MA35660B1 - Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile - Google Patents

Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile

Info

Publication number
MA35660B1
MA35660B1 MA37064A MA37064A MA35660B1 MA 35660 B1 MA35660 B1 MA 35660B1 MA 37064 A MA37064 A MA 37064A MA 37064 A MA37064 A MA 37064A MA 35660 B1 MA35660 B1 MA 35660B1
Authority
MA
Morocco
Prior art keywords
fragile
syndrome
treatment
inhibitors
pak protein
Prior art date
Application number
MA37064A
Other languages
English (en)
Inventor
John C Mckew
Wenwei Huang
David Campbell
Sergio G Duron
Mark Behnke
Min Shen
Original Assignee
Afraxis Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afraxis Holdings Inc filed Critical Afraxis Holdings Inc
Publication of MA35660B1 publication Critical patent/MA35660B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne des inhibiteurs de la protéine pak et des méthodes d'utilisation d'inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile.
MA37064A 2011-11-04 2014-05-26 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile MA35660B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161555902P 2011-11-04 2011-11-04
PCT/US2012/063426 WO2013067434A1 (fr) 2011-11-04 2012-11-02 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile

Publications (1)

Publication Number Publication Date
MA35660B1 true MA35660B1 (fr) 2014-11-01

Family

ID=48192852

Family Applications (2)

Application Number Title Priority Date Filing Date
MA37065A MA35661B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire
MA37064A MA35660B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA37065A MA35661B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire

Country Status (20)

Country Link
US (2) US20130116263A1 (fr)
EP (2) EP2773643A4 (fr)
JP (2) JP2015501786A (fr)
KR (2) KR20140105451A (fr)
CN (2) CN104039786A (fr)
AR (1) AR089175A1 (fr)
AU (2) AU2012327183A1 (fr)
BR (2) BR112014010631A2 (fr)
CA (2) CA2854471A1 (fr)
CL (2) CL2014001132A1 (fr)
CO (1) CO7030960A2 (fr)
CR (2) CR20140251A (fr)
EA (2) EA201490927A1 (fr)
IL (2) IL232154A0 (fr)
MA (2) MA35661B1 (fr)
MX (2) MX2014005296A (fr)
PH (2) PH12014500956A1 (fr)
SG (2) SG11201401996TA (fr)
TW (1) TW201326169A (fr)
WO (2) WO2013067423A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2580216A4 (fr) * 2010-06-10 2014-07-23 Afraxis Holdings Inc 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc
BR112014010644A2 (pt) 2011-11-04 2017-04-25 Hoffmann La Roche novos derivados de aril-quinolina
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP3943087A1 (fr) 2013-03-15 2022-01-26 Celgene CAR LLC Composés hétéroaryle et utilisations associées
WO2015011252A1 (fr) * 2013-07-26 2015-01-29 F. Hoffmann-La Roche Ag Inhibiteurs pyrimidine-pyridinone de sérine/thréonine kinase
US9815834B2 (en) * 2014-02-07 2017-11-14 Principia Biopharma, Inc. Quinolone derivatives as fibroblast growth factor receptor inhibitors
MA38393B1 (fr) 2014-03-13 2018-11-30 Sanofi Sa Composés hétéroaryle et utilisations associées
WO2016015598A1 (fr) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido [2,3-d] pyrimidin -7 (8h)-one utilisés en tant qu'inhibiteurs de cdk et utilisations de ceux-ci
EP3288556A4 (fr) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
EP3416555A1 (fr) * 2016-02-17 2018-12-26 Nuralogix Corporation Système et procédé de détection d'état physiologique
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
WO2017220516A1 (fr) * 2016-06-23 2017-12-28 F. Hoffmann-La Roche Ag Dérivés de triazolo[4,5-d]pyrimidine
US11685954B2 (en) * 2016-07-15 2023-06-27 Dana-Farber Cancer Institute, Inc. Biomarkers predictive of endocrine resistance in breast cancer
CN106818805A (zh) * 2016-12-27 2017-06-13 东莞市联洲知识产权运营管理有限公司 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用
CN107083428B (zh) * 2017-04-10 2020-09-25 徐州医科大学 Pak5在癌症诊断预后治疗及药物筛选中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
US20220002429A1 (en) * 2018-10-24 2022-01-06 Northwestern University Tumor cell aggregation inhibitors' for treating cancer
TWI748317B (zh) * 2019-01-03 2021-12-01 美商建南德克公司 吡啶并－嘧啶酮與喋啶酮化合物及使用方法
CN112213400B (zh) * 2019-07-09 2022-06-07 四川弘合生物科技有限公司 一种β-榄香烯及其有关物质的检测方法
CN110496128B (zh) * 2019-09-23 2022-09-30 吉林大学 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用
JP2023549540A (ja) 2020-11-18 2023-11-27 デシフェラ・ファーマシューティカルズ，エルエルシー Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法
WO2022152259A1 (fr) * 2021-01-15 2022-07-21 江苏先声药业有限公司 Inhibiteur de cdk2/4/6, son procédé de préparation et son application
CN113046323A (zh) * 2021-04-02 2021-06-29 四川农业大学 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法
JP2024544632A (ja) 2021-12-03 2024-12-03 デシフェラ・ファーマシューティカルズ，エルエルシー Ｇｃｎ２及びｐｅｒｋキナーゼ阻害剤としての複素環式化合物
WO2025257301A1 (fr) * 2024-06-13 2025-12-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Traitement de la neurofibromatose de type 2 par des inhibiteurs de g6pd, acsl3 et/ou oxsm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
JP2010509265A (ja) * 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー キナーゼ阻害剤としての置換６−フェニル−ピリド［２，３−ｄ］ピリミジン−７−オン誘導体及びそれの使用方法
EP2112150B1 (fr) * 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
US8674095B2 (en) * 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions
CA2776770A1 (fr) * 2009-10-09 2011-04-14 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles de snc
US8912203B2 (en) * 2010-06-09 2014-12-16 Afraxis Holdings, Inc. 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders
EP2580216A4 (fr) * 2010-06-10 2014-07-23 Afraxis Holdings Inc 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc

Also Published As

Publication number Publication date
CR20140251A (es) 2014-08-20
EP2773642A1 (fr) 2014-09-10
EP2773643A4 (fr) 2015-07-29
SG11201401914WA (en) 2014-05-29
IL232215A0 (en) 2014-06-30
EA201490927A1 (ru) 2014-10-30
MX2014005296A (es) 2014-08-27
WO2013067434A1 (fr) 2013-05-10
CL2014001131A1 (es) 2014-08-22
AU2012327183A1 (en) 2013-05-30
EP2773643A1 (fr) 2014-09-10
WO2013067423A1 (fr) 2013-05-10
BR112014010631A2 (pt) 2017-04-25
KR20140096098A (ko) 2014-08-04
EA201490925A1 (ru) 2014-09-30
JP2014532724A (ja) 2014-12-08
CN104039786A (zh) 2014-09-10
CA2854471A1 (fr) 2013-05-10
CR20140250A (es) 2014-08-20
PH12014500995A1 (en) 2014-08-04
AR089175A1 (es) 2014-08-06
IL232154A0 (en) 2014-05-28
MA35661B1 (fr) 2014-11-01
AU2012327187A8 (en) 2013-07-25
CO7030960A2 (es) 2014-08-21
CL2014001132A1 (es) 2014-08-22
CA2854462A1 (fr) 2013-05-10
JP2015501786A (ja) 2015-01-19
PH12014500956A1 (en) 2014-06-30
MX2014005292A (es) 2014-09-11
US20150031693A1 (en) 2015-01-29
CN104093717A (zh) 2014-10-08
AU2012327187A1 (en) 2013-05-23
BR112014010420A2 (pt) 2017-04-25
TW201326169A (zh) 2013-07-01
AU2012327183A8 (en) 2013-07-18
SG11201401996TA (en) 2014-05-29
KR20140105451A (ko) 2014-09-01
US20130116263A1 (en) 2013-05-09

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