MA28427B1 - Reactions de couplage utilisees pour la preparation de derives (1h-tetrazol-5-yl)-biphenyl - Google Patents

Reactions de couplage utilisees pour la preparation de derives (1h-tetrazol-5-yl)-biphenyl

Info

Publication number
MA28427B1
MA28427B1 MA29224A MA29224A MA28427B1 MA 28427 B1 MA28427 B1 MA 28427B1 MA 29224 A MA29224 A MA 29224A MA 29224 A MA29224 A MA 29224A MA 28427 B1 MA28427 B1 MA 28427B1
Authority
MA
Morocco
Prior art keywords
tetrazol
preparation
coupling reactions
reactions used
biphenyl derivatives
Prior art date
Application number
MA29224A
Other languages
English (en)
Inventor
Christoph Krell
Hans Hirt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA28427B1 publication Critical patent/MA28427B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La présente invention concerne un procédé permettant de fabriquer des produits intermédiaires qui peuvent être utilisés pour la fabrication de ARB (également appelés antagonistes des récepteurs de l'angiotensine II ou antagonistes des récepteurs AT1) comprenant, en tant qu'élément structurel commun, un noyau (IH-tetrazol-5-yl)-biphényl.
MA29224A 2004-02-02 2006-08-01 Reactions de couplage utilisees pour la preparation de derives (1h-tetrazol-5-yl)-biphenyl MA28427B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0402262.0A GB0402262D0 (en) 2004-02-02 2004-02-02 Process for the manufacture of organic compounds

Publications (1)

Publication Number Publication Date
MA28427B1 true MA28427B1 (fr) 2007-02-01

Family

ID=31985494

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29224A MA28427B1 (fr) 2004-02-02 2006-08-01 Reactions de couplage utilisees pour la preparation de derives (1h-tetrazol-5-yl)-biphenyl

Country Status (19)

Country Link
US (2) US7700784B2 (fr)
EP (2) EP2246348A1 (fr)
JP (1) JP2007519684A (fr)
KR (1) KR20060128993A (fr)
CN (1) CN100528868C (fr)
AU (1) AU2005211500B2 (fr)
BR (1) BRPI0507352A (fr)
CA (1) CA2553246A1 (fr)
CO (1) CO5700717A2 (fr)
EC (1) ECSP066727A (fr)
GB (1) GB0402262D0 (fr)
IL (2) IL176904A0 (fr)
MA (1) MA28427B1 (fr)
NO (1) NO20063920L (fr)
NZ (1) NZ548690A (fr)
RU (2) RU2426728C2 (fr)
TN (1) TNSN06238A1 (fr)
WO (1) WO2005075462A1 (fr)
ZA (1) ZA200605462B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
JP5023720B2 (ja) * 2006-08-04 2012-09-12 東ソー株式会社 ハロゲン化ビフェニル類の製造方法
EP3067043B1 (fr) * 2007-11-06 2022-11-30 Novartis AG Compositions pharmaceutiques basées sur des superstructures d'antagoniste/bloqueur du récepteur de l'angiotensine (arb) et de l'inhibiteur de l'endopeptidase neutre (nep)
AR070176A1 (es) 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
JP5261140B2 (ja) * 2008-11-07 2013-08-14 東ソー株式会社 ビニル芳香族化合物の製造方法
JP5203144B2 (ja) * 2008-11-07 2013-06-05 東ソー株式会社 スチレン類の製造方法
AU2011295170B2 (en) 2010-08-23 2014-12-18 Novartis Ag Process for the preparation of intermediates for the manufacture of NEP inhibitors
WO2012026565A1 (fr) * 2010-08-27 2012-03-01 帝人ファーマ株式会社 Procédé de production d'un dérivé hétérocyclique substitué par un phényle à l'aide d'un procédé de couplage utilisant un composé de palladium
CN103467341B (zh) * 2013-08-29 2015-02-25 河南师范大学 一种沙坦联苯的制备方法
CN104987327A (zh) * 2015-07-13 2015-10-21 朱绍清 一种四唑类衍生物的催化合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (fr) 1986-07-11 1995-01-24 David John Carini Imidazoles bloquant les recepteurs de l'angiotensine ii
US4874867A (en) * 1987-05-22 1989-10-17 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
SG52330A1 (en) 1989-06-14 1998-09-28 Smithkline Beecham Corp Imidazolyl-alkenoic acids
DE122007000050I1 (de) 1990-02-19 2007-11-08 Novartis Ag Acylverbindungen
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
IE910913A1 (en) 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CA2229000C (fr) 1991-02-21 2002-04-09 Sankyo Company, Limited Derives de 1-biphenylimidazole, leur preparation et leur utilisation therapeutique
TW226375B (fr) 1991-10-24 1994-07-11 American Home Prod
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
FR2688503B1 (fr) 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
EP0550313A1 (fr) 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
AU3868595A (en) 1994-10-27 1996-05-23 Novartis Ag Process for the preparation of tetrazoles
JP3763869B2 (ja) * 1994-12-26 2006-04-05 東ソー・ファインケム株式会社 ビフェニル化合物の製造方法
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
DE10057679A1 (de) 2000-11-21 2002-05-29 Forschungszentrum Juelich Gmbh Brennstoffzellenstapel mit Kreislaufführung
CN100381425C (zh) * 2002-07-19 2008-04-16 记忆药物公司 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑及其药物组合物和用途
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
US7038060B2 (en) * 2003-02-05 2006-05-02 Teva Pharmaceutical Industries Ltd. Synthesis of 2-butyl-3-(2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one
PT1631313E (pt) 2003-06-05 2015-07-02 Genentech Inc Terapêutica de combinação para distúrbios de células b

Also Published As

Publication number Publication date
US7700784B2 (en) 2010-04-20
NO20063920L (no) 2006-10-30
GB0402262D0 (en) 2004-03-10
BRPI0507352A (pt) 2007-07-03
KR20060128993A (ko) 2006-12-14
IL176904A0 (en) 2006-12-10
NZ548690A (en) 2009-08-28
CO5700717A2 (es) 2006-11-30
US20100152458A1 (en) 2010-06-17
AU2005211500B2 (en) 2009-04-02
EP2246348A1 (fr) 2010-11-03
EP1716140A1 (fr) 2006-11-02
CN1914197A (zh) 2007-02-14
CN100528868C (zh) 2009-08-19
WO2005075462A1 (fr) 2005-08-18
TNSN06238A1 (en) 2007-12-03
ZA200605462B (en) 2009-06-24
RU2006131460A (ru) 2008-03-10
AU2005211500A1 (en) 2005-08-18
IL208409A0 (en) 2011-08-01
JP2007519684A (ja) 2007-07-19
RU2010136996A (ru) 2012-03-20
US20070129413A1 (en) 2007-06-07
CA2553246A1 (fr) 2005-08-18
RU2426728C2 (ru) 2011-08-20
ECSP066727A (es) 2006-10-31

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