PL2626428T3 - Sposób syntezy enzymatycznej kwasu (7S)-3,4-dimetoksybicyklo[4.2.0]okta-1,3,5-trien-7-karboksylowego lub jego estrów i zastosowania do syntezy iwabradyny i jej soli - Google Patents

Sposób syntezy enzymatycznej kwasu (7S)-3,4-dimetoksybicyklo[4.2.0]okta-1,3,5-trien-7-karboksylowego lub jego estrów i zastosowania do syntezy iwabradyny i jej soli

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Publication number
PL2626428T3
PL2626428T3 PL13154505T PL13154505T PL2626428T3 PL 2626428 T3 PL2626428 T3 PL 2626428T3 PL 13154505 T PL13154505 T PL 13154505T PL 13154505 T PL13154505 T PL 13154505T PL 2626428 T3 PL2626428 T3 PL 2626428T3
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PL
Poland
Prior art keywords
synthesis
dimethoxybicyclo
ivabradine
triene
octa
Prior art date
Application number
PL13154505T
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English (en)
Inventor
Moreau Sandrine Pedragosa
François Lefoulon
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Servier Lab
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Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PL2626428T3 publication Critical patent/PL2626428T3/pl

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    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
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    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
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    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
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PL13154505T 2012-02-09 2013-02-08 Sposób syntezy enzymatycznej kwasu (7S)-3,4-dimetoksybicyklo[4.2.0]okta-1,3,5-trien-7-karboksylowego lub jego estrów i zastosowania do syntezy iwabradyny i jej soli PL2626428T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1251195A FR2986804A1 (fr) 2012-02-09 2012-02-09 Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
EP13154505.5A EP2626428B1 (fr) 2012-02-09 2013-02-08 Procédé de synthèse enzymatique de l'acide (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylique ou de ses esters, et application à la synthèse de l'ivabradine et de ses sels

Publications (1)

Publication Number Publication Date
PL2626428T3 true PL2626428T3 (pl) 2015-10-30

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PL13154505T PL2626428T3 (pl) 2012-02-09 2013-02-08 Sposób syntezy enzymatycznej kwasu (7S)-3,4-dimetoksybicyklo[4.2.0]okta-1,3,5-trien-7-karboksylowego lub jego estrów i zastosowania do syntezy iwabradyny i jej soli

Country Status (31)

Country Link
US (1) US9506095B2 (pl)
EP (1) EP2626428B1 (pl)
JP (1) JP5764151B2 (pl)
KR (1) KR101463787B1 (pl)
CN (1) CN103243146A (pl)
AR (1) AR089927A1 (pl)
AU (2) AU2013200482A1 (pl)
BR (1) BR102013003214A2 (pl)
CA (1) CA2805831C (pl)
CY (1) CY1116477T1 (pl)
DK (1) DK2626428T3 (pl)
EA (1) EA024316B1 (pl)
ES (1) ES2546102T3 (pl)
FR (1) FR2986804A1 (pl)
GE (1) GEP20156235B (pl)
HR (1) HRP20150872T1 (pl)
HU (1) HUE026805T2 (pl)
JO (1) JO3054B1 (pl)
MA (1) MA34503B1 (pl)
MD (1) MD4467C1 (pl)
MX (1) MX341712B (pl)
PL (1) PL2626428T3 (pl)
PT (1) PT2626428E (pl)
RS (1) RS54076B1 (pl)
SA (1) SA113340275B1 (pl)
SG (1) SG193081A1 (pl)
SI (1) SI2626428T1 (pl)
TW (1) TWI467019B (pl)
UA (1) UA115765C2 (pl)
UY (1) UY34611A (pl)
WO (1) WO2013117869A2 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN113387791B (zh) * 2021-03-05 2022-08-02 株洲壹诺生物技术有限公司 一种盐酸伊伐布雷定关键中间体的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319024B1 (en) * 1987-12-03 1994-10-26 Sumitomo Chemical Company, Limited Process for producing optically active alpha-isopropyl-p-chlorophenylacetic acid
US5089637A (en) * 1990-03-21 1992-02-18 Pfizer Inc. Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
CA2132411A1 (en) * 1994-09-19 1996-03-20 Michael Trani Enzymatic esterification of long-chain racemic acids and alcohols
PL334293A1 (en) * 1996-12-27 2000-02-14 Smithkline Beecham Plc Enzymatic separation of benzodiazepinacetic esters by means of lipase
JP2003517266A (ja) * 1998-02-17 2003-05-27 ジー・ディー・サール・アンド・カンパニー ラクタムの酵素分割方法
JPWO2004108944A1 (ja) * 2003-06-04 2006-07-20 三菱瓦斯化学株式会社 光学活性クロマンカルボン酸エステルの製造方法
GB0314260D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GB0607911D0 (en) * 2006-04-21 2006-05-31 Ineos Fluor Holdings Ltd Process
US20100165918A1 (en) * 2006-08-23 2010-07-01 Tsukasa Kobayashi Mobile communication system, radio network controller, cellular and locating cell display method for use therewith
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
FR2933975B1 (fr) 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
US20110251407A1 (en) * 2008-10-29 2011-10-13 Mitsubishi Gas Chemical Company, Inc. Process for production of optically active organic carboxylic acid
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels

Also Published As

Publication number Publication date
UA115765C2 (uk) 2017-12-26
AU2013200646B2 (en) 2014-12-18
EP2626428B1 (fr) 2015-05-27
RS54076B1 (en) 2015-10-30
TW201333206A (zh) 2013-08-16
WO2013117869A2 (fr) 2013-08-15
BR102013003214A2 (pt) 2016-04-19
HRP20150872T1 (hr) 2015-09-25
FR2986804A1 (fr) 2013-08-16
US20130210091A1 (en) 2013-08-15
EP2626428A3 (fr) 2013-10-30
KR101463787B1 (ko) 2014-11-20
MD4467B1 (ro) 2017-02-28
TWI467019B (zh) 2015-01-01
AU2013200646A1 (en) 2013-08-29
SG193081A1 (en) 2013-09-30
KR20130092483A (ko) 2013-08-20
MD4467C1 (ro) 2017-09-30
HUE026805T2 (en) 2016-07-28
WO2013117869A3 (fr) 2013-11-14
JO3054B1 (ar) 2017-03-15
UY34611A (es) 2013-09-30
EA201300100A2 (ru) 2013-08-30
CA2805831C (fr) 2015-11-24
AR089927A1 (es) 2014-10-01
CA2805831A1 (fr) 2013-08-09
AU2013200482A1 (en) 2013-08-29
JP5764151B2 (ja) 2015-08-12
EA024316B1 (ru) 2016-09-30
MD20130008A2 (en) 2013-07-31
CY1116477T1 (el) 2017-03-15
EA201300100A3 (ru) 2013-10-30
DK2626428T3 (en) 2015-08-31
EP2626428A2 (fr) 2013-08-14
PT2626428E (pt) 2015-08-21
ES2546102T3 (es) 2015-09-18
SI2626428T1 (sl) 2015-10-30
MX2013001458A (es) 2013-08-28
MA34503B1 (fr) 2013-09-02
CN103243146A (zh) 2013-08-14
MX341712B (es) 2016-08-31
SA113340275B1 (ar) 2015-08-18
US9506095B2 (en) 2016-11-29
JP2013162788A (ja) 2013-08-22
GEP20156235B (en) 2015-01-26

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