LT4234B - Compositions for treating mast-cell inflamatory condition - Google Patents
Compositions for treating mast-cell inflamatory condition Download PDFInfo
- Publication number
- LT4234B LT4234B LT97-065A LT97065A LT4234B LT 4234 B LT4234 B LT 4234B LT 97065 A LT97065 A LT 97065A LT 4234 B LT4234 B LT 4234B
- Authority
- LT
- Lithuania
- Prior art keywords
- cis
- piperazinecarboxylate
- bis
- compound
- cyclooctylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C271/34—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31226994A | 1994-09-23 | 1994-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT97065A LT97065A (en) | 1997-08-25 |
| LT4234B true LT4234B (en) | 1997-10-27 |
Family
ID=23210670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT97-065A LT4234B (en) | 1994-09-23 | 1997-04-10 | Compositions for treating mast-cell inflamatory condition |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6022969A (et) |
| EP (1) | EP0782571A1 (et) |
| JP (1) | JPH10506390A (et) |
| KR (1) | KR970706267A (et) |
| CN (1) | CN1160398A (et) |
| AU (1) | AU694275B2 (et) |
| CA (1) | CA2200561A1 (et) |
| CZ (1) | CZ87097A3 (et) |
| EE (1) | EE03525B1 (et) |
| FI (1) | FI971171A (et) |
| HR (1) | HRP950499B1 (et) |
| HU (1) | HUT77770A (et) |
| IL (1) | IL115405A (et) |
| LT (1) | LT4234B (et) |
| LV (1) | LV11865B (et) |
| MX (1) | MX9702125A (et) |
| NO (1) | NO309605B1 (et) |
| NZ (1) | NZ294392A (et) |
| PL (1) | PL183552B1 (et) |
| RU (1) | RU2159229C2 (et) |
| SI (1) | SI9520101A (et) |
| SK (1) | SK37997A3 (et) |
| TW (1) | TW442478B (et) |
| WO (1) | WO1996009297A1 (et) |
| ZA (1) | ZA958028B (et) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0003267A3 (en) * | 1996-07-30 | 2002-02-28 | Arris Pharmaceutical Corp San | Heteroaryl derivatives, pharmaceutical compositions containing them and process for producing them |
| WO1998024886A1 (en) * | 1996-12-04 | 1998-06-11 | Brigham And Women's Hospital, Inc. | Mast cell protease that cleaves fibrinogen |
| WO1998033812A1 (en) * | 1997-02-05 | 1998-08-06 | Brigham And Women's Hospital, Inc. | Mast cell protease peptide inhibitors |
| AU8997498A (en) * | 1997-09-05 | 1999-03-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Tryptase inhibitor |
| EP1030844A1 (en) * | 1997-11-10 | 2000-08-30 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| US6221914B1 (en) * | 1997-11-10 | 2001-04-24 | Array Biopharma Inc. | Sulfonamide bridging compounds that inhibit tryptase activity |
| WO1999040083A2 (de) * | 1998-02-06 | 1999-08-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Bifunktionelle tryptase-inhibitoren |
| US6613769B1 (en) | 1998-02-06 | 2003-09-02 | Max-Planck-Gesellschaft zur Föderung der Wissenschaften. e.V. | Tryptase inhibitors |
| EP1115731A2 (de) * | 1998-09-04 | 2001-07-18 | Byk Gulden Lomberg Chemische Fabrik GmbH | Neue pyranosen |
| US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| CN1378538A (zh) | 1999-08-10 | 2002-11-06 | 比克·古尔顿·劳姆贝尔格化学公司 | 二氮芳辛－二酮衍生物及其作为类胰蛋白酶抑制剂的应用 |
| JP2003509417A (ja) * | 1999-09-14 | 2003-03-11 | アルタナ ファルマ アクチエンゲゼルシャフト | トリプターゼインヒビター |
| GB9923710D0 (en) * | 1999-10-08 | 1999-12-08 | Proteus Molecular Design | Chemical compounds |
| AU1413301A (en) * | 1999-11-17 | 2001-05-30 | Sumitomo Pharmaceuticals Company, Limited | Diabetic remedy containing dipiperazine derivative |
| WO2001046168A1 (en) * | 1999-12-20 | 2001-06-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tryptase inhibitors |
| US6815557B2 (en) | 1999-12-20 | 2004-11-09 | Altana Pharma Ag | Tryptase inhibitors |
| WO2001052883A1 (en) * | 2000-01-20 | 2001-07-26 | Amgen Inc. | Inhibitors of protease-activated receptor-2 (par-2) as novel asthma therapeutics |
| US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| DE60200935T2 (de) | 2001-01-31 | 2005-09-01 | Altana Pharma Ag | Diazocinderivate und deren verwendung als tryptase inhibitoren |
| ATE364037T1 (de) * | 2001-02-21 | 2007-06-15 | Altana Pharma Ag | Tryptasehemmer |
| WO2002066430A1 (en) | 2001-02-21 | 2002-08-29 | Altana Pharma Ag | Tryptase inhibitors |
| WO2002074732A2 (en) * | 2001-03-15 | 2002-09-26 | Altana Pharma Ag | Tryptase-inhibitors |
| EP1370518A2 (en) * | 2001-03-15 | 2003-12-17 | ALTANA Pharma AG | Tryptase-inhibitors |
| US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2002314165B2 (en) | 2001-06-19 | 2008-02-21 | Altana Pharma Ag | Tryptase inhibitors |
| AU2002352382A1 (en) * | 2001-12-13 | 2003-06-23 | Kowa Company Ltd | Use of protease-activated receptor-2 inhibitor in the manifacture of a medicament for treating delayed hypersensitivity |
| US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| TW200524849A (en) * | 2003-07-02 | 2005-08-01 | Hoffmann La Roche | Hydroxyalkylamide derivatives |
| US20050255154A1 (en) * | 2004-05-11 | 2005-11-17 | Lena Pereswetoff-Morath | Method and composition for treating rhinitis |
| TW200815351A (en) * | 2006-05-02 | 2008-04-01 | Astrazeneca Ab | Novel compounds |
| TWI414527B (zh) * | 2010-10-06 | 2013-11-11 | Ind Tech Res Inst | 異山梨糖醇衍生物及包含該衍生物之液晶顯示器 |
| CN102453037B (zh) * | 2010-10-25 | 2014-06-25 | 财团法人工业技术研究院 | 异山梨糖醇衍生物及包含该衍生物的液晶显示器 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR208414A1 (es) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
| US4746737A (en) * | 1985-07-26 | 1988-05-24 | Kowa Co., Ltd. | Phenyl guanidinobenzoate derivatives which have protease inhibitory activity |
| NZ263084A (en) * | 1993-03-12 | 1997-08-22 | Arris Pharm Corp | Dipeptide derivatives, treatment of immunomediated inflammatory disorders |
| PL176941B1 (pl) * | 1993-03-12 | 1999-08-31 | Axys Pharmaceuticals | Nowe peptydy i środek farmaceutyczny do leczenia immunologicznych stanów zapalnych |
| EP0763016B1 (en) * | 1994-06-01 | 2000-01-26 | Axys Pharmaceuticals, Inc. | Compositions and methods for treating mast-cell mediated conditions |
-
1995
- 1995-09-14 JP JP8511002A patent/JPH10506390A/ja not_active Ceased
- 1995-09-14 EP EP95934993A patent/EP0782571A1/en not_active Withdrawn
- 1995-09-14 NZ NZ294392A patent/NZ294392A/xx unknown
- 1995-09-14 CN CN95195191A patent/CN1160398A/zh active Pending
- 1995-09-14 PL PL95319587A patent/PL183552B1/pl unknown
- 1995-09-14 HU HU9702059A patent/HUT77770A/hu unknown
- 1995-09-14 AU AU37180/95A patent/AU694275B2/en not_active Ceased
- 1995-09-14 CZ CZ97870A patent/CZ87097A3/cs unknown
- 1995-09-14 RU RU97106347/04A patent/RU2159229C2/ru not_active IP Right Cessation
- 1995-09-14 US US08/522,157 patent/US6022969A/en not_active Expired - Fee Related
- 1995-09-14 MX MX9702125A patent/MX9702125A/es not_active IP Right Cessation
- 1995-09-14 KR KR1019970701960A patent/KR970706267A/ko not_active Application Discontinuation
- 1995-09-14 SI SI9520101A patent/SI9520101A/sl unknown
- 1995-09-14 EE EE9700089A patent/EE03525B1/et not_active IP Right Cessation
- 1995-09-14 SK SK379-97A patent/SK37997A3/sk unknown
- 1995-09-14 WO PCT/US1995/011814 patent/WO1996009297A1/en not_active Application Discontinuation
- 1995-09-14 CA CA002200561A patent/CA2200561A1/en not_active Abandoned
- 1995-09-22 ZA ZA958028A patent/ZA958028B/xx unknown
- 1995-09-22 IL IL11540595A patent/IL115405A/en not_active IP Right Cessation
- 1995-09-22 HR HR950499A patent/HRP950499B1/xx not_active IP Right Cessation
- 1995-09-26 TW TW084110031A patent/TW442478B/zh active
-
1997
- 1997-03-20 FI FI971171A patent/FI971171A/fi unknown
- 1997-03-20 NO NO971305A patent/NO309605B1/no unknown
- 1997-04-10 LT LT97-065A patent/LT4234B/lt not_active IP Right Cessation
- 1997-04-22 LV LVP-97-70A patent/LV11865B/en unknown
-
1999
- 1999-03-29 US US09/280,227 patent/US6211228B1/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| CAUGHEY GH ET AL.: "Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase", J. PHARMACOL. EXP. THER., 1988, pages 947 - 951 |
| HOOD ET AL.: "Immunology" |
| PETER VANDERSLICE ET AL.: "Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation", BIOCHEMISTRY, 1989, pages 4148 - 4155 |
| VANDERSLICE, P. ET AL.: "Human mast cell tryptase: Multiple cDNAs and genes reveal a multigene serine protease", PROC NATL ACAD SCI U S A., 1990, pages 3811 - 3815, XP002092772, DOI: doi:10.1073/pnas.87.10.3811 |
Also Published As
| Publication number | Publication date |
|---|---|
| CZ87097A3 (en) | 1997-11-12 |
| TW442478B (en) | 2001-06-23 |
| AU3718095A (en) | 1996-04-09 |
| EE03525B1 (et) | 2001-10-15 |
| HRP950499A2 (en) | 1997-08-31 |
| IL115405A (en) | 2002-07-25 |
| FI971171A0 (fi) | 1997-03-20 |
| US6211228B1 (en) | 2001-04-03 |
| LV11865A (lv) | 1997-10-20 |
| EE9700089A (et) | 1997-10-15 |
| JPH10506390A (ja) | 1998-06-23 |
| SI9520101A (en) | 1997-12-31 |
| PL319587A1 (en) | 1997-08-18 |
| SK37997A3 (en) | 1998-12-02 |
| NO309605B1 (no) | 2001-02-26 |
| WO1996009297A1 (en) | 1996-03-28 |
| NO971305D0 (no) | 1997-03-20 |
| NZ294392A (en) | 1999-05-28 |
| ZA958028B (en) | 1996-04-18 |
| LV11865B (en) | 1998-01-20 |
| RU2159229C2 (ru) | 2000-11-20 |
| AU694275B2 (en) | 1998-07-16 |
| KR970706267A (ko) | 1997-11-03 |
| HUT77770A (hu) | 1998-08-28 |
| HRP950499B1 (en) | 2003-04-30 |
| CN1160398A (zh) | 1997-09-24 |
| CA2200561A1 (en) | 1996-03-28 |
| NO971305L (no) | 1997-05-06 |
| FI971171A (fi) | 1997-03-20 |
| LT97065A (en) | 1997-08-25 |
| MX9702125A (es) | 1998-04-30 |
| EP0782571A1 (en) | 1997-07-09 |
| US6022969A (en) | 2000-02-08 |
| IL115405A0 (en) | 1995-12-31 |
| PL183552B1 (pl) | 2002-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD9A | Change of patent owner |
Free format text: AXYS PHARMACEUTICALS, INC,385 OYSTER POINT BOULEVARD, SOUTH SAN FRANCISCO, CA 94080,US,19991015 |
|
| MM9A | Lapsed patents |
Effective date: 20030914 |