YU64185A - PROCESS FOR PREPARATION OF NEW S-TRIAZINO (1.5A) PYRIMIDINES - Google Patents

PROCESS FOR PREPARATION OF NEW S-TRIAZINO (1.5A) PYRIMIDINES

Info

Publication number
YU64185A
YU64185A YU64185A YU64185A YU64185A YU 64185 A YU64185 A YU 64185A YU 64185 A YU64185 A YU 64185A YU 64185 A YU64185 A YU 64185A YU 64185 A YU64185 A YU 64185A
Authority
YU
Yugoslavia
Prior art keywords
group
formula
triazino
pyrimidines
preparation
Prior art date
Application number
YU64185A
Other languages
Serbo-Croatian (sh)
Other versions
YU47167B (en
Inventor
M. Ballnus
E. Tenor
E. Thomas
R. Pasche
H.J. Mest
H.U. Block
P. Mentz
I. Heinroth
Original Assignee
Veb Deutsches Hydrierwerk Rodleben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veb Deutsches Hydrierwerk Rodleben filed Critical Veb Deutsches Hydrierwerk Rodleben
Priority to SI8510641A priority Critical patent/SI8510641A/en
Publication of YU64185A publication Critical patent/YU64185A/en
Priority to HR931017A priority patent/HRP931017A2/en
Publication of YU47167B publication Critical patent/YU47167B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

OPISAN JE POSTUPAK ZA DOBIJANJE NOVIH S-TRIAZINO (1,5A) PIRIMIDINA opšte formule: u kojoj R2 i R3 predstavljaju atome vodonika, C1-3alkil grupe ili atome halogena; R4 je C4-9 alkil grupa pravog ili račvastog niza, aralkil grupa supstituisana sa C1-3alkil ili C1-3alkoksi grupom, 2,5-dioksaheptil ili 3-oksaheksil grupa; R5 je atom vodonika, C1-3alkil, hidroksietil ili hidroksipropil grupa; i R6 i R7 predstavljaju atome vodonika, C1-5alkil grupe pravog ili račvastog niza, ili R6 i R7, zajedno sa azotovim atomom za koji su vezani, grade heteroalifatični prsten; pri čemu se grupe NR4R5 i NR6R7 mogu i medjusobno zamenjivati, naznače n time, što jedinjenje formule: u kojoj su R2 i R3 kao što je definisano gore, a Hal predstavlja atom hlora ili broma, u pogodnom rastvaraču, reaguje u dve faze sa aminima formule: gde su R4, R5, R6 i R7 kao što je definisano gore, pri čemu se reakcija sa aminom u prvoj fazi odvija na temperaturi do oko 293 K, a reakcija sa drugim aminom, u drugoj fazi, na temperaturi do tačke ključanja rastvarača.A process for the preparation of novel S-TRIAZINO (1,5A) PYRIMIDINES of the general formula is described: in which R 2 and R 3 represent hydrogen atoms, C 1-3 alkyl groups or halogen atoms; R4 is a straight or branched C4-9 alkyl group, an aralkyl group substituted with a C1-3alkyl or C1-3alkoxy group, a 2,5-dioxaheptyl or 3-oxahexyl group; R5 is a hydrogen atom, a C1-3alkyl, hydroxyethyl or hydroxypropyl group; and R6 and R7 represent hydrogen atoms, a straight or branched C1-5alkyl group, or R6 and R7, together with the nitrogen atom to which they are attached, form a heteroaliphatic ring; wherein the groups NR4R5 and NR6R7 may also be interchanged, wherein the compound of formula: wherein R 2 and R 3 are as defined above and Hal represents a chlorine or bromine atom, in a suitable solvent, reacts in two phases with amines of the formula: wherein R 4, R 5, R 6 and R 7 are as defined above, wherein the reaction with the amine in the first phase takes place at a temperature of up to about 293 K and the reaction with the second amine, in the second phase, at the boiling point of the solvent .

YU64185A 1984-04-17 1985-04-16 PROCEDURE FOR OBTAINING NEW S-TRIAZOLO (1,5-A) PYRIMIDINE YU47167B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8510641A SI8510641A (en) 1984-04-17 1985-04-16 New triazolopyrimidines and process of their production
HR931017A HRP931017A2 (en) 1984-04-17 1993-07-01 New triazolopyrimidines and a process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD84262043A DD228811A1 (en) 1984-04-17 1984-04-17 PROCESS FOR THE PREPARATION OF NEW TRIAZOLOPYRIMIDINES

Publications (2)

Publication Number Publication Date
YU64185A true YU64185A (en) 1992-09-07
YU47167B YU47167B (en) 1995-01-31

Family

ID=5556238

Family Applications (1)

Application Number Title Priority Date Filing Date
YU64185A YU47167B (en) 1984-04-17 1985-04-16 PROCEDURE FOR OBTAINING NEW S-TRIAZOLO (1,5-A) PYRIMIDINE

Country Status (15)

Country Link
JP (1) JPS60224692A (en)
AT (1) AT391866B (en)
BE (2) BE902218A (en)
CH (1) CH669196A5 (en)
DD (1) DD228811A1 (en)
DE (1) DE3512629C2 (en)
ES (1) ES8706682A1 (en)
FR (1) FR2562895B1 (en)
GB (1) GB2157684B (en)
LT (1) LT2594B (en)
MD (1) MD59C2 (en)
NL (1) NL8501111A (en)
SE (1) SE466104B (en)
SU (1) SU1468423A3 (en)
YU (1) YU47167B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
KR100231230B1 (en) * 1995-08-08 1999-11-15 우에노 도시오 Hydroxamic acid derivatives useful for inhibiting gelatinase
JP2001322933A (en) 2000-05-15 2001-11-20 Ucb Sa Cd40 signal blocker
US8186931B2 (en) 2006-08-17 2012-05-29 Steven Borntrager Powered hand truck
MD4246C1 (en) * 2012-03-12 2014-03-31 Иван ПРИДА Barrel for aging alcoholic products
US11066410B2 (en) 2017-03-24 2021-07-20 3100 Central Expressway Llc Fused triazolo-pyrimidine compounds having useful pharmaceutical application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD61269A (en) *
DE61269C (en) * 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Washing machine
CH569734A5 (en) * 1967-07-01 1975-11-28 Hydrierwerk Rodleben Veb 5-and 7-basically subst s-triazolo 1 5-a pyrimidines
DE1720004A1 (en) * 1968-03-08 1971-05-19 Hydrierwerk Rodleben Veb Process for the preparation of s-triazolo (1.5-a) pyrimidines which are substituted in the 5- and 7-positions by basic groups

Also Published As

Publication number Publication date
GB2157684B (en) 1987-11-11
NL8501111A (en) 1985-11-18
SE8501835D0 (en) 1985-04-15
ES542269A0 (en) 1987-07-01
DE3512629A1 (en) 1986-10-09
SE8501835L (en) 1985-10-18
DE3512629C2 (en) 1995-07-06
GB8509561D0 (en) 1985-05-22
ATA105085A (en) 1990-06-15
SE466104B (en) 1991-12-16
YU47167B (en) 1995-01-31
LT2594B (en) 1994-03-25
SU1468423A3 (en) 1989-03-23
FR2562895B1 (en) 1988-10-07
AT391866B (en) 1990-12-10
MD59C2 (en) 1995-01-31
DD228811A1 (en) 1985-10-23
BE902218A (en) 1985-08-16
JPS60224692A (en) 1985-11-09
CH669196A5 (en) 1989-02-28
ES8706682A1 (en) 1987-07-01
GB2157684A (en) 1985-10-30
FR2562895A1 (en) 1985-10-18
MD59B1 (en) 1994-08-31
JPH0455193B2 (en) 1992-09-02
BE903828R (en) 1986-04-01

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