MA46085A - Dérivés d'imidazole et leur utilisation dans le traitement de maladies ou de cancers auto-immuns ou inflammatoires - Google Patents

Dérivés d'imidazole et leur utilisation dans le traitement de maladies ou de cancers auto-immuns ou inflammatoires

Info

Publication number
MA46085A
MA46085A MA046085A MA46085A MA46085A MA 46085 A MA46085 A MA 46085A MA 046085 A MA046085 A MA 046085A MA 46085 A MA46085 A MA 46085A MA 46085 A MA46085 A MA 46085A
Authority
MA
Morocco
Prior art keywords
autoimmune
cancers
treatment
inflammatory diseases
imidazole derivatives
Prior art date
Application number
MA046085A
Other languages
English (en)
Inventor
Andrew Baxter
John Alexander Brown
David Hirst
Philip Humphreys
Katherine Louise Jones
Vipulkumar Kantibhai Patel
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of MA46085A publication Critical patent/MA46085A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA046085A 2016-09-02 2017-08-31 Dérivés d'imidazole et leur utilisation dans le traitement de maladies ou de cancers auto-immuns ou inflammatoires MA46085A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1614934.6A GB201614934D0 (en) 2016-09-02 2016-09-02 Chemical compounds

Publications (1)

Publication Number Publication Date
MA46085A true MA46085A (fr) 2019-07-10

Family

ID=57140084

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046085A MA46085A (fr) 2016-09-02 2017-08-31 Dérivés d'imidazole et leur utilisation dans le traitement de maladies ou de cancers auto-immuns ou inflammatoires

Country Status (24)

Country Link
US (1) US20190175571A1 (fr)
EP (1) EP3507283A1 (fr)
JP (1) JP2019526577A (fr)
KR (1) KR20190042701A (fr)
CN (1) CN109790147A (fr)
AR (1) AR109487A1 (fr)
AU (1) AU2017317724A1 (fr)
BR (1) BR112019004241A2 (fr)
CA (1) CA3035312A1 (fr)
CL (1) CL2019000538A1 (fr)
CO (1) CO2019001871A2 (fr)
CR (1) CR20190106A (fr)
DO (1) DOP2019000047A (fr)
EA (1) EA201990410A1 (fr)
GB (1) GB201614934D0 (fr)
JO (1) JOP20190029A1 (fr)
MA (1) MA46085A (fr)
MX (1) MX2019002491A (fr)
PE (1) PE20190478A1 (fr)
PH (1) PH12019500460A1 (fr)
SG (1) SG11201901673SA (fr)
TW (1) TW201817724A (fr)
UY (1) UY37393A (fr)
WO (1) WO2018041947A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019002313A (es) 2016-09-02 2019-07-08 Cyclerion Therapeutics Inc Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.
CN111686107B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物plx51107用于制备预防或治疗非洲猪瘟药物的新用途
CN111588725B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物arv-825用于制备预防或治疗非洲猪瘟药物的新用途
CN111588721B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物zl0580用于制备预防或治疗非洲猪瘟药物的新用途
CN111686114B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物i-bet-762用于制备预防或治疗非洲猪瘟药物的新用途
WO2024018423A1 (fr) * 2022-07-21 2024-01-25 Tay Therapeutics Limited Pyrroles et imidazoles utilisés comme inhibiteurs de protéines bet
CN117257964B (zh) * 2023-10-25 2024-04-02 苏州大学 基于碳酸氢铵的微波诱导吲哚美辛原位无定形化增溶技术

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
DE4034060A1 (de) * 1990-10-26 1992-04-30 Basf Ag Biskationische azofarbstoffe
DE19809994B4 (de) * 1997-03-19 2006-02-09 Basf Ag Clathrate von Bis-[6-hydroxy-4-methyl-5-(3-methylimidazolium-1-yl)-3-(phen-4-ylazo)-pyridin-2-on]ethylen
GB0201677D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
PE20060285A1 (es) * 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
GB0515584D0 (en) 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
AR058289A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Colector para ser usado en dispensador de medicamento
US8273738B2 (en) * 2006-09-05 2012-09-25 Kyowa Hakko Kirin Co., Ltd. Imidazole derivatives
AU2009227013B2 (en) * 2008-03-21 2013-01-10 Novartis Ag Novel heterocyclic compounds and uses therof
JP5627574B2 (ja) * 2008-06-03 2014-11-19 インターミューン, インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919434D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102933079B (zh) * 2010-03-04 2016-02-17 默沙东公司 儿茶酚-o-甲基转移酶抑制剂及其在治疗精神障碍中的用途
AR092742A1 (es) * 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2895905A1 (fr) * 2012-12-21 2014-06-26 Zenith Epigenetics Corp. Nouveaux composes heterocycliques en tant qu'inhibiteurs de bromodomaine
CN104788423B (zh) * 2015-03-13 2016-10-26 成都理工大学 一种新的囊性纤维化跨膜传导调节因子抑制剂
GB201504689D0 (en) * 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Chemical compounds

Also Published As

Publication number Publication date
KR20190042701A (ko) 2019-04-24
GB201614934D0 (en) 2016-10-19
JOP20190029A1 (ar) 2019-02-25
US20190175571A1 (en) 2019-06-13
CR20190106A (es) 2019-05-02
TW201817724A (zh) 2018-05-16
EP3507283A1 (fr) 2019-07-10
AU2017317724A1 (en) 2019-03-21
PE20190478A1 (es) 2019-04-04
UY37393A (es) 2018-03-23
SG11201901673SA (en) 2019-03-28
AR109487A1 (es) 2018-12-12
MX2019002491A (es) 2019-07-08
CN109790147A (zh) 2019-05-21
CA3035312A1 (fr) 2018-03-08
BR112019004241A2 (pt) 2019-06-04
DOP2019000047A (es) 2019-03-15
WO2018041947A1 (fr) 2018-03-08
EA201990410A1 (ru) 2019-09-30
CL2019000538A1 (es) 2019-05-17
PH12019500460A1 (en) 2019-12-16
CO2019001871A2 (es) 2019-03-08
JP2019526577A (ja) 2019-09-19

Similar Documents

Publication Publication Date Title
MA46085A (fr) Dérivés d'imidazole et leur utilisation dans le traitement de maladies ou de cancers auto-immuns ou inflammatoires
MA45550A (fr) Dérivés de diazépinone et leur utilisation dans le traitement des infections par l'hépatite b
MA49458A (fr) Composés interagissant avec la superfamille ras destinés à être utilisés dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques
MA45089A (fr) Utilisation d'indazoles 2-substitués pour le traitement et la prophylaxie de maladies auto-immunes
MA45481A (fr) Utilisation d'exosomes pour le traitement de maladies
MA49767A (fr) Conjugués de cytokine pour le traitement de maladies auto-immunes
FR22C1011I2 (fr) Promedicaments de fumarates et leur utilisation pour le traitement de diverses maladies
MA50790A (fr) Posologie de vidofludimus à utiliser dans la prévention ou le traitement de maladies inflammatoires chroniques et/ou auto-immunes
MA39960A (fr) Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer
MA45122A (fr) Inhibiteurs hétérocycliques de cbp/ep300 et leur utilisation dans le traitement du cancer
MA51200A (fr) Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies
MA50482A (fr) Dérivés cyclisés de sulfamoylarylamide et leur utilisation comme médicaments pour le traitement de l'hépatite b
MA47688A (fr) Compositions utiles dans le traitement de l'amyotrophie spinale
MA43767A (fr) Anticorps non antagonistes dirigés contre la chaine alpha du domaine extracellulaire du récepteur de l'il-7 et leur utilisation dans le traitement du cancer
MA49884A (fr) Composés imidazo[4,5-c]quinolin-2-one deutérés et leur utilisation dans le traitement du cancer
MA56392A (fr) Dérivés de 2h-indazole et leur utilisation dans le traitement de maladies
MA46061A (fr) Traitement ascaroside de maladies auto-immunes et inflammatoires
MA47450A (fr) Sulfinylpyridines et leur utilisation dans le traitement du cancer
MA54515A (fr) Dérivés de quinoléine destinés à être utilisés dans le traitement de maladies inflammatoires
MA44762A (fr) Sémaglutide utilisé dans le traitement de maladies cardiovasculaires
MA47503A (fr) Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
MA54456A (fr) Composés et leur utilisation dans le traitement d'une déficience en ?1-antitrypsine
MA53127A (fr) Utilisation de stimulateurs gcs pour le traitement de maladies mitochondriales
MA55143A (fr) Composés aryl-aniline et hétéroaryl-aniline pour le traitement de cancers de la peau
MA41996A (fr) Utilisation de triméthazine dans la préparation de médicaments pour la prévention et le traitement de maladies hépatiques