MD20170071A2 - Compoziţii injectabile de paracetamol - Google Patents
Compoziţii injectabile de paracetamolInfo
- Publication number
- MD20170071A2 MD20170071A2 MDA20170071A MD20170071A MD20170071A2 MD 20170071 A2 MD20170071 A2 MD 20170071A2 MD A20170071 A MDA20170071 A MD A20170071A MD 20170071 A MD20170071 A MD 20170071A MD 20170071 A2 MD20170071 A2 MD 20170071A2
- Authority
- MD
- Moldova
- Prior art keywords
- paracetamol
- injectable formulations
- pharmaceutically acceptable
- acceptable salt
- slow
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005489 paracetamol Drugs 0.000 title abstract 3
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000001297 phlebitis Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la compoziţii injectabile cu volum redus de paracetamol sau o sare farmaceutic acceptabilă a acestuia şi la o metodă de obţinere a acestora. Compoziţiile asigură o concentraţie mare de paracetamol sau de o sare farmaceutic acceptabilă a acestuia într-un sistem de solvenţi şi pot fi administrate nu numai intramuscular şi prin perfuzie intravenoasă, dar sunt potrivite şi pentru administrare lentă intravenoasă în bolus după diluare cu soluţii apoase până la un volum final de cel mult 20 ml. Aceste compoziţii injectabile rămân stabile şi sunt, de asemenea, potrivite pentru administrare pe cale intravenoasă lentă cu efecte secundare minime, cum sunt flebita, durerea etc.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4102MU2014 | 2014-12-20 | ||
| PCT/IB2015/058876 WO2016097899A1 (en) | 2014-12-20 | 2015-11-17 | Injectable formulations of paracetamol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD20170071A2 true MD20170071A2 (ro) | 2017-09-30 |
Family
ID=55022620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20170071A MD20170071A2 (ro) | 2014-12-20 | 2015-11-17 | Compoziţii injectabile de paracetamol |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20180000940A1 (ro) |
| EP (1) | EP3233055A1 (ro) |
| JP (1) | JP2017538762A (ro) |
| KR (1) | KR20170099911A (ro) |
| CN (1) | CN107205924A (ro) |
| AR (1) | AR103188A1 (ro) |
| AU (1) | AU2015365533A1 (ro) |
| BR (1) | BR112017012975B1 (ro) |
| CA (1) | CA2969303A1 (ro) |
| CL (1) | CL2017001629A1 (ro) |
| CO (1) | CO2017006268A2 (ro) |
| CU (1) | CU20170088A7 (ro) |
| DO (1) | DOP2017000134A (ro) |
| EA (1) | EA201791409A1 (ro) |
| EC (1) | ECSP17038668A (ro) |
| IL (1) | IL252729A0 (ro) |
| JO (1) | JO3689B1 (ro) |
| MA (1) | MA40599A1 (ro) |
| MD (1) | MD20170071A2 (ro) |
| MX (1) | MX2017008264A (ro) |
| PE (1) | PE20171305A1 (ro) |
| PH (1) | PH12017501005A1 (ro) |
| SG (1) | SG11201704435PA (ro) |
| TN (1) | TN2017000232A1 (ro) |
| TW (1) | TWI649097B (ro) |
| UA (1) | UA122136C2 (ro) |
| UY (1) | UY36466A (ro) |
| WO (1) | WO2016097899A1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107229455B (zh) | 2016-03-24 | 2019-09-17 | 阿里巴巴集团控股有限公司 | 一种业务处理方法、装置及系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751875B1 (fr) | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| IT1301976B1 (it) | 1998-07-31 | 2000-07-20 | Angelini Ricerche Spa | Composizione farmaceutica iniettabile a base di paracetamolo |
| IT1313579B1 (it) | 1999-07-30 | 2002-09-09 | Acraf | Composizione farmaceutica liquida a base di paracetamolo. |
| ITMI20012135A1 (it) | 2001-10-16 | 2003-04-16 | Bioren S A | Soluzioni iniettabili pronte all'uso di paracetamolo |
| EP1895983A2 (en) * | 2005-05-27 | 2008-03-12 | Panacea Biotec Ltd. | Injectable compositions and process for preparation of such compositions |
| PT1973527E (pt) * | 2005-12-15 | 2010-01-04 | Acusphere Inc | Processos de produção de formulações farmacêuticas à base de partículas destinadas a administração parentérica |
| AR067048A1 (es) | 2007-06-18 | 2009-09-30 | Combino Pharm Sl | Formulaciones acuosas de acetaminofen para inyeccion. |
| WO2009098716A2 (en) | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| MX2011003695A (es) * | 2008-10-09 | 2011-08-17 | A F S P A Aziende Chimiche Riunite Angelini Francesco A C R | Formulacion farmaceutica liquida con contenido de paracetamol. |
| PT2588097T (pt) * | 2010-06-30 | 2021-05-25 | Troikaa Pharmaceuticals Ltd | Composições farmacêuticas que compreendem paracetamol e processo para preparar as mesmas |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Ｖｉｉｖ醫療保健公司 | 醫藥組合物 |
| CN102258485A (zh) * | 2011-01-11 | 2011-11-30 | 北京润德康医药技术有限公司 | 一种含对乙酰氨基酚的注射用制剂及其应用 |
| CN102600068A (zh) * | 2011-01-24 | 2012-07-25 | 联康药业克雷恩特塞提斯制药实验室有限责任公司 | 稳定即用的可注射扑热息痛制剂 |
-
2015
- 2015-11-17 KR KR1020177017759A patent/KR20170099911A/ko not_active Application Discontinuation
- 2015-11-17 CN CN201580069391.5A patent/CN107205924A/zh active Pending
- 2015-11-17 MX MX2017008264A patent/MX2017008264A/es unknown
- 2015-11-17 JP JP2017533277A patent/JP2017538762A/ja active Pending
- 2015-11-17 WO PCT/IB2015/058876 patent/WO2016097899A1/en active Application Filing
- 2015-11-17 AU AU2015365533A patent/AU2015365533A1/en not_active Abandoned
- 2015-11-17 BR BR112017012975-2A patent/BR112017012975B1/pt active IP Right Grant
- 2015-11-17 EP EP15816228.9A patent/EP3233055A1/en active Pending
- 2015-11-17 CU CUP2017000088A patent/CU20170088A7/es unknown
- 2015-11-17 SG SG11201704435PA patent/SG11201704435PA/en unknown
- 2015-11-17 TN TN2017000232A patent/TN2017000232A1/en unknown
- 2015-11-17 CA CA2969303A patent/CA2969303A1/en not_active Abandoned
- 2015-11-17 UA UAA201706668A patent/UA122136C2/uk unknown
- 2015-11-17 MD MDA20170071A patent/MD20170071A2/ro not_active Application Discontinuation
- 2015-11-17 MA MA40599A patent/MA40599A1/fr unknown
- 2015-11-17 EA EA201791409A patent/EA201791409A1/ru unknown
- 2015-11-17 PE PE2017001066A patent/PE20171305A1/es unknown
- 2015-11-17 US US15/537,642 patent/US20180000940A1/en not_active Abandoned
- 2015-11-27 TW TW104139783A patent/TWI649097B/zh not_active IP Right Cessation
- 2015-12-09 JO JOP/2015/0303A patent/JO3689B1/ar active
- 2015-12-21 AR ARP150104211A patent/AR103188A1/es unknown
- 2015-12-21 UY UY0001036466A patent/UY36466A/es unknown
-
2017
- 2017-05-31 PH PH12017501005A patent/PH12017501005A1/en unknown
- 2017-06-06 IL IL252729A patent/IL252729A0/en unknown
- 2017-06-09 DO DO2017000134A patent/DOP2017000134A/es unknown
- 2017-06-20 EC ECIEPI201738668A patent/ECSP17038668A/es unknown
- 2017-06-20 CL CL2017001629A patent/CL2017001629A1/es unknown
- 2017-06-23 CO CONC2017/0006268A patent/CO2017006268A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TN2017000232A1 (en) | 2018-10-19 |
| KR20170099911A (ko) | 2017-09-01 |
| US20180000940A1 (en) | 2018-01-04 |
| CN107205924A (zh) | 2017-09-26 |
| CL2017001629A1 (es) | 2018-03-16 |
| UA122136C2 (uk) | 2020-09-25 |
| MA40599A1 (fr) | 2017-11-30 |
| AU2015365533A1 (en) | 2017-07-06 |
| JP2017538762A (ja) | 2017-12-28 |
| CU20170088A7 (es) | 2018-03-13 |
| EA201791409A1 (ru) | 2017-10-31 |
| EP3233055A1 (en) | 2017-10-25 |
| PH12017501005A1 (en) | 2017-12-11 |
| AR103188A1 (es) | 2017-04-19 |
| CO2017006268A2 (es) | 2017-10-20 |
| ECSP17038668A (es) | 2017-12-01 |
| PE20171305A1 (es) | 2017-09-05 |
| BR112017012975B1 (pt) | 2023-09-26 |
| BR112017012975A2 (pt) | 2018-02-27 |
| SG11201704435PA (en) | 2017-06-29 |
| JO3689B1 (ar) | 2020-08-27 |
| CA2969303A1 (en) | 2016-06-23 |
| UY36466A (es) | 2016-07-29 |
| WO2016097899A1 (en) | 2016-06-23 |
| TW201622703A (zh) | 2016-07-01 |
| IL252729A0 (en) | 2017-08-31 |
| DOP2017000134A (es) | 2017-09-15 |
| TWI649097B (zh) | 2019-02-01 |
| MX2017008264A (es) | 2017-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Abandonment or withdrawal of application (patent for invention) |