LT4704B - Junginiai ir kompozicijos, skirti gydyti susirgimus, susijusius su serino proteazės, konkrečiai triptazės, aktyvumu - Google Patents
Junginiai ir kompozicijos, skirti gydyti susirgimus, susijusius su serino proteazės, konkrečiai triptazės, aktyvumu Download PDFInfo
- Publication number
- LT4704B LT4704B LT99-131A LT99131A LT4704B LT 4704 B LT4704 B LT 4704B LT 99131 A LT99131 A LT 99131A LT 4704 B LT4704 B LT 4704B
- Authority
- LT
- Lithuania
- Prior art keywords
- benzoimidazol
- alkyl
- ethyl
- methyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83367497A | 1997-04-07 | 1997-04-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT99131A LT99131A (en) | 2000-04-25 |
| LT4704B true LT4704B (lt) | 2000-09-25 |
Family
ID=25264996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT99-131A LT4704B (lt) | 1997-04-07 | 1999-11-05 | Junginiai ir kompozicijos, skirti gydyti susirgimus, susijusius su serino proteazės, konkrečiai triptazės, aktyvumu |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1019382A1 (et) |
| JP (1) | JP2001519806A (et) |
| KR (1) | KR20010006119A (et) |
| CN (1) | CN1251579A (et) |
| AU (1) | AU752064B2 (et) |
| CA (1) | CA2285454A1 (et) |
| EE (1) | EE04055B1 (et) |
| HU (1) | HUP0001522A3 (et) |
| LT (1) | LT4704B (et) |
| LV (1) | LV12495B (et) |
| NO (1) | NO314183B1 (et) |
| NZ (1) | NZ500029A (et) |
| PL (1) | PL336233A1 (et) |
| SI (1) | SI20115A (et) |
| SK (1) | SK136799A3 (et) |
| WO (1) | WO1998045275A1 (et) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221914B1 (en) | 1997-11-10 | 2001-04-24 | Array Biopharma Inc. | Sulfonamide bridging compounds that inhibit tryptase activity |
| WO1999026932A1 (en) * | 1997-11-26 | 1999-06-03 | Axys Pharmaceuticals, Inc. | By amidino group substituted heterocyclic derivatives and their use as anticoagulants |
| AU1608399A (en) * | 1997-11-26 | 1999-06-15 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| GT199900167A (es) * | 1998-10-01 | 2001-03-21 | Nuevos bis-benzimidazoles. | |
| WO2000020400A1 (en) * | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| DE60007310D1 (de) * | 1999-06-04 | 2004-01-29 | Elan Pharma Int Ltd | Zusammensetzungen und methoden zur verhinderung des zelltods |
| DE19953899A1 (de) * | 1999-11-10 | 2001-05-17 | Boehringer Ingelheim Pharma | Carboxamid-substituierte Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2001231030A1 (en) * | 2000-01-20 | 2001-07-31 | Amgen Inc | Inhibitors of protease-activated receptor-2 (par-2) as novel asthma therapeutics |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| DE10048715A1 (de) * | 2000-09-30 | 2004-05-19 | Grünenthal GmbH | Verwendung von Aminosäure zur Behandlung von Schmerz |
| JP4176477B2 (ja) * | 2001-03-01 | 2008-11-05 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体 |
| GB0406282D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| DE102011111991A1 (de) | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
| AP2014007662A0 (en) * | 2011-11-29 | 2014-05-31 | Perosphere Inc | Anticoagulant reversal agents |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| EP3974434A4 (en) * | 2019-05-21 | 2023-11-08 | Zhejiang Hisun Pharmaceutical Co., Ltd. | MACROLIDE DERIVATIVES, PRODUCTION PROCESS AND USE THEREOF |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3105837A (en) * | 1961-10-20 | 1963-10-01 | Upjohn Co | 2, 2'-alkylenebisbenzimidazoles |
| US3210370A (en) * | 1964-06-22 | 1965-10-05 | Upjohn Co | Process for preparing 2, 2'-methylene-bisareneimiazoles |
| IL111011A0 (en) * | 1993-09-22 | 1994-11-28 | Wellcome Found | Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them |
| US6815461B1 (en) * | 1994-01-20 | 2004-11-09 | The University Of North Carolina At Chapel Hill | Method of inhibiting retroviral integrase |
| US5693515A (en) * | 1995-04-28 | 1997-12-02 | Arris Pharmaceutical Corporation | Metal complexed serine protease inhibitors |
-
1997
- 1997-12-01 KR KR1019997009197A patent/KR20010006119A/ko not_active Application Discontinuation
- 1997-12-01 EP EP97954520A patent/EP1019382A1/en not_active Withdrawn
- 1997-12-01 SK SK1367-99A patent/SK136799A3/sk unknown
- 1997-12-01 CN CN97182098A patent/CN1251579A/zh active Pending
- 1997-12-01 SI SI9720094A patent/SI20115A/sl unknown
- 1997-12-01 PL PL97336233A patent/PL336233A1/xx unknown
- 1997-12-01 EE EEP199900477A patent/EE04055B1/et not_active IP Right Cessation
- 1997-12-01 JP JP54273998A patent/JP2001519806A/ja active Pending
- 1997-12-01 NZ NZ500029A patent/NZ500029A/en unknown
- 1997-12-01 WO PCT/US1997/021849 patent/WO1998045275A1/en not_active Application Discontinuation
- 1997-12-01 AU AU58950/98A patent/AU752064B2/en not_active Ceased
- 1997-12-01 HU HU0001522A patent/HUP0001522A3/hu unknown
- 1997-12-01 CA CA002285454A patent/CA2285454A1/en not_active Abandoned
-
1999
- 1999-10-06 NO NO19994858A patent/NO314183B1/no unknown
- 1999-11-02 LV LVP-99-153A patent/LV12495B/en unknown
- 1999-11-05 LT LT99-131A patent/LT4704B/lt not_active IP Right Cessation
Non-Patent Citations (5)
| Title |
|---|
| B. SCHWARTZ ET AL.: "Tryptase Levels as an Indicator of Mast-Cell Activation in Systemic Anaphylaxis and Mastocytosis", N ENGL J MED., 1987, pages 1622 - 1626 |
| CAUGHEY GH ET AL.: "Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase", J. PHARMACOL. EXP. THER., 1988, pages 133 - 137 |
| CLARK JM ET AL.: "Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.", AM J RESPIR CRIT CARE MED., 1995, pages 2076 - 2083, XP001020840 |
| FRANCONI GM ET AL.: "Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret", J. PHARMACOL. EXP. THER., 1988, pages 947 - 951 |
| J. F. MOLINARI ET AL.: "Role of tryptase in immediate cutaneous responses in allergic sheep", JOURNAL OF APPLIED PHYSIOLOGY, 1995, pages 1966 - 1970 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010006119A (ko) | 2001-01-26 |
| LT99131A (en) | 2000-04-25 |
| LV12495B (en) | 2001-01-20 |
| NZ500029A (en) | 2001-02-23 |
| HUP0001522A2 (hu) | 2001-05-28 |
| LV12495A (en) | 2000-06-20 |
| CA2285454A1 (en) | 1998-10-15 |
| PL336233A1 (en) | 2000-06-19 |
| CN1251579A (zh) | 2000-04-26 |
| AU752064B2 (en) | 2002-09-05 |
| NO994858L (no) | 1999-12-06 |
| WO1998045275A1 (en) | 1998-10-15 |
| NO314183B1 (no) | 2003-02-10 |
| SI20115A (sl) | 2000-06-30 |
| EE04055B1 (et) | 2003-06-16 |
| SK136799A3 (en) | 2000-07-11 |
| EE9900477A (et) | 2000-06-15 |
| NO994858D0 (no) | 1999-10-06 |
| JP2001519806A (ja) | 2001-10-23 |
| AU5895098A (en) | 1998-10-30 |
| HUP0001522A3 (en) | 2001-08-28 |
| EP1019382A1 (en) | 2000-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LT4704B (lt) | Junginiai ir kompozicijos, skirti gydyti susirgimus, susijusius su serino proteazės, konkrečiai triptazės, aktyvumu | |
| JP3120075B2 (ja) | 化合物 | |
| US5314880A (en) | Benzimidazole derivatives | |
| ES2244979T3 (es) | Derivados de benzimidazol. | |
| US7714009B2 (en) | Nitrogen-containing fused heterocyclic compounds | |
| CA2908408C (en) | Dihydropyrido pyrimidine compounds as autotaxin inhibitors | |
| US5338756A (en) | Benzimidazole compounds | |
| US6962922B2 (en) | Alkynylated quinazoline compounds | |
| KR20050122210A (ko) | 히스톤 탈아세틸화 효소 억제제 | |
| JPH07502742A (ja) | Ｐａｆ−レセプタ拮抗剤としてのアミノ酸誘導体 | |
| JP2004520387A (ja) | 複素環式置換２−メチル−ベンズイミダゾール抗ウイルス剤 | |
| IE59624B1 (en) | New thiazole compounds, processes for the preparation thereof and pharmaceutical compositions comprising the same | |
| WO2003033478A1 (en) | Alkynylated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitors | |
| AU662384B2 (en) | Heterocyclic sulfonamide derivatives as antagonists of paf and angiotensin II | |
| JP2002521334A (ja) | 置換ベンズイミダゾール抗ウィルス剤 | |
| CZ184099A3 (cs) | Sloučenina, farmaceutický prostředek a způsob prevence nebo léčby | |
| US5451676A (en) | Biphenyl ether heterobicyclic platelet activating factor antagonists | |
| US6562854B2 (en) | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders | |
| EP0774462A1 (en) | Heterocyclic compound | |
| JPH09507846A (ja) | フェニルメチルヘキサンアミドおよびその使用 | |
| EP0605434B1 (en) | Imidazo (4,5-c) pyridine derivatives as paf antagonists | |
| CZ345499A3 (cs) | Sloučeniny a prostředky pro léčbu nemocí spojených s aktivitou serinové proteasy, zejména tryptasy | |
| MXPA99009006A (en) | Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity | |
| JPH07507271A (ja) | アンジオテンシン１１拮抗剤としてのベンズイミダゾール誘導体 | |
| JPH07179426A (ja) | キノリン化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 20031201 |