LV12814A - Cyclic gmp-binding cyclic gmp-specific phosphodiesterase materials and methods - Google Patents

Cyclic gmp-binding cyclic gmp-specific phosphodiesterase materials and methods Download PDF

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Publication number
LV12814A
LV12814A LV010167A LV010167A LV12814A LV 12814 A LV12814 A LV 12814A LV 010167 A LV010167 A LV 010167A LV 010167 A LV010167 A LV 010167A LV 12814 A LV12814 A LV 12814A
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LV
Latvia
Prior art keywords
pde
cgb
leu
glu
ala
Prior art date
Application number
LV010167A
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English (en)
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LV12814B (lv
Inventor
Joseph A Beavo
Jackie D Corbin
Kenneth M Ferguson
Sharron H Francis
Ann Kadlecek
Kate Loughney
Linda M Mcallister-Lucas
William K Sonnenburg
Meliss K Thomas
Original Assignee
Univ Washington
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22080121&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV12814(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Washington, Icos Corp filed Critical Univ Washington
Publication of LV12814A publication Critical patent/LV12814A/lv
Publication of LV12814B publication Critical patent/LV12814B/lv

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Claims (21)

  1. LV 12814 IZGUDROJUMA FORMULA 1. Attīrīts un izdalīts polinukleotīds, kas kodē cilvēku cikliskas GMP-saistošas, cikliskas GMP-specifiskas fosfodiesterāzes (cGB-PDE) polipeptīdu, kā norādīts secībā SEQ DD NO: 23.
  2. 2. Attīrīts un izdalīts polinukleotīds, kas kodē cGB-PDE polipeptīda, kā norādīts secībā SEQ ID NO: 23, cilvēku alēlu variantu, kas atšķiras ar to, ka šo polinukleotīdu hibridizē 65 °C temperatūrā 3X SSC, 20 mM nātrija fosfāta ar pH 6,8, atmazgājot 65 °C temperatūrā 2X SSC līdz DNS, kā norādīts secībā SEQ ID NO: 22, nekodējošās spirāles.
  3. 3. Polinukleotīds saskaņā ar 1. vai 2.punktu, kurš ir DNS.
  4. 4. DNS saskaņā ar 3.punktu, kura ir kDNS.
  5. 5. DNS saskaņā ar 3.punktu, kura ir genoma DNS.
  6. 6. DNS saskaņā ar 5.punktu RNS transkripts.
  7. 7. DNS saskaņā ar 5.punktu, kurā papildus ietilpst endogēnas ekspresijas DNS kontrolsecība.
  8. 8. Vektors, kurā ietilpst DNS saskaņā ar 3.punktu.
  9. 9. Vektors saskaņā ar 8.punktu, kas atšķiras ar to, ka DNS operatīvi saistīta ar ekspresijas kontrolsecību.
  10. 10. Saimnieka šūna stabili transformēta vai transfektēta ar DNS secību saskaņā ar 3.punktu tādā veidā, kas ļauj cGB-PDE ar secību SEQ ID NO: 23 ekspresiju saimnieka šūnā.
  11. 11. cGB-PDE polipeptīda producēšanas paņēmiens, kurā ietilpst saimnieka šūnas saskaņā ar 10.punktu augšana pieņemamā barotnē un cGB-PDE polipeptīda izdalīšana no šūnas vai barotnes, kurā šis polipeptīds aug.
  12. 12. cGB-PDE polinukleotīds, kas producēts pēc paņēmiena saskaņā ar 11.punktu. 2
  13. 13. Attīrīts un izdalīts polinukleotīds, kurā ietilpst DNS secība, kā noradīts secībā SEQ ID NO: 22.
  14. 14. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 516- 875.
  15. 15. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ Π) NO: 23 aminoskābes 1-494.
  16. 16. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 1-549.
  17. 17. Cilvēku cGB-PDE fragments, kurā ietilpst secības SEQ ID NO: 23 aminoskābes 515-879.
  18. 18. Antiviela specifiski imūnreaktīva ar cGB-PDE, kā norādīts secībā SEQ ID NO: 23.
  19. 19. Antiviela saskaņā ar 18.punktu, kura ir monoklonāla antiviela.
  20. 20. Hibridomas šūnu līnija, kas producē antivielu saskaņā ar 19.punktu.
  21. 21. Antiviela saskaņā ar 18.punktu, kura ir humanizēta antiviela.
LVP-01-167A 1993-05-27 2001-12-12 Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni LV12814B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6805193A 1993-05-27 1993-05-27

Publications (2)

Publication Number Publication Date
LV12814A true LV12814A (lv) 2002-04-20
LV12814B LV12814B (lv) 2002-10-20

Family

ID=22080121

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-01-167A LV12814B (lv) 1993-05-27 2001-12-12 Cikliskas gmp-saistošas, cikliskas gmp-specifiskas fosfodiesterāzes materiāli un producēšanas paņēmieni

Country Status (13)

Country Link
US (7) US5702936A (lv)
EP (2) EP1038963B1 (lv)
JP (3) JP4150070B2 (lv)
AT (2) ATE199569T1 (lv)
CA (3) CA2698716A1 (lv)
DE (3) DE69426804T4 (lv)
DK (2) DK1038963T3 (lv)
ES (2) ES2333691T3 (lv)
GR (1) GR3035616T3 (lv)
HK (1) HK1013427A1 (lv)
LV (1) LV12814B (lv)
PT (2) PT652960E (lv)
WO (1) WO1994028144A1 (lv)

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US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
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JP2004500425A (ja) 2000-04-19 2004-01-08 リリー　アイコス　リミテッド　ライアビリティ　カンパニー パーキンソン病の処置に対する環状ｇｍｐ特異的ホスホジエステラーゼインヒビターの使用
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US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
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Also Published As

Publication number Publication date
JP2010042035A (ja) 2010-02-25
CA2363537A1 (en) 1994-12-08
DE69426804T4 (de) 2005-10-13
WO1994028144A1 (en) 1994-12-08
LV12814B (lv) 2002-10-20
CA2141060C (en) 2002-02-19
EP1038963B1 (en) 2009-08-05
US20060216809A1 (en) 2006-09-28
US5955583A (en) 1999-09-21
JP4450767B2 (ja) 2010-04-14
EP0652960B1 (en) 2001-03-07
ATE199569T1 (de) 2001-03-15
ES2156898T3 (es) 2001-08-01
US5702936A (en) 1997-12-30
US20050196833A1 (en) 2005-09-08
DK1038963T3 (da) 2009-11-23
ES2333691T3 (es) 2010-02-26
US20030054992A1 (en) 2003-03-20
PT1038963E (pt) 2009-10-13
DE69435227D1 (de) 2009-09-17
US6037119A (en) 2000-03-14
CA2698716A1 (en) 1994-12-08
US5652131A (en) 1997-07-29
DK0652960T3 (da) 2001-04-17
DE69426804T2 (de) 2001-07-19
GR3035616T3 (en) 2001-06-29
JP4150070B2 (ja) 2008-09-17
ATE438723T1 (de) 2009-08-15
DE69426804D1 (de) 2001-04-12
JP2005245467A (ja) 2005-09-15
EP1038963A2 (en) 2000-09-27
CA2141060A1 (en) 1994-12-08
JPH08502900A (ja) 1996-04-02
EP1038963A3 (en) 2000-10-04
PT652960E (pt) 2001-08-30
EP0652960A1 (en) 1995-05-17
HK1013427A1 (en) 1999-08-27
CA2363537C (en) 2010-07-06
EP0652960B9 (en) 2004-10-27

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