LT4225B - Immuno-stimulatory monoclonal antibodies - Google Patents

Immuno-stimulatory monoclonal antibodies Download PDF

Info

Publication number
LT4225B
LT4225B LT96-115A LT96115A LT4225B LT 4225 B LT4225 B LT 4225B LT 96115 A LT96115 A LT 96115A LT 4225 B LT4225 B LT 4225B
Authority
LT
Lithuania
Prior art keywords
bat
cells
mak
monoclonal antibody
cell line
Prior art date
Application number
LT96-115A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT96115A (en
Inventor
Britta Hardy
Avraham Novogrodsky
Original Assignee
Mor Research Applic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mor Research Applic Ltd filed Critical Mor Research Applic Ltd
Publication of LT96115A publication Critical patent/LT96115A/xx
Publication of LT4225B publication Critical patent/LT4225B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
LT96-115A 1994-01-31 1996-07-30 Immuno-stimulatory monoclonal antibodies LT4225B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10850194A IL108501A (en) 1994-01-31 1994-01-31 Antibodies and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
LT96115A LT96115A (en) 1997-05-26
LT4225B true LT4225B (en) 1997-10-27

Family

ID=11065761

Family Applications (1)

Application Number Title Priority Date Filing Date
LT96-115A LT4225B (en) 1994-01-31 1996-07-30 Immuno-stimulatory monoclonal antibodies

Country Status (20)

Country Link
US (1) US5897862A (fr)
EP (1) EP0742795B1 (fr)
JP (1) JP3478398B2 (fr)
CN (1) CN1052733C (fr)
AT (1) ATE171461T1 (fr)
AU (1) AU693526B2 (fr)
CA (1) CA2182289C (fr)
DE (1) DE69504955T2 (fr)
DK (1) DK0742795T3 (fr)
EE (1) EE03285B1 (fr)
ES (1) ES2124533T3 (fr)
FI (1) FI963004A (fr)
IL (1) IL108501A (fr)
LT (1) LT4225B (fr)
LV (1) LV11624B (fr)
MD (1) MD1374G2 (fr)
MX (1) MX9603080A (fr)
NO (1) NO317020B1 (fr)
RU (1) RU2155190C2 (fr)
WO (1) WO1995020605A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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IL129299A0 (en) * 1999-03-31 2000-02-17 Mor Research Applic Ltd Monoclonal antibodies antigens and diagnosis of malignant diseases
IL145926A0 (en) 2001-10-15 2002-07-25 Mor Research Applic Ltd Peptide epitopes of mimotopes useful in immunomodulation
IL149820A0 (en) * 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
DE10161767T1 (de) 2002-07-03 2018-06-07 Honjo Tasuku Immunopotenzierende Zusammensetzungen, die einen Anti-PD-L1 Antikörper enthalten
DE10311248A1 (de) * 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
WO2006021955A2 (fr) * 2004-08-23 2006-03-02 Mor Research Applications Ltd. Utilisation d'anticorps monoclonaux bat pour l'immunotherapie
NZ563193A (en) 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
DK1907424T3 (en) 2005-07-01 2015-11-09 Squibb & Sons Llc HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED death ligand 1 (PD-L1)
EP2170959B1 (fr) * 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Anticorps dirigés contre le récepteur humain de mort programmée pd-1
CN101970499B (zh) 2008-02-11 2014-12-31 治疗科技公司 用于肿瘤治疗的单克隆抗体
MD3972C2 (ro) * 2009-03-11 2010-07-31 Ион МЕРЕУЦЭ Remediu şi metodă de tratament al stărilor precanceroase
CA2840018C (fr) 2011-07-24 2019-07-16 Curetech Ltd. Variants d'anticorps monoclonaux immunomodulateurs humanises
EP3757130A1 (fr) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Méthodes de traitement de cancers hématologiques
US9580504B1 (en) 2013-11-07 2017-02-28 Curetech Ltd. Pidilizumab monoclonal antibody therapy following stem cell transplantation
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JP6681905B2 (ja) 2014-09-13 2020-04-15 ノバルティス アーゲー Ａｌｋ阻害剤の併用療法
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
PL3328419T3 (pl) 2015-07-30 2021-12-27 Macrogenics, Inc. Cząsteczki wiążące pd-1 i sposoby ich zastosowania
CN114605548A (zh) 2015-09-01 2022-06-10 艾吉纳斯公司 抗-pd-1抗体及其使用方法
KR20180054824A (ko) 2015-09-29 2018-05-24 셀진 코포레이션 Pd-1 결합 단백질 및 이의 사용 방법
SG11201803520PA (en) 2015-11-03 2018-05-30 Janssen Biotech Inc Antibodies specifically binding pd-1 and their uses
KR102424513B1 (ko) 2015-12-14 2022-07-25 마크로제닉스, 인크. Pd-1 및 ctla-4과의 면역반응성을 가진 이중특이적 분자, 및 이것의 사용 방법
EP3471753A1 (fr) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 et cytokines il-2
BR112019004733A2 (pt) 2016-09-19 2019-05-28 Celgene Corp métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1
US10766958B2 (en) 2016-09-19 2020-09-08 Celgene Corporation Methods of treating vitiligo using PD-1 binding antibodies
MA50948A (fr) 2016-12-07 2020-10-14 Agenus Inc Anticorps et procédés d'utilisation de ceux-ci
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
US20240294651A1 (en) 2023-01-30 2024-09-05 Kymab Limited Antibodies

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US5182368A (en) * 1986-06-13 1993-01-26 Ledbetter Jeffrey A Ligands and methods for augmenting B-cell proliferation

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
B. HARDY ET AL.: "A monoclonal antibody to human B lyphoblastoid cells activates human and murine T lymphocytes", CELL IMMUNOL., 1989, pages 22 - 29
E. A. CLARK, J.A. LEDBETTER: "Amplification of the immune response by agonistic antibodies", IMMUNOL. TODAY., 1986, pages 267 - 270, XP023943599, DOI: doi:10.1016/0167-5699(86)90008-3
G. JUNG ET AL.: "Induction of cytotoxicity in human peripheral blood mononuclear cells by monoclonal antibody OKT3", J IMMUNOL., 1987, pages 639 - 644
GLASSY MC, SURH CD: "Immunodetection of cell-bound antigens using both mouse and human monoclonal antibodies", J IMMUNOL METHODS, 1985, pages 115, XP023992301, DOI: doi:10.1016/0022-1759(85)90127-9
J. D. ELLENHORN ET AL.: "In vivo administration of an anti-CD3 prevents malignant progressor tumor growth", SCIENCE, 1988, pages 569 - 571, XP001084126, DOI: doi:10.1126/science.2902689
JAMIESON G. A. ET AL.: "Isolation and characterization of plasma membranes and intact nuclei from lymphoid cells", J. BIOL. CHEM., 1977, pages 2137
KÖHLER G, MILSTEIN C.: "Continuous cultures of fused cells secreting antibody of predefined specificity", NATURE, 1975, pages 495, XP002024548
M. K. JENKINS ET AL.: "CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells", J IMMUNOL., 1991, pages 2461 - 2466
MORETTA ET AL.: "CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta", J EXP MED., 1991, pages 1393 - 1398, XP055219293, DOI: doi:10.1084/jem.174.6.1393
R. A. VAN LIER ET AL.: "Signals involved in T-cell activation. T cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies", EUR. J. IMMUNOL., 1988, pages 167 - 172
R. VAN LIER ET AL.: "Studies on monocyte dependence on T-cell proliferation induced by monoclonal antibodies directed against region I and II of CD2 antigen", IMMUNOLOGY, 1989, pages 333 - 338
S. C. MEUER ET AL.: "Triggering of the T3-T1 antigen-receptor complex results in clonal T cell proliferation through an interleukin-2 dependent autocrine pathway", PROC. NATL. ACAD. SCI. USA, 1984, pages 1509 - 1513
S. E. TOWNSEND, J. P ALLISON: "Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells", SCIENCE, 1993, pages 368 - 370, XP000943266, DOI: doi:10.1126/science.7678351
S. GALLINGER ET AL.: "Comparison of cellular immunotherapies and anti-CD3 inthe treatment of MCA-38-LD experimental hepatic metastases in C57BL/6 mice", CANCER RES., 1990, pages 2476 - 2480
VAN WAUVE J. P. ET AL.: "OKT3: a monoclonal anti-human T lymphocyte antibody and potent mitogenic properties", J IMMUNOL., 1980, pages 2708 - 2713

Also Published As

Publication number Publication date
DK0742795T3 (da) 1999-06-14
MD1374G2 (ro) 2000-09-30
DE69504955T2 (de) 1999-05-27
DE69504955D1 (de) 1998-10-29
EP0742795B1 (fr) 1998-09-23
JP3478398B2 (ja) 2003-12-15
JPH09508390A (ja) 1997-08-26
ES2124533T3 (es) 1999-02-01
NO963168L (no) 1996-09-27
NO317020B1 (no) 2004-07-26
RU2155190C2 (ru) 2000-08-27
ATE171461T1 (de) 1998-10-15
IL108501A0 (en) 1994-05-30
FI963004A0 (fi) 1996-07-29
NO963168D0 (no) 1996-07-29
FI963004A (fi) 1996-09-27
LT96115A (en) 1997-05-26
IL108501A (en) 1998-10-30
CA2182289A1 (fr) 1995-08-03
AU1868695A (en) 1995-08-15
CN1145077A (zh) 1997-03-12
AU693526B2 (en) 1998-07-02
LV11624B (en) 1997-06-20
CN1052733C (zh) 2000-05-24
WO1995020605A1 (fr) 1995-08-03
MD1374F2 (en) 1999-12-31
CA2182289C (fr) 2003-10-21
EE03285B1 (et) 2000-08-15
LV11624A (en) 1996-12-20
EP0742795A1 (fr) 1996-11-20
MX9603080A (es) 1998-01-31
US5897862A (en) 1999-04-27

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