MA37455B1 - Utilisation d'un dérivé de pyrazole dans le traitement d'exacerbations aigues d'une maladie pulmonaire obstructive chronique - Google Patents
Utilisation d'un dérivé de pyrazole dans le traitement d'exacerbations aigues d'une maladie pulmonaire obstructive chroniqueInfo
- Publication number
- MA37455B1 MA37455B1 MA37455A MA37455A MA37455B1 MA 37455 B1 MA37455 B1 MA 37455B1 MA 37455 A MA37455 A MA 37455A MA 37455 A MA37455 A MA 37455A MA 37455 B1 MA37455 B1 MA 37455B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- pulmonary disease
- chronic obstructive
- obstructive pulmonary
- acute exacerbations
- Prior art date
Links
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 title abstract 2
- 230000009798 acute exacerbation Effects 0.000 title abstract 2
- 150000003217 pyrazoles Chemical class 0.000 title 1
- VGUSQKZDZHAAEE-UHFFFAOYSA-N 3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide Chemical compound CC1=CC=C(C(=O)NC2CC2)C=C1N(C=1N)N=CC=1C(=O)C1=CC=CC(C#N)=C1 VGUSQKZDZHAAEE-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613187P | 2012-03-20 | 2012-03-20 | |
| PCT/EP2013/055730 WO2013139809A1 (en) | 2012-03-20 | 2013-03-19 | Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37455A1 MA37455A1 (fr) | 2016-08-31 |
| MA37455B1 true MA37455B1 (fr) | 2017-03-31 |
Family
ID=47901996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37455A MA37455B1 (fr) | 2012-03-20 | 2013-03-19 | Utilisation d'un dérivé de pyrazole dans le traitement d'exacerbations aigues d'une maladie pulmonaire obstructive chronique |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9339491B2 (https=) |
| EP (1) | EP2827860B1 (https=) |
| JP (1) | JP6091593B2 (https=) |
| KR (1) | KR101793777B1 (https=) |
| CN (1) | CN104203234B (https=) |
| AU (1) | AU2013237503B2 (https=) |
| BR (1) | BR112014023107B1 (https=) |
| CA (1) | CA2866108C (https=) |
| CL (1) | CL2014002471A1 (https=) |
| CY (1) | CY1118327T1 (https=) |
| DK (1) | DK2827860T3 (https=) |
| ES (1) | ES2605942T3 (https=) |
| HR (1) | HRP20161514T1 (https=) |
| HU (1) | HUE032004T2 (https=) |
| IL (1) | IL234537A (https=) |
| LT (1) | LT2827860T (https=) |
| MA (1) | MA37455B1 (https=) |
| MX (1) | MX351996B (https=) |
| NZ (1) | NZ628392A (https=) |
| PH (1) | PH12014502107B1 (https=) |
| PL (1) | PL2827860T3 (https=) |
| PT (1) | PT2827860T (https=) |
| RU (1) | RU2625762C2 (https=) |
| SG (1) | SG11201404941WA (https=) |
| SI (1) | SI2827860T1 (https=) |
| TN (1) | TN2014000350A1 (https=) |
| TW (1) | TWI583381B (https=) |
| WO (1) | WO2013139809A1 (https=) |
| ZA (1) | ZA201405871B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2600822C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронического обструктивного бронхита |
| RU2600833C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронической обструктивной болезни легких |
| BR112018067454A2 (pt) * | 2016-03-08 | 2019-01-15 | Mereo Biopharma 1 Ltd | regime de dosagem para o tratamento de exacerbações agudas de doença pulmonar obstrutiva crônica |
| AU2016397046B2 (en) * | 2016-03-08 | 2022-05-12 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of inflammatory conditions |
| US10331542B2 (en) * | 2016-06-23 | 2019-06-25 | International Business Machines Corporation | System and method for detecting and alerting unexpected behavior of software applications |
| GB201612240D0 (en) * | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
| GB201612238D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| AU2018382895B2 (en) * | 2017-12-11 | 2024-05-16 | Mereo Biopharma 1 Limited | Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| HUE054266T2 (hu) | 2017-12-11 | 2021-08-30 | Mereo Biopharma 1 Ltd | 3-[5-amino-4-(3-cianobenzoil)-pirazol-1-il]-N-ciklopropil-4-metilbenzamid alkalmazása krónikus obstruktív tüdõbetegség akut megjelenésének megelõzésében |
| CN114141383A (zh) * | 2021-12-17 | 2022-03-04 | 湖南大学 | 慢阻肺智能护理方法、装置及系统 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101120857B1 (ko) * | 2003-06-26 | 2012-04-12 | 노파르티스 아게 | 5원의 헤테로사이클-기재 ｐ38 키나제 억제제 |
| GB0603684D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
-
2013
- 2013-03-19 RU RU2014141893A patent/RU2625762C2/ru active
- 2013-03-19 TW TW102109739A patent/TWI583381B/zh active
- 2013-03-19 CN CN201380015703.5A patent/CN104203234B/zh active Active
- 2013-03-19 MX MX2014011291A patent/MX351996B/es active IP Right Grant
- 2013-03-19 SI SI201330397A patent/SI2827860T1/sl unknown
- 2013-03-19 HR HRP20161514TT patent/HRP20161514T1/hr unknown
- 2013-03-19 LT LTEP13710851.0T patent/LT2827860T/lt unknown
- 2013-03-19 CA CA2866108A patent/CA2866108C/en active Active
- 2013-03-19 US US14/386,174 patent/US9339491B2/en active Active
- 2013-03-19 PT PT137108510T patent/PT2827860T/pt unknown
- 2013-03-19 DK DK13710851.0T patent/DK2827860T3/en active
- 2013-03-19 EP EP13710851.0A patent/EP2827860B1/en active Active
- 2013-03-19 HU HUE13710851A patent/HUE032004T2/en unknown
- 2013-03-19 ES ES13710851.0T patent/ES2605942T3/es active Active
- 2013-03-19 JP JP2015500892A patent/JP6091593B2/ja active Active
- 2013-03-19 WO PCT/EP2013/055730 patent/WO2013139809A1/en not_active Ceased
- 2013-03-19 KR KR1020147025904A patent/KR101793777B1/ko active Active
- 2013-03-19 AU AU2013237503A patent/AU2013237503B2/en active Active
- 2013-03-19 NZ NZ628392A patent/NZ628392A/en unknown
- 2013-03-19 SG SG11201404941WA patent/SG11201404941WA/en unknown
- 2013-03-19 BR BR112014023107-9A patent/BR112014023107B1/pt active IP Right Grant
- 2013-03-19 MA MA37455A patent/MA37455B1/fr unknown
- 2013-03-19 PL PL13710851T patent/PL2827860T3/pl unknown
-
2014
- 2014-08-11 ZA ZA2014/05871A patent/ZA201405871B/en unknown
- 2014-08-11 TN TNP2014000350A patent/TN2014000350A1/fr unknown
- 2014-09-08 IL IL234537A patent/IL234537A/en active IP Right Grant
- 2014-09-17 CL CL2014002471A patent/CL2014002471A1/es unknown
- 2014-09-22 PH PH12014502107A patent/PH12014502107B1/en unknown
-
2016
- 2016-04-29 US US15/143,356 patent/US20160243081A1/en not_active Abandoned
- 2016-11-18 CY CY20161101194T patent/CY1118327T1/el unknown
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