MA35937B1 - Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium - Google Patents

Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium

Info

Publication number
MA35937B1
MA35937B1 MA37344A MA37344A MA35937B1 MA 35937 B1 MA35937 B1 MA 35937B1 MA 37344 A MA37344 A MA 37344A MA 37344 A MA37344 A MA 37344A MA 35937 B1 MA35937 B1 MA 35937B1
Authority
MA
Morocco
Prior art keywords
receptor modulators
substituted compounds
calcium receptor
relates
compounds
Prior art date
Application number
MA37344A
Other languages
English (en)
Inventor
Venkata P Palle
Rajender Kumar Kamboj
Manojkumar Ramprasad Shukla
Ankush Gangaram Sarde
Rajeshkumar Maganlal Loriya
Vipul Dilip Pachpute
Navnath Bajirao Walke
Talha Hussain Khan
Sanjeev Anant Kulkarni
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MA35937B1 publication Critical patent/MA35937B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

La présente invention concerne des modulateurs des récepteurs de détection du calcium (casr). La présente invention concerne notamment des composés utiles pour le traitement, la prise en charge, et/ou l'atténuation de la gravité de maladies, de troubles, de syndromes et/ou d'affections associés à la modulation des récepteurs de détection du calcium (casr). La présente invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que des procédés de traitement, de prise en charge, et/ou d'atténuation de la gravité de maladies, de troubles, de syndromes et/ou d'affections associés à la modulation des casr. L'invention concerne en outre un procédé de préparation des composés de l'invention.
MA37344A 2012-02-24 2014-09-10 Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium MA35937B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN178KO2012 2012-02-24
IN1030KO2012 2012-09-07
PCT/IB2013/051445 WO2013124828A1 (fr) 2012-02-24 2013-02-22 Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium

Publications (1)

Publication Number Publication Date
MA35937B1 true MA35937B1 (fr) 2014-12-01

Family

ID=54261188

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37344A MA35937B1 (fr) 2012-02-24 2014-09-10 Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium

Country Status (44)

Country Link
US (3) US9163001B2 (fr)
EP (1) EP2817299B1 (fr)
JP (1) JP6114316B2 (fr)
KR (1) KR102041154B1 (fr)
CN (1) CN104350047B (fr)
AP (1) AP2014007919A0 (fr)
AR (1) AR090135A1 (fr)
AU (1) AU2013223715B2 (fr)
BR (1) BR112014021133B1 (fr)
CA (1) CA2864332C (fr)
CL (1) CL2014002218A1 (fr)
CO (1) CO7160018A2 (fr)
CR (1) CR20140424A (fr)
CU (1) CU24325B1 (fr)
CY (1) CY1122017T1 (fr)
DK (1) DK2817299T3 (fr)
DO (1) DOP2014000193A (fr)
EA (1) EA026940B9 (fr)
ES (1) ES2743492T3 (fr)
GE (1) GEP20186911B (fr)
GT (1) GT201400179A (fr)
HK (1) HK1205117A1 (fr)
HR (1) HRP20191606T1 (fr)
HU (1) HUE046172T2 (fr)
IL (1) IL234252A (fr)
IN (1) IN2014MN01672A (fr)
LT (1) LT2817299T (fr)
MA (1) MA35937B1 (fr)
MX (1) MX355670B (fr)
MY (1) MY171374A (fr)
NI (1) NI201400094A (fr)
NZ (1) NZ628627A (fr)
PE (1) PE20142281A1 (fr)
PH (1) PH12014501891A1 (fr)
PL (1) PL2817299T3 (fr)
PT (1) PT2817299T (fr)
RS (1) RS59172B1 (fr)
SG (1) SG11201405117SA (fr)
SI (1) SI2817299T1 (fr)
TN (1) TN2014000352A1 (fr)
TW (1) TWI617549B (fr)
UA (1) UA112679C2 (fr)
WO (1) WO2013124828A1 (fr)
ZA (1) ZA201405990B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE046172T2 (hu) * 2012-02-24 2020-02-28 Lupin Ltd Szubsztituált krománvegyületek mint kalcium-szenzor receptor modulátorok
JP2015528462A (ja) * 2012-08-27 2015-09-28 ルピン・リミテッドLupin Limited カルシウム感知受容体モジュレーターとしてのアリールアルキルアミン化合物
TW201602062A (zh) 2013-08-12 2016-01-16 魯賓有限公司 取代聯苯基化合物作為鈣敏感受體調節劑
AU2014313835A1 (en) 2013-08-28 2016-03-03 Lupin Atlantis Holdings Sa Substituted naphthalene compounds as calcium sensing receptor modulators
WO2015162538A1 (fr) 2014-04-21 2015-10-29 Lupin Limited Composés hétérocycliques en tant que modulateurs des récepteurs de détection du calcium pour le traitement de l'hyperparathyroïdie, de l'insuffisance rénale chronique et de la néphropathie chronique
WO2017037616A1 (fr) 2015-08-31 2017-03-09 Lupin Limited Composés d'arylalkylamine comme modulateurs des récepteurs sensibles au calcium
EP4061805A1 (fr) 2019-11-19 2022-09-28 Lupin Limited Procédé de préparation de composés chromane
MX2022007939A (es) 2019-12-27 2022-07-27 Lupin Ltd Composiciones farmaceuticas de moduladores de casr y metodos y usos de las mismas.
CA3166512A1 (fr) * 2020-01-17 2021-07-22 Lupin Limited Procedes, processus et intermediaires pour la preparation de composes chromane

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3063585D1 (en) * 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
FR2812875B1 (fr) 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
WO2004069793A2 (fr) 2003-01-28 2004-08-19 Bristol-Myers Squibb Company Nouveaux amines cycliques substitues en position 2 comme modulateurs du recepteur de detection de calcium
WO2004106280A1 (fr) 2003-05-28 2004-12-09 Japan Tobacco Inc. Antagoniste de casr
CN101175724B (zh) 2005-05-19 2011-12-07 安斯泰来制药有限公司 吡咯烷衍生物或其盐
TW200815388A (en) 2006-04-18 2008-04-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
MX2009003673A (es) 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
JP5470653B2 (ja) * 2006-10-26 2014-04-16 アムジエン・インコーポレーテツド カルシウム受容体調節剤
CA2669635A1 (fr) 2006-11-16 2008-05-22 Astellas Pharma Inc. Derives de piperidine ou sels de ceux-ci
AU2008311974B2 (en) * 2007-10-15 2013-11-21 Amgen Inc. Calcium receptor modulating agents
KR20100108348A (ko) 2007-11-23 2010-10-06 레오 파마 에이/에스 질병 치료용의 신규한 사이클릭 탄화수소 화합물
KR101700152B1 (ko) 2008-10-03 2017-01-26 이에이 파마 가부시키가이샤 CaSR 효능제
WO2010042642A1 (fr) 2008-10-08 2010-04-15 Amgen Inc. Agents modulateurs des récepteurs de calcium
WO2010136037A1 (fr) 2009-05-27 2010-12-02 Leo Pharma A/S Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique
WO2010150837A1 (fr) 2009-06-25 2010-12-29 第一三共株式会社 Dérivé de l'indoline
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014500882A (ja) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
CA2828415A1 (fr) 2011-03-10 2012-09-13 Lupin Limited Morpholines substituees en tant que modulateurs pour le recepteur de calcium
JP6033835B2 (ja) 2011-03-18 2016-11-30 ルピン アトランティス ホールディングス エスエー カルシウム感知受容体モジュレーターとしてのベンゾ[b][1,4]オキサジン誘導体
HUE046172T2 (hu) * 2012-02-24 2020-02-28 Lupin Ltd Szubsztituált krománvegyületek mint kalcium-szenzor receptor modulátorok

Also Published As

Publication number Publication date
DK2817299T3 (da) 2019-09-16
MX355670B (es) 2018-04-25
EP2817299B1 (fr) 2019-06-12
HUE046172T2 (hu) 2020-02-28
US20170209410A1 (en) 2017-07-27
DOP2014000193A (es) 2017-01-15
ZA201405990B (en) 2015-11-25
KR20140135731A (ko) 2014-11-26
HRP20191606T1 (hr) 2019-12-13
KR102041154B1 (ko) 2019-11-07
EA026940B1 (ru) 2017-06-30
CL2014002218A1 (es) 2015-03-06
AR090135A1 (es) 2014-10-22
EP2817299A1 (fr) 2014-12-31
UA112679C2 (uk) 2016-10-10
BR112014021133A2 (pt) 2018-09-11
PL2817299T3 (pl) 2019-12-31
JP2015508097A (ja) 2015-03-16
AU2013223715A1 (en) 2014-08-28
US9163001B2 (en) 2015-10-20
MX2014010139A (es) 2015-09-04
BR112014021133B1 (pt) 2022-06-28
CA2864332A1 (fr) 2013-08-29
US9598391B2 (en) 2017-03-21
CU24325B1 (es) 2018-03-13
SG11201405117SA (en) 2014-09-26
EA201491582A1 (ru) 2014-12-30
PT2817299T (pt) 2019-09-23
GT201400179A (es) 2016-03-01
JP6114316B2 (ja) 2017-04-12
CA2864332C (fr) 2020-08-25
PH12014501891B1 (en) 2015-02-09
MY171374A (en) 2019-10-10
CN104350047B (zh) 2017-05-24
US20150368222A1 (en) 2015-12-24
RS59172B1 (sr) 2019-10-31
NI201400094A (es) 2015-03-27
CN104350047A (zh) 2015-02-11
US9987249B2 (en) 2018-06-05
GEP20186911B (en) 2018-10-25
HK1205117A1 (en) 2015-12-11
CR20140424A (es) 2015-01-13
EA026940B9 (ru) 2017-11-30
TW201336831A (zh) 2013-09-16
NZ628627A (en) 2017-02-24
TN2014000352A1 (en) 2015-12-21
LT2817299T (lt) 2019-09-25
CO7160018A2 (es) 2015-01-15
PE20142281A1 (es) 2015-01-16
CU20140103A7 (es) 2015-01-29
TWI617549B (zh) 2018-03-11
AP2014007919A0 (en) 2014-09-30
IL234252A (en) 2017-02-28
SI2817299T1 (sl) 2019-10-30
WO2013124828A1 (fr) 2013-08-29
CY1122017T1 (el) 2020-10-14
ES2743492T3 (es) 2020-02-19
IN2014MN01672A (fr) 2015-05-29
PH12014501891A1 (en) 2015-02-09
US20150038546A1 (en) 2015-02-05
AU2013223715B2 (en) 2017-09-14

Similar Documents

Publication Publication Date Title
MA35937B1 (fr) Composés substitués de chromane en tant que modulateurs des récepteurs de détection du calcium
MA34969B1 (fr) Composes et compositions en tant qu inibiteurs de trk
MA42376A (fr) Dérivés d'oxopyridine substitués
MA35460B1 (fr) Composés et compositions en tant qu'inhibiteurs de kinase c-kit
MA35459B1 (fr) Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit
MA40290A1 (fr) Agents immunorégulateurs
MA54231B1 (fr) Composés de 2-formyl-3-hydroxyphényloxyméthyle capables de moduler l'hémoglobine
MA33419B1 (fr) Composés et compositions pour le traitement de maladies parasitaires
MA34019B1 (fr) Aryltriazolone liée à un bis-aryle et son utilisation
MA33604B1 (fr) Composés et compositions en tant qu'inhibiteurs de protéine kinase
BR112013027554A2 (pt) "usos de compostos no tratamento de mal de alzheimer, doença de huntington, autismo e outros distúrbios"
MA35444B1 (fr) Ligands du récepteur ep1
MA42397B1 (fr) 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b
MA37888A1 (fr) Composition pharmaceutique enrobée contenant du régorafenib
MA34474B1 (fr) Agonistes de gpr40
MA38349A1 (fr) Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
MA38810B1 (fr) Inhibiteurs de rorc2 méthodes d'utilisation associées
MA35455B1 (fr) (wo2013045407) dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments
EA201490539A1 (ru) Соединения и композиции в качестве ингибиторов c-kit киназы
MA38076A1 (fr) Dérivés d'oxazolidin-2-one-pyrimidine
MA34724B1 (fr) Nouvelle forme d'administration d'un inhibiteur de l'enképhalinase
MA33457B1 (fr) L-sérine pour son utilisation en tant que médicament pour prévenir et/ou traiter une réaction inflammatoire de la peau
MA38925B1 (fr) Dérivés de phénylalanine substitués
MA35407B1 (fr) Modulateurs allostériques positifs des récepteurs nicotiniques d'acétylcholine
EA201001586A1 (ru) Соединения и композиции в качестве ингибиторов itpkb