MA29851B1 - Composes et compositions contenant de la diarylamine et utilisation en tant que modulateurs de recepteurs de c-kit - Google Patents

Composes et compositions contenant de la diarylamine et utilisation en tant que modulateurs de recepteurs de c-kit

Info

Publication number
MA29851B1
MA29851B1 MA30814A MA30814A MA29851B1 MA 29851 B1 MA29851 B1 MA 29851B1 MA 30814 A MA30814 A MA 30814A MA 30814 A MA30814 A MA 30814A MA 29851 B1 MA29851 B1 MA 29851B1
Authority
MA
Morocco
Prior art keywords
compounds
modulators
kit receptors
compositions containing
methods
Prior art date
Application number
MA30814A
Other languages
English (en)
French (fr)
Inventor
Valentina Molteni
Xiaolin Li
Donatella Chianelli
Jon Loren
Yi Liu
Donald S Karanewsky
Pascal Furet
Vito Guagnano
Shuli You
Juliet Nabakka
Xiaodong Liu
Shifeng Pan
Original Assignee
Irm Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc, Novartis Ag filed Critical Irm Llc
Publication of MA29851B1 publication Critical patent/MA29851B1/fr

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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1890703B1 (en) * 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP1928236B1 (en) * 2005-09-27 2011-11-23 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
US8835451B2 (en) * 2006-03-31 2014-09-16 Novartis Ag Compounds
CA2686378C (en) 2007-05-04 2012-07-24 Irm Llc Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
JP5603770B2 (ja) 2007-05-31 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体拮抗薬およびその使用
KR101218926B1 (ko) * 2007-08-22 2013-01-04 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
AU2008289135B2 (en) * 2007-08-22 2012-02-23 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
US20090170842A1 (en) 2007-11-14 2009-07-02 University Of Kansas Brca1-based breast or ovarian cancer prevention agents and methods of use
PE20091492A1 (es) 2008-02-22 2009-10-22 Irm Llc Compuestos y composiciones como inhibidores de c-kit y de la cinasa pdgfr
WO2009131598A1 (en) 2008-04-21 2009-10-29 Taigen Biotechnology Co., Ltd. Heterocyclic compounds
WO2010070032A1 (en) 2008-12-19 2010-06-24 Boehringer Ingelheim International Gmbh Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
PE20121614A1 (es) 2009-12-17 2012-12-21 Boehringer Ingelheim Int Derivados de 6-amino,4-carbonil-pirimidina sustituida como antagonistas del receptor ccr2
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
GB201009603D0 (en) 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
US8921398B2 (en) * 2011-06-09 2014-12-30 Boehringer Ingelheim International Gmbh N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
SMT201900585T1 (it) 2013-03-13 2019-11-13 Forma Therapeutics Inc Derivati di 2-idrossi-1-4-[(4-fenilfenil)carbonil]piperazin-1-iletan-1-one e composti correlati come inibitori di acido grasso sintetasi (fasn) per il trattamento del cancro
US9820488B2 (en) * 2013-11-18 2017-11-21 Elanco Tiergesundheit Ag Compounds for the control of endoparasites
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
JP6917910B2 (ja) 2015-07-02 2021-08-11 セントレクシオン セラピューティクス コーポレイション （４−（（３ｒ，４ｒ）−３−メトキシテトラヒドロ−ピラン−４−イルアミノ）ピペリジン−１−イル）（５−メチル−６−（（（２ｒ，６ｓ）−６−（ｐ−トリル）テトラヒドロ−２ｈ−ピラン−２−イル）メチルアミノ）ピリミジン−４イル）メタノンクエン酸塩
MX2018015452A (es) 2016-12-15 2020-02-10 Soc Des Produits Nestle S A Star Composiciones y metodos que modulan fosforo o las enzimas en un aminal de compañia.
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
EP3873214A4 (en) 2018-10-29 2022-07-13 Forma Therapeutics, Inc. Solid forms of (4-(2-fluoro-4-(1-methyl-1 h-benzo[d]imidazol-5-yl)benzoyl) piperazin-1-yl)(1-hydroxycyclopropyl)methanone
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN114763342A (zh) * 2021-01-09 2022-07-19 江苏天士力帝益药业有限公司 一种高纯度4-甲基哌嗪-1-甲酸酯的合成方法
TW202237082A (zh) * 2021-01-22 2022-10-01 南韓商日東製藥股份有限公司 安諾特明６（Ａｎｏｃｔａｍｉｎ ６）之抑制劑及其用途
EP4366724A4 (en) * 2021-07-09 2025-06-18 CZ Biohub SF, LLC CDK19 selective inhibitors and methods of using them

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670536B2 (de) * 1966-11-09 1975-05-28 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Neue 2-Anilino-5-acylamino-pyrimidlne
DE1918073A1 (de) * 1969-04-09 1970-10-15 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer 5-Aryl-1H-1,5-benzodiazepin-2,4-dione
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
CZ281874B6 (cs) * 1991-11-25 1997-03-12 Pfizer Inc. Indolové deriváty, způsob jejich přípravy, meziprodukty tohoto postupu, farmaceutické prostředky obsahující tyto indolové deriváty a použití.
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
JP2003523942A (ja) * 1999-06-30 2003-08-12 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害剤化合物
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
US7129242B2 (en) * 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
CA2450934A1 (en) * 2001-06-19 2002-12-27 Marco Dodier Pyrimidine inhibitors of phosphodiesterase (pde) 7
JP2004530722A (ja) * 2001-06-29 2004-10-07 アブ サイエンス 骨喪失を治療するためのチロシンキナーゼ阻害剤の使用法
WO2003011837A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003031406A2 (en) * 2001-10-12 2003-04-17 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
US7232825B2 (en) * 2003-05-02 2007-06-19 Guoqing P Chen Phenylaminopyrimidine derivatives and methods of use
BRPI0510032A (pt) * 2004-05-20 2007-10-02 Sugen Inc tiofeno heteroaril aminas
US20060247250A1 (en) * 2005-03-16 2006-11-02 Targegen, Inc. Pyrimidine inhibitors of kinases
US20060292203A1 (en) * 2005-06-08 2006-12-28 Targegen, Inc. Methods and compositions for the treatment of ocular disorders
EP1928236B1 (en) * 2005-09-27 2011-11-23 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors

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