MA45089A - Utilisation d'indazoles 2-substitués pour le traitement et la prophylaxie de maladies auto-immunes - Google Patents
Utilisation d'indazoles 2-substitués pour le traitement et la prophylaxie de maladies auto-immunesInfo
- Publication number
- MA45089A MA45089A MA045089A MA45089A MA45089A MA 45089 A MA45089 A MA 45089A MA 045089 A MA045089 A MA 045089A MA 45089 A MA45089 A MA 45089A MA 45089 A MA45089 A MA 45089A
- Authority
- MA
- Morocco
- Prior art keywords
- indazoles
- prophylaxis
- substitute
- treatment
- autoimmune diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16172507 | 2016-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45089A true MA45089A (fr) | 2019-04-10 |
Family
ID=56097014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045089A MA45089A (fr) | 2016-06-01 | 2017-05-24 | Utilisation d'indazoles 2-substitués pour le traitement et la prophylaxie de maladies auto-immunes |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20190125736A1 (fr) |
| EP (1) | EP3463354A1 (fr) |
| JP (1) | JP7099966B2 (fr) |
| KR (1) | KR102460362B1 (fr) |
| CN (1) | CN109152771B (fr) |
| AU (1) | AU2017273771B2 (fr) |
| CA (1) | CA3025826A1 (fr) |
| CL (1) | CL2018003409A1 (fr) |
| EA (1) | EA201892790A1 (fr) |
| HK (1) | HK1258914A1 (fr) |
| IL (1) | IL263230B (fr) |
| JO (1) | JOP20170136B1 (fr) |
| MA (1) | MA45089A (fr) |
| MX (1) | MX2018014897A (fr) |
| NZ (1) | NZ748907A (fr) |
| PH (1) | PH12018502531A1 (fr) |
| SG (2) | SG11201810769QA (fr) |
| TN (1) | TN2018000409A1 (fr) |
| TW (1) | TWI784954B (fr) |
| UA (1) | UA123916C2 (fr) |
| WO (1) | WO2017207386A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| WO2017186689A1 (fr) | 2016-04-29 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Synthèse d'indazoles |
| AU2017256659B2 (en) | 2016-04-29 | 2021-05-27 | Bayer Pharma Aktiengesellschaft | Synthesis of indazoles |
| JP7004677B2 (ja) * | 2016-06-01 | 2022-01-21 | バイエル・アニマル・ヘルス・ゲーエムベーハー | 動物におけるアレルギー性および／または炎症性疾患の治療および予防に有用な置換インダゾール |
| WO2020036830A1 (fr) * | 2018-08-13 | 2020-02-20 | Gilead Sciences, Inc. | Dérivés de pyrrolo [1,2-b] pyridazine en tant qu'inhibiteurs d'irak4 |
| CN111499612B (zh) * | 2019-01-30 | 2022-12-30 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物及其制备方法和用途 |
| GB201904374D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compunds and pharmaceutical composistions thereof for the treatment of inflammatory disorders |
| JP2022541265A (ja) * | 2019-07-18 | 2022-09-22 | ブリストル－マイヤーズ スクイブ カンパニー | ＩＲＡＫ４阻害剤として有用なピラゾロ［３，４－ｄ］ピロロ［１，２－ｂ］ピリダジニル化合物 |
| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| CN113521079A (zh) * | 2020-04-20 | 2021-10-22 | 上海领泰生物医药科技有限公司 | Irak4抑制剂在治疗ali/ards中的应用 |
| US11866405B2 (en) | 2020-12-10 | 2024-01-09 | Astrazeneca Ab | Substituted indazoles as IRAK4 inhibitors |
| CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
| JP7555519B2 (ja) | 2022-02-14 | 2024-09-24 | アストラゼネカ・アクチエボラーグ | Ｉｒａｋ４阻害剤 |
| WO2023227703A1 (fr) | 2022-05-26 | 2023-11-30 | Astrazeneca Ab | Formes solides d'hétérocyclylamides utilisées comme inhibiteurs de l'irak 4 |
| WO2024108010A1 (fr) * | 2022-11-17 | 2024-05-23 | Bayer Animal Health Gmbh | Procédés et compositions pour lutter contre la douleur et l'inflammation |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2246606B1 (es) | 2002-07-23 | 2007-06-01 | Izar Construcciones Navales S.A. | Unidad semi-sumergible auto-propulsada para transporte y engorde de peces vivos. |
| WO2005082866A2 (fr) | 2004-02-20 | 2005-09-09 | Pfizer Limited | Derives de triazole substitues utilises en tant qu'antagonistes de l'oxytocine |
| JP2008523046A (ja) | 2004-12-08 | 2008-07-03 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | メチレン誘導体 |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| US7745477B2 (en) | 2006-02-07 | 2010-06-29 | Hoffman-La Roche Inc. | Heteroaryl and benzyl amide compounds |
| EP2045253A4 (fr) | 2006-06-29 | 2013-01-23 | Nissan Chemical Ind Ltd | DÉRIVÉ D'ACIDE alpha-AMINÉ ET PRODUIT PHARMACEUTIQUE QUI LE COMPREND EN TANT QUE MATIÈRE ACTIVE |
| WO2009117421A2 (fr) | 2008-03-17 | 2009-09-24 | Kalypsys, Inc. | Modulateurs hétérocycliques de gpr119 pour le traitement d’une maladie |
| US20100094000A1 (en) | 2008-09-03 | 2010-04-15 | Takeda Pharmaceutical Company Limited | Pyrazole compounds |
| US20140113898A1 (en) | 2010-11-08 | 2014-04-24 | Zalicus Pharmaceuticals Ltd. | Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers |
| US8748432B2 (en) | 2011-02-10 | 2014-06-10 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| EP2489663A1 (fr) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Composés en tant qu'inhibiteurs de la syk kinase |
| US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
| JP6234444B2 (ja) | 2012-05-21 | 2017-11-22 | バイエル ファーマ アクチエンゲゼルシャフト | チエノピリミジン類 |
| TWI667233B (zh) * | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| AU2015205348A1 (en) * | 2014-01-10 | 2016-07-28 | Aurigene Discovery Technologies Limited | Indazole compounds as IRAK4 inhibitors |
| SG11201610009XA (en) * | 2014-06-20 | 2017-01-27 | Aurigene Discovery Tech Ltd | Substituted indazole compounds as irak4 inhibitors |
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| UY36660A (es) * | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
| JP2018524372A (ja) | 2015-07-15 | 2018-08-30 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ−４阻害剤としてのインダゾール及びアザインダゾール化合物 |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| EP3219329A1 (fr) | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinaisons de copanlisib |
| AU2017256659B2 (en) | 2016-04-29 | 2021-05-27 | Bayer Pharma Aktiengesellschaft | Synthesis of indazoles |
| WO2017186689A1 (fr) | 2016-04-29 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Synthèse d'indazoles |
| JP7004677B2 (ja) | 2016-06-01 | 2022-01-21 | バイエル・アニマル・ヘルス・ゲーエムベーハー | 動物におけるアレルギー性および／または炎症性疾患の治療および予防に有用な置換インダゾール |
-
2017
- 2017-05-24 SG SG11201810769QA patent/SG11201810769QA/en unknown
- 2017-05-24 AU AU2017273771A patent/AU2017273771B2/en active Active
- 2017-05-24 US US16/306,506 patent/US20190125736A1/en not_active Abandoned
- 2017-05-24 KR KR1020187034445A patent/KR102460362B1/ko active IP Right Grant
- 2017-05-24 CN CN201780032157.4A patent/CN109152771B/zh active Active
- 2017-05-24 CA CA3025826A patent/CA3025826A1/fr active Pending
- 2017-05-24 EP EP17725268.1A patent/EP3463354A1/fr active Pending
- 2017-05-24 NZ NZ748907A patent/NZ748907A/en unknown
- 2017-05-24 WO PCT/EP2017/062535 patent/WO2017207386A1/fr unknown
- 2017-05-24 MA MA045089A patent/MA45089A/fr unknown
- 2017-05-24 MX MX2018014897A patent/MX2018014897A/es unknown
- 2017-05-24 UA UAA201812728A patent/UA123916C2/uk unknown
- 2017-05-24 SG SG10202011653WA patent/SG10202011653WA/en unknown
- 2017-05-24 EA EA201892790A patent/EA201892790A1/ru unknown
- 2017-05-24 JP JP2018562651A patent/JP7099966B2/ja active Active
- 2017-05-24 TN TNP/2018/000409A patent/TN2018000409A1/en unknown
- 2017-05-31 JO JOP/2017/0136A patent/JOP20170136B1/ar active
- 2017-06-01 TW TW106118056A patent/TWI784954B/zh active
-
2018
- 2018-11-22 IL IL263230A patent/IL263230B/en unknown
- 2018-11-29 PH PH12018502531A patent/PH12018502531A1/en unknown
- 2018-11-30 CL CL2018003409A patent/CL2018003409A1/es unknown
-
2019
- 2019-01-28 HK HK19101391.2A patent/HK1258914A1/zh unknown
-
2020
- 2020-04-30 US US16/863,330 patent/US20210085664A1/en not_active Abandoned
-
2022
- 2022-02-16 US US17/673,644 patent/US11992481B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018014897A (es) | 2019-04-24 |
| EP3463354A1 (fr) | 2019-04-10 |
| EA201892790A1 (ru) | 2019-06-28 |
| JP7099966B2 (ja) | 2022-07-12 |
| UA123916C2 (uk) | 2021-06-23 |
| TW201742862A (zh) | 2017-12-16 |
| NZ748907A (en) | 2023-04-28 |
| IL263230B (en) | 2021-09-30 |
| US11992481B2 (en) | 2024-05-28 |
| CA3025826A1 (fr) | 2017-12-07 |
| KR20190015251A (ko) | 2019-02-13 |
| CN109152771B (zh) | 2022-07-19 |
| JP2019517495A (ja) | 2019-06-24 |
| CL2018003409A1 (es) | 2019-03-22 |
| SG11201810769QA (en) | 2018-12-28 |
| US20190125736A1 (en) | 2019-05-02 |
| CN109152771A (zh) | 2019-01-04 |
| AU2017273771A1 (en) | 2018-12-20 |
| JOP20170136B1 (ar) | 2023-09-17 |
| AU2017273771B2 (en) | 2022-09-29 |
| SG10202011653WA (en) | 2020-12-30 |
| US20210085664A1 (en) | 2021-03-25 |
| KR102460362B1 (ko) | 2022-10-28 |
| US20220249456A1 (en) | 2022-08-11 |
| TWI784954B (zh) | 2022-12-01 |
| PH12018502531A1 (en) | 2019-10-21 |
| WO2017207386A1 (fr) | 2017-12-07 |
| HK1258914A1 (zh) | 2019-11-22 |
| IL263230A (en) | 2019-01-31 |
| TN2018000409A1 (en) | 2020-06-15 |
| BR112018074919A2 (pt) | 2020-11-03 |
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