LV12814B - Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni - Google Patents

Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni Download PDF

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Publication number
LV12814B
LV12814B LVP-01-167A LV010167A LV12814B LV 12814 B LV12814 B LV 12814B LV 010167 A LV010167 A LV 010167A LV 12814 B LV12814 B LV 12814B
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LV
Latvia
Prior art keywords
cgb
pde
dna
seq
human
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LVP-01-167A
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English (en)
Other versions
LV12814A (lv
Inventor
Joseph A. Beavo
Jackie D. CORBIN
Kenneth M. Ferguson
Sharron H. FRANCIS
Ann Kadlecek
Kate LOUGHNEY
Linda M. Mcallister-Lucas
William K. SONNENBURG
Meliss K. Thomas
Original Assignee
Board Of Regents Of The University Of Washington
Icos Corporation
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Application filed by Board Of Regents Of The University Of Washington, Icos Corporation filed Critical Board Of Regents Of The University Of Washington
Publication of LV12814A publication Critical patent/LV12814A/lv
Publication of LV12814B publication Critical patent/LV12814B/lv

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Saccharide Compounds (AREA)

Claims (21)

  1. IZGUDROJUMA FORMULA
    1. Attīrīts un izdalīts polinukleotīds, kas kodē cilvēku cikliskas GMP-saistošas, cikliskas GMP-specifiskas fosfodiesterāzes (cGB-PDE) polipeptīdu, kā norādīts secībā SEQ ID NO:
    23.
  2. 2. Attīrīts un izdalīts polinukleotīds, kas kodē cGB-PDE polipeptīda, kā norādīts secībā SEQ ID NO: 23, cilvēku alēlu variantu, kas atšķiras ar to, ka šo polinukleotīdu hibridizē 65 °C temperatūrā 3X SSC, 20 mM nātrija fosfāta ar pH 6,8, atmazgājot 65 °C temperatūrā 2X SSC līdz DNS, kā norādīts secībā SEQ ID NO: 22, nekodējošās spirāles.
  3. 3. Polinukleotīds saskaņā ar 1. vai 2.punktu, kurš ir DNS.
  4. 4. DNS saskaņā ar 3.punktu, kura ir kDNS.
  5. 5. DNS saskaņā ar 3.punktu, kura ir genoma DNS.
  6. 6. DNS saskaņā ar 5.punktu RNS transkripts.
  7. 7. DNS saskaņā ar 5.punktu, kurā papildus ietilpst endogēnas ekspresijas DNS kontrolsecība.
  8. 8. Vektors, kurā ietilpst DNS saskaņā ar 3.punktu.
  9. 9. Vektors saskaņā ar 8.punktu, kas atšķiras ar to, ka DNS operatīvi saistīta ar ekspresijas kontrolsecību.
  10. 10. Saimnieka šūna stabili transformēta vai transfektēta ar DNS secību saskaņā ar 3.punktu tādā veidā, kas ļauj cGB-PDE ar secību SEQ ID NO: 23 ekspresiju saimnieka šūnā.
  11. 11. cGB-PDE polipeptīda producēšanas paņēmiens, kurā ietilpst saimnieka šūnas saskaņā ar
    10.punktu augšana pieņemamā barotnē un cGB-PDE polipeptīda izdalīšana no šūnas vai barotnes, kurā šis polipeptīds aug.
  12. 12. cGB-PDE polinukleotīds, kas producēts pēc paņēmiena saskaņa ar 11.punktu.
  13. 13. Attīrīts un izdalīts polinukleotids, kurā ietilpst DNS secība, kā noradīts secība SEQ ID
    NO: 22. ·
  14. 14. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 516- 875.
  15. 15. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 1-494.
  16. 16. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 1-549.
  17. 17. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 515-879.
  18. 18. Antiviela specifiski imūnreaktīva ar cGB-PDE, kā norādīts secībā SEQ ID NO: 23.
  19. 19. Antiviela saskaņā ar 18.punktu, kura ir monoklonāla antiviela.
  20. 20. Hibridomas šūnu līnija, kas producē antivielu saskaņā ar 19.punktu.
  21. 21. Antiviela saskaņa ar 18.punktu, kura ir humanizēta antiviela.
LVP-01-167A 1993-05-27 2001-12-12 Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni LV12814B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6805193A 1993-05-27 1993-05-27

Publications (2)

Publication Number Publication Date
LV12814A LV12814A (lv) 2002-04-20
LV12814B true LV12814B (lv) 2002-10-20

Family

ID=22080121

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-01-167A LV12814B (lv) 1993-05-27 2001-12-12 Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni

Country Status (13)

Country Link
US (7) US5702936A (lv)
EP (2) EP1038963B1 (lv)
JP (3) JP4150070B2 (lv)
AT (2) ATE438723T1 (lv)
CA (3) CA2363537C (lv)
DE (3) DE69426804D1 (lv)
DK (2) DK0652960T3 (lv)
ES (2) ES2156898T3 (lv)
GR (1) GR3035616T3 (lv)
HK (1) HK1013427A1 (lv)
LV (1) LV12814B (lv)
PT (2) PT1038963E (lv)
WO (1) WO1994028144A1 (lv)

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US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
AU2002211228A1 (en) * 2000-09-14 2002-03-26 Mount Sinai School Of Medicine Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
MXPA03009580A (es) * 2001-04-20 2004-12-06 Sinai School Medicine Tir3, un receptor de sabor novedoso.
US20070213407A1 (en) * 2001-06-29 2007-09-13 Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc Compounds to treat Alzheimer's disease
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Also Published As

Publication number Publication date
EP0652960A1 (en) 1995-05-17
EP1038963A3 (en) 2000-10-04
US5955583A (en) 1999-09-21
EP1038963B1 (en) 2009-08-05
US5652131A (en) 1997-07-29
EP0652960B9 (en) 2004-10-27
JP2005245467A (ja) 2005-09-15
CA2141060C (en) 2002-02-19
US20060216809A1 (en) 2006-09-28
DK1038963T3 (da) 2009-11-23
EP0652960B1 (en) 2001-03-07
JPH08502900A (ja) 1996-04-02
ATE199569T1 (de) 2001-03-15
JP2010042035A (ja) 2010-02-25
CA2698716A1 (en) 1994-12-08
JP4150070B2 (ja) 2008-09-17
DK0652960T3 (da) 2001-04-17
DE69426804D1 (de) 2001-04-12
PT652960E (pt) 2001-08-30
DE69426804T4 (de) 2005-10-13
CA2363537C (en) 2010-07-06
ES2156898T3 (es) 2001-08-01
US6037119A (en) 2000-03-14
GR3035616T3 (en) 2001-06-29
EP1038963A2 (en) 2000-09-27
LV12814A (lv) 2002-04-20
DE69426804T2 (de) 2001-07-19
ES2333691T3 (es) 2010-02-26
US20030054992A1 (en) 2003-03-20
CA2363537A1 (en) 1994-12-08
PT1038963E (pt) 2009-10-13
ATE438723T1 (de) 2009-08-15
JP4450767B2 (ja) 2010-04-14
US5702936A (en) 1997-12-30
WO1994028144A1 (en) 1994-12-08
CA2141060A1 (en) 1994-12-08
DE69435227D1 (de) 2009-09-17
HK1013427A1 (en) 1999-08-27
US20050196833A1 (en) 2005-09-08

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