MA37618A1 - Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx - Google Patents

Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx

Info

Publication number
MA37618A1
MA37618A1 MA37618A MA37618A MA37618A1 MA 37618 A1 MA37618 A1 MA 37618A1 MA 37618 A MA37618 A MA 37618A MA 37618 A MA37618 A MA 37618A MA 37618 A1 MA37618 A1 MA 37618A1
Authority
MA
Morocco
Prior art keywords
heptane
fluor
receptor agonists
alx receptor
bridged derivatives
Prior art date
Application number
MA37618A
Other languages
English (en)
Other versions
MA37618B1 (fr
Inventor
Olivier Corminboeuf
Davide Pozzi
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA37618A1 publication Critical patent/MA37618A1/fr
Publication of MA37618B1 publication Critical patent/MA37618B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Abstract

La présente invention concerne des dérivés pontés fluorés de spiro[2.4]heptane de formule (i), où n et r
MA37618A 2012-05-16 2013-05-14 Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx MA37618B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12168322 2012-05-16
PCT/IB2013/053976 WO2013171694A1 (fr) 2012-05-16 2013-05-15 Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx

Publications (2)

Publication Number Publication Date
MA37618A1 true MA37618A1 (fr) 2016-12-30
MA37618B1 MA37618B1 (fr) 2017-08-31

Family

ID=48699893

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37618A MA37618B1 (fr) 2012-05-16 2013-05-14 Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx

Country Status (23)

Country Link
US (1) US9139524B2 (fr)
EP (1) EP2850060B1 (fr)
JP (1) JP6101789B2 (fr)
KR (1) KR20150013285A (fr)
CN (1) CN104321309B (fr)
AR (1) AR091059A1 (fr)
AU (1) AU2013261091B2 (fr)
BR (1) BR112014028358A2 (fr)
CA (1) CA2871336A1 (fr)
CL (1) CL2014002918A1 (fr)
EA (1) EA025264B1 (fr)
ES (1) ES2595219T3 (fr)
HK (1) HK1208441A1 (fr)
IL (1) IL235660A0 (fr)
MA (1) MA37618B1 (fr)
MX (1) MX355221B (fr)
NZ (1) NZ702971A (fr)
PH (1) PH12014502465A1 (fr)
PL (1) PL2850060T3 (fr)
SG (1) SG11201406971WA (fr)
TW (1) TWI579269B (fr)
WO (1) WO2013171694A1 (fr)
ZA (1) ZA201409249B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2640699B1 (fr) 2010-11-17 2015-10-07 Actelion Pharmaceuticals Ltd. Dérivés d'esters de spiro[2.4]heptane pontés
ES2604135T3 (es) 2010-12-07 2017-03-03 Actelion Pharmaceuticals Ltd. Derivados de aminotriazol hidroxilados como agonistas del receptor ALX
EP2850058B1 (fr) 2012-05-16 2016-07-13 Actelion Pharmaceuticals Ltd. Dérivés de 1- (p-tolyl) cyclopropyl substituted bridged spiro [2,4] heptane en tant qu' agonistes du récepteur alx.
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
AU2014292064B2 (en) 2013-07-18 2018-07-05 Idorsia Pharmaceuticals Ltd Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
CN106459076B (zh) 2014-05-13 2019-01-04 诺华股份有限公司 用于诱导软骨发生的化合物和组合物
EP3331884B1 (fr) 2015-05-27 2020-06-17 Kyorin Pharmaceutical Co., Ltd. Dérivé de l'urée ou sel pharmacologiquement acceptable de ce dernier
EP3303284B1 (fr) 2015-05-27 2020-04-08 Kyorin Pharmaceutical Co., Ltd. Dérivé d'urée ou sel pharmacologiquement acceptable de celui-ci
CN111233751B (zh) * 2020-03-25 2021-02-02 丽水绿氟科技有限公司 一种3,3-二氟-4-氨基哌啶类化合物及其衍生物的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09500133A (ja) * 1993-07-16 1997-01-07 メルク エンド カンパニー インコーポレーテッド オキシトシンのアンタゴニストである置換ピペラジニル樟脳誘導体
AU2003214249A1 (en) 2002-04-03 2003-10-13 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
JP2007508260A (ja) 2003-10-09 2007-04-05 アクテリオン　ファマシューティカルズ　リミテッド 新規なテトラヒドロピリジン誘導体
KR20060130064A (ko) 2003-11-07 2006-12-18 아카디아 파마슈티칼스 인코포레이티드 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도
TW200538098A (en) 2004-03-22 2005-12-01 Astrazeneca Ab Therapeutic agents
US7820699B2 (en) 2005-04-27 2010-10-26 Hoffmann-La Roche Inc. Cyclic amines
CN101679422A (zh) 2007-03-28 2010-03-24 阵列生物制药公司 作为受体酪氨酸激酶抑制剂的咪唑并[1,2-a]吡啶化合物
AR069650A1 (es) 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
NZ586735A (en) 2007-12-18 2012-06-29 Actelion Pharmaceuticals Ltd Aminotriazole derivatives as alx agonists
TWI490190B (zh) * 2009-05-18 2015-07-01 Actelion Pharmaceuticals Ltd 橋聯螺〔２．４〕庚烷衍生物
WO2010143116A1 (fr) 2009-06-09 2010-12-16 Actelion Pharmaceuticals Ltd Dérivés fluorés de l'aminotriazole
CA2760887A1 (fr) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Derives de l'oxazole et du thiazole en tant qu'agonistes du recepteur alx
CA2803920A1 (fr) 2010-06-24 2011-12-29 Richard Beard Derives d'acides cycloalkyl- et cycloalcenyl-1,2-dicarboxyliques presentant une activite agoniste ou antagoniste du recepteur fprl-1
EP2640699B1 (fr) 2010-11-17 2015-10-07 Actelion Pharmaceuticals Ltd. Dérivés d'esters de spiro[2.4]heptane pontés
ES2604135T3 (es) 2010-12-07 2017-03-03 Actelion Pharmaceuticals Ltd. Derivados de aminotriazol hidroxilados como agonistas del receptor ALX
MX2013006418A (es) 2010-12-07 2013-07-15 Actelion Pharmaceuticals Ltd Derivados de oxazolil-metileter como agonistas del receptor de alx.
WO2013009543A1 (fr) * 2011-07-11 2013-01-17 Allergan, Inc. Dérivés polycycliques de pyrrolidine-2,5-dione en tant que modulateurs du récepteur fprl-1 (récepteur de n-formyl peptide de type 1)
EP2850058B1 (fr) 2012-05-16 2016-07-13 Actelion Pharmaceuticals Ltd. Dérivés de 1- (p-tolyl) cyclopropyl substituted bridged spiro [2,4] heptane en tant qu' agonistes du récepteur alx.
KR20210024691A (ko) 2013-03-06 2021-03-05 알러간, 인코포레이티드 피부 질환 치료용 포르밀 펩티드 수용체 2의 항진제의 용도
JP6196327B2 (ja) 2013-03-06 2017-09-13 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用

Also Published As

Publication number Publication date
ZA201409249B (en) 2016-09-28
KR20150013285A (ko) 2015-02-04
CA2871336A1 (fr) 2013-11-21
JP2015516463A (ja) 2015-06-11
AU2013261091B2 (en) 2017-04-06
SG11201406971WA (en) 2014-11-27
IL235660A0 (en) 2015-02-01
WO2013171694A1 (fr) 2013-11-21
CN104321309B (zh) 2016-06-22
CL2014002918A1 (es) 2015-02-06
EP2850060B1 (fr) 2016-07-13
EA201401259A1 (ru) 2015-04-30
EA025264B1 (ru) 2016-12-30
AR091059A1 (es) 2014-12-30
TW201348198A (zh) 2013-12-01
MA37618B1 (fr) 2017-08-31
NZ702971A (en) 2016-09-30
PH12014502465A1 (en) 2014-12-22
MX2014013829A (es) 2015-02-04
EP2850060A1 (fr) 2015-03-25
CN104321309A (zh) 2015-01-28
JP6101789B2 (ja) 2017-03-22
BR112014028358A2 (pt) 2020-07-21
PL2850060T3 (pl) 2017-01-31
US20150118258A1 (en) 2015-04-30
US9139524B2 (en) 2015-09-22
ES2595219T3 (es) 2016-12-28
HK1208441A1 (en) 2016-03-04
AU2013261091A1 (en) 2015-01-22
TWI579269B (zh) 2017-04-21
MX355221B (es) 2018-04-10

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