LU93229I2 - "pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" - Google Patents
"pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" Download PDFInfo
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- LU93229I2 LU93229I2 LU93229C LU93229C LU93229I2 LU 93229 I2 LU93229 I2 LU 93229I2 LU 93229 C LU93229 C LU 93229C LU 93229 C LU93229 C LU 93229C LU 93229 I2 LU93229 I2 LU 93229I2
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- LU
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- Prior art keywords
- pitolisant
- hydrochloride
- pharmaceutically acceptable
- acceptable salts
- histamine
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
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- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
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- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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- C07D215/42—Nitrogen atoms attached in position 4
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
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- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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EP98401944A EP0978512A1 (fr) | 1998-07-29 | 1998-07-29 | Non-imidazole aryloxy- (ou arylthio)alkylamines comme antagonistes du recepteur H3 et leur application thérapeutique |
EP98403351A EP0982300A3 (fr) | 1998-07-29 | 1998-12-31 | Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique |
EP04003944A EP1428820B1 (fr) | 1998-07-29 | 1999-07-29 | Alkylamines sans imidazoles comme ligands de récepteur H-3 d'histamine et leurs applications therapeutiques |
EP99941543A EP1100503B1 (fr) | 1998-07-29 | 1999-07-29 | Alkylamines sans imidazoles comme ligands de recepteur h 3? d'histamine et leurs applications therapeutiques |
Publications (1)
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LU93229I2 true LU93229I2 (fr) | 2016-11-21 |
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LU93229C LU93229I2 (fr) | 1998-07-29 | 2016-09-21 | "pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" |
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US (4) | US7138413B1 (fr) |
EP (4) | EP0982300A3 (fr) |
JP (2) | JP4553487B2 (fr) |
AT (2) | ATE276751T1 (fr) |
AU (1) | AU5511999A (fr) |
BE (1) | BE2016C048I2 (fr) |
CA (1) | CA2321881C (fr) |
CY (1) | CY2016032I2 (fr) |
DE (2) | DE69931409T2 (fr) |
DK (2) | DK1428820T3 (fr) |
ES (2) | ES2226423T3 (fr) |
FR (1) | FR16C0038I2 (fr) |
LU (1) | LU93229I2 (fr) |
PT (2) | PT1428820E (fr) |
WO (1) | WO2000006254A2 (fr) |
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BE588558A (fr) * | 1959-03-13 | 1960-09-12 | ||
DE1269134B (de) * | 1962-12-18 | 1968-05-30 | Hydrierwerk Rodleben Veb | Verfahren zur Herstellung von Dialkylaminoalkylaethern von Phenolen |
US3312696A (en) * | 1964-02-20 | 1967-04-04 | Turbanti Luigi | 2-tertiary amino alkoxy-betaphenyl-propiophenones |
US3947434A (en) * | 1973-06-06 | 1976-03-30 | Morton-Norwich Products, Inc. | 9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines |
DE2408530A1 (de) * | 1974-02-22 | 1975-09-04 | Basf Ag | Verfahren zur herstellung von betahalogenalkylaminosulfonylhalogeniden |
GB1513092A (en) * | 1975-06-05 | 1978-06-07 | Bottu | O-aminophenol derivatives |
GB1512880A (en) * | 1975-06-19 | 1978-06-01 | Mitsubishi Chem Ind | 2-substituted-1-(omega-aminoalkoxy) benzenes |
DE3381617D1 (de) * | 1982-03-17 | 1990-07-05 | Asahi Chemical Ind | Indazol-derivate. |
DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
US5348964A (en) * | 1990-07-25 | 1994-09-20 | Merrell Dow Pharmaceuticals Inc. | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
EP0982300A3 (fr) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique |
FR2788775B1 (fr) * | 1999-01-22 | 2001-04-13 | Pf Medicament | Nouvelles n-alcoyl-n-[1-(omega-(arylalcoyloxy)alcoyl] piperidin-4-yl]-4h-3,1-benzo(thia/oxa)zines-2-amines substituees, leur preparation et leur application en therapeutique |
-
1998
- 1998-12-31 EP EP98403351A patent/EP0982300A3/fr not_active Withdrawn
-
1999
- 1999-07-29 US US09/622,199 patent/US7138413B1/en not_active Expired - Lifetime
- 1999-07-29 WO PCT/EP1999/005744 patent/WO2000006254A2/fr active IP Right Grant
- 1999-07-29 EP EP99941543A patent/EP1100503B1/fr not_active Expired - Lifetime
- 1999-07-29 CA CA2321881A patent/CA2321881C/fr not_active Expired - Lifetime
- 1999-07-29 ES ES99941543T patent/ES2226423T3/es not_active Expired - Lifetime
- 1999-07-29 EP EP06002726A patent/EP2000462A3/fr not_active Withdrawn
- 1999-07-29 AU AU55119/99A patent/AU5511999A/en not_active Abandoned
- 1999-07-29 DE DE69931409T patent/DE69931409T2/de not_active Expired - Lifetime
- 1999-07-29 DE DE69920472T patent/DE69920472T2/de not_active Expired - Lifetime
- 1999-07-29 EP EP04003944A patent/EP1428820B1/fr not_active Expired - Lifetime
- 1999-07-29 PT PT04003944T patent/PT1428820E/pt unknown
- 1999-07-29 DK DK04003944T patent/DK1428820T3/da active
- 1999-07-29 JP JP2000562103A patent/JP4553487B2/ja not_active Expired - Lifetime
- 1999-07-29 PT PT99941543T patent/PT1100503E/pt unknown
- 1999-07-29 AT AT99941543T patent/ATE276751T1/de active
- 1999-07-29 AT AT04003944T patent/ATE326446T1/de active
- 1999-07-29 DK DK99941543T patent/DK1100503T3/da active
- 1999-07-29 ES ES04003944T patent/ES2260703T3/es not_active Expired - Lifetime
-
2004
- 2004-06-01 US US10/856,838 patent/US7169928B2/en not_active Expired - Lifetime
-
2006
- 2006-07-03 US US11/478,682 patent/US7910605B2/en not_active Expired - Fee Related
-
2010
- 2010-06-02 JP JP2010127067A patent/JP5301501B2/ja not_active Expired - Lifetime
- 2010-12-15 US US12/968,807 patent/US20110281844A1/en not_active Abandoned
-
2016
- 2016-09-21 LU LU93229C patent/LU93229I2/fr unknown
- 2016-09-23 BE BE2016C048C patent/BE2016C048I2/fr unknown
- 2016-09-26 FR FR16C0038C patent/FR16C0038I2/fr active Active
- 2016-09-28 CY CY2016032C patent/CY2016032I2/el unknown
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