MD4467C1 - Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic sau a esterilor săi şi aplicarea lor în sinteza ivabradinei şi a sărurilor sale - Google Patents

Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic sau a esterilor săi şi aplicarea lor în sinteza ivabradinei şi a sărurilor sale

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Publication number
MD4467C1
MD4467C1 MDA20130008A MD20130008A MD4467C1 MD 4467 C1 MD4467 C1 MD 4467C1 MD A20130008 A MDA20130008 A MD A20130008A MD 20130008 A MD20130008 A MD 20130008A MD 4467 C1 MD4467 C1 MD 4467C1
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MD
Moldova
Prior art keywords
synthesis
dimethoxybicyclo
ivabradine
triene
octa
Prior art date
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MDA20130008A
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English (en)
Russian (ru)
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MD20130008A2 (ro
MD4467B1 (ro
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МОРО Сандрин ПЕДРАГОСА
Франсуа Лефулон
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Les Laboratoires Servier
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Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of MD20130008A2 publication Critical patent/MD20130008A2/ro
Publication of MD4467B1 publication Critical patent/MD4467B1/ro
Publication of MD4467C1 publication Critical patent/MD4467C1/ro

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    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
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    • C—CHEMISTRY; METALLURGY
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    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
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    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
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Abstract

Prezenta invenţie se referă la un procedeu de sinteză enzimatică a compusului cu formula (I):unde R1 reprezintă un atom de hidrogen sau o grupă alchil C1-C6, de preferinţă metil, precum şi la aplicarea acestuia în sinteza ivabradinei (3-{3-[{[(7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}(metil)amino]propil}-7,8-dimetoxi-1,3,4,5-tetrahidro-2H-3-benzazepin-2-ona) cu formula (II):a sărurilor sale de adiţie cu acizi farmaceutic acceptabili şi a hidraţilor acestora.Utilizarea lipazelor Pseudomonas fluorescens şi Candida antarctica permite obţinerea compuşilor chirali - principalii intermediari în sinteza ingredientelor farmaceutic active - în excese enantiomerice înalte şi randamente bune.
MDA20130008A 2012-02-09 2013-02-07 Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic sau a esterilor săi şi aplicarea lor în sinteza ivabradinei şi a sărurilor sale MD4467C1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1251195A FR2986804A1 (fr) 2012-02-09 2012-02-09 Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels

Publications (3)

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MD20130008A2 MD20130008A2 (ro) 2013-07-31
MD4467B1 MD4467B1 (ro) 2017-02-28
MD4467C1 true MD4467C1 (ro) 2017-09-30

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MDA20130008A MD4467C1 (ro) 2012-02-09 2013-02-07 Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic sau a esterilor săi şi aplicarea lor în sinteza ivabradinei şi a sărurilor sale

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US (1) US9506095B2 (ro)
EP (1) EP2626428B1 (ro)
JP (1) JP5764151B2 (ro)
KR (1) KR101463787B1 (ro)
CN (1) CN103243146A (ro)
AR (1) AR089927A1 (ro)
AU (2) AU2013200482A1 (ro)
BR (1) BR102013003214A2 (ro)
CA (1) CA2805831C (ro)
CY (1) CY1116477T1 (ro)
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EA (1) EA024316B1 (ro)
ES (1) ES2546102T3 (ro)
FR (1) FR2986804A1 (ro)
GE (1) GEP20156235B (ro)
HR (1) HRP20150872T1 (ro)
HU (1) HUE026805T2 (ro)
JO (1) JO3054B1 (ro)
MA (1) MA34503B1 (ro)
MD (1) MD4467C1 (ro)
MX (1) MX341712B (ro)
PL (1) PL2626428T3 (ro)
PT (1) PT2626428E (ro)
RS (1) RS54076B1 (ro)
SA (1) SA113340275B1 (ro)
SG (1) SG193081A1 (ro)
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UA (1) UA115765C2 (ro)
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Publication number Priority date Publication date Assignee Title
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN113387791B (zh) * 2021-03-05 2022-08-02 株洲壹诺生物技术有限公司 一种盐酸伊伐布雷定关键中间体的合成方法

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HRP20150872T1 (hr) 2015-09-25
EA201300100A3 (ru) 2013-10-30
MA34503B1 (fr) 2013-09-02
AU2013200482A1 (en) 2013-08-29
JO3054B1 (ar) 2017-03-15
MX341712B (es) 2016-08-31
ES2546102T3 (es) 2015-09-18
EA201300100A2 (ru) 2013-08-30
UY34611A (es) 2013-09-30
GEP20156235B (en) 2015-01-26
SA113340275B1 (ar) 2015-08-18
EP2626428B1 (fr) 2015-05-27
EA024316B1 (ru) 2016-09-30
US9506095B2 (en) 2016-11-29
AU2013200646A1 (en) 2013-08-29
KR20130092483A (ko) 2013-08-20
SI2626428T1 (sl) 2015-10-30
CN103243146A (zh) 2013-08-14
WO2013117869A3 (fr) 2013-11-14
CA2805831C (fr) 2015-11-24
EP2626428A3 (fr) 2013-10-30
MD20130008A2 (ro) 2013-07-31
JP5764151B2 (ja) 2015-08-12
FR2986804A1 (fr) 2013-08-16
MD4467B1 (ro) 2017-02-28
JP2013162788A (ja) 2013-08-22
DK2626428T3 (en) 2015-08-31
EP2626428A2 (fr) 2013-08-14
MX2013001458A (es) 2013-08-28
KR101463787B1 (ko) 2014-11-20
RS54076B1 (en) 2015-10-30
TW201333206A (zh) 2013-08-16
TWI467019B (zh) 2015-01-01
BR102013003214A2 (pt) 2016-04-19
PT2626428E (pt) 2015-08-21
UA115765C2 (uk) 2017-12-26
SG193081A1 (en) 2013-09-30
PL2626428T3 (pl) 2015-10-30
CA2805831A1 (fr) 2013-08-09
AR089927A1 (es) 2014-10-01
HUE026805T2 (en) 2016-07-28
WO2013117869A2 (fr) 2013-08-15
AU2013200646B2 (en) 2014-12-18
US20130210091A1 (en) 2013-08-15
CY1116477T1 (el) 2017-03-15

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