BR112022013865A2 - Métodos e composto - Google Patents

Métodos e composto

Info

Publication number
BR112022013865A2
BR112022013865A2 BR112022013865A BR112022013865A BR112022013865A2 BR 112022013865 A2 BR112022013865 A2 BR 112022013865A2 BR 112022013865 A BR112022013865 A BR 112022013865A BR 112022013865 A BR112022013865 A BR 112022013865A BR 112022013865 A2 BR112022013865 A2 BR 112022013865A2
Authority
BR
Brazil
Prior art keywords
methyl
intermediates
compound
methods
chroman
Prior art date
Application number
BR112022013865A
Other languages
English (en)
Inventor
Kumar Kamboj Rajender
Jyotindra Padiya Kamlesh
Prabakaran Kamalakannan
Ram Naik Kumar
Shankar Rajesh Bhavani
Powar Rajendra Ganpati
Ingawale Sachin Subhash
Karche Amit Dattatray
Dange Santoshkumar Shankar
Sitaram Rambhau Barve
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of BR112022013865A2 publication Critical patent/BR112022013865A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MÉTODOS E COMPOSTO. Esta revelação descreve um método e processo econômico e escalável para sintetizar o agente modulador do receptor sensível ao cálcio (CaSR) ácido 2-metil-5-((2R,4S)-2-((((R)-1-(naftalen-1-il)etil)amino)metil)croman-4-il)benzoico, seus intermediários e sais farmaceuticamente aceitáveis do mesmo. Também são descritos no presente documento usos dos ditos intermediários para a síntese de compostos que podem ser intermediários para a síntese de ácido 2-metil-5-((2R,4S)-2-((((R)-1-(naftalen-1-il)etil)amino)metil)croman-4-il)benzoico.
BR112022013865A 2020-01-17 2021-01-17 Métodos e composto BR112022013865A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202021002110 2020-01-17
PCT/IN2021/050045 WO2021144814A1 (en) 2020-01-17 2021-01-17 Methods, processes and intermediates for preparing chroman compounds

Publications (1)

Publication Number Publication Date
BR112022013865A2 true BR112022013865A2 (pt) 2022-09-13

Family

ID=74550720

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022013865A BR112022013865A2 (pt) 2020-01-17 2021-01-17 Métodos e composto

Country Status (10)

Country Link
US (1) US20230140054A1 (pt)
EP (1) EP4090654A1 (pt)
JP (1) JP2023512918A (pt)
CN (1) CN114981253A (pt)
AU (1) AU2021207775A1 (pt)
BR (1) BR112022013865A2 (pt)
CA (1) CA3166512A1 (pt)
MX (1) MX2022008805A (pt)
WO (1) WO2021144814A1 (pt)
ZA (1) ZA202207850B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113979982A (zh) * 2021-11-03 2022-01-28 中国人民解放军空军军医大学 一种手性二氢色酮-2-羧酸类化合物及其衍生物的制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171865A (en) * 1988-02-29 1992-12-15 Sanwa Kagaku Kenkyusho Co., Ltd. Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
FR2812875B1 (fr) 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
EP1630157A4 (en) 2003-05-28 2007-05-23 Japan Tobacco Inc ANTAGONIST OF CASR
PT1882684E (pt) 2005-05-19 2015-02-10 Astellas Pharma Inc Derivado de pirrolidina ou um seu sal
KR101129868B1 (ko) 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체
EP2085383A4 (en) 2006-11-16 2010-09-22 Astellas Pharma Inc Piperidin derivatives or salts thereof
WO2009065406A2 (en) 2007-11-23 2009-05-28 Leo Pharma A/S Novel cyclic hydrocarbon compounds for the treatment of diseases
CN102239136B (zh) 2008-10-03 2014-09-17 味之素株式会社 CaSR激动剂
WO2010042642A1 (en) 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010136037A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
WO2010150837A1 (ja) 2009-06-25 2010-12-29 第一三共株式会社 インドリン誘導体
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
US20130267516A1 (en) 2010-11-26 2013-10-10 Leo Pharma A/S Substituted cyclopentyl-azines as casr-active compounds
AU2012226375B2 (en) 2011-03-10 2017-04-13 Lupin Atlantis Holdings Sa Substituted morpholines as modulators for the calcium sensing receptor
KR20140051846A (ko) * 2011-03-18 2014-05-02 루핀 리미티드 칼슘 감지 수용체 조절자로서의 벤조[ｂ][1,4]옥사진 유도체
HUE046172T2 (hu) 2012-02-24 2020-02-28 Lupin Ltd Szubsztituált krománvegyületek mint kalcium-szenzor receptor modulátorok

Also Published As

Publication number Publication date
EP4090654A1 (en) 2022-11-23
WO2021144814A1 (en) 2021-07-22
CN114981253A (zh) 2022-08-30
CA3166512A1 (en) 2021-07-22
MX2022008805A (es) 2022-08-11
US20230140054A1 (en) 2023-05-04
ZA202207850B (en) 2023-11-29
AU2021207775A1 (en) 2022-08-11
JP2023512918A (ja) 2023-03-30

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