MD4146C1 - Procedeu de obţinere a brevicolinei-bază din Carex brevicollis D. C. - Google Patents
Procedeu de obţinere a brevicolinei-bază din Carex brevicollis D. C. Download PDFInfo
- Publication number
- MD4146C1 MD4146C1 MDA20110013A MD20110013A MD4146C1 MD 4146 C1 MD4146 C1 MD 4146C1 MD A20110013 A MDA20110013 A MD A20110013A MD 20110013 A MD20110013 A MD 20110013A MD 4146 C1 MD4146 C1 MD 4146C1
- Authority
- MD
- Moldova
- Prior art keywords
- extract
- extraction
- brevicollis
- carex
- sulfuric acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 241001232689 Carex brevicollis Species 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 239000000284 extract Substances 0.000 claims abstract description 41
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000000605 extraction Methods 0.000 claims abstract description 33
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 241000196324 Embryophyta Species 0.000 claims abstract description 7
- 239000002253 acid Substances 0.000 claims abstract description 7
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 5
- 239000000725 suspension Substances 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000005406 washing Methods 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims abstract description 3
- 235000013311 vegetables Nutrition 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 5
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 4
- 230000021962 pH elevation Effects 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 238000013019 agitation Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 2
- 244000038559 crop plants Species 0.000 abstract 1
- 238000003801 milling Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 28
- 235000011149 sulphuric acid Nutrition 0.000 description 18
- 229930013930 alkaloid Natural products 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 8
- 239000012670 alkaline solution Substances 0.000 description 5
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910052593 corundum Inorganic materials 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000010438 granite Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 description 2
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical compound N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 description 2
- 241001290610 Abildgaardia Species 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- -1 CHCL2 Chemical compound 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002803 maceration Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000012261 resinous substance Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Extraction Or Liquid Replacement (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110013A MD4146C1 (ro) | 2011-02-04 | 2011-02-04 | Procedeu de obţinere a brevicolinei-bază din Carex brevicollis D. C. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110013A MD4146C1 (ro) | 2011-02-04 | 2011-02-04 | Procedeu de obţinere a brevicolinei-bază din Carex brevicollis D. C. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4146B1 MD4146B1 (en) | 2012-01-31 |
| MD4146C1 true MD4146C1 (ro) | 2012-08-31 |
Family
ID=45815354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20110013A MD4146C1 (ro) | 2011-02-04 | 2011-02-04 | Procedeu de obţinere a brevicolinei-bază din Carex brevicollis D. C. |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4146C1 (mo) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2221581C2 (ru) * | 2001-05-30 | 2004-01-20 | Кубанский государственный аграрный университет | Фитопрепарат для лечения эндометритов у сельскохозяйственных животных |
-
2011
- 2011-02-04 MD MDA20110013A patent/MD4146C1/ro not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2221581C2 (ru) * | 2001-05-30 | 2004-01-20 | Кубанский государственный аграрный университет | Фитопрепарат для лечения эндометритов у сельскохозяйственных животных |
Non-Patent Citations (3)
| Title |
|---|
| Бревиколлин - алкалоид осоки парвской. АН МССР.Кишинев. 1969, с.86. * |
| Лазуревский Г.В., Терентьева И.В., Шамшурин А.А. Практические работы по химии природных соединений. Москва, Высшая школа, 1966, с.197-200 * |
| Современные методы эксперимента в органической химии. Москва, Госхимиздат, 1960, с.568-569. Găsit în internet URL: <www.trwirpx.com/file 428017> * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4146B1 (en) | 2012-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |