MA30005B1 - Sel dihydrogenophosphate d'un antagoniste du recepteur de la prostaglandine d2 - Google Patents
Sel dihydrogenophosphate d'un antagoniste du recepteur de la prostaglandine d2Info
- Publication number
- MA30005B1 MA30005B1 MA30890A MA30890A MA30005B1 MA 30005 B1 MA30005 B1 MA 30005B1 MA 30890 A MA30890 A MA 30890A MA 30890 A MA30890 A MA 30890A MA 30005 B1 MA30005 B1 MA 30005B1
- Authority
- MA
- Morocco
- Prior art keywords
- iii
- formula
- urticaria
- pruritus
- inflammation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne l'acide 2-(3-{6-[2-(2,4-dichlorophényl)-éthylamino]-2-méthoxy-pyrimidin-4-yl}-phényl)-2-méthyl-propionique de formule (III), une composition pharmaceutique comprenant une quantité pharmaceutiquement efficace du composé de formule (III) et un support pharmaceutiquement acceptable; et un procédé de traitement d'un patient souffrant d'un trouble médié par la PGD2 y compris, mais sans y être limité, une maladie allergique (telle que la rhinite allergique, la conjonctivite allergique, la dermatite atopique, l'asthme bronchique et une allergie alimentaire), une mastocytose systémique, des troubles s'accompagnant d'une activation systémique des mastocytes, un choc anaphylactique, une bronchoconstriction, une bronchite, une urticaire, un eczéma, des maladies s'accompagnant d'un prurit (telles qu'une dermatite atopique et une urticaire), des maladies (telles que la cataracte, le décollement de la rétine, une inflammation, une infection et des troubles du sommeil) qui sont des conséquences secondaires d'un comportement s'accompagnant d'un prurit (tel que le fait de se gratter et se frapper), une inflammation, des bronchopneumopathies chroniques obstructives, une lésion de reperfusion ischémique, un accident cérébrovasculaire, une polyarthrite rhumatoïde chronique, une pleurésie, une colite ulcéreuse et similaires, par l'administration audit patient d'une quantité pharmaceutiquement efficace du composé de formule (III).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72629005P | 2005-10-13 | 2005-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30005B1 true MA30005B1 (fr) | 2008-12-01 |
Family
ID=37963090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30890A MA30005B1 (fr) | 2005-10-13 | 2008-05-02 | Sel dihydrogenophosphate d'un antagoniste du recepteur de la prostaglandine d2 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7642249B2 (fr) |
| EP (1) | EP1948620B1 (fr) |
| JP (1) | JP2009511591A (fr) |
| KR (1) | KR101365480B1 (fr) |
| CN (1) | CN101287714B (fr) |
| AR (1) | AR058085A1 (fr) |
| AU (1) | AU2006304187B2 (fr) |
| BR (1) | BRPI0617311A2 (fr) |
| CA (1) | CA2625563C (fr) |
| CR (1) | CR9870A (fr) |
| DK (1) | DK1948620T3 (fr) |
| DO (2) | DOP2006000220A (fr) |
| EC (1) | ECSP088362A (fr) |
| ES (1) | ES2409833T3 (fr) |
| GT (1) | GT200600457A (fr) |
| HK (1) | HK1125133A1 (fr) |
| HN (1) | HN2008000603A (fr) |
| HR (1) | HRP20130341T1 (fr) |
| IL (1) | IL190673A (fr) |
| MA (1) | MA30005B1 (fr) |
| MY (1) | MY145648A (fr) |
| NI (1) | NI200800116A (fr) |
| NO (1) | NO20082072L (fr) |
| NZ (1) | NZ567433A (fr) |
| PE (1) | PE20070791A1 (fr) |
| PL (1) | PL1948620T3 (fr) |
| PT (1) | PT1948620E (fr) |
| RS (1) | RS52799B (fr) |
| RU (1) | RU2419614C2 (fr) |
| SI (1) | SI1948620T1 (fr) |
| TN (1) | TNSN08131A1 (fr) |
| TW (1) | TW200728288A (fr) |
| UA (1) | UA93062C2 (fr) |
| UY (1) | UY29862A1 (fr) |
| WO (1) | WO2007047378A2 (fr) |
| ZA (1) | ZA200802586B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2005000795A (es) * | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| DOP2007000068A (es) * | 2006-04-12 | 2007-10-31 | Sanofi Aventis Us Llc | Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2 |
| AU2007257841A1 (en) * | 2006-06-09 | 2007-12-21 | Icos Corporation | Substituted phenyl acetic acids as DP-2 antagonists |
| ATE531699T1 (de) * | 2007-06-29 | 2011-11-15 | Sanofi Sa | Verfahren zur herstellung von 2-(3-ä6-ä2-(2,4- |
| US8168678B2 (en) | 2008-02-01 | 2012-05-01 | Panmira Pharmaceuticals, Inc. | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors |
| WO2009108720A2 (fr) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonistes des récepteurs d2 de la prostaglandine |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (fr) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Antagonistes d’hétéroaryle des récepteurs de la prostaglandine d2 |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| WO2010045633A2 (fr) * | 2008-10-17 | 2010-04-22 | National Jewish Health | Mesure et analyse de leucotriènes |
| AR074776A1 (es) * | 2008-12-18 | 2011-02-09 | Sanofi Aventis | Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente |
| EP2461809A4 (fr) | 2009-07-31 | 2013-06-19 | Panmira Pharmaceuticals Llc | Compositions pharmaceutiques ophtalmiques d'antagonsites du récepteur dp2 |
| KR20120047273A (ko) | 2009-08-05 | 2012-05-11 | 판미라 파마슈티칼스, 엘엘씨 | Ｄｐ2 길항제 및 이의 용도 |
| WO2012004800A1 (fr) | 2010-07-08 | 2012-01-12 | Ramot At Tel-Aviv University Ltd. | Utilisation de fts et de ses analogues dans le traitement des états inflammatoires allergiques et non allergiques non auto-immuns |
| EP2621276B1 (fr) * | 2010-09-30 | 2017-12-27 | Merck Sharp & Dohme Corp. | 2-alcoxy pyrimidine inhibiteur de pde10 |
| EP3382391A1 (fr) | 2012-10-24 | 2018-10-03 | NYU Winthrop Hospital | Biomarqueur non invasif pour identifier des sujets à risque d'accouchement prématuré |
| WO2016193939A1 (fr) | 2015-06-04 | 2016-12-08 | Aurigene Discovery Technologies Limited | Dérivés hétérocyclyle substitués en tant qu'inhibiteurs de cdk |
| KR20200109293A (ko) | 2017-09-13 | 2020-09-22 | 프로제너티, 인크. | 자간전증 바이오마커 및 관련된 시스템 및 방법 |
| EP4070113A4 (fr) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60236322D1 (de) * | 2001-12-07 | 2010-06-17 | Vertex Pharma | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
| CA2530538A1 (fr) * | 2003-07-09 | 2005-01-20 | Keith Roger Bley | Thiophenyl amino imidazolines |
| HN2005000795A (es) * | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
-
2006
- 2006-10-11 GT GT200600457A patent/GT200600457A/es unknown
- 2006-10-12 CA CA2625563A patent/CA2625563C/fr not_active Expired - Fee Related
- 2006-10-12 ES ES06825836T patent/ES2409833T3/es active Active
- 2006-10-12 DK DK06825836.7T patent/DK1948620T3/da active
- 2006-10-12 KR KR1020087008805A patent/KR101365480B1/ko not_active IP Right Cessation
- 2006-10-12 WO PCT/US2006/039901 patent/WO2007047378A2/fr active Application Filing
- 2006-10-12 PE PE2006001242A patent/PE20070791A1/es not_active Application Discontinuation
- 2006-10-12 PT PT68258367T patent/PT1948620E/pt unknown
- 2006-10-12 BR BRPI0617311-0A patent/BRPI0617311A2/pt not_active IP Right Cessation
- 2006-10-12 JP JP2008535672A patent/JP2009511591A/ja not_active Abandoned
- 2006-10-12 AU AU2006304187A patent/AU2006304187B2/en not_active Ceased
- 2006-10-12 NZ NZ567433A patent/NZ567433A/en not_active IP Right Cessation
- 2006-10-12 CN CN2006800378860A patent/CN101287714B/zh not_active Expired - Fee Related
- 2006-10-12 AR ARP060104475A patent/AR058085A1/es not_active Application Discontinuation
- 2006-10-12 UA UAA200806196A patent/UA93062C2/ru unknown
- 2006-10-12 RS RS20130225A patent/RS52799B/en unknown
- 2006-10-12 PL PL06825836T patent/PL1948620T3/pl unknown
- 2006-10-12 EP EP06825836A patent/EP1948620B1/fr active Active
- 2006-10-12 MY MYPI20081085A patent/MY145648A/en unknown
- 2006-10-12 SI SI200631572T patent/SI1948620T1/sl unknown
- 2006-10-12 RU RU2008118491/04A patent/RU2419614C2/ru not_active IP Right Cessation
- 2006-10-13 UY UY29862A patent/UY29862A1/es unknown
- 2006-10-13 DO DO2006000220A patent/DOP2006000220A/es unknown
- 2006-10-13 TW TW095137635A patent/TW200728288A/zh unknown
- 2006-10-13 DO DO2006P000223A patent/DOP2006000223A/es unknown
-
2008
- 2008-03-19 TN TNP2008000131A patent/TNSN08131A1/en unknown
- 2008-03-20 ZA ZA200802586A patent/ZA200802586B/xx unknown
- 2008-04-07 CR CR9870A patent/CR9870A/es not_active Application Discontinuation
- 2008-04-07 IL IL190673A patent/IL190673A/en not_active IP Right Cessation
- 2008-04-10 EC EC2008008362A patent/ECSP088362A/es unknown
- 2008-04-11 NI NI200800116A patent/NI200800116A/es unknown
- 2008-04-11 US US12/101,282 patent/US7642249B2/en not_active Expired - Fee Related
- 2008-04-11 HN HN2008000603A patent/HN2008000603A/es unknown
- 2008-05-02 NO NO20082072A patent/NO20082072L/no not_active Application Discontinuation
- 2008-05-02 MA MA30890A patent/MA30005B1/fr unknown
-
2009
- 2009-04-14 HK HK09103427.8A patent/HK1125133A1/xx not_active IP Right Cessation
-
2013
- 2013-04-17 HR HRP20130341TT patent/HRP20130341T1/hr unknown
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