ZA200802586B - Dihyrdogen phosphate salt of a prostaglandin D2 receptor antagonist - Google Patents

Dihyrdogen phosphate salt of a prostaglandin D2 receptor antagonist

Info

Publication number
ZA200802586B
ZA200802586B ZA200802586A ZA200802586A ZA200802586B ZA 200802586 B ZA200802586 B ZA 200802586B ZA 200802586 A ZA200802586 A ZA 200802586A ZA 200802586 A ZA200802586 A ZA 200802586A ZA 200802586 B ZA200802586 B ZA 200802586B
Authority
ZA
South Africa
Prior art keywords
dihyrdogen
prostaglandin
receptor antagonist
phosphate salt
phosphate
Prior art date
Application number
ZA200802586A
Other languages
English (en)
Inventor
Langevin Beverly
Orton Edward
Sherer Daniel
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of ZA200802586B publication Critical patent/ZA200802586B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200802586A 2005-10-13 2008-03-20 Dihyrdogen phosphate salt of a prostaglandin D2 receptor antagonist ZA200802586B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72629005P 2005-10-13 2005-10-13

Publications (1)

Publication Number Publication Date
ZA200802586B true ZA200802586B (en) 2009-09-30

Family

ID=37963090

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802586A ZA200802586B (en) 2005-10-13 2008-03-20 Dihyrdogen phosphate salt of a prostaglandin D2 receptor antagonist

Country Status (36)

Country Link
US (1) US7642249B2 (fr)
EP (1) EP1948620B1 (fr)
JP (1) JP2009511591A (fr)
KR (1) KR101365480B1 (fr)
CN (1) CN101287714B (fr)
AR (1) AR058085A1 (fr)
AU (1) AU2006304187B2 (fr)
BR (1) BRPI0617311A2 (fr)
CA (1) CA2625563C (fr)
CR (1) CR9870A (fr)
DK (1) DK1948620T3 (fr)
DO (2) DOP2006000220A (fr)
EC (1) ECSP088362A (fr)
ES (1) ES2409833T3 (fr)
GT (1) GT200600457A (fr)
HK (1) HK1125133A1 (fr)
HN (1) HN2008000603A (fr)
HR (1) HRP20130341T1 (fr)
IL (1) IL190673A (fr)
MA (1) MA30005B1 (fr)
MY (1) MY145648A (fr)
NI (1) NI200800116A (fr)
NO (1) NO20082072L (fr)
NZ (1) NZ567433A (fr)
PE (1) PE20070791A1 (fr)
PL (1) PL1948620T3 (fr)
PT (1) PT1948620E (fr)
RS (1) RS52799B (fr)
RU (1) RU2419614C2 (fr)
SI (1) SI1948620T1 (fr)
TN (1) TNSN08131A1 (fr)
TW (1) TW200728288A (fr)
UA (1) UA93062C2 (fr)
UY (1) UY29862A1 (fr)
WO (1) WO2007047378A2 (fr)
ZA (1) ZA200802586B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2005000795A (es) * 2004-10-15 2010-08-19 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
AR060403A1 (es) * 2006-04-12 2008-06-11 Sanofi Aventis Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2
WO2007146838A2 (fr) * 2006-06-09 2007-12-21 Icos Corporation Acides phénylacétiques substitués utilisés en tant qu'antagonistes de dp-2
ATE531699T1 (de) * 2007-06-29 2011-11-15 Sanofi Sa Verfahren zur herstellung von 2-(3-ä6-ä2-(2,4-
CA2713139C (fr) 2008-02-01 2013-04-23 Amira Pharmaceuticals, Inc. Antagonistes aminoalkylbiphenyle disubstitues par n,n des recepteurs de la prostaglandine d2
JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体アンタゴニスト
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010042652A2 (fr) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Antagonistes hétéroalkyl biphényle des récepteurs de la prostaglandine d2
WO2010045633A2 (fr) * 2008-10-17 2010-04-22 National Jewish Health Mesure et analyse de leucotriènes
TW201034675A (en) * 2008-12-18 2010-10-01 Sanofi Aventis Method for treating macular degeneration
CA2768492A1 (fr) 2009-07-31 2011-02-03 Panmira Pharmaceuticals, Llc Compositions pharmaceutiques ophtalmiques d'antagonsites du recepteur dp2
CN102596902A (zh) 2009-08-05 2012-07-18 潘米拉制药公司 Dp2拮抗剂及其用途
US20130123365A1 (en) 2010-07-08 2013-05-16 Ramot At Tel-Aviv University Ltd. Use of fts and analogs to treat non-autoimmune-allergic and non-allergic inflammatory conditions
US8785467B2 (en) * 2010-09-30 2014-07-22 Merck Sharp & Dohme Corp. Alkoxy pyrimidine PDE10 inhibitors
US9797903B2 (en) 2012-10-24 2017-10-24 Winthrop-University Hospital Non-invasive biomarker to identify subject at risk of preterm delivery
EP4420734A2 (fr) 2015-02-13 2024-08-28 Institut National de la Santé et de la Recherche Médicale Antagonistes de ptgdr-1 et/ou ptgdr-2 pour la prévention et/ou le traitement du lupus érythémateux systémique
CA2987552A1 (fr) 2015-06-04 2016-12-08 Aurigene Discovery Technologies Limited Derives heterocyclyle substitues en tant qu'inhibiteurs de cdk
EP3682250A4 (fr) 2017-09-13 2021-03-03 Progenity, Inc. Biomarqueurs de pré-éclampsie ainsi que systèmes et procédés associés
EP4070113A4 (fr) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198867A1 (fr) 2001-12-07 2010-06-23 Vertex Pharmaceuticals, Inc. Composés à base de pyrimidine utiles en tant qu'inhibiteurs de GSK-3
JP2009513521A (ja) 2003-07-09 2009-04-02 エフ．ホフマン−ラ ロシュ アーゲー プロスタグランジンｉ２アンタゴニストとしてのチオフェニルアミノイミダゾリン類
HN2005000795A (es) * 2004-10-15 2010-08-19 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2

Also Published As

Publication number Publication date
NZ567433A (en) 2010-06-25
SI1948620T1 (sl) 2013-05-31
RS52799B (en) 2013-10-31
DOP2006000223A (es) 2007-05-15
CN101287714A (zh) 2008-10-15
CA2625563A1 (fr) 2007-04-26
TNSN08131A1 (en) 2009-07-14
IL190673A0 (en) 2008-11-03
ECSP088362A (es) 2008-05-30
PE20070791A1 (es) 2007-08-16
PL1948620T3 (pl) 2013-08-30
CR9870A (es) 2008-06-18
HK1125133A1 (en) 2009-07-31
PT1948620E (pt) 2013-05-06
ES2409833T8 (es) 2013-09-26
NO20082072L (no) 2008-05-02
KR20080057275A (ko) 2008-06-24
DK1948620T3 (da) 2013-06-24
AR058085A1 (es) 2008-01-23
KR101365480B1 (ko) 2014-02-21
MY145648A (en) 2012-03-15
RU2419614C2 (ru) 2011-05-27
HRP20130341T1 (en) 2013-05-31
IL190673A (en) 2011-12-29
AU2006304187B2 (en) 2011-04-28
WO2007047378A2 (fr) 2007-04-26
DOP2006000220A (es) 2007-05-15
EP1948620A2 (fr) 2008-07-30
GT200600457A (es) 2007-04-27
HN2008000603A (es) 2010-11-03
TW200728288A (en) 2007-08-01
US7642249B2 (en) 2010-01-05
MA30005B1 (fr) 2008-12-01
RU2008118491A (ru) 2009-11-20
US20080194600A1 (en) 2008-08-14
EP1948620B1 (fr) 2013-03-20
AU2006304187A1 (en) 2007-04-26
NI200800116A (es) 2011-12-15
ES2409833T3 (es) 2013-06-28
CA2625563C (fr) 2011-04-19
BRPI0617311A2 (pt) 2011-07-19
JP2009511591A (ja) 2009-03-19
CN101287714B (zh) 2011-04-06
UA93062C2 (ru) 2011-01-10
WO2007047378A3 (fr) 2007-08-02
UY29862A1 (es) 2007-05-31

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