MA34939B1 - Hétérocyclylbenzyle-pyrazoles substituées et leur utilisation - Google Patents
Hétérocyclylbenzyle-pyrazoles substituées et leur utilisationInfo
- Publication number
- MA34939B1 MA34939B1 MA35350A MA35350A MA34939B1 MA 34939 B1 MA34939 B1 MA 34939B1 MA 35350 A MA35350 A MA 35350A MA 35350 A MA35350 A MA 35350A MA 34939 B1 MA34939 B1 MA 34939B1
- Authority
- MA
- Morocco
- Prior art keywords
- diseases
- prevention
- treatment
- heterocyclylbenzyl
- pyrazoles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne de nouveaux dérivés de 1-[3-(hétérocyclyl)benzyl]-1H-pyrazole, leur procédé de fabrication, leur utilisation pour le traitement et/ou la prévention de maladies ainsi que leur utilisation pour la fabrication de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de maladies hyperprolifératives et angiogéniques telles que ces maladies qui sont provoquées par une adaptation métabolique à des états hypoxiques. De tels traitements peuvent avoir lieu en tant que monothérapie ou aussi en combinaison avec d'autres médicaments ou d'autres mesures thérapeutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10004855 | 2010-05-08 | ||
PCT/EP2011/057021 WO2011141326A1 (fr) | 2010-05-08 | 2011-05-03 | Hétérocyclylbenzyle-pyrazoles substituées et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34939B1 true MA34939B1 (fr) | 2014-03-01 |
Family
ID=44063276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35350A MA34939B1 (fr) | 2010-05-08 | 2011-05-03 | Hétérocyclylbenzyle-pyrazoles substituées et leur utilisation |
Country Status (25)
Country | Link |
---|---|
US (2) | US20130172311A1 (fr) |
EP (1) | EP2569312B1 (fr) |
JP (1) | JP5727002B2 (fr) |
KR (1) | KR20130108997A (fr) |
CN (1) | CN103003269B (fr) |
AR (1) | AR081368A1 (fr) |
AU (1) | AU2011252223A1 (fr) |
BR (1) | BR112012028651A2 (fr) |
CA (1) | CA2798375A1 (fr) |
CO (1) | CO6640218A2 (fr) |
CR (1) | CR20120570A (fr) |
CU (1) | CU20120157A7 (fr) |
DO (1) | DOP2012000284A (fr) |
EA (1) | EA201291167A1 (fr) |
EC (1) | ECSP12012288A (fr) |
ES (1) | ES2462522T3 (fr) |
IL (1) | IL222851A0 (fr) |
MA (1) | MA34939B1 (fr) |
MX (1) | MX2012012960A (fr) |
PE (1) | PE20130228A1 (fr) |
SG (1) | SG185459A1 (fr) |
TN (1) | TN2012000531A1 (fr) |
TW (1) | TW201200510A (fr) |
UY (1) | UY33369A (fr) |
WO (1) | WO2011141326A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8759258B2 (en) * | 2007-05-01 | 2014-06-24 | Hill's Pet Nutrition, Inc. | Methods and compositions for diagnosing osteoarthritis in a feline |
CN101765596B (zh) * | 2007-05-18 | 2015-04-29 | 拜耳知识产权有限责任公司 | 用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂 |
ES2462522T3 (es) * | 2010-05-08 | 2014-05-23 | Bayer Intellectual Property Gmbh | Heterociclilbencilpirazoles sustituidos y uso de los mismos |
MX352351B (es) | 2012-07-02 | 2017-11-21 | Monsanto Technology Llc | Procesos para la preparacion de 1,2,4-oxadiazoles 3,5-disustituidos. |
EP2888253A4 (fr) | 2012-08-24 | 2016-01-06 | Univ Texas | Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies |
EP2888255B1 (fr) | 2012-08-24 | 2018-07-18 | Board of Regents, The University of Texas System | Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies |
WO2014031928A2 (fr) * | 2012-08-24 | 2014-02-27 | Philip Jones | Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies |
EP3110420B8 (fr) | 2014-02-25 | 2019-07-10 | Board of Regents, The University of Texas System | Sels de modulateurs hétérocycliques de l'activité de hif pour le traitement de maladies |
US10191597B2 (en) | 2015-06-30 | 2019-01-29 | Synaptics Incorporated | Modulating a reference voltage to preform capacitive sensing |
KR102544307B1 (ko) * | 2017-01-13 | 2023-06-15 | 닛산 가가쿠 가부시키가이샤 | 방향족 디아민 화합물 전구체의 제조 방법 |
CN115944626B (zh) * | 2022-12-08 | 2024-04-19 | 桂林医学院附属医院 | 小分子化合物在制备抗缺氧或缺血再灌注损伤药物中的应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610726B2 (en) * | 2001-06-29 | 2003-08-26 | North Shore-Long Island Jewish Research Institute | Compositions and agents for modulating cellular proliferation and angiogenesis |
WO2004089303A2 (fr) | 2003-04-03 | 2004-10-21 | Merck & Co., Inc. | Modulateurs au pyrazole a substitution diaryle du recepteur-5 de glutamate metabotropique |
AU2004275694B2 (en) | 2003-06-30 | 2008-03-06 | Bizbiotech Co., Ltd. | Compounds, compositions and methods |
CN1842332A (zh) * | 2003-06-30 | 2006-10-04 | Hif生物公司 | 化合物、组合物及方法 |
GB0508472D0 (en) * | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
WO2007065010A2 (fr) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Composes anti-angiogenese |
CN101765596B (zh) * | 2007-05-18 | 2015-04-29 | 拜耳知识产权有限责任公司 | 用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂 |
DE102008057344A1 (de) * | 2008-11-14 | 2010-05-20 | Bayer Schering Pharma Aktiengesellschaft | Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung |
CA2743536A1 (fr) * | 2008-11-14 | 2010-05-20 | Bayer Schering Pharma Aktiengesellschaft | Composes aryles substitues par heterocycle comme inhibiteurs de hif |
EP2356112A1 (fr) * | 2008-11-14 | 2011-08-17 | Bayer Schering Pharma Aktiengesellschaft | Composés hétéroaromatiques pour une utilisation comme inhibiteurs de hif |
EP2202232A1 (fr) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | Dérivés du 1,2,4-oxadiazole et leur application thérapeutique |
WO2010085584A1 (fr) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Dérivés de pyrazole-1,2,4-oxadiazole en tant qu'agonistes de sphingosine-1-phosphate |
ES2462522T3 (es) * | 2010-05-08 | 2014-05-23 | Bayer Intellectual Property Gmbh | Heterociclilbencilpirazoles sustituidos y uso de los mismos |
-
2011
- 2011-05-03 ES ES11716595.1T patent/ES2462522T3/es active Active
- 2011-05-03 WO PCT/EP2011/057021 patent/WO2011141326A1/fr active Application Filing
- 2011-05-03 BR BR112012028651A patent/BR112012028651A2/pt not_active IP Right Cessation
- 2011-05-03 MA MA35350A patent/MA34939B1/fr unknown
- 2011-05-03 AU AU2011252223A patent/AU2011252223A1/en not_active Abandoned
- 2011-05-03 JP JP2013509505A patent/JP5727002B2/ja not_active Expired - Fee Related
- 2011-05-03 KR KR1020127032069A patent/KR20130108997A/ko not_active Application Discontinuation
- 2011-05-03 US US13/696,878 patent/US20130172311A1/en not_active Abandoned
- 2011-05-03 EA EA201291167A patent/EA201291167A1/ru unknown
- 2011-05-03 CA CA2798375A patent/CA2798375A1/fr not_active Abandoned
- 2011-05-03 SG SG2012082145A patent/SG185459A1/en unknown
- 2011-05-03 CN CN201180033637.5A patent/CN103003269B/zh not_active Expired - Fee Related
- 2011-05-03 EP EP11716595.1A patent/EP2569312B1/fr active Active
- 2011-05-03 PE PE2012002121A patent/PE20130228A1/es not_active Application Discontinuation
- 2011-05-03 MX MX2012012960A patent/MX2012012960A/es active IP Right Grant
- 2011-05-04 AR ARP110101533A patent/AR081368A1/es not_active Application Discontinuation
- 2011-05-04 UY UY0001033369A patent/UY33369A/es not_active Application Discontinuation
- 2011-05-06 TW TW100115869A patent/TW201200510A/zh unknown
- 2011-05-09 US US13/103,305 patent/US8470811B2/en not_active Expired - Fee Related
-
2012
- 2012-11-05 IL IL222851A patent/IL222851A0/en unknown
- 2012-11-07 CU CU2012000157A patent/CU20120157A7/es unknown
- 2012-11-07 TN TNP2012000531A patent/TN2012000531A1/en unknown
- 2012-11-07 DO DO2012000284A patent/DOP2012000284A/es unknown
- 2012-11-08 EC ECSP12012288 patent/ECSP12012288A/es unknown
- 2012-11-08 CO CO12201711A patent/CO6640218A2/es not_active Application Discontinuation
- 2012-11-08 CR CR20120570A patent/CR20120570A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ES2462522T3 (es) | 2014-05-23 |
CR20120570A (es) | 2013-04-22 |
IL222851A0 (en) | 2012-12-31 |
MX2012012960A (es) | 2012-12-17 |
AU2011252223A1 (en) | 2012-12-06 |
ECSP12012288A (es) | 2012-12-28 |
DOP2012000284A (es) | 2013-03-31 |
CU20120157A7 (es) | 2013-03-27 |
BR112012028651A2 (pt) | 2016-08-09 |
PE20130228A1 (es) | 2013-03-15 |
SG185459A1 (en) | 2012-12-28 |
CO6640218A2 (es) | 2013-03-22 |
JP2013526497A (ja) | 2013-06-24 |
WO2011141326A1 (fr) | 2011-11-17 |
EA201291167A1 (ru) | 2013-05-30 |
CA2798375A1 (fr) | 2011-11-17 |
US20130172311A1 (en) | 2013-07-04 |
CN103003269A (zh) | 2013-03-27 |
EP2569312A1 (fr) | 2013-03-20 |
TN2012000531A1 (en) | 2014-04-01 |
AR081368A1 (es) | 2012-08-29 |
KR20130108997A (ko) | 2013-10-07 |
TW201200510A (en) | 2012-01-01 |
US8470811B2 (en) | 2013-06-25 |
UY33369A (es) | 2011-12-01 |
JP5727002B2 (ja) | 2015-06-03 |
CN103003269B (zh) | 2015-11-25 |
US20120028950A1 (en) | 2012-02-02 |
EP2569312B1 (fr) | 2014-03-26 |
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