LV12211B - HOMERYTHROMICINE-A DERIVATIVES - Google Patents

HOMERYTHROMICINE-A DERIVATIVES Download PDF

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Publication number
LV12211B
LV12211B LVP-98-187A LV980187A LV12211B LV 12211 B LV12211 B LV 12211B LV 980187 A LV980187 A LV 980187A LV 12211 B LV12211 B LV 12211B
Authority
LV
Latvia
Prior art keywords
deoxo
groups
aza
hydrogen
quot
Prior art date
Application number
LVP-98-187A
Other languages
English (en)
Latvian (lv)
Other versions
LV12211A (lv
Inventor
James V. Heck
William J. Leanza
Ronald W. Ratcliffe
Thomas N. Salzmann
Robert R. Wilkening
Michael J. SZYMONIFKA
Kothandarman SHANKARAN
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/855,242 external-priority patent/US5985844A/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of LV12211A publication Critical patent/LV12211A/xx
Publication of LV12211B publication Critical patent/LV12211B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
LVP-98-187A 1991-04-04 1998-09-23 HOMERYTHROMICINE-A DERIVATIVES LV12211B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68021791A 1991-04-04 1991-04-04
US81116191A 1991-12-19 1991-12-19
US07/855,242 US5985844A (en) 1992-03-26 1992-03-26 Homoerythromycin A derivatives modified at the 4"-and 8A-positions

Publications (2)

Publication Number Publication Date
LV12211A LV12211A (lv) 1999-01-20
LV12211B true LV12211B (en) 1999-03-20

Family

ID=27418367

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-98-187A LV12211B (en) 1991-04-04 1998-09-23 HOMERYTHROMICINE-A DERIVATIVES

Country Status (12)

Country Link
EP (1) EP0508699B1 (fr)
JP (1) JP2503156B2 (fr)
AT (1) ATE164165T1 (fr)
CA (1) CA2064634C (fr)
CY (1) CY2097B1 (fr)
DE (1) DE69224765T2 (fr)
DK (1) DK0508699T3 (fr)
ES (1) ES2113410T3 (fr)
GR (1) GR3026677T3 (fr)
HK (1) HK1009649A1 (fr)
IE (1) IE921076A1 (fr)
LV (1) LV12211B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2064985A1 (fr) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoerythromycine (lactames cycliques)
EP0549040A1 (fr) * 1991-12-20 1993-06-30 Merck & Co. Inc. Méthodes pour fabriquer 4" dérivés de 9-désoxo-8a-aza-8a-alkyl-8a-homoérythromycin A
DE69403963T2 (de) * 1993-05-19 1997-11-20 Pfizer Zwischenprodukt für azithromycin
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5958888A (en) * 1996-07-02 1999-09-28 Merial, Inc. Water miscible macrolide solutions
AU4911097A (en) * 1996-11-15 1998-06-03 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
GB9705323D0 (en) * 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
GB9806029D0 (en) * 1998-03-20 1998-05-20 Merck & Co Inc 8a-Azalides as veterinary antimicrobial agents
KR100426510B1 (ko) * 1997-09-10 2004-04-13 머크 앤드 캄파니 인코포레이티드 수의용 항미생물제로서의 8ａ-아잘리드
JP2003512290A (ja) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての８ａ−アザライド
WO1999019331A1 (fr) * 1997-10-16 1999-04-22 Merck & Co., Inc. 8a-azalides, compositions contenant de tels composes, et methodes de traitement associees
US6733767B2 (en) * 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
EP1437360A3 (fr) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-carbamates des macrolides antibactériens
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6353096B1 (en) 1999-04-01 2002-03-05 Merial Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2
FR2788524B1 (fr) * 1999-01-18 2002-04-26 Merial Sas Procede utile pour transformer la fonction 4"(s)-oh du motif cladinose d'un aza macrolide en 4"(r)-nh2
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
US6590084B2 (en) 1999-12-20 2003-07-08 Merial Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
FR2802534B1 (fr) * 1999-12-20 2002-02-01 Merial Sas Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
US6562953B2 (en) 2000-05-30 2003-05-13 Merial Process which is useful for converting the carbonyl function in position 4″ of the cladinose unit of an aza-macrolide into an amine derivative
FR2809728B1 (fr) * 2000-05-30 2003-02-28 Merial Sas Procede utile pour transformer la fonction carbonyle en position 4" du motif cladinose d'un aza macrolide en un derive amine
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
WO2002088158A1 (fr) 2001-04-27 2002-11-07 Pfizer Products Inc. Procede de preparation de derives de 9-deoxo-9a-aza-9a-homoerythromycine a substitues en 4''
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US20080312167A1 (en) * 2005-05-10 2008-12-18 Sulejman Alihodzic 4'' Amino Linked Macrolides Useful for the Treatment of Microbial Infections
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
EP2358732B1 (fr) * 2008-10-24 2013-06-19 Merial Ltd. Méthode de synthèse de composés macrolides
CN112521617B (zh) * 2020-05-21 2022-05-10 南阳师范学院 一种可用于吸附抗生素的多酸基金属有机框架材料及其制备方法和用途
CN113332238A (zh) * 2021-06-09 2021-09-03 四川恒通动保生物科技有限公司 一种加米霉素的复合溶液剂的制备方法
AU2022343476A1 (en) * 2021-09-07 2024-03-21 Zoetis Services Llc Immunomodulating azalides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
YU149889A (en) * 1989-07-26 1991-02-28 Pliva Zagreb Process for preparing biologically active derivatives of tylozine
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje

Also Published As

Publication number Publication date
ES2113410T3 (es) 1998-05-01
JPH05255375A (ja) 1993-10-05
EP0508699B1 (fr) 1998-03-18
ATE164165T1 (de) 1998-04-15
CY2097B1 (en) 2002-04-05
DK0508699T3 (da) 1998-05-04
LV12211A (lv) 1999-01-20
HK1009649A1 (en) 1999-06-04
DE69224765T2 (de) 1998-10-15
CA2064634A1 (fr) 1992-10-05
EP0508699A1 (fr) 1992-10-14
IE921076A1 (en) 1992-10-07
CA2064634C (fr) 1998-08-04
JP2503156B2 (ja) 1996-06-05
DE69224765D1 (de) 1998-04-23
GR3026677T3 (en) 1998-07-31

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