MX2019013148A - Compuestos heterociclicos biciclicos sustituidos como inhibidores de la nadph oxidasa. - Google Patents
Compuestos heterociclicos biciclicos sustituidos como inhibidores de la nadph oxidasa.Info
- Publication number
- MX2019013148A MX2019013148A MX2019013148A MX2019013148A MX2019013148A MX 2019013148 A MX2019013148 A MX 2019013148A MX 2019013148 A MX2019013148 A MX 2019013148A MX 2019013148 A MX2019013148 A MX 2019013148A MX 2019013148 A MX2019013148 A MX 2019013148A
- Authority
- MX
- Mexico
- Prior art keywords
- oxidase inhibitors
- nadph oxidase
- heterocyclic compounds
- bicyclic heterocyclic
- substituted bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a compuestos de heteroarilo y heterocíclicos fusionados sustituidos, útiles como inhibidores de la nicotinamida adenina dinucleótido fosfato oxidasa (inhibidores de la NADPH oxidasa), procesos para su preparación, composiciones farmacéuticas que comprenden los compuestos, y el uso de los compuestos o las composiciones en el tratamiento o prevención de diversas enfermedades, afecciones y/o trastornos mediados por la NADPH oxidasa.(ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201721015787 | 2017-05-04 | ||
PCT/IB2018/053121 WO2018203298A1 (en) | 2017-05-04 | 2018-05-04 | Substituted bicyclic heterocyclic compounds as nadph oxidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019013148A true MX2019013148A (es) | 2019-12-18 |
Family
ID=62245373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019013148A MX2019013148A (es) | 2017-05-04 | 2018-05-04 | Compuestos heterociclicos biciclicos sustituidos como inhibidores de la nadph oxidasa. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20200247800A1 (es) |
EP (1) | EP3619209A1 (es) |
JP (1) | JP2020518624A (es) |
KR (1) | KR20200013665A (es) |
CN (1) | CN110914263A (es) |
AU (1) | AU2018262528A1 (es) |
BR (1) | BR112019023109A2 (es) |
CA (1) | CA3062185A1 (es) |
CL (1) | CL2019003107A1 (es) |
CO (1) | CO2019013655A2 (es) |
EA (1) | EA201992343A1 (es) |
MX (1) | MX2019013148A (es) |
PE (1) | PE20191789A1 (es) |
PH (1) | PH12019502462A1 (es) |
SG (1) | SG11201910172VA (es) |
WO (1) | WO2018203298A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210087033A (ko) | 2018-10-01 | 2021-07-09 | 젠자임 코포레이션 | UDP 글리코실트랜스퍼라제 억제제로서의 티에노[3,2-b]피리딘 유도체 및 사용 방법 |
CN115215767B (zh) * | 2021-04-16 | 2023-09-12 | 帕潘纳(北京)科技有限公司 | 制备2-氰基-3-乙氧基丙烯酸乙酯衍生物的方法 |
CN113292496B (zh) * | 2021-05-17 | 2023-03-10 | 安徽联创生物医药股份有限公司 | 一种劳拉替尼中间体的合成方法 |
WO2023217764A1 (en) | 2022-05-09 | 2023-11-16 | Calliditas Therapeutics Suisse Sa | Nox inhibitors for use in the treatment of alport syndrome |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2004089412A1 (ja) * | 2003-04-08 | 2006-07-06 | 三菱ウェルファーマ株式会社 | 特異的nad(p)hオキシダーゼ抑制剤 |
JP2007133750A (ja) * | 2005-11-11 | 2007-05-31 | Canon Inc | 情報処理方法及び情報処理装置 |
EP2002835A1 (en) | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
FR2929276B1 (fr) * | 2008-04-01 | 2010-04-23 | Servier Lab | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP2166008A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166010A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166009A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
EP2165707A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
GB201104600D0 (en) * | 2011-03-18 | 2011-05-04 | Pronoxis Ab | New compounds and medical uses |
KR20180096644A (ko) * | 2015-11-25 | 2018-08-29 | 이펙터 테라퓨틱스, 인크. | Eif4a-억제 화합물 및 이에 관련된 방법 |
-
2018
- 2018-05-04 WO PCT/IB2018/053121 patent/WO2018203298A1/en unknown
- 2018-05-04 CN CN201880044473.8A patent/CN110914263A/zh active Pending
- 2018-05-04 EP EP18727437.8A patent/EP3619209A1/en not_active Withdrawn
- 2018-05-04 CA CA3062185A patent/CA3062185A1/en not_active Abandoned
- 2018-05-04 MX MX2019013148A patent/MX2019013148A/es unknown
- 2018-05-04 PE PE2019002276A patent/PE20191789A1/es unknown
- 2018-05-04 SG SG11201910172V patent/SG11201910172VA/en unknown
- 2018-05-04 KR KR1020197035127A patent/KR20200013665A/ko unknown
- 2018-05-04 US US16/610,351 patent/US20200247800A1/en not_active Abandoned
- 2018-05-04 AU AU2018262528A patent/AU2018262528A1/en not_active Abandoned
- 2018-05-04 JP JP2019560286A patent/JP2020518624A/ja active Pending
- 2018-05-04 EA EA201992343A patent/EA201992343A1/ru unknown
- 2018-05-04 BR BR112019023109-9A patent/BR112019023109A2/pt not_active Application Discontinuation
-
2019
- 2019-10-29 CL CL2019003107A patent/CL2019003107A1/es unknown
- 2019-10-31 PH PH12019502462A patent/PH12019502462A1/en unknown
- 2019-12-03 CO CONC2019/0013655A patent/CO2019013655A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2019013655A2 (es) | 2020-04-01 |
CA3062185A1 (en) | 2018-11-08 |
EA201992343A1 (ru) | 2020-04-16 |
PE20191789A1 (es) | 2019-12-24 |
EP3619209A1 (en) | 2020-03-11 |
AU2018262528A1 (en) | 2019-11-21 |
SG11201910172VA (en) | 2019-11-28 |
BR112019023109A2 (pt) | 2020-05-26 |
US20200247800A1 (en) | 2020-08-06 |
KR20200013665A (ko) | 2020-02-07 |
CN110914263A (zh) | 2020-03-24 |
CL2019003107A1 (es) | 2020-03-13 |
PH12019502462A1 (en) | 2020-06-29 |
JP2020518624A (ja) | 2020-06-25 |
WO2018203298A1 (en) | 2018-11-08 |
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