MA37380B1 - Expression d'un gène effecteur dans une lignée germinale d'arthropode - Google Patents
Expression d'un gène effecteur dans une lignée germinale d'arthropodeInfo
- Publication number
- MA37380B1 MA37380B1 MA37380A MA37380A MA37380B1 MA 37380 B1 MA37380 B1 MA 37380B1 MA 37380 A MA37380 A MA 37380A MA 37380 A MA37380 A MA 37380A MA 37380 B1 MA37380 B1 MA 37380B1
- Authority
- MA
- Morocco
- Prior art keywords
- expression
- transcription factor
- effector gene
- arthropod
- gene
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 8
- 239000012636 effector Substances 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 241000238421 Arthropoda Species 0.000 title abstract 3
- 210000004602 germ cell Anatomy 0.000 title abstract 3
- 108091023040 Transcription factor Proteins 0.000 abstract 7
- 102000040945 Transcription factor Human genes 0.000 abstract 7
- 230000001105 regulatory effect Effects 0.000 abstract 3
- 238000011144 upstream manufacturing Methods 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0337—Genetically modified Arthropods
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0337—Genetically modified Arthropods
- A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M99/00—Subject matter not provided for in other groups of this subclass
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/002—Vectors comprising a special translation-regulating system controllable or inducible
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Insects & Arthropods (AREA)
- Pest Control & Pesticides (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
L'invention concerne un système d'expression génique de lignée germinale d'arthropode mâle approprié pour l'expression conditionnelle d'un gène effecteur dans une lignée germinale d'arthropode. Le système comprend une première unité d'expression renfermant un gène effecteur et un promoteur fonctionnellement relié audit gène effecteur ; et une seconde unité d'expression. La seconde unité comprend une séquence de codage pour un facteur de transcription et un élément de régulation amont relié fonctionnellement audit facteur de transcription, ce dernier étant capable d'agir sur le promoteur dans la première unité d'expression afin d'entraîner l'expression du gène effecteur. L'élément de régulation amont comprend un promoteur pour le facteur de transcription ; et un 5' utr adjacent à un site de départ de la séquence de codage du facteur de transcription. L'élément de régulation amont entraîne une expression suffisante du facteur de transcription de telle sorte que la protéine de facteur de transcription entraîne à son tour une transcription du gène effecteur avant la méiose. L'invention concerne également les utilisations du système, par exemple, dans des procédés de lutte biologique et de contrôle de qualité.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1203850.1A GB2500113A (en) | 2012-03-05 | 2012-03-05 | Arthropod male germline gene expression system |
PCT/EP2013/054417 WO2013131920A1 (fr) | 2012-03-05 | 2013-03-05 | Lutte biologique |
Publications (2)
Publication Number | Publication Date |
---|---|
MA37380A1 MA37380A1 (fr) | 2016-05-31 |
MA37380B1 true MA37380B1 (fr) | 2017-01-31 |
Family
ID=46003145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37380A MA37380B1 (fr) | 2012-03-05 | 2014-09-26 | Expression d'un gène effecteur dans une lignée germinale d'arthropode |
Country Status (23)
Country | Link |
---|---|
US (2) | US9487801B2 (fr) |
EP (2) | EP3395949A1 (fr) |
JP (1) | JP6363023B2 (fr) |
CN (2) | CN104271747B (fr) |
AR (2) | AR091314A1 (fr) |
AU (2) | AU2013229578B2 (fr) |
BR (1) | BR112014021922B1 (fr) |
CA (1) | CA2866411A1 (fr) |
CL (1) | CL2014002369A1 (fr) |
CO (1) | CO7160024A2 (fr) |
CR (1) | CR20140439A (fr) |
CY (1) | CY1120531T1 (fr) |
ES (1) | ES2683039T3 (fr) |
GB (1) | GB2500113A (fr) |
GT (1) | GT201400188A (fr) |
MA (1) | MA37380B1 (fr) |
MX (1) | MX359468B (fr) |
MY (1) | MY169450A (fr) |
PE (1) | PE20142278A1 (fr) |
PH (1) | PH12014501993B1 (fr) |
SG (2) | SG10201702181PA (fr) |
WO (1) | WO2013131920A1 (fr) |
ZA (1) | ZA201406925B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
JP6747974B2 (ja) * | 2014-01-08 | 2020-08-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Rna誘導型遺伝子ドライブ |
GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
GB201810256D0 (en) * | 2018-06-22 | 2018-08-08 | Imperial Innovations Ltd | Polynucleotide |
GB201810253D0 (en) * | 2018-06-22 | 2018-08-08 | Imperial Innovations Ltd | Gene drive |
PE20210980A1 (es) * | 2018-08-14 | 2021-06-01 | Oxitec Ltd | Autoseleccion de artropodos machos esteriles |
CN109105341A (zh) * | 2018-09-04 | 2019-01-01 | 安徽师范大学 | 一种用于防治斑翅果蝇的辐照不育方法 |
GB2579224A (en) * | 2018-11-26 | 2020-06-17 | Zyzzle Ltd | Apparatus for producing an improved animal population |
EP3660053A1 (fr) * | 2018-11-27 | 2020-06-03 | Fraunhofer Gesellschaft zur Förderung der Angewand | Systèmes d'expression multiprotéique conçus pour la lutte contre les parasites |
WO2020178822A1 (fr) * | 2019-03-05 | 2020-09-10 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Oiseaux à édition de génome |
CN114395018A (zh) * | 2021-12-31 | 2022-04-26 | 天津大学 | CifA和CifB突变蛋白用于调控胞质不相容性的用途 |
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US5180873A (en) | 1985-04-16 | 1993-01-19 | Dna Plant Technology Corporation | Transformation of plants to introduce closely linked markers |
GB8901677D0 (en) | 1989-01-26 | 1989-03-15 | Ici Plc | Hybrid seed production |
US5643776A (en) | 1988-11-01 | 1997-07-01 | The Regents Of The University Of California | Insect diagnostic and control compositions |
US5254801A (en) | 1990-12-03 | 1993-10-19 | Monsanto Company | Heterologous dominant conditional lethal gene which is a phosphonate monoester hydrolase and use thereof in plants |
GB9216151D0 (en) | 1992-07-29 | 1992-09-09 | Ici Plc | Containment of plant germplasm |
US6225121B1 (en) | 1992-09-14 | 2001-05-01 | Institute Of Molecular Biology And Biotechnology/Forth | Eukaryotic transposable element |
GB9313975D0 (en) | 1993-07-06 | 1993-08-18 | Sandoz Ltd | Improvements in or relating to organic compounds |
EG23907A (en) | 1994-08-01 | 2007-12-30 | Delta & Pine Land Co | Control of plant gene expression |
US5633447A (en) | 1994-08-25 | 1997-05-27 | Mycogen Plant Science, Inc. | Plant tissue comprising a subgenomic promoter |
US5753434A (en) | 1995-02-10 | 1998-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for altering sexual behavior |
US5851796A (en) | 1995-06-07 | 1998-12-22 | Yale University | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
FR2737731B1 (fr) | 1995-08-07 | 1997-10-10 | Pasteur Institut | Sequence de retroelements naturels ou synthetiques ayant pour fonction de permettre l'insertion de sequences nucleotidiques dans une cellule eucaryote |
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CA2262519A1 (fr) | 1996-08-26 | 1998-03-05 | Genencor International, Inc. | Identification et clonage d'un transposon mobile issu d'aspergillus |
AU722221B2 (en) * | 1996-10-01 | 2000-07-27 | American Cyanamid Company | Biological insect control agents expressing insect-specific mite toxin genes, methods and compositions |
US7135608B1 (en) | 1997-08-28 | 2006-11-14 | The Salk Institute For Biological Studies | Site-specific recombination in eukaryotes and constructs useful therefor |
US6338040B1 (en) | 1999-02-12 | 2002-01-08 | Agren, Inc. | Method for delaying the development in pest species of resistance to control techniques, using insurance to encourage correct uses of refuges |
ATE532872T1 (de) | 1999-06-01 | 2011-11-15 | Univ Utah Res Found | Methode zur expression von transgene in der keimbahn von caenorhabditis elegans |
GB2355459B (en) * | 1999-11-29 | 2001-09-26 | Isis Innovation | A dominant conditional lethal genetic system |
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AU2001265187A1 (en) | 2000-05-30 | 2001-12-11 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
US6962810B2 (en) | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
CA2431246A1 (fr) | 2000-12-05 | 2002-06-13 | Wisconsin Alumni Research Foundation | Procedes de transposition double destines a la manipulation d'acides nucleiques |
ITRM20010120A1 (it) | 2001-03-08 | 2002-09-08 | Univ Napoli Federico Ii | Gene cctra come strumento per produrre progenie di soli maschi nella mosca mediterranea ceratitis capitata. |
FR2825579B1 (fr) | 2001-06-11 | 2004-07-23 | Rhobio | Methode d'obtention de plante monocotyledone contenant un gene d'interet sans sequence auxiliaire etrangere |
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US8677934B2 (en) * | 2007-07-30 | 2014-03-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Sex-peptides resistant to proteolytic degradation and their use in biological control of insects |
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PT3456190T (pt) | 2008-06-27 | 2022-02-15 | Merus Nv | Animal murino transgénico produtor de anticorpo |
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2012
- 2012-03-05 GB GB1203850.1A patent/GB2500113A/en not_active Withdrawn
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2013
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2016
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