MA53043A1 - Dérivés de thiéno[3,2-b]pyridine utilisés en tant qu'inhibiteurs de l'udp-glycosyltransférase et procédés d'utilisation - Google Patents
Dérivés de thiéno[3,2-b]pyridine utilisés en tant qu'inhibiteurs de l'udp-glycosyltransférase et procédés d'utilisationInfo
- Publication number
- MA53043A1 MA53043A1 MA53043A MA53043A MA53043A1 MA 53043 A1 MA53043 A1 MA 53043A1 MA 53043 A MA53043 A MA 53043A MA 53043 A MA53043 A MA 53043A MA 53043 A1 MA53043 A1 MA 53043A1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- thieno
- udp
- pyridine derivatives
- derivatives used
- Prior art date
Links
- 239000003297 glycosyltransferase inhibitor Substances 0.000 title 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 208000010055 Globoid Cell Leukodystrophy Diseases 0.000 abstract 1
- 208000028226 Krabbe disease Diseases 0.000 abstract 1
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un composé de formule (i), tel que décrit ici, et des sels pharmaceutiquement acceptables de celui-ci. L'invention concerne également des compositions et l'utilisation de telles compositions dans des procédés de traitement de toute une série de maladies et d'états, en particulier la maladie de krabbe (mk) et la leucodystrophie métachromatique (mld).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862739405P | 2018-10-01 | 2018-10-01 | |
PCT/US2019/054085 WO2020072504A1 (fr) | 2018-10-01 | 2019-10-01 | Dérivés de thiéno[3,2-b]pyridine utilisés en tant qu'inhibiteurs de l'udp-glycosyltransférase et procédés d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
MA53043A1 true MA53043A1 (fr) | 2022-08-31 |
MA53043B2 MA53043B2 (fr) | 2024-05-31 |
Family
ID=68296740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA53043A MA53043B2 (fr) | 2018-10-01 | 2019-10-01 | Dérivés de thiéno[3,2-b]pyridine utilisés en tant qu'inhibiteurs de l'udp-glycosyltransférase et procédés d'utilisation |
Country Status (15)
Country | Link |
---|---|
US (1) | US11098056B2 (fr) |
EP (1) | EP3861000A1 (fr) |
JP (1) | JP2022508523A (fr) |
KR (1) | KR20210087033A (fr) |
CN (1) | CN113423711B (fr) |
AU (1) | AU2019355870B2 (fr) |
BR (1) | BR112021005914A2 (fr) |
CA (1) | CA3114722A1 (fr) |
CO (1) | CO2021005738A2 (fr) |
IL (1) | IL281811A (fr) |
MA (1) | MA53043B2 (fr) |
MX (1) | MX2021003794A (fr) |
SG (1) | SG11202102987VA (fr) |
TW (1) | TWI821426B (fr) |
WO (1) | WO2020072504A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024507222A (ja) * | 2021-02-19 | 2024-02-16 | カルビスタ・ファーマシューティカルズ・リミテッド | 第XIIa因子阻害剤 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3763156A (en) * | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
AU6621600A (en) * | 1999-08-04 | 2001-03-05 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
CA2703600C (fr) * | 2007-11-15 | 2017-04-25 | Ym Biosciences Australia Pty Ltd | Composes heterocycliques de thieno ou pyrrolo pyrimidine fusionnes et leur utilisation comme inhibiteurs de jak1, jak2 ou jak3 |
SG173584A1 (en) * | 2009-02-06 | 2011-09-29 | Elan Pharm Inc | Inhibitors of jun n-terminal kinase |
JP2014511391A (ja) * | 2011-03-07 | 2014-05-15 | フォンダッツィオーネ・テレソン | Tfebリン酸化阻害剤およびその使用 |
ES2928714T3 (es) * | 2015-01-16 | 2022-11-22 | Massachusetts Gen Hospital | Compuestos para mejorar el empalme del ARNm |
SG11201804901WA (en) * | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
US11168087B2 (en) | 2016-05-05 | 2021-11-09 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
EP3468954A1 (fr) | 2016-06-10 | 2019-04-17 | BioMarin Pharmaceutical Inc. | Inhibiteurs de la céramide galactosyltransférase pour le traitement de maladies |
US20190322676A1 (en) | 2016-12-20 | 2019-10-24 | Biomarin Pharmaceutical Inc. | Ceramide galactosyltransferase inhibitors for the treatment of disease |
MX2019013148A (es) * | 2017-05-04 | 2019-12-18 | Glenmark Pharmaceuticals Sa | Compuestos heterociclicos biciclicos sustituidos como inhibidores de la nadph oxidasa. |
CA3066939A1 (fr) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Composes interagissant avec la superfamille ras destines a etre utilises dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques |
-
2019
- 2019-10-01 JP JP2021542086A patent/JP2022508523A/ja active Pending
- 2019-10-01 EP EP19791011.0A patent/EP3861000A1/fr active Pending
- 2019-10-01 MA MA53043A patent/MA53043B2/fr unknown
- 2019-10-01 CA CA3114722A patent/CA3114722A1/fr active Pending
- 2019-10-01 TW TW108135781A patent/TWI821426B/zh active
- 2019-10-01 WO PCT/US2019/054085 patent/WO2020072504A1/fr unknown
- 2019-10-01 CN CN201980076707.1A patent/CN113423711B/zh active Active
- 2019-10-01 US US16/590,027 patent/US11098056B2/en active Active
- 2019-10-01 BR BR112021005914-8A patent/BR112021005914A2/pt unknown
- 2019-10-01 MX MX2021003794A patent/MX2021003794A/es unknown
- 2019-10-01 AU AU2019355870A patent/AU2019355870B2/en active Active
- 2019-10-01 KR KR1020217013167A patent/KR20210087033A/ko unknown
- 2019-10-01 SG SG11202102987VA patent/SG11202102987VA/en unknown
-
2021
- 2021-03-25 IL IL281811A patent/IL281811A/en unknown
- 2021-04-29 CO CONC2021/0005738A patent/CO2021005738A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
US11098056B2 (en) | 2021-08-24 |
BR112021005914A2 (pt) | 2021-06-29 |
TW202035419A (zh) | 2020-10-01 |
US20200102324A1 (en) | 2020-04-02 |
AU2019355870B2 (en) | 2023-11-16 |
MA53043B2 (fr) | 2024-05-31 |
JP2022508523A (ja) | 2022-01-19 |
MX2021003794A (es) | 2021-09-08 |
KR20210087033A (ko) | 2021-07-09 |
CN113423711A (zh) | 2021-09-21 |
CO2021005738A2 (es) | 2021-05-10 |
SG11202102987VA (en) | 2021-04-29 |
IL281811A (en) | 2021-05-31 |
CA3114722A1 (fr) | 2020-04-09 |
WO2020072504A1 (fr) | 2020-04-09 |
EP3861000A1 (fr) | 2021-08-11 |
CN113423711B (zh) | 2024-03-15 |
TWI821426B (zh) | 2023-11-11 |
AU2019355870A1 (en) | 2021-05-20 |
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