BE902218A - TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS. - Google Patents

TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS.

Info

Publication number
BE902218A
BE902218A BE0/214861A BE214861A BE902218A BE 902218 A BE902218 A BE 902218A BE 0/214861 A BE0/214861 A BE 0/214861A BE 214861 A BE214861 A BE 214861A BE 902218 A BE902218 A BE 902218A
Authority
BE
Belgium
Prior art keywords
alkyl
triazolopyrimidines
preparation process
branched
linear
Prior art date
Application number
BE0/214861A
Other languages
French (fr)
Inventor
M Ballnus
E Tenor
E Thomas
R Pasche
H J Mest
H U Block
P Mentz
I Heinroth
Original Assignee
Hydrierwerk Rodleben Veb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hydrierwerk Rodleben Veb filed Critical Hydrierwerk Rodleben Veb
Publication of BE902218A publication Critical patent/BE902218A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

s-Triazolo-(1,5-a)-pyrimidines répondant à la formule (I) où R2 et R3 = H, alkyle en C2-C3 ou halogène, R4 = alkyle linéaire ou ramifié en C4-C9, aralkyle éventuellement substitué, 2,5-dioxaheptyle ou 3-oxaheptyle, R5 = H, alkyle en C1-C3, hydroxyéthyle ou hydroxypropyle, R6 et R7 = H, alkyle linéaire ou ramifé en C1-C5 ou éléments d'un noyau cycloaliphatique, les substituants en position 5 et 7 pouvant etre échangés. Les nouveaux composés peuvent etre utilisés comme médicaments présentant des effets sur la circulation coronariennes-Triazolo- (1,5-a) -pyrimidines corresponding to formula (I) where R2 and R3 = H, C2-C3 or halogenated alkyl, R4 = linear or branched C4-C9 alkyl, optionally substituted aralkyl, 2,5-dioxaheptyl or 3-oxaheptyl, R5 = H, C1-C3 alkyl, hydroxyethyl or hydroxypropyl, R6 and R7 = H, linear or branched C1-C5 alkyl or elements of a cycloaliphatic nucleus, the substituents in position 5 and 7 can be exchanged. New compounds can be used as drugs with effects on coronary circulation

BE0/214861A 1984-04-17 1985-04-17 TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS. BE902218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD84262043A DD228811A1 (en) 1984-04-17 1984-04-17 PROCESS FOR THE PREPARATION OF NEW TRIAZOLOPYRIMIDINES

Publications (1)

Publication Number Publication Date
BE902218A true BE902218A (en) 1985-08-16

Family

ID=5556238

Family Applications (2)

Application Number Title Priority Date Filing Date
BE0/214861A BE902218A (en) 1984-04-17 1985-04-17 TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS.
BE0/215989A BE903828R (en) 1984-04-17 1985-12-10 TRIAZOLOPYRIMIDINES AND THEIR PREPARATION PROCESS.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE0/215989A BE903828R (en) 1984-04-17 1985-12-10 TRIAZOLOPYRIMIDINES AND THEIR PREPARATION PROCESS.

Country Status (15)

Country Link
JP (1) JPS60224692A (en)
AT (1) AT391866B (en)
BE (2) BE902218A (en)
CH (1) CH669196A5 (en)
DD (1) DD228811A1 (en)
DE (1) DE3512629C2 (en)
ES (1) ES8706682A1 (en)
FR (1) FR2562895B1 (en)
GB (1) GB2157684B (en)
LT (1) LT2594B (en)
MD (1) MD59C2 (en)
NL (1) NL8501111A (en)
SE (1) SE466104B (en)
SU (1) SU1468423A3 (en)
YU (1) YU47167B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
KR100231230B1 (en) * 1995-08-08 1999-11-15 우에노 도시오 Hydroxamic acid derivatives useful for inhibiting gelatinase
JP2001322933A (en) 2000-05-15 2001-11-20 Ucb Sa Cd40 signal blocker
US8186931B2 (en) 2006-08-17 2012-05-29 Steven Borntrager Powered hand truck
MD4246C1 (en) * 2012-03-12 2014-03-31 Иван ПРИДА Barrel for aging alcoholic products
US11066410B2 (en) 2017-03-24 2021-07-20 3100 Central Expressway Llc Fused triazolo-pyrimidine compounds having useful pharmaceutical application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD61269A (en) *
DE61269C (en) * 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Washing machine
CH569734A5 (en) * 1967-07-01 1975-11-28 Hydrierwerk Rodleben Veb 5-and 7-basically subst s-triazolo 1 5-a pyrimidines
DE1720004A1 (en) * 1968-03-08 1971-05-19 Hydrierwerk Rodleben Veb Process for the preparation of s-triazolo (1.5-a) pyrimidines which are substituted in the 5- and 7-positions by basic groups

Also Published As

Publication number Publication date
GB2157684B (en) 1987-11-11
NL8501111A (en) 1985-11-18
SE8501835D0 (en) 1985-04-15
ES542269A0 (en) 1987-07-01
DE3512629A1 (en) 1986-10-09
SE8501835L (en) 1985-10-18
DE3512629C2 (en) 1995-07-06
GB8509561D0 (en) 1985-05-22
ATA105085A (en) 1990-06-15
SE466104B (en) 1991-12-16
YU47167B (en) 1995-01-31
LT2594B (en) 1994-03-25
SU1468423A3 (en) 1989-03-23
FR2562895B1 (en) 1988-10-07
AT391866B (en) 1990-12-10
MD59C2 (en) 1995-01-31
DD228811A1 (en) 1985-10-23
YU64185A (en) 1992-09-07
JPS60224692A (en) 1985-11-09
CH669196A5 (en) 1989-02-28
ES8706682A1 (en) 1987-07-01
GB2157684A (en) 1985-10-30
FR2562895A1 (en) 1985-10-18
MD59B1 (en) 1994-08-31
JPH0455193B2 (en) 1992-09-02
BE903828R (en) 1986-04-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RODLEBEN PHARMA G.M.B.H.

Effective date: 20000430