LTIP175A - Nauji selektyviai aromatazę inhibuojantys 4(5)-imidazolai - Google Patents

Nauji selektyviai aromatazę inhibuojantys 4(5)-imidazolai

Info

Publication number
LTIP175A
LTIP175A LTIP175A LTIP175A LTIP175A LT IP175 A LTIP175 A LT IP175A LT IP175 A LTIP175 A LT IP175A LT IP175 A LTIP175 A LT IP175A LT IP175 A LTIP175 A LT IP175A
Authority
LT
Lithuania
Prior art keywords
imidazoles
selective aromatase
aromatase inhibiting
new selective
halogen
Prior art date
Application number
LTIP175A
Other languages
English (en)
Inventor
Johannes Arto KARJALAINEN
Liisa Marja SOEDERVALL
Marketta Arja KALAPUDAS
Olavi Reino Pelkonen
Marja Aire LAINE
Arvo Sakari Risto Lammintausta
Sakari Jarmo Salonen
Original Assignee
Orion-Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919113142A external-priority patent/GB9113142D0/en
Application filed by Orion-Yhtymae Oy filed Critical Orion-Yhtymae Oy
Publication of LTIP175A publication Critical patent/LTIP175A/lt
Publication of LT3164B publication Critical patent/LT3164B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nauji 4(5)-imidazolodariniai, aprašomi formule@@@@@@@@@@@@@@@@kurioje vienas iš R1 ir R2 yra CN, o kitas yra H,CH3,OCH3,NO2,NH2,CN,CF3, CHF2,CH2F arba halogenas;@@R' yra H arba ,kur R3 yra H, Ch3 arba halogenas;@@@R4 yra H irR5 yra H arba R4 ir R5 kartu sudaro ryšį, n yra 1 arba 2 ir y yra nuo0 iki 2, jų stereoizomerai ir jų netoksiškos, farmaciškai priimtinos rūgščių druskos, pasižyminčios selektyviai aromatazę inhibuojančiomis savybes, palyginus su desmolazę inhibuojančiomis jų savybėmis. Išradimo junginiai yra vertingi, gydant nuo ekstrogeno priklausančias ligas, pvz., krūties vėžį arba gėrybinę prostatos hiperplaziją(GPH).
LTIP175A 1991-06-18 1992-08-28 New selective aromatase inhibiting 4(5)-imidazoles LT3164B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113142A GB9113142D0 (en) 1991-06-18 1991-06-18 New selective aromatase inhibiting 4(5)-imidazoles
GB919125924A GB9125924D0 (en) 1991-06-18 1991-12-05 Stereoisomers of an imidazole derivative

Publications (2)

Publication Number Publication Date
LTIP175A true LTIP175A (lt) 1994-08-25
LT3164B LT3164B (en) 1995-02-27

Family

ID=26299089

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP175A LT3164B (en) 1991-06-18 1992-08-28 New selective aromatase inhibiting 4(5)-imidazoles

Country Status (25)

Country Link
US (1) US5559141A (lt)
EP (1) EP0589975A1 (lt)
JP (1) JPH06508119A (lt)
KR (1) KR940701386A (lt)
CN (1) CN1068819A (lt)
AU (1) AU665002B2 (lt)
BG (1) BG98306A (lt)
CA (1) CA2111469A1 (lt)
CZ (1) CZ280293A3 (lt)
FI (1) FI935658A (lt)
GB (1) GB9125924D0 (lt)
HR (1) HRP920170A2 (lt)
HU (1) HUT67325A (lt)
IE (1) IE921963A1 (lt)
IL (2) IL102216A (lt)
LT (1) LT3164B (lt)
LV (1) LV10093B (lt)
MX (1) MX9203000A (lt)
NO (1) NO934688L (lt)
NZ (1) NZ243139A (lt)
PT (1) PT100604A (lt)
SI (1) SI9200113A (lt)
SK (1) SK144393A3 (lt)
TW (1) TW206217B (lt)
WO (1) WO1992022537A1 (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
SE9302333D0 (sv) * 1993-07-06 1993-07-06 Ab Astra New compounds
JP2000504024A (ja) * 1996-04-03 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6297239B1 (en) * 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001275794A1 (en) 2000-07-28 2002-02-13 Sumitomo Pharmaceuticals Co. Ltd. Pyrrole derivatives
BRPI0415179A (pt) 2003-10-07 2006-11-28 Renovis Inc derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20080300243A1 (en) * 2005-02-28 2008-12-04 Kelly Michael G Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
US7902247B2 (en) * 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
JPH032168A (ja) * 1989-03-30 1991-01-08 Farmos Yhtymae Oy アロマターゼ阻害活性を有する新規な４（５）―イミダゾール
US5439928A (en) * 1989-03-30 1995-08-08 Orion-Yhtyma Oy Aromatase inhibiting 4(5)-imidazoles
GB2248058B (en) * 1990-09-21 1994-09-14 Orion Yhtymae Oy Aromatase inhibiting 4(5)-imidazoles

Also Published As

Publication number Publication date
CZ280293A3 (en) 1994-05-18
HU9303653D0 (en) 1994-04-28
JPH06508119A (ja) 1994-09-14
TW206217B (lt) 1993-05-21
CN1068819A (zh) 1993-02-10
GB9125924D0 (en) 1992-02-05
SK144393A3 (en) 1994-11-09
NZ243139A (en) 1994-08-26
NO934688D0 (no) 1993-12-17
WO1992022537A1 (en) 1992-12-23
KR940701386A (ko) 1994-05-28
LV10093B (en) 1995-02-20
LT3164B (en) 1995-02-27
PT100604A (pt) 1993-10-29
HRP920170A2 (en) 1994-08-31
IL102216A (en) 1996-06-18
LV10093A (lv) 1994-05-10
MX9203000A (es) 1993-02-01
FI935658A0 (fi) 1993-12-16
CA2111469A1 (en) 1992-12-23
IE921963A1 (en) 1992-12-30
SI9200113A (en) 1992-12-31
IL102216A0 (en) 1993-01-14
AU665002B2 (en) 1995-12-14
IL115439A0 (en) 1995-12-31
NO934688L (no) 1993-12-17
BG98306A (bg) 1994-08-30
US5559141A (en) 1996-09-24
HUT67325A (en) 1995-03-28
FI935658A (fi) 1993-12-16
EP0589975A1 (en) 1994-04-06
AU1978392A (en) 1993-01-12

Similar Documents

Publication Publication Date Title
LTIP175A (lt) Nauji selektyviai aromatazę inhibuojantys 4(5)-imidazolai
JPS63230671A (ja) ビスーナフタルイミド及びこれを含有する腫瘍抑制及び抗白血病作用を有する医薬
FI952867A0 (fi) Uudet selektiiviset aromataasia inhiboivat yhdisteet
FI942882A0 (fi) Substituoituja imidatsolijohdannaisia ja niiden valmistus ja käyttö
JPH0881433A (ja) 殺虫性ｎ，ｎ’−ジ置換−ｎ，ｎ’−ジアシルヒドラジン
HUT56343A (en) Process for producing 3-aminopyrrol derivatives and pahrmaceutical compositions comprising same
Eldin Cyanothioacetamide and its derivatives in heterocyclic synthesis: a new route for the synthesis of several pyridine and thieno [2, 3-b] pyridine derivatives and their biological evaluation
NO172797C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte imidazolforbindelser
NO913712L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.
Sen Gupta et al. Synthesis and pesticidal activity of some quinazolin‐4 (3H)‐one derivatives
ATE212842T1 (de) Quinoxalin-derivate zur behandlung von tinnitus
YU54292A (sh) Novi 4(5)-imidazoli koji selektivno inhibiraju aromatazu
RU93058561A (ru) Селективно ингибирующие ароматозу производные 4(5)-имидазолы, фармкомпозиции на их основе
ATE277890T1 (de) Substituierte benzamide für die immunstärkung, die behandlung von krebs, infektionen und manisch-depressive erkrankungen
RU94035756A (ru) Производные имидазола, являющиеся ингибиторами питокинов, способы их получения, фармацевтическая композиция

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19970828