LV12125B - CYCLFILINE ROTAMASE ACTIVITIES INHIBITORS - Google Patents
CYCLFILINE ROTAMASE ACTIVITIES INHIBITORS Download PDFInfo
- Publication number
- LV12125B LV12125B LVP-98-114A LV980114A LV12125B LV 12125 B LV12125 B LV 12125B LV 980114 A LV980114 A LV 980114A LV 12125 B LV12125 B LV 12125B
- Authority
- LV
- Latvia
- Prior art keywords
- group
- neurological activity
- activity
- neurological
- fluorinated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56068595A | 1995-11-20 | 1995-11-20 | |
PCT/US1996/017677 WO1997018828A1 (en) | 1995-11-20 | 1996-11-15 | Inhibitors of cyclophilin rotamase activity |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12125A LV12125A (lv) | 1998-09-20 |
LV12125B true LV12125B (en) | 1998-12-20 |
Family
ID=24238888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-98-114A LV12125B (en) | 1995-11-20 | 1998-07-16 | CYCLFILINE ROTAMASE ACTIVITIES INHIBITORS |
Country Status (18)
Country | Link |
---|---|
US (2) | US6444643B1 (es) |
EP (1) | EP0880358B1 (es) |
JP (1) | JP3089350B2 (es) |
KR (1) | KR19990071482A (es) |
CN (1) | CN1123360C (es) |
AT (1) | ATE246510T1 (es) |
AU (1) | AU714482B2 (es) |
BR (1) | BR9611624A (es) |
CA (1) | CA2238050C (es) |
CZ (1) | CZ154098A3 (es) |
DE (1) | DE69629392T2 (es) |
ES (1) | ES2206608T3 (es) |
LV (1) | LV12125B (es) |
MX (1) | MX9804011A (es) |
NO (1) | NO982264L (es) |
PL (1) | PL327994A1 (es) |
TR (1) | TR199800890T2 (es) |
WO (1) | WO1997018828A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
PA8442401A1 (es) * | 1996-12-09 | 2000-05-24 | Guilford Pharm Inc | Inhibidores polipropilos de ciclofilina |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
AU8918998A (en) | 1997-08-26 | 1999-03-16 | Wisconsin Alumni Research Foundation | Non-immunosuppressive cyclosporins and their use in the prevention and treatmentof hiv infection |
US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
JP4350898B2 (ja) | 1998-07-01 | 2009-10-21 | デビオファーム・ソシエテ・アノニム | 活性の特徴が改善された新規のシクロスポリン |
US6030825A (en) * | 1998-08-19 | 2000-02-29 | Incyte Pharmaceuticals, Inc. | Cyclophilin-type peptidyl-prolyl cis/trans isomerase |
JP2002526453A (ja) * | 1998-09-23 | 2002-08-20 | キープ,マルカス | 選択的なニューロンの放射線保護のためのニューロイムノフィリン類 |
JP2002541264A (ja) | 1999-04-08 | 2002-12-03 | ユーエイビー・リサーチ・ファウンデーション | 冨gオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法 |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
EP1214293A1 (en) | 1999-09-08 | 2002-06-19 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
US20030068321A1 (en) * | 2001-09-07 | 2003-04-10 | Guilford Pharmaceuticals, Inc. | Methods of effecting neuronal activity |
US20040204340A1 (en) * | 2003-04-11 | 2004-10-14 | Guilford Pharmaceuticals, Inc. | Polyprolyl inhibitors of cyclophilin |
CN1984670A (zh) * | 2004-07-13 | 2007-06-20 | 诺瓦提斯公司 | 治疗阿尔茨海默病的环孢菌素 |
US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
ES2373450T3 (es) * | 2004-10-01 | 2012-02-03 | Scynexis, Inc. | Derivados de ciclosporina sustituidos con 3-éter y 3-tioéter para el tratamiento y la prevención de infección por hepatitis c. |
JP2008545663A (ja) * | 2005-05-27 | 2008-12-18 | クイーンズ ユニバーシティ アット キングストン | タンパク質フォールディング障害の治療 |
JP5322647B2 (ja) * | 2005-09-30 | 2013-10-23 | スシネキス インク | ウイルス感染の治療及び予防のためのシクロスポリンaのアリールアルキル及びヘテロアリールアルキル誘導体 |
ES2361635T3 (es) | 2006-05-19 | 2011-06-20 | Scynexis, Inc. | Ciclosporinas para el tratamiento y prevención de trastornos oculares. |
JP2009539292A (ja) * | 2006-06-02 | 2009-11-12 | ぺリション、クロード、アニー | 活性電子の管理 |
US7576057B2 (en) * | 2006-11-20 | 2009-08-18 | Scynexis, Inc. | Cyclic peptides |
WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
NZ584356A (en) | 2007-09-26 | 2011-10-28 | Univ Oregon Health & Science | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
JP5820722B2 (ja) * | 2008-06-06 | 2015-11-24 | スシネキス インク | シクロスポリン類似体及びhcv感染の治療におけるその使用 |
JP5726733B2 (ja) * | 2008-07-30 | 2015-06-03 | シクロフィリン ファーマシューティカルズ コープ. | 非免疫抑制性シクロスポリン類似体分子 |
US8555875B2 (en) * | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
CA2748389A1 (en) * | 2008-12-31 | 2010-07-08 | Scynexis, Inc. | Derivatives of cyclosporin a |
WO2012079172A1 (en) | 2010-12-15 | 2012-06-21 | Isotechnika Pharma Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3260468D1 (en) * | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
US4885276A (en) * | 1987-06-03 | 1989-12-05 | Merck & Co., Inc. | Cyclosporin analogs with modified "C-9 amino acids" |
EP0296123B1 (en) * | 1987-06-19 | 1994-08-31 | Sandoz Ag | Cyclic peptolides |
US4914188A (en) * | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5284826A (en) * | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
EP0484281B2 (en) * | 1990-11-02 | 2000-11-22 | Novartis AG | Cyclosporins |
US5321009A (en) | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5898029A (en) | 1994-04-12 | 1999-04-27 | The John Hopkins University | Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
-
1996
- 1996-05-02 JP JP08111414A patent/JP3089350B2/ja not_active Expired - Fee Related
- 1996-11-15 KR KR1019980703753A patent/KR19990071482A/ko not_active Application Discontinuation
- 1996-11-15 WO PCT/US1996/017677 patent/WO1997018828A1/en not_active Application Discontinuation
- 1996-11-15 AT AT96940289T patent/ATE246510T1/de not_active IP Right Cessation
- 1996-11-15 EP EP96940289A patent/EP0880358B1/en not_active Expired - Lifetime
- 1996-11-15 CA CA2238050A patent/CA2238050C/en not_active Expired - Fee Related
- 1996-11-15 CN CN96199455A patent/CN1123360C/zh not_active Expired - Fee Related
- 1996-11-15 TR TR1998/00890T patent/TR199800890T2/xx unknown
- 1996-11-15 ES ES96940289T patent/ES2206608T3/es not_active Expired - Lifetime
- 1996-11-15 AU AU77210/96A patent/AU714482B2/en not_active Ceased
- 1996-11-15 CZ CZ981540A patent/CZ154098A3/cs unknown
- 1996-11-15 BR BR9611624A patent/BR9611624A/pt not_active Application Discontinuation
- 1996-11-15 PL PL96327994A patent/PL327994A1/xx unknown
- 1996-11-15 DE DE69629392T patent/DE69629392T2/de not_active Expired - Lifetime
-
1998
- 1998-05-18 NO NO982264A patent/NO982264L/no not_active Application Discontinuation
- 1998-05-20 MX MX9804011A patent/MX9804011A/es unknown
- 1998-07-16 LV LVP-98-114A patent/LV12125B/en unknown
-
1999
- 1999-05-28 US US09/321,762 patent/US6444643B1/en not_active Expired - Lifetime
-
2002
- 2002-07-22 US US10/199,107 patent/US20030013645A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH09143198A (ja) | 1997-06-03 |
AU714482B2 (en) | 2000-01-06 |
DE69629392T2 (de) | 2004-06-24 |
KR19990071482A (ko) | 1999-09-27 |
JP3089350B2 (ja) | 2000-09-18 |
BR9611624A (pt) | 1999-06-01 |
US20030013645A1 (en) | 2003-01-16 |
MX9804011A (es) | 1998-09-30 |
CA2238050A1 (en) | 1997-05-29 |
PL327994A1 (en) | 1999-01-04 |
ATE246510T1 (de) | 2003-08-15 |
CA2238050C (en) | 2010-09-28 |
EP0880358B1 (en) | 2003-08-06 |
EP0880358A1 (en) | 1998-12-02 |
CZ154098A3 (cs) | 1998-12-16 |
WO1997018828A1 (en) | 1997-05-29 |
CN1123360C (zh) | 2003-10-08 |
US6444643B1 (en) | 2002-09-03 |
AU7721096A (en) | 1997-06-11 |
CN1207043A (zh) | 1999-02-03 |
NO982264D0 (no) | 1998-05-18 |
EP0880358A4 (en) | 2001-04-18 |
DE69629392D1 (de) | 2003-09-11 |
LV12125A (lv) | 1998-09-20 |
NO982264L (no) | 1998-07-20 |
ES2206608T3 (es) | 2004-05-16 |
TR199800890T2 (xx) | 1998-08-21 |
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