MA47381A - Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1 - Google Patents

Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1

Info

Publication number
MA47381A
MA47381A MA047381A MA47381A MA47381A MA 47381 A MA47381 A MA 47381A MA 047381 A MA047381 A MA 047381A MA 47381 A MA47381 A MA 47381A MA 47381 A MA47381 A MA 47381A
Authority
MA
Morocco
Prior art keywords
butanediol
organisms
derivatives
micro
manufacture
Prior art date
Application number
MA047381A
Other languages
English (en)
Inventor
Lily Yuin Chao
Kevin Lee Dietzel
Mark Anton Held
Tina Huynh
James Kealey
Matthias Helmut Schamlisch
Na Trinh
Bryan Yeh
Xinhua Zhao
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MA47381A publication Critical patent/MA47381A/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/12—Alkadienes
    • C07C11/16—Alkadienes with four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/023—Methane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01076—(S,S)-Butanediol dehydrogenase (1.1.1.76)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01304—Diacetyl reductase, (S)-acetoin forming (1.1.1.304)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01005—Acetolactate decarboxylase (4.1.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01004—R,R-butanediol dehydrogenase (1.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01006—Acetolactate synthase (2.2.1.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA047381A 2017-01-30 2018-01-30 Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1 MA47381A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762451819P 2017-01-30 2017-01-30
US201762504626P 2017-05-11 2017-05-11
US201762512312P 2017-05-30 2017-05-30
US201762588985P 2017-11-21 2017-11-21

Publications (1)

Publication Number Publication Date
MA47381A true MA47381A (fr) 2021-04-14

Family

ID=62978733

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047381A MA47381A (fr) 2017-01-30 2018-01-30 Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1

Country Status (14)

Country Link
US (5) US11198877B2 (fr)
EP (2) EP3574092A4 (fr)
KR (2) KR102525517B1 (fr)
CN (1) CN110475850B (fr)
AU (2) AU2018213387B2 (fr)
BR (1) BR112019015754A2 (fr)
CA (2) CA3052072A1 (fr)
IL (2) IL268337B2 (fr)
MA (1) MA47381A (fr)
MX (1) MX2019009032A (fr)
PH (2) PH12019501768A1 (fr)
SG (3) SG11201907012VA (fr)
WO (2) WO2018140936A1 (fr)
ZA (3) ZA201905094B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11421235B2 (en) 2017-04-28 2022-08-23 Precigen, Inc. Methods and microorganisms for the fermentation of methane to multi-carbon compounds
DE112018006599T5 (de) * 2018-08-24 2020-09-10 Jiangsu Academy Of Agricultural Sciences Gegen Pyrimidinylsalicylat-Herbizid resistentes Rapsgen und dessen Verwendung
KR102481504B1 (ko) * 2019-04-16 2022-12-27 경희대학교 산학협력단 2,3-부탄디올 생산용 메탄자화균 형질전환체
KR20210045752A (ko) 2019-10-17 2021-04-27 경희대학교 산학협력단 1,3-부탄다이올 생산용 형질전환 메탄자화균 및 이의 용도
CN114731793A (zh) * 2022-04-07 2022-07-12 中山大学 一种降低稻田土壤甲烷排放的方法
CN115058374B (zh) * 2022-05-24 2023-08-01 天津大学前沿技术研究院有限公司 一种利用丙酮酸合成乙偶姻的重组运动发酵单胞菌及其构建方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE377649T1 (de) 2000-03-24 2007-11-15 Xoma Technology Ltd Verfahren und zelle zur expression von rekombinanten proteinprodukten
EP2287179A3 (fr) 2004-01-09 2011-05-18 Novozymes A/S Expression améliorée de Bacillus YweA
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
US20080014619A1 (en) * 2006-07-12 2008-01-17 Lixuan Lisa Huang Method of production of para-hydroxycinnamic acid
CN102015995B (zh) * 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
WO2013102147A2 (fr) 2011-12-30 2013-07-04 Butamax (Tm) Advanced Biofuels Llc Interrupteurs génétiques utilisables en vue de la production de butanol
US20150315599A1 (en) * 2012-12-07 2015-11-05 Ginkgo Bioworks, Inc Methods and Systems for Methylotrophic Production of Organic Compounds
WO2014092562A1 (fr) * 2012-12-11 2014-06-19 Photanol B.V. Synthèse d'acétoïne, de 2,3-butanediol et de 2-butanol par des cyanobactéries par expression hétérologue d'une voie catabolique
US9267158B2 (en) * 2013-03-14 2016-02-23 Intrexon Corporation Biological production of multi-carbon compounds from methane
CA2950304A1 (fr) 2014-06-18 2015-12-23 Calysta, Inc. Acides nucleique et vecteurs destines a etre utilises avec des bacteries methanotrophes
JP6862349B2 (ja) * 2014-12-08 2021-04-21 ランザテク・ニュージーランド・リミテッド 発酵経路を経由するフラックスの増大を示す組み換え微生物体
US10858661B2 (en) * 2017-01-10 2020-12-08 University-Industry Cooperation Group Of Kyung Hee University Use of Methylomonas sp. DH-1 strain and its transformants
US11421235B2 (en) 2017-04-28 2022-08-23 Precigen, Inc. Methods and microorganisms for the fermentation of methane to multi-carbon compounds

Also Published As

Publication number Publication date
IL268339A (en) 2019-09-26
KR20190112044A (ko) 2019-10-02
CA3052046A1 (fr) 2018-08-02
RU2019124480A (ru) 2021-03-01
IL268337B2 (en) 2024-09-01
EP3574081A1 (fr) 2019-12-04
US20220049259A1 (en) 2022-02-17
PH12019501767A1 (en) 2020-06-01
US11111496B2 (en) 2021-09-07
CN110475850B (zh) 2023-11-07
WO2018140928A1 (fr) 2018-08-02
EP3574092A1 (fr) 2019-12-04
US11198877B2 (en) 2021-12-14
RU2019124480A3 (fr) 2021-12-15
AU2018213387A1 (en) 2019-08-15
CN110475850A (zh) 2019-11-19
PH12019501768A1 (en) 2020-03-16
US11939584B2 (en) 2024-03-26
AU2018213395B2 (en) 2024-09-05
ZA201905095B (en) 2022-12-21
US20240263182A1 (en) 2024-08-08
SG11201907008RA (en) 2019-08-27
US20220112506A1 (en) 2022-04-14
SG10202107750TA (en) 2021-09-29
EP3574081A4 (fr) 2021-04-14
ZA201905094B (en) 2022-01-26
WO2018140936A1 (fr) 2018-08-02
US20200115713A1 (en) 2020-04-16
US20200040344A1 (en) 2020-02-06
SG11201907012VA (en) 2019-08-27
ZA202105423B (en) 2023-12-20
BR112019015754A2 (pt) 2020-06-09
CA3052072A1 (fr) 2018-08-02
IL268337A (en) 2019-09-26
EP3574092A4 (fr) 2021-01-13
MX2019009032A (es) 2019-09-10
US12091667B2 (en) 2024-09-17
KR20230142696A (ko) 2023-10-11
KR102525517B1 (ko) 2023-04-25
IL268337B1 (en) 2024-05-01
AU2018213395A1 (en) 2019-08-15
AU2018213387B2 (en) 2024-06-13

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