MA37676B1 - Nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation - Google Patents

Nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation

Info

Publication number
MA37676B1
MA37676B1 MA37676A MA37676A MA37676B1 MA 37676 B1 MA37676 B1 MA 37676B1 MA 37676 A MA37676 A MA 37676A MA 37676 A MA37676 A MA 37676A MA 37676 B1 MA37676 B1 MA 37676B1
Authority
MA
Morocco
Prior art keywords
rebamipid
prodrug
manufacturing process
manufacture
new prodrug
Prior art date
Application number
MA37676A
Other languages
English (en)
Other versions
MA37676A1 (fr
Inventor
Eui-Hwan Cho
Sung Ju Choi
Sung Woo Lee
Hee Jong Shin
Ho Seok Kwon
Jae Woong Lee
Jeong Ho Joo
Hyun Tae Kim
Woo-Heon Song
Jong Bae Yoon
Ki Seok Park
Ho Joon Park
Ho Tae Nam
Original Assignee
Samjin Pharm Co Ltd
Astech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49783488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37676(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samjin Pharm Co Ltd, Astech Co Ltd filed Critical Samjin Pharm Co Ltd
Publication of MA37676A1 publication Critical patent/MA37676A1/fr
Publication of MA37676B1 publication Critical patent/MA37676B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)

Abstract

La présente invention concerne un nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation, et, de façon plus spécifique, un nouveau promédicament de rebamipide, son procédé de fabrication et une composition pharmaceutique le contenant comme principe actif. Le nouveau promédicament de rebamipide selon la présente invention a une vitesse d'absorption dans le corps d'approximativement 25 fois la vitesse d'absorption du rebamipide, et ainsi peut être utilisé de façon efficace, à la place du rebamipide, dans la prévention ou le traitement de l'ulcère gastrique, de la gastrite aiguë et chronique, du syndrome de sécheresse oculaire, du cancer, de l'arthrose, de la polyarthrite rhumatoïde ou de l'obésité.
MA37676A 2012-06-26 2013-06-26 Nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation MA37676B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120068394 2012-06-26
PCT/KR2013/005622 WO2014003424A1 (fr) 2012-06-26 2013-06-26 Nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation

Publications (2)

Publication Number Publication Date
MA37676A1 MA37676A1 (fr) 2016-10-31
MA37676B1 true MA37676B1 (fr) 2017-07-31

Family

ID=49783488

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37676A MA37676B1 (fr) 2012-06-26 2013-06-26 Nouveau promédicament de rebamipide, son procédé de fabrication et son utilisation

Country Status (27)

Country Link
US (1) US11420963B2 (fr)
EP (1) EP2865669B1 (fr)
JP (1) JP6032451B2 (fr)
KR (1) KR101452277B1 (fr)
CN (1) CN104662004B (fr)
AP (1) AP2015008233A0 (fr)
AR (1) AR097226A1 (fr)
AU (1) AU2013281442B2 (fr)
BR (1) BR112014032627A8 (fr)
CA (1) CA2877853C (fr)
CL (1) CL2014003496A1 (fr)
CO (1) CO7240352A2 (fr)
ES (1) ES2875863T3 (fr)
IL (1) IL236479A0 (fr)
MA (1) MA37676B1 (fr)
MX (1) MX2015000023A (fr)
NZ (1) NZ704023A (fr)
PE (2) PE20150904A1 (fr)
PH (1) PH12015500172B1 (fr)
RU (1) RU2612509C2 (fr)
SA (1) SA113340675B1 (fr)
SG (1) SG11201408711PA (fr)
TW (1) TWI483727B (fr)
UA (1) UA113990C2 (fr)
UY (1) UY34882A (fr)
WO (1) WO2014003424A1 (fr)
ZA (1) ZA201500450B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101692578B1 (ko) * 2013-04-18 2017-01-03 삼진제약주식회사 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물
WO2016108319A1 (fr) * 2015-01-02 2016-07-07 삼진제약 주식회사 Nouveau sel de promédicament du rébamipide et son utilisation
KR20170094584A (ko) * 2016-02-11 2017-08-21 삼진제약주식회사 레바미피드 전구체를 포함하는 면역질환 및 대사성질환의 예방 또는 치료를 위한 경구투여용 약제학적 조성물
KR102190019B1 (ko) * 2018-10-23 2020-12-15 삼진제약주식회사 쇼그렌 증후군 예방 또는 치료용 조성물
CN111595985B (zh) * 2020-07-09 2022-03-29 苏州正济药业有限公司 一种用hplc测定瑞巴派特有关物质的分析方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
JPS6019767A (ja) 1983-07-11 1985-01-31 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体を有効成分とする抗潰瘍剤
JP3621463B2 (ja) 1995-04-26 2005-02-16 大塚製薬株式会社 カルボスチリル誘導体ビスマス塩
KR100669823B1 (ko) 2001-02-20 2007-01-17 경동제약 주식회사 2-(4-클로로벤조일아미노)-3-[2(1h)-퀴놀리논-4-일]프로피온산의 제조방법 및 그 중간체
EP1336602A1 (fr) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Prodrogues nitrées capable de libérer du monoxyde d'azote de manière controlée et sélective ainsi que leur utilisation pour la prévention et le traitement de maladies inflammatoires, ischémiques et proliferatives
KR20040104020A (ko) 2003-06-02 2004-12-10 진양제약주식회사 신규 레바미피드 리지네이트와 레바미피드 아르기니네이트및 이 신규 레바미피드 리지네이트와 레바미피드아르기니네이트를 유효성분으로 함유하는 약학적 제제
TWI363626B (en) * 2004-11-15 2012-05-11 Otsuka Pharma Co Ltd Aqueous ophthalmic suspension of crystalline rebamipide
WO2006059781A1 (fr) * 2004-12-01 2006-06-08 Otsuka Pharmaceutical Co., Ltd. Procédé amélioré de synthèse du rebamipide
JP2008105970A (ja) 2006-10-24 2008-05-08 Ohara Yakuhin Kogyo Kk ジヒドロキノリン誘導体の製造方法及びその中間体
WO2008074853A1 (fr) 2006-12-21 2008-06-26 Novartis Ag Solution ophtalmique de rebamipide
KR101032600B1 (ko) 2008-08-11 2011-05-06 동우신테크 주식회사 고순도 레바미피드의 제조방법
KR101182114B1 (ko) * 2010-03-05 2012-09-12 한림제약(주) 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물
CN102174015B (zh) * 2011-03-07 2013-10-16 江西同和药业有限责任公司 瑞巴派特的精制方法

Also Published As

Publication number Publication date
CN104662004B (zh) 2017-04-19
EP2865669A4 (fr) 2015-12-02
MX2015000023A (es) 2015-10-05
NZ704023A (en) 2016-03-31
KR20140001767A (ko) 2014-01-07
TWI483727B (zh) 2015-05-11
AU2013281442B2 (en) 2016-09-15
AP2015008233A0 (en) 2015-01-31
UA113990C2 (xx) 2017-04-10
ES2875863T3 (es) 2021-11-11
EP2865669A1 (fr) 2015-04-29
IL236479A0 (en) 2015-02-26
SG11201408711PA (en) 2015-01-29
JP2015522585A (ja) 2015-08-06
CA2877853C (fr) 2018-01-02
US11420963B2 (en) 2022-08-23
JP6032451B2 (ja) 2016-11-30
PE20150904A1 (es) 2015-06-13
BR112014032627A8 (pt) 2021-08-31
CL2014003496A1 (es) 2015-08-07
RU2015102043A (ru) 2016-08-10
RU2612509C2 (ru) 2017-03-09
TW201402118A (zh) 2014-01-16
PE20160285A1 (es) 2016-04-27
US20150141409A1 (en) 2015-05-21
CO7240352A2 (es) 2015-04-17
SA113340675B1 (ar) 2015-08-16
BR112014032627A2 (pt) 2017-06-27
CA2877853A1 (fr) 2014-01-03
ZA201500450B (en) 2016-05-25
WO2014003424A1 (fr) 2014-01-03
UY34882A (es) 2014-01-31
AR097226A1 (es) 2016-03-02
EP2865669B1 (fr) 2021-04-28
PH12015500172A1 (en) 2015-03-16
CN104662004A (zh) 2015-05-27
PH12015500172B1 (en) 2015-03-16
AU2013281442A1 (en) 2015-02-12
MA37676A1 (fr) 2016-10-31
KR101452277B1 (ko) 2014-10-24

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