LT4800B - Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas - Google Patents

Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas Download PDF

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Publication number
LT4800B
LT4800B LT2000082A LT2000082A LT4800B LT 4800 B LT4800 B LT 4800B LT 2000082 A LT2000082 A LT 2000082A LT 2000082 A LT2000082 A LT 2000082A LT 4800 B LT4800 B LT 4800B
Authority
LT
Lithuania
Prior art keywords
compound
group
sustained release
angiotensin
acid
Prior art date
Application number
LT2000082A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2000082A (en
Inventor
Yasutaka Igari
Akira Saikawa
Yoshiyuki Inada
Shigeru Kamei
Original Assignee
Takeda Chemical Industries,Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries,Ltd filed Critical Takeda Chemical Industries,Ltd
Publication of LT2000082A publication Critical patent/LT2000082A/xx
Publication of LT4800B publication Critical patent/LT4800B/lt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LT2000082A 1998-03-04 2000-08-31 Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas LT4800B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5236698 1998-03-04

Publications (2)

Publication Number Publication Date
LT2000082A LT2000082A (en) 2001-03-26
LT4800B true LT4800B (lt) 2001-06-25

Family

ID=12912818

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2000082A LT4800B (lt) 1998-03-04 2000-08-31 Aii antagonisto sulėtinto atpalaidavimo preparatas, jo gavimas ir panaudojimas

Country Status (21)

Country Link
US (2) US6589547B1 (de)
EP (1) EP1058541B1 (de)
KR (1) KR20010086245A (de)
CN (1) CN1291888A (de)
AT (1) ATE258430T1 (de)
AU (1) AU2745199A (de)
BR (1) BR9908474A (de)
CA (1) CA2318446C (de)
DE (1) DE69914460T2 (de)
EE (1) EE200000499A (de)
ES (1) ES2214013T3 (de)
HU (1) HUP0101439A3 (de)
ID (1) ID25640A (de)
IL (1) IL137979A0 (de)
LT (1) LT4800B (de)
LV (1) LV12585B (de)
NO (1) NO20004350L (de)
PL (1) PL342684A1 (de)
SK (1) SK11902000A3 (de)
WO (1) WO1999044590A1 (de)
ZA (1) ZA991706B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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DE69914460T2 (de) * 1998-03-04 2004-10-28 Takeda Chemical Industries, Ltd. Zubereitung mit verzögerter wirkstoffabgabe für aii antagonisten, ihre herstellung und verwendung
CN1172719C (zh) 1999-04-28 2004-10-27 武田药品工业株式会社 单纯性视网膜病或前增殖性视网膜病的预防剂、治疗剂、发展抑制剂
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
BR0013704A (pt) 1999-08-30 2002-05-07 Aventis Pharma Gmbh Uso de inibidores do sistema renina-angiotensina na prevenção de casos cardiovasculares
KR20030016229A (ko) * 2000-02-18 2003-02-26 다케다 야쿠힌 고교 가부시키가이샤 TNF-α 억제제
AU2001232348A1 (en) * 2000-02-21 2001-08-27 Takeda Chemical Industries Ltd. Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same
CA2420055C (en) * 2000-08-25 2010-06-01 Takeda Chemical Industries, Ltd. Fibrinogen-lowering agent
AU2002210925A1 (en) * 2000-10-25 2002-05-06 Takeda Chemical Industries Ltd. Preventives/remedies for portal hypertension
US20040121008A1 (en) * 2001-03-16 2004-06-24 Keiko Shiraishi Process for producing sustained release preparation
CA2456034A1 (en) * 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Sustained-release medicines
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
WO2003041739A1 (fr) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Agents anticancer
EP1452176A4 (de) * 2001-12-03 2009-01-21 Takeda Pharmaceutical Mittel zur verbesserung der insulinresistenz
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
CN100438911C (zh) * 2002-12-27 2008-12-03 武田药品工业株式会社 体重增加抑制剂
US20050038093A1 (en) * 2003-05-02 2005-02-17 Boehringer Ingelheim International Gmbh Treating diabetic retinopathy with angiotensin II receptor blockers
CN1795198B (zh) * 2003-05-29 2011-08-17 杰伊·W·佩特格尤 对神经精神疾病进行医学成像所用的甘油磷酸胆碱及其衍生物
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
WO2005097109A1 (en) * 2004-04-01 2005-10-20 Daniel Batlle Methods for achieving a protective ace2 expression level
EP1750862B1 (de) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Irbesartan enthaltende pharmazeutische zusammensetzung
AU2005290394A1 (en) * 2004-10-07 2006-04-13 Takeda Pharmaceutical Company Limited Agent for prophylaxis or treatment of metabolic syndrome
KR20070074576A (ko) * 2004-10-29 2007-07-12 코와 가부시키가이샤 사구체 질환 치료제
CA2598410A1 (fr) * 2005-02-21 2006-08-24 Flamel Technologies Forme pharmaceutique orale de losartan
HRP20080552A9 (en) * 2005-03-30 2009-08-31 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
JP2009504800A (ja) * 2005-08-22 2009-02-05 アレンビク リミテッド バルサルタンの調製方法
WO2008018569A1 (en) * 2006-08-10 2008-02-14 Takeda Pharmaceutical Company Limited Pharmaceutical composition
PE20081364A1 (es) * 2006-09-04 2008-12-04 Novartis Ag Composicion farmaceutica que comprende valsartan
EP1897537A1 (de) * 2006-09-04 2008-03-12 Novartis AG Zusammensetzung enthaltend einen Angiotensin II antagonisten
EP1908469A1 (de) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II Rezeptor Antagonisten zur Behandlung von systemischen Krankheiten bei Katzen
NO347209B1 (no) 2006-12-18 2023-07-03 Takeda Pharmaceutical Sammensetning med forlenget frigjøring og fremgangsmåte for å produsere det samme
CN101011393B (zh) * 2007-02-16 2010-10-06 广州柏赛罗药业有限公司 厄贝沙坦胃内滞留型缓释药物组合物
CA2681143C (en) * 2007-03-28 2017-01-03 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent
CN102065847A (zh) * 2008-04-29 2011-05-18 韩诺生物制约株式会社 含有血管紧张素-ⅱ受体阻断剂的药物制剂
WO2010133638A1 (de) 2009-05-20 2010-11-25 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische telmisartan-trinklösung
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Citations (23)

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JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5798270A (en) 1980-10-21 1982-06-18 Takeda Chem Ind Ltd 1,2-disubstituted-4-chloroimidazole-5-acetic acid derivative
JPS58157768A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
EP0253310A2 (de) 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptorblockierende Imidazole
EP0291969A2 (de) 1987-05-22 1988-11-23 E.I. Du Pont De Nemours And Company Tetrazol-Derivate als Zwischenprodukte zu antihypertensiven Verbindungen
EP0323841A2 (de) 1988-01-07 1989-07-12 E.I. Du Pont De Nemours And Company Substituierte Pyrrol-, Pyrazol- und Triazol-angiotensin II-Antagonisten
EP0324377A2 (de) 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin-II-Rezeptor blockende Imidazole und deren Kombinationen mit Diuretica und NSAids
US4880804A (en) 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0392317A2 (de) 1989-04-08 1990-10-17 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0399731A1 (de) 1989-05-23 1990-11-28 Zeneca Limited Azaindene
EP0403158A2 (de) 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-Alkensäuren
EP0407342A2 (de) 1989-07-06 1991-01-09 Ciba-Geigy Ag Neue Pyrimidin Derivate
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EP0409332A2 (de) 1989-07-19 1991-01-23 Merck & Co. Inc. Substituierte Triazole als Angiotensin II-Antagonisten
EP0411766A1 (de) 1989-07-03 1991-02-06 Merck & Co. Inc. Substituierte Chinazolinone als Angiotensin II-Antagonisten
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EP0442473A1 (de) 1990-02-15 1991-08-21 Takeda Chemical Industries, Ltd. Pyrimidindionderivate, deren Herstellung und Verwendung
EP0443568A1 (de) 1990-02-22 1991-08-28 Takeda Chemical Industries, Ltd. Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung
EP0518033A1 (de) 1991-04-16 1992-12-16 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
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EP0603712A2 (de) 1992-12-22 1994-06-29 Takeda Chemical Industries, Ltd. Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
JPH10504017A (ja) 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
US4340598A (en) 1979-11-12 1982-07-20 Takeda Chemical Industries, Ltd. Hypotensive imidazole derivatives
US4355040A (en) 1979-11-12 1982-10-19 Takeda Chemical Industries, Ltd. Hypotensive imidazole-5-acetic acid derivatives
JPS5798270A (en) 1980-10-21 1982-06-18 Takeda Chem Ind Ltd 1,2-disubstituted-4-chloroimidazole-5-acetic acid derivative
JPS58157768A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
EP0253310A2 (de) 1986-07-11 1988-01-20 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptorblockierende Imidazole
EP0291969A2 (de) 1987-05-22 1988-11-23 E.I. Du Pont De Nemours And Company Tetrazol-Derivate als Zwischenprodukte zu antihypertensiven Verbindungen
EP0323841A2 (de) 1988-01-07 1989-07-12 E.I. Du Pont De Nemours And Company Substituierte Pyrrol-, Pyrazol- und Triazol-angiotensin II-Antagonisten
EP0324377A2 (de) 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Angiotensin-II-Rezeptor blockende Imidazole und deren Kombinationen mit Diuretica und NSAids
US4880804A (en) 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0392317A2 (de) 1989-04-08 1990-10-17 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0399731A1 (de) 1989-05-23 1990-11-28 Zeneca Limited Azaindene
EP0403158A2 (de) 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-Alkensäuren
WO1991000277A1 (en) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
EP0411766A1 (de) 1989-07-03 1991-02-06 Merck & Co. Inc. Substituierte Chinazolinone als Angiotensin II-Antagonisten
EP0407342A2 (de) 1989-07-06 1991-01-09 Ciba-Geigy Ag Neue Pyrimidin Derivate
EP0409332A2 (de) 1989-07-19 1991-01-23 Merck & Co. Inc. Substituierte Triazole als Angiotensin II-Antagonisten
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EP0434038A1 (de) 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
EP0442473A1 (de) 1990-02-15 1991-08-21 Takeda Chemical Industries, Ltd. Pyrimidindionderivate, deren Herstellung und Verwendung
EP0443568A1 (de) 1990-02-22 1991-08-28 Takeda Chemical Industries, Ltd. Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung
EP0518033A1 (de) 1991-04-16 1992-12-16 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
EP0603712A2 (de) 1992-12-22 1994-06-29 Takeda Chemical Industries, Ltd. Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
JPH10504017A (ja) 1994-05-03 1998-04-14 アルカームズ コントロールド セラピューティックス,インコーポレイテッド 生体適合性ポリマーからの薬物放出調節方法

Non-Patent Citations (1)

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Title
PATRICE HILDGEN ET AL.: "Improved Activity of a New Angiotensin Receptor Antagonist by an Injectable Spray-Dried Polymer Microsphere Preparation", PHARMACEUTICAL RESEARCH, 1997, pages 887 - 891, XP002109157, DOI: doi:10.1023/A:1012147700014

Also Published As

Publication number Publication date
HUP0101439A3 (en) 2002-09-30
NO20004350D0 (no) 2000-09-01
US6589547B1 (en) 2003-07-08
CA2318446C (en) 2008-09-23
LV12585B (en) 2001-03-20
KR20010086245A (ko) 2001-09-10
LT2000082A (en) 2001-03-26
DE69914460T2 (de) 2004-10-28
ZA991706B (en) 2000-10-03
NO20004350L (no) 2000-10-03
DE69914460D1 (de) 2004-03-04
AU2745199A (en) 1999-09-20
BR9908474A (pt) 2000-12-05
ID25640A (id) 2000-10-19
LV12585A (en) 2000-12-20
ATE258430T1 (de) 2004-02-15
SK11902000A3 (sk) 2001-02-12
EE200000499A (et) 2002-02-15
EP1058541A1 (de) 2000-12-13
CA2318446A1 (en) 1999-09-10
WO1999044590A1 (en) 1999-09-10
US20030198676A1 (en) 2003-10-23
CN1291888A (zh) 2001-04-18
IL137979A0 (en) 2001-10-31
EP1058541B1 (de) 2004-01-28
HUP0101439A2 (hu) 2001-10-28
PL342684A1 (en) 2001-07-02
ES2214013T3 (es) 2004-09-01
US7294344B2 (en) 2007-11-13

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