PT2817299T - Compostos de cromano substituídos como moduladores de recetores sensores de cálcio - Google Patents

Compostos de cromano substituídos como moduladores de recetores sensores de cálcio

Info

Publication number
PT2817299T
PT2817299T PT13712928T PT13712928T PT2817299T PT 2817299 T PT2817299 T PT 2817299T PT 13712928 T PT13712928 T PT 13712928T PT 13712928 T PT13712928 T PT 13712928T PT 2817299 T PT2817299 T PT 2817299T
Authority
PT
Portugal
Prior art keywords
receptor modulators
sensing receptor
calcium sensing
chroman compounds
substituted chroman
Prior art date
Application number
PT13712928T
Other languages
English (en)
Inventor
Ramprasad Shukla Manojkumar
Gangaram Sarde Ankush
Maganlal Loriya Rajeshkumar
Dilip Pachpute Vipul
Bajirao Walke Navnath
Hussain Khan Talha
Anant Kulkarni Sanjeev
P Palle Venkata
Kumar Kamboj Rajender
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of PT2817299T publication Critical patent/PT2817299T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
PT13712928T 2012-02-24 2013-02-22 Compostos de cromano substituídos como moduladores de recetores sensores de cálcio PT2817299T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN178KO2012 2012-02-24
IN1030KO2012 2012-09-07

Publications (1)

Publication Number Publication Date
PT2817299T true PT2817299T (pt) 2019-09-23

Family

ID=54261188

Family Applications (1)

Application Number Title Priority Date Filing Date
PT13712928T PT2817299T (pt) 2012-02-24 2013-02-22 Compostos de cromano substituídos como moduladores de recetores sensores de cálcio

Country Status (44)

Country Link
US (3) US9163001B2 (pt)
EP (1) EP2817299B1 (pt)
JP (1) JP6114316B2 (pt)
KR (1) KR102041154B1 (pt)
CN (1) CN104350047B (pt)
AP (1) AP2014007919A0 (pt)
AR (1) AR090135A1 (pt)
AU (1) AU2013223715B2 (pt)
BR (1) BR112014021133B1 (pt)
CA (1) CA2864332C (pt)
CL (1) CL2014002218A1 (pt)
CO (1) CO7160018A2 (pt)
CR (1) CR20140424A (pt)
CU (1) CU24325B1 (pt)
CY (1) CY1122017T1 (pt)
DK (1) DK2817299T3 (pt)
DO (1) DOP2014000193A (pt)
EA (1) EA026940B9 (pt)
ES (1) ES2743492T3 (pt)
GE (1) GEP20186911B (pt)
GT (1) GT201400179A (pt)
HK (1) HK1205117A1 (pt)
HR (1) HRP20191606T1 (pt)
HU (1) HUE046172T2 (pt)
IL (1) IL234252A (pt)
IN (1) IN2014MN01672A (pt)
LT (1) LT2817299T (pt)
MA (1) MA35937B1 (pt)
MX (1) MX355670B (pt)
MY (1) MY171374A (pt)
NI (1) NI201400094A (pt)
NZ (1) NZ628627A (pt)
PE (1) PE20142281A1 (pt)
PH (1) PH12014501891B1 (pt)
PL (1) PL2817299T3 (pt)
PT (1) PT2817299T (pt)
RS (1) RS59172B1 (pt)
SG (1) SG11201405117SA (pt)
SI (1) SI2817299T1 (pt)
TN (1) TN2014000352A1 (pt)
TW (1) TWI617549B (pt)
UA (1) UA112679C2 (pt)
WO (1) WO2013124828A1 (pt)
ZA (1) ZA201405990B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9163001B2 (en) * 2012-02-24 2015-10-20 Lupin Limited Substituted chroman compounds as calcium sensing receptor modulators
IN2015MN00421A (pt) * 2012-08-27 2015-09-04 Lupin Ltd
TW201602062A (zh) 2013-08-12 2016-01-16 魯賓有限公司 取代聯苯基化合物作為鈣敏感受體調節劑
WO2015028938A1 (en) 2013-08-28 2015-03-05 Lupin Limited Substituted naphthalene compounds as calcium sensing receptor modulators
WO2015162538A1 (en) 2014-04-21 2015-10-29 Lupin Limited Heterocyclic compounds as calcium sensing receptor modulators for the treatment of hyperparathyroidism, chronic renal failure and chronic kidney disease
WO2017037616A1 (en) 2015-08-31 2017-03-09 Lupin Limited Arylalkylamine compounds as calcium sensing receptor modulators
JP2023503067A (ja) * 2019-11-19 2023-01-26 ルピン・リミテッド クロマン化合物を調製する方法
AU2020415502A1 (en) * 2019-12-27 2022-07-14 Lupin Limited Pharmaceutical composition of CaSR modulators and methods and uses thereof
CA3166512A1 (en) * 2020-01-17 2021-07-22 Lupin Limited Methods, processes and intermediates for preparing chroman compounds

Family Cites Families (24)

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DE3063585D1 (en) * 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
FR2812875B1 (fr) 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
JPWO2004106280A1 (ja) 2003-05-28 2006-07-20 日本たばこ産業株式会社 CaSRアンタゴニスト
DK1882684T3 (en) 2005-05-19 2015-01-05 Astellas Pharma Inc PYRROLIDE INGREDIENTS OR SALTS THEREOF
TW200815388A (en) 2006-04-18 2008-04-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
MX2009003673A (es) 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
MX2009003981A (es) * 2006-10-26 2009-04-27 Amgen Inc Agentes moduladores del receptor de calcio.
CA2669635A1 (en) 2006-11-16 2008-05-22 Astellas Pharma Inc. Piperidine derivative or salt thereof
JP5478496B2 (ja) * 2007-10-15 2014-04-23 アムジエン・インコーポレーテツド カルシウム受容体調節剤
CN101970394B (zh) 2007-11-23 2015-05-27 利奥制药有限公司 用于治疗疾病的新的环烃化合物
WO2010038895A1 (ja) 2008-10-03 2010-04-08 味の素株式会社 CaSRアゴニスト
WO2010042642A1 (en) 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010136037A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
WO2010150837A1 (ja) 2009-06-25 2010-12-29 第一三共株式会社 インドリン誘導体
US20130267516A1 (en) 2010-11-26 2013-10-10 Leo Pharma A/S Substituted cyclopentyl-azines as casr-active compounds
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
EP2683697B1 (en) 2011-03-10 2017-09-06 Lupin Atlantis Holdings SA Substituted morpholines as modulators for the calcium sensing receptor
JP6033835B2 (ja) 2011-03-18 2016-11-30 ルピン アトランティス ホールディングス エスエー カルシウム感知受容体モジュレーターとしてのベンゾ[b][1,4]オキサジン誘導体
US9163001B2 (en) * 2012-02-24 2015-10-20 Lupin Limited Substituted chroman compounds as calcium sensing receptor modulators

Also Published As

Publication number Publication date
WO2013124828A1 (en) 2013-08-29
EA026940B1 (ru) 2017-06-30
TWI617549B (zh) 2018-03-11
PH12014501891A1 (en) 2015-02-09
TW201336831A (zh) 2013-09-16
HUE046172T2 (hu) 2020-02-28
PH12014501891B1 (en) 2015-02-09
HRP20191606T1 (hr) 2019-12-13
US20150038546A1 (en) 2015-02-05
DOP2014000193A (es) 2017-01-15
US20150368222A1 (en) 2015-12-24
CY1122017T1 (el) 2020-10-14
PL2817299T3 (pl) 2019-12-31
JP2015508097A (ja) 2015-03-16
CL2014002218A1 (es) 2015-03-06
NZ628627A (en) 2017-02-24
DK2817299T3 (da) 2019-09-16
TN2014000352A1 (en) 2015-12-21
MA35937B1 (fr) 2014-12-01
BR112014021133A2 (pt) 2018-09-11
AP2014007919A0 (en) 2014-09-30
JP6114316B2 (ja) 2017-04-12
CA2864332C (en) 2020-08-25
AU2013223715B2 (en) 2017-09-14
EP2817299A1 (en) 2014-12-31
US9598391B2 (en) 2017-03-21
IL234252A (en) 2017-02-28
MY171374A (en) 2019-10-10
GT201400179A (es) 2016-03-01
EA201491582A1 (ru) 2014-12-30
EA026940B9 (ru) 2017-11-30
LT2817299T (lt) 2019-09-25
MX2014010139A (es) 2015-09-04
US20170209410A1 (en) 2017-07-27
KR102041154B1 (ko) 2019-11-07
US9163001B2 (en) 2015-10-20
CU20140103A7 (es) 2015-01-29
CA2864332A1 (en) 2013-08-29
IN2014MN01672A (pt) 2015-05-29
BR112014021133B1 (pt) 2022-06-28
SI2817299T1 (sl) 2019-10-30
CU24325B1 (es) 2018-03-13
AU2013223715A1 (en) 2014-08-28
NI201400094A (es) 2015-03-27
ZA201405990B (en) 2015-11-25
RS59172B1 (sr) 2019-10-31
SG11201405117SA (en) 2014-09-26
AR090135A1 (es) 2014-10-22
MX355670B (es) 2018-04-25
CN104350047B (zh) 2017-05-24
HK1205117A1 (en) 2015-12-11
KR20140135731A (ko) 2014-11-26
ES2743492T3 (es) 2020-02-19
CO7160018A2 (es) 2015-01-15
CN104350047A (zh) 2015-02-11
PE20142281A1 (es) 2015-01-16
US9987249B2 (en) 2018-06-05
UA112679C2 (uk) 2016-10-10
EP2817299B1 (en) 2019-06-12
GEP20186911B (en) 2018-10-25
CR20140424A (es) 2015-01-13

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