SG11201907012VA - Molecular switches - Google Patents

Molecular switches

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Publication number
SG11201907012VA
SG11201907012VA SG11201907012VA SG11201907012VA SG11201907012VA SG 11201907012V A SG11201907012V A SG 11201907012VA SG 11201907012V A SG11201907012V A SG 11201907012VA SG 11201907012V A SG11201907012V A SG 11201907012VA SG 11201907012V A SG11201907012V A SG 11201907012VA
Authority
SG
Singapore
Prior art keywords
international
california
rule
bdo
butanol
Prior art date
Application number
SG11201907012VA
Inventor
Mark Anton Held
Xinhua Zhao
Lily Yuin Chao
Na Trinh
James Kealey
Kevin Lee Dietzel
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of SG11201907012VA publication Critical patent/SG11201907012VA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/12—Alkadienes
    • C07C11/16—Alkadienes with four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/023—Methane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01076—(S,S)-Butanediol dehydrogenase (1.1.1.76)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01304—Diacetyl reductase, (S)-acetoin forming (1.1.1.304)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01006—Acetolactate synthase (2.2.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01004—R,R-butanediol dehydrogenase (1.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01005—Acetolactate decarboxylase (4.1.1.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

90 80 - 70 - 60 - 50 40 30 20 7 10 - 0 C.) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIPO I PCT mu °million °nolo 01IIII111111mOIIIIII (10) International Publication Number WO 2018/140936 Al (51) International Patent Classification: C12N 9/04 (2006.01) C12N 15/53 (2006.01) C12N 9/88 (2006.01) C12N 15/60 (2006.01) C12N 15/52 (2006.01) (21) International Application Number: PCT/US2018/015925 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,819 30 January 2017 (30.01.2017) US 62/504,626 11 May 2017 (11.05.2017) US 62/512,312 30 May 2017 (30.05.2017) US 62/588,985 21 November 2017 (21.11.2017) US (71) Applicant: INTREXON CORPORATION [US/US]; 1750 Kraft Drive, Suite 1400, Blacksburg, Virginia 24060 (US). (72) Inventors: HELD, Mark Anton; 1030 45th Street, REAR, Emeryville, California 94608 (US). ZHAO, Xinhua; 2771 Alliston Loop, Dublin, California 94568 (US). CHAO, Lily Yuin; 72 Langton Street, Unit 3, San Francisco, Califor- nia 94103 (US). TRINH, Na; 1839 Ygnacio Valley Road #181, Walnut Creek, California 94598 (US). KEALEY, James; 945 Midpine Way, Sebastopol, California 95472 (US). DIETZEL, Kevin Lee; 963 Fassler Avenue, Pacifi- ca, California 94044 (US). (74) Agent: KELLY, David A. et al.; Barnes & Thornburg LLP, 11 South Meridian Street, Indianapolis, IN 46204-3535 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, W O 20 18/ 140936 Al (54) Title: MOLECULAR SWITCHES (57) : Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyralde- hyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capa- ble of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-bu- tanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression. [Continued on next page] WO 2018/140936 Al MIDEDIMOMMIDIREEMOMMEENCIMOMEN EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201907012VA 2017-01-30 2018-01-30 Molecular switches SG11201907012VA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762451819P 2017-01-30 2017-01-30
US201762504626P 2017-05-11 2017-05-11
US201762512312P 2017-05-30 2017-05-30
US201762588985P 2017-11-21 2017-11-21
PCT/US2018/015925 WO2018140936A1 (en) 2017-01-30 2018-01-30 Molecular switches

Publications (1)

Publication Number Publication Date
SG11201907012VA true SG11201907012VA (en) 2019-08-27

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ID=62978733

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201907008RA SG11201907008RA (en) 2017-01-30 2018-01-30 Methods and microorganisms for making 2,3-butanediol and derivatives thereof from c1 carbons
SG11201907012VA SG11201907012VA (en) 2017-01-30 2018-01-30 Molecular switches
SG10202107750TA SG10202107750TA (en) 2017-01-30 2018-01-30 Molecular switches

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SG11201907008RA SG11201907008RA (en) 2017-01-30 2018-01-30 Methods and microorganisms for making 2,3-butanediol and derivatives thereof from c1 carbons

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SG10202107750TA SG10202107750TA (en) 2017-01-30 2018-01-30 Molecular switches

Country Status (14)

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US (4) US11111496B2 (en)
EP (2) EP3574081A4 (en)
KR (2) KR102525517B1 (en)
CN (1) CN110475850B (en)
AU (2) AU2018213387B2 (en)
BR (1) BR112019015754A2 (en)
CA (2) CA3052072A1 (en)
IL (2) IL268337B1 (en)
MA (1) MA47381A (en)
MX (1) MX2019009032A (en)
PH (2) PH12019501768A1 (en)
SG (3) SG11201907008RA (en)
WO (2) WO2018140928A1 (en)
ZA (3) ZA201905095B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018200894A1 (en) * 2017-04-28 2018-11-01 Intrexon Corporation Methods and microorganisms for the fermentation of methane to multi-carbon compounds
DE112018006599T5 (en) * 2018-08-24 2020-09-10 Jiangsu Academy Of Agricultural Sciences Canola gene resistant to pyrimidinyl salicylate herbicide and its uses
KR102481504B1 (en) * 2019-04-16 2022-12-27 경희대학교 산학협력단 Engineered methanotrophs for producing 2,3-BOD
KR20210045752A (en) 2019-10-17 2021-04-27 경희대학교 산학협력단 Transformed methanotrophs for producing 1,3-butanediol and uses thereof
CN114731793A (en) * 2022-04-07 2022-07-12 中山大学 Method for reducing methane emission of rice field soil
CN115058374B (en) * 2022-05-24 2023-08-01 天津大学前沿技术研究院有限公司 Recombinant zymomonas mobilis for synthesizing acetoin by utilizing pyruvic acid as well as construction method and application thereof

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WO2001073082A2 (en) 2000-03-24 2001-10-04 Xoma Technology Ltd. Methods and cells for expression of recombinant protein products
EP3018140A3 (en) 2004-01-09 2016-08-17 Basf Se Inactivation of glutamylpolypeptide synthesis in bacillus
US8206970B2 (en) * 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US20080014619A1 (en) 2006-07-12 2008-01-17 Lixuan Lisa Huang Method of production of para-hydroxycinnamic acid
CN102015995B (en) * 2008-03-03 2014-10-22 焦耳无限科技公司 Engineered CO2 fixing microorganisms producing carbon-based products of interest
AU2012362144A1 (en) * 2011-12-30 2014-07-03 Butamax (Tm) Advanced Biofuels Llc Genetic switches for butanol production
WO2014089436A1 (en) 2012-12-07 2014-06-12 Ginkgo Bioworks, Inc. Methods and systems for methylotrophic production of organic compounds
WO2014092562A1 (en) * 2012-12-11 2014-06-19 Photanol B.V. Synthesis of acetoin, 2,3-butanediol and 2-butanol by cyanobacteria by heterologous expression of a catabolic pathway
US9267158B2 (en) * 2013-03-14 2016-02-23 Intrexon Corporation Biological production of multi-carbon compounds from methane
DK3158065T3 (en) 2014-06-18 2019-04-08 Calysta Inc NUCLEIC ACIDS AND VECTORS FOR USE WITH METHANOTROPHIC BACTERIES
DK3230459T3 (en) 2014-12-08 2020-12-07 Lanzatech New Zealand Ltd Recombinant microorganisms with increased flow through a fermentation pathway
US10858661B2 (en) * 2017-01-10 2020-12-08 University-Industry Cooperation Group Of Kyung Hee University Use of Methylomonas sp. DH-1 strain and its transformants
WO2018200894A1 (en) 2017-04-28 2018-11-01 Intrexon Corporation Methods and microorganisms for the fermentation of methane to multi-carbon compounds

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Publication number Publication date
WO2018140936A1 (en) 2018-08-02
US11198877B2 (en) 2021-12-14
EP3574081A4 (en) 2021-04-14
CA3052072A1 (en) 2018-08-02
RU2019124480A3 (en) 2021-12-15
US11939584B2 (en) 2024-03-26
PH12019501768A1 (en) 2020-03-16
IL268339A (en) 2019-09-26
CA3052046A1 (en) 2018-08-02
MA47381A (en) 2021-04-14
PH12019501767A1 (en) 2020-06-01
ZA201905094B (en) 2022-01-26
AU2018213387B2 (en) 2024-06-13
KR20230142696A (en) 2023-10-11
AU2018213395A1 (en) 2019-08-15
US20220112506A1 (en) 2022-04-14
KR20190112044A (en) 2019-10-02
IL268337A (en) 2019-09-26
EP3574092A1 (en) 2019-12-04
MX2019009032A (en) 2019-09-10
EP3574092A4 (en) 2021-01-13
CN110475850A (en) 2019-11-19
AU2018213387A1 (en) 2019-08-15
SG10202107750TA (en) 2021-09-29
IL268337B1 (en) 2024-05-01
SG11201907008RA (en) 2019-08-27
US11111496B2 (en) 2021-09-07
BR112019015754A2 (en) 2020-06-09
US20200115713A1 (en) 2020-04-16
KR102525517B1 (en) 2023-04-25
CN110475850B (en) 2023-11-07
EP3574081A1 (en) 2019-12-04
ZA202105423B (en) 2023-12-20
WO2018140928A1 (en) 2018-08-02
RU2019124480A (en) 2021-03-01
ZA201905095B (en) 2022-12-21
US20220049259A1 (en) 2022-02-17
US20200040344A1 (en) 2020-02-06

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