16
BE902218A (en) 1985-08-16
MD59B1 (en) 1994-08-31
SU1468423A3 (en) 1989-03-23
DD228811A1 (en) 1985-10-23
YU47167B (en) 1995-01-31
SE8501835L (en) 1985-10-18

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Legal Events

Date Code Title Description
1M4A Expiration of terms