LT5353B - Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui - Google Patents

Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui Download PDF

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Publication number
LT5353B
LT5353B LT2005101A LT2005101A LT5353B LT 5353 B LT5353 B LT 5353B LT 2005101 A LT2005101 A LT 2005101A LT 2005101 A LT2005101 A LT 2005101A LT 5353 B LT5353 B LT 5353B
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LT
Lithuania
Prior art keywords
changed
light chain
antibody
heavy
variable region
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Application number
LT2005101A
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English (en)
Lithuanian (lt)
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LT2005101A (en
Inventor
Loudes Tatiana Roque Navarro
Cristina Maria Mateo De Acosta Del Rio
Mabel Rodriguez Gonzalez
Gertrudis Rojas Dorantes
Ariel Talavera Perez
Ernesto Moreno Frais
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Centro De Immunologia Molecular
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Publication date
Application filed by Centro De Immunologia Molecular filed Critical Centro De Immunologia Molecular
Publication of LT2005101A publication Critical patent/LT2005101A/xx
Publication of LT5353B publication Critical patent/LT5353B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LT2005101A 2003-04-23 2005-11-21 Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui LT5353B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030092A CU23403A1 (es) 2003-04-23 2003-04-23 Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores

Publications (2)

Publication Number Publication Date
LT2005101A LT2005101A (en) 2006-03-27
LT5353B true LT5353B (lt) 2006-07-25

Family

ID=40261249

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2005101A LT5353B (lt) 2003-04-23 2005-11-21 Rekombinantiniai antikūniai ir jų fragmentai, atpažįstantys n-glikolil-gm3 gangliozidus, ir jų panaudojimas auglių diagnozei ir gydymui

Country Status (32)

Country Link
EP (1) EP1623997B1 (es)
JP (1) JP2006524194A (es)
KR (1) KR20060006937A (es)
CN (2) CN1809592A (es)
AR (1) AR044076A1 (es)
AU (1) AU2004232391B2 (es)
BR (1) BRPI0409664A (es)
CA (1) CA2523449C (es)
CL (1) CL2004000843A1 (es)
CR (1) CR8105A (es)
CU (1) CU23403A1 (es)
EA (1) EA008353B1 (es)
ES (1) ES2535813T3 (es)
GE (1) GEP20084476B (es)
HK (1) HK1183492A1 (es)
HR (1) HRP20050922A2 (es)
HU (1) HUE025266T2 (es)
IL (1) IL171541A (es)
LT (1) LT5353B (es)
LV (1) LV13427B (es)
MX (1) MXPA05011368A (es)
MY (1) MY144620A (es)
NZ (1) NZ543345A (es)
PE (1) PE20050422A1 (es)
PL (1) PL1623997T3 (es)
RS (2) RS20110319A3 (es)
SI (1) SI1623997T1 (es)
TN (1) TNSN05274A1 (es)
TW (1) TWI343923B (es)
UY (1) UY28289A1 (es)
WO (1) WO2004094477A1 (es)
ZA (1) ZA200509457B (es)

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AU2011250920B2 (en) 2010-05-14 2015-05-21 Amgen Inc. High concentration antibody formulations
AU2012223358A1 (en) 2011-03-01 2013-09-05 Amgen Inc. Sclerostin and DKK-1 bispecific binding agents
SG193610A1 (en) 2011-03-25 2013-11-29 Amgen Inc Anti - sclerostin antibody crystals and formulations thereof
CA2842432C (en) 2011-08-04 2022-10-04 Amgen Inc. Method for treating bone gap defects
CU24070B1 (es) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3)
BR112014016108A2 (pt) 2011-12-28 2018-09-11 Amgen Inc método de tratamento de perda óssea alvelar
CU24120B1 (es) * 2012-03-01 2015-08-27 Ct De Inmunología Molecular Anticuerpos recombinantes con especificidad dual por los gangliósidos n-acetil gm3 y n-glicolil gm3
AU2013285488B2 (en) 2012-07-05 2018-03-22 Ucb Pharma S.A. Treatment for bone diseases
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
EP3119423B1 (en) 2014-03-15 2022-12-14 Novartis AG Treatment of cancer using chimeric antigen receptor
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
CN104651314B (zh) 2015-02-14 2018-06-19 百泰生物药业有限公司 获得高产稳定表达细胞克隆的方法及由此获得的抗体分子
US20180298068A1 (en) 2015-04-23 2018-10-18 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
US11667691B2 (en) 2015-08-07 2023-06-06 Novartis Ag Treatment of cancer using chimeric CD3 receptor proteins
MX2018008106A (es) 2015-12-30 2019-03-14 Novartis Ag Terapias con celulas inmunoefectoras de una eficacia mejorada.
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
WO2018140725A1 (en) 2017-01-26 2018-08-02 Novartis Ag Cd28 compositions and methods for chimeric antigen receptor therapy
JP2020506700A (ja) 2017-01-31 2020-03-05 ノバルティス アーゲー 多重特異性を有するキメラｔ細胞受容体タンパク質を用いた癌の治療
EP3700926A1 (en) 2017-10-25 2020-09-02 Novartis AG Methods of making chimeric antigen receptor-expressing cells
EP3700933A1 (en) 2017-10-25 2020-09-02 Novartis AG Antibodies targeting cd32b and methods of use thereof
CU20170173A7 (es) * 2017-12-27 2019-11-04 Ct Inmunologia Molecular Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras
MA52217A (fr) 2018-03-30 2021-02-17 Amgen Inc Variants d'anticorps anti-c-terminal
WO2019210153A1 (en) 2018-04-27 2019-10-31 Novartis Ag Car t cell therapies with enhanced efficacy
EP3801769A1 (en) 2018-05-25 2021-04-14 Novartis AG Combination therapy with chimeric antigen receptor (car) therapies
US20210123075A1 (en) 2018-06-08 2021-04-29 Novartis Ag Compositions and methods for immunooncology
KR102344948B1 (ko) * 2018-09-03 2021-12-28 세종대학교산학협력단 인간 순수만능줄기세포에 특이적인 단일클론항체 n1-a4
JP2022514315A (ja) 2018-12-20 2022-02-10 ノバルティス アーゲー ３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体を含む投与計画及び薬剤組み合わせ
WO2020165833A1 (en) 2019-02-15 2020-08-20 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN110208409A (zh) * 2019-06-05 2019-09-06 中国海洋大学 一种乳腺癌的生物标志物及其应用
US20230056470A1 (en) 2019-12-20 2023-02-23 Novartis Ag Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
US20230141511A1 (en) 2019-12-20 2023-05-11 Ludwig Institute For Cancer Research Ltd Car-t cell therapy targeting ngcgm3
WO2024089639A1 (en) 2022-10-26 2024-05-02 Novartis Ag Lentiviral formulations

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US5712120A (en) 1994-06-30 1998-01-27 Centro De Immunologia Molecular Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them

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EP0796334A1 (en) 1994-10-28 1997-09-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Tumor-specific antibody fragments, fusion proteins, and uses thereof

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Also Published As

Publication number Publication date
HRP20050922A2 (en) 2007-03-31
WO2004094477A1 (es) 2004-11-04
CA2523449C (en) 2012-09-18
LV13427B (en) 2006-09-20
CN103012586A (zh) 2013-04-03
CL2004000843A1 (es) 2005-04-15
ES2535813T3 (es) 2015-05-18
RS51853B (en) 2012-02-29
HUE025266T2 (en) 2016-02-29
RS20110319A3 (en) 2012-10-31
PL1623997T3 (pl) 2015-08-31
BRPI0409664A (pt) 2006-04-18
AU2004232391B2 (en) 2008-10-30
IL171541A (en) 2013-11-28
LT2005101A (en) 2006-03-27
KR20060006937A (ko) 2006-01-20
AR044076A1 (es) 2005-08-24
CU23403A1 (es) 2009-08-04
EP1623997A1 (en) 2006-02-08
AU2004232391A1 (en) 2004-11-04
EA008353B1 (ru) 2007-04-27
GEP20084476B (en) 2008-09-10
SI1623997T1 (sl) 2015-07-31
EA200501653A1 (ru) 2006-06-30
CN1809592A (zh) 2006-07-26
CA2523449A1 (en) 2004-11-04
JP2006524194A (ja) 2006-10-26
TW200504090A (en) 2005-02-01
CR8105A (es) 2006-05-31
UY28289A1 (es) 2004-11-30
RS20050795A (en) 2007-12-31
MY144620A (en) 2011-10-14
NZ543345A (en) 2009-09-25
ZA200509457B (en) 2006-07-26
CN103012586B (zh) 2014-08-06
TWI343923B (en) 2011-06-21
HK1183492A1 (en) 2013-12-27
TNSN05274A1 (en) 2007-07-10
RS20110319A2 (en) 2012-02-29
PE20050422A1 (es) 2005-06-29
EP1623997B1 (en) 2015-04-22
MXPA05011368A (es) 2006-03-08

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