MX2022008805A - Metodos, procesos e intermedios para preparar compuestos cromanos. - Google Patents

Metodos, procesos e intermedios para preparar compuestos cromanos.

Info

Publication number
MX2022008805A
MX2022008805A MX2022008805A MX2022008805A MX2022008805A MX 2022008805 A MX2022008805 A MX 2022008805A MX 2022008805 A MX2022008805 A MX 2022008805A MX 2022008805 A MX2022008805 A MX 2022008805A MX 2022008805 A MX2022008805 A MX 2022008805A
Authority
MX
Mexico
Prior art keywords
intermediates
processes
methods
chroman compounds
chroman
Prior art date
Application number
MX2022008805A
Other languages
English (en)
Inventor
Rajender Kumar Kamboj
Kamlesh Jyotindra Padiya
Kumar Ram Naik
Bhavani Shankar Rajesh
Kamalakannan Prabakaran
Ganpati Powar Rajendra
Subhash Ingawale Sachin
Dattatray Karche Amit
Shankar Dange Santoshkumar
Rambhau Barve Sitaram
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2022008805A publication Critical patent/MX2022008805A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta divulgación describe un método y un proceso económicos y escalables para sintetizar el agente modulador del receptor de detección de calcio (CaSR) ácido 2-metil-5-((2R,4S)-2-((((R)-1-(na ftalina-1-il)etil)amino)metil)croman-4-il)benzoico, sus intermedios y sus sales farmacéuticamente aceptables. Usos de dichos intermedios para la síntesis de compuestos que pueden ser intermedios para la síntesis de ácido 2-metil-5-((2R,4S)-2-((((R)- 1-(naftalen-1-il)etil)amino) )metil)croman-4-il)benzoico también se describen en este documento.
MX2022008805A 2020-01-17 2021-01-17 Metodos, procesos e intermedios para preparar compuestos cromanos. MX2022008805A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202021002110 2020-01-17
PCT/IN2021/050045 WO2021144814A1 (en) 2020-01-17 2021-01-17 Methods, processes and intermediates for preparing chroman compounds

Publications (1)

Publication Number Publication Date
MX2022008805A true MX2022008805A (es) 2022-08-11

Family

ID=74550720

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022008805A MX2022008805A (es) 2020-01-17 2021-01-17 Metodos, procesos e intermedios para preparar compuestos cromanos.

Country Status (10)

Country Link
US (1) US20230140054A1 (es)
EP (1) EP4090654A1 (es)
JP (1) JP2023512918A (es)
CN (1) CN114981253A (es)
AU (1) AU2021207775A1 (es)
BR (1) BR112022013865A2 (es)
CA (1) CA3166512A1 (es)
MX (1) MX2022008805A (es)
WO (1) WO2021144814A1 (es)
ZA (1) ZA202207850B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113979982A (zh) * 2021-11-03 2022-01-28 中国人民解放军空军军医大学 一种手性二氢色酮-2-羧酸类化合物及其衍生物的制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171865A (en) * 1988-02-29 1992-12-15 Sanwa Kagaku Kenkyusho Co., Ltd. Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
FR2812875B1 (fr) 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
JPWO2004106280A1 (ja) 2003-05-28 2006-07-20 日本たばこ産業株式会社 ＣａＳＲアンタゴニスト
CA2608957C (en) 2005-05-19 2013-12-10 Astellas Pharma Inc. Pyrrolidine derivative or salt thereof
CN101547922B (zh) 2006-10-04 2012-06-20 辉瑞产品公司 作为钙受体拮抗剂的吡啶并[4,3-d]嘧啶-4(3H)-酮衍生物
CA2669635A1 (en) 2006-11-16 2008-05-22 Astellas Pharma Inc. Piperidine derivative or salt thereof
AU2008328362A1 (en) 2007-11-23 2009-05-28 Leo Pharma A/S Novel cyclic hydrocarbon compounds for the treatment of diseases
WO2010038895A1 (ja) 2008-10-03 2010-04-08 味の素株式会社 ＣａＳＲアゴニスト
WO2010042642A1 (en) 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010136037A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
WO2010150837A1 (ja) 2009-06-25 2010-12-29 第一三共株式会社 インドリン誘導体
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014500882A (ja) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
CA2828415A1 (en) 2011-03-10 2012-09-13 Lupin Limited Substituted morpholines as modulators for the calcium sensing receptor
US9464063B2 (en) 2011-03-18 2016-10-11 Lupin Atlantis Holdings Sa Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators
UA112679C2 (uk) * 2012-02-24 2016-10-10 Люпін Лімітед Заміщені хроманові сполуки як модулятори рецептора, чутливого до кальцію

Also Published As

Publication number Publication date
CA3166512A1 (en) 2021-07-22
JP2023512918A (ja) 2023-03-30
EP4090654A1 (en) 2022-11-23
US20230140054A1 (en) 2023-05-04
BR112022013865A2 (pt) 2022-09-13
CN114981253A (zh) 2022-08-30
ZA202207850B (en) 2023-11-29
AU2021207775A1 (en) 2022-08-11
WO2021144814A1 (en) 2021-07-22

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