CY2016032I2 - Αλκυλαμινες μη-ιμιδαζολιου σαν συνδετηρες η3-υποδοχεα ισταμινης και θepαπευτικες εφαρμογες αυτων - Google Patents
Αλκυλαμινες μη-ιμιδαζολιου σαν συνδετηρες η3-υποδοχεα ισταμινης και θepαπευτικες εφαρμογες αυτωνInfo
- Publication number
- CY2016032I2 CY2016032I2 CY2016032C CY2016032C CY2016032I2 CY 2016032 I2 CY2016032 I2 CY 2016032I2 CY 2016032 C CY2016032 C CY 2016032C CY 2016032 C CY2016032 C CY 2016032C CY 2016032 I2 CY2016032 I2 CY 2016032I2
- Authority
- CY
- Cyprus
- Prior art keywords
- histamine
- therapeutic applications
- receptor binders
- alkylamines
- imidazole
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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Applications Claiming Priority (4)
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EP98401944A EP0978512A1 (en) | 1998-07-29 | 1998-07-29 | Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications |
EP98403351A EP0982300A3 (en) | 1998-07-29 | 1998-12-31 | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
EP04003944A EP1428820B1 (en) | 1998-07-29 | 1999-07-29 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications |
EP99941543A EP1100503B1 (en) | 1998-07-29 | 1999-07-29 | Non-imidazole alkylamines as histamine h 3?-receptor ligands and their therapeutic applications |
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CY2016032I1 CY2016032I1 (el) | 2017-03-15 |
CY2016032I2 true CY2016032I2 (el) | 2017-03-15 |
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CY2016032C CY2016032I2 (el) | 1998-07-29 | 2016-09-28 | Αλκυλαμινες μη-ιμιδαζολιου σαν συνδετηρες η3-υποδοχεα ισταμινης και θepαπευτικες εφαρμογες αυτων |
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EP (4) | EP0982300A3 (el) |
JP (2) | JP4553487B2 (el) |
AT (2) | ATE276751T1 (el) |
AU (1) | AU5511999A (el) |
BE (1) | BE2016C048I2 (el) |
CA (1) | CA2321881C (el) |
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DE (2) | DE69931409T2 (el) |
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LU (1) | LU93229I2 (el) |
PT (2) | PT1428820E (el) |
WO (1) | WO2000006254A2 (el) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
US6620839B2 (en) | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
US6515013B2 (en) | 2000-07-13 | 2003-02-04 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
DE60117814T2 (de) | 2000-08-08 | 2006-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden |
DE60118754T2 (de) | 2000-08-08 | 2007-01-11 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclische verbindungen als h3 rezeptor liganden |
MXPA03001268A (es) | 2000-08-08 | 2004-09-06 | Johnson & Johnson | Ariloxipiperidinas sin imidazol. |
ATE502928T1 (de) | 2000-11-01 | 2011-04-15 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
US6316475B1 (en) * | 2000-11-17 | 2001-11-13 | Abbott Laboratories | Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications |
MXPA03008319A (es) * | 2001-03-16 | 2003-12-11 | Abbott Lab | Nuevas aminas como ligantes del receptor de histamina-3 y sus aplicaciones terapeuticas. |
US6969730B2 (en) | 2001-03-16 | 2005-11-29 | Abbott Laboratories | Amines as histamine-3 receptor ligands and their therapeutic applications |
AU2002254114A1 (en) * | 2001-03-23 | 2002-10-08 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
WO2003031432A1 (en) * | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
US7064135B2 (en) | 2001-10-12 | 2006-06-20 | Novo Nordisk Inc. | Substituted piperidines |
US20050009815A1 (en) * | 2001-11-27 | 2005-01-13 | Devita Robert J. | 4-Aminoquinoline compounds |
US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
EP1539704A1 (en) * | 2002-08-20 | 2005-06-15 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
AU2003274053A1 (en) * | 2002-10-22 | 2004-05-13 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
MXPA05005116A (es) * | 2002-11-12 | 2005-07-01 | Abbott Lab | Aminas biciclicas sustituidas en la forma de ligandos del receptor de histamina-3. |
US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
BR0317483A (pt) | 2002-12-20 | 2005-11-16 | Glaxo Group Ltd | Derivados de benzodiazepina para o tratamento de desordens neurológicas |
GB0229820D0 (en) * | 2002-12-20 | 2003-01-29 | Glaxo Group Ltd | Novel compounds |
US7265122B2 (en) * | 2003-02-28 | 2007-09-04 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
JPWO2004089410A1 (ja) * | 2003-04-03 | 2006-07-06 | 協和醗酵工業株式会社 | 神経因性疼痛の予防及び/または治療剤 |
US7094790B2 (en) | 2003-05-07 | 2006-08-22 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
FR2856596B1 (fr) * | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
FR2874215B1 (fr) * | 2004-08-11 | 2006-09-29 | Sanofi Synthelabo | Derives de cyclopropylmethanones, leur preparation et leur utilisation en therapeutique |
WO2005082893A2 (en) | 2004-02-25 | 2005-09-09 | Eli Lilly And Company | Histamine h3 receptor antagonists, preparation and therapeutic uses |
US7456164B2 (en) | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
EP1595881A1 (en) | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands |
US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
US20050256309A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands |
EP1756094A1 (en) * | 2004-06-18 | 2007-02-28 | Glaxo Group Limited | 3-cycloalkylbenzazepines as histamine h3 antagonists |
WO2006024955A1 (en) * | 2004-09-01 | 2006-03-09 | Pfizer Products Inc. | Azabicyclic amine histamine-3 receptor antagonists |
US20060141072A1 (en) * | 2004-12-29 | 2006-06-29 | Arvanitidou Evangelia S | Oxidation resistant dentifrice compositions |
EP1690858B1 (en) * | 2005-02-10 | 2008-04-09 | Bioprojet | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine |
EP1707203A1 (en) * | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
EP1707204A1 (en) * | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of epilepsy with non-imidazole alkylamines histamine H3-receptor ligands |
EP1877761A4 (en) * | 2005-04-29 | 2010-03-24 | Rel S Ambrozy | SEALING DISPLAY UNDER USE OF POLYMER YELLOWS |
EP1717233A1 (en) * | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
EP1717234A1 (en) * | 2005-04-29 | 2006-11-02 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
EP1717235A3 (en) * | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
AR054530A1 (es) * | 2005-07-08 | 2007-06-27 | Ferrer Int | Procedimiento para la preparacion de 1-[3-[3-(4-clorofenil)-propoxi]propil]-piperidina |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
TW200808773A (en) | 2006-06-23 | 2008-02-16 | Abbott Lab | Cyclopropyl amine derivatives |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2011002984A1 (en) * | 2009-07-02 | 2011-01-06 | Cephalon, Inc. | Substituted phenoxypropylcycloamine derivatives as histamine-3 (h3) receptor ligands |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
RU2014151017A (ru) | 2012-05-17 | 2016-07-10 | Аррэй Байофарма Инк. | Способ получения гидроксилированных циклопентилпиримидинов |
CA2873658C (en) | 2012-05-17 | 2021-01-26 | Genentech, Inc. | Process for making amino acid compounds |
JP6283663B2 (ja) | 2012-05-17 | 2018-02-21 | ジェネンテック, インコーポレイテッド | Aktを阻害するピリミジニルシクロペンタン化合物の非晶質形態、組成物およびその方法 |
RU2643811C2 (ru) | 2012-05-17 | 2018-02-06 | Аррэй Байофарма Инк. | Способ получения гидроксилированных циклопентилпиримидиновых соединений |
CA2873661C (en) | 2012-05-17 | 2020-07-21 | Genentech, Inc. | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
CA3217159A1 (en) * | 2013-02-01 | 2014-08-07 | Wellstat Therapeutics Corporation | Substituted quinazolin-4-amine compounds and pharmaceutical compositions thereof having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
CN103435575A (zh) * | 2013-08-06 | 2013-12-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 1-( 3-( 3-( 4-氯苯基)丙氧基)丙基)哌啶盐酸盐的制备方法 |
EP3239138A1 (en) * | 2016-04-25 | 2017-11-01 | Sandoz Ag | Hydrogen fumarate salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine |
EP3378477A1 (en) * | 2017-03-21 | 2018-09-26 | BIOPROJET Pharma | New therapeutical use of h3-ligands |
WO2020092604A1 (en) * | 2018-10-30 | 2020-05-07 | Concert Pharmaceuticals, Inc. | Deuterated pitolisant |
KR102669877B1 (ko) * | 2019-12-19 | 2024-05-29 | 삼성전자주식회사 | 통신 장치 및 통신 방법 |
WO2022113008A1 (en) | 2020-11-27 | 2022-06-02 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
US11945788B2 (en) | 2021-06-07 | 2024-04-02 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
US11623920B2 (en) | 2021-06-07 | 2023-04-11 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
EP4374854A1 (en) | 2022-11-28 | 2024-05-29 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical mixture comprising amorphous pitolisant |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE184968C (el) * | ||||
US2870151A (en) * | 1959-01-20 | Mqrpholine -ethers | ||
DE965813C (de) * | 1950-09-29 | 1957-06-19 | Abbott Lab | Verfahren zur Herstellung von AEthern von Morpholinoalkanolen |
DE1007774B (de) * | 1954-09-08 | 1957-05-09 | Hoffmann La Roche | Verfahren zur Herstellung von substituierten therapeutisch wirksamen 2, 6, 6-Trimethylcyclohexen-(1)-yl-(1)-propyl- oder -butylaminen bzw. deren Salzen oder quaternaerenAmmoniumverbindungen |
BE588558A (el) * | 1959-03-13 | 1960-09-12 | ||
DE1269134B (de) * | 1962-12-18 | 1968-05-30 | Hydrierwerk Rodleben Veb | Verfahren zur Herstellung von Dialkylaminoalkylaethern von Phenolen |
US3312696A (en) * | 1964-02-20 | 1967-04-04 | Turbanti Luigi | 2-tertiary amino alkoxy-betaphenyl-propiophenones |
US3947434A (en) * | 1973-06-06 | 1976-03-30 | Morton-Norwich Products, Inc. | 9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines |
DE2408530A1 (de) * | 1974-02-22 | 1975-09-04 | Basf Ag | Verfahren zur herstellung von betahalogenalkylaminosulfonylhalogeniden |
GB1513092A (en) * | 1975-06-05 | 1978-06-07 | Bottu | O-aminophenol derivatives |
GB1512880A (en) * | 1975-06-19 | 1978-06-01 | Mitsubishi Chem Ind | 2-substituted-1-(omega-aminoalkoxy) benzenes |
DE3381617D1 (de) * | 1982-03-17 | 1990-07-05 | Asahi Chemical Ind | Indazol-derivate. |
DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
US5348964A (en) * | 1990-07-25 | 1994-09-20 | Merrell Dow Pharmaceuticals Inc. | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
FR2788775B1 (fr) * | 1999-01-22 | 2001-04-13 | Pf Medicament | Nouvelles n-alcoyl-n-[1-(omega-(arylalcoyloxy)alcoyl] piperidin-4-yl]-4h-3,1-benzo(thia/oxa)zines-2-amines substituees, leur preparation et leur application en therapeutique |
-
1998
- 1998-12-31 EP EP98403351A patent/EP0982300A3/en not_active Withdrawn
-
1999
- 1999-07-29 US US09/622,199 patent/US7138413B1/en not_active Expired - Lifetime
- 1999-07-29 WO PCT/EP1999/005744 patent/WO2000006254A2/en active IP Right Grant
- 1999-07-29 EP EP99941543A patent/EP1100503B1/en not_active Expired - Lifetime
- 1999-07-29 CA CA2321881A patent/CA2321881C/en not_active Expired - Lifetime
- 1999-07-29 ES ES99941543T patent/ES2226423T3/es not_active Expired - Lifetime
- 1999-07-29 EP EP06002726A patent/EP2000462A3/en not_active Withdrawn
- 1999-07-29 AU AU55119/99A patent/AU5511999A/en not_active Abandoned
- 1999-07-29 DE DE69931409T patent/DE69931409T2/de not_active Expired - Lifetime
- 1999-07-29 DE DE69920472T patent/DE69920472T2/de not_active Expired - Lifetime
- 1999-07-29 EP EP04003944A patent/EP1428820B1/en not_active Expired - Lifetime
- 1999-07-29 PT PT04003944T patent/PT1428820E/pt unknown
- 1999-07-29 DK DK04003944T patent/DK1428820T3/da active
- 1999-07-29 JP JP2000562103A patent/JP4553487B2/ja not_active Expired - Lifetime
- 1999-07-29 PT PT99941543T patent/PT1100503E/pt unknown
- 1999-07-29 AT AT99941543T patent/ATE276751T1/de active
- 1999-07-29 AT AT04003944T patent/ATE326446T1/de active
- 1999-07-29 DK DK99941543T patent/DK1100503T3/da active
- 1999-07-29 ES ES04003944T patent/ES2260703T3/es not_active Expired - Lifetime
-
2004
- 2004-06-01 US US10/856,838 patent/US7169928B2/en not_active Expired - Lifetime
-
2006
- 2006-07-03 US US11/478,682 patent/US7910605B2/en not_active Expired - Fee Related
-
2010
- 2010-06-02 JP JP2010127067A patent/JP5301501B2/ja not_active Expired - Lifetime
- 2010-12-15 US US12/968,807 patent/US20110281844A1/en not_active Abandoned
-
2016
- 2016-09-21 LU LU93229C patent/LU93229I2/fr unknown
- 2016-09-23 BE BE2016C048C patent/BE2016C048I2/fr unknown
- 2016-09-26 FR FR16C0038C patent/FR16C0038I2/fr active Active
- 2016-09-28 CY CY2016032C patent/CY2016032I2/el unknown
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