MD1374G2 - Anticorpi monoclonali imunostimulatori, procedeu de obţinere a acestora, linii celulare, metodă de tratare a maladiilor şi compoziţie farmaceutică - Google Patents

Anticorpi monoclonali imunostimulatori, procedeu de obţinere a acestora, linii celulare, metodă de tratare a maladiilor şi compoziţie farmaceutică Download PDF

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Publication number
MD1374G2
MD1374G2 MD96-0296A MD960296A MD1374G2 MD 1374 G2 MD1374 G2 MD 1374G2 MD 960296 A MD960296 A MD 960296A MD 1374 G2 MD1374 G2 MD 1374G2
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MD
Moldova
Prior art keywords
monoclonal
immunostimulatin
antibodies
obtaining
pharmaceutical composition
Prior art date
Application number
MD96-0296A
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English (en)
Russian (ru)
Other versions
MD1374F2 (ro
Inventor
Britta Hardy
Avraham Novogrodsky
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Mor Research Application Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mor Research Application Ltd filed Critical Mor Research Application Ltd
Publication of MD1374F2 publication Critical patent/MD1374F2/ro
Publication of MD1374G2 publication Critical patent/MD1374G2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Detergent Compositions (AREA)

Abstract

Invenţia se referă la medicină şi anume la imunoterapie.Esenţa invenţiei constă în aceea că anticorpul monoclonal imunostimulator sau fragmentul lui legând un antigen, careá legându-se cu celulele B limfoblastoide, induce proliferarea şi activarea limfocitelor sângelui periferic, asigură efectul antitumoral. Anticorpul propus se obţine prin imunizarea animalului cu un imunogen selectat din grupul constituit din celule B limfoblastoide, celule B limfoblastoide lizate sau preparate membranoase din ele, dezvoltarea ulterioară a reacţiei imune la animalul imunizat, extragerea limfocitelor B, creşterea, imortalizarea şi selectarea liniilor celulare, care secretează anticorpul revendicat. De asemenea, se declară linia celulară a hibridomului, depozitat în CNCM sub nr. 1-1397. Se propune o metodă de tratare a maladiilor, care include administrarea unei cantităţi eficiente de anticorp monoclonal propus. Se revendică o compoziţie farmaceutică, ce include în calitate de ingredient activ anticorpul monoclonal imunostimulator indicat. În plus, compoziţia farmaceutică poate suplimentar să conţină un agent care sporeşte activitatea limfocitelor citotoxice.Rezultatul este proliferarea şi activarea limfocitelor, asigurând efectul antitumoral.
MD96-0296A 1994-01-31 1995-01-30 Anticorpi monoclonali imunostimulatori, procedeu de obţinere a acestora, linii celulare, metodă de tratare a maladiilor şi compoziţie farmaceutică MD1374G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL10850194A IL108501A (en) 1994-01-31 1994-01-31 Antibodies and pharmaceutical compositions containing them
PCT/US1995/001137 WO1995020605A1 (en) 1994-01-31 1995-01-30 Immuno-stimulatory monoclonal antibodies

Publications (2)

Publication Number Publication Date
MD1374F2 MD1374F2 (ro) 1999-12-31
MD1374G2 true MD1374G2 (ro) 2000-09-30

Family

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Application Number Title Priority Date Filing Date
MD96-0296A MD1374G2 (ro) 1994-01-31 1995-01-30 Anticorpi monoclonali imunostimulatori, procedeu de obţinere a acestora, linii celulare, metodă de tratare a maladiilor şi compoziţie farmaceutică

Country Status (20)

Country Link
US (1) US5897862A (ro)
EP (1) EP0742795B1 (ro)
JP (1) JP3478398B2 (ro)
CN (1) CN1052733C (ro)
AT (1) ATE171461T1 (ro)
AU (1) AU693526B2 (ro)
CA (1) CA2182289C (ro)
DE (1) DE69504955T2 (ro)
DK (1) DK0742795T3 (ro)
EE (1) EE03285B1 (ro)
ES (1) ES2124533T3 (ro)
FI (1) FI963004L (ro)
IL (1) IL108501A (ro)
LT (1) LT4225B (ro)
LV (1) LV11624B (ro)
MD (1) MD1374G2 (ro)
MX (1) MX9603080A (ro)
NO (1) NO317020B1 (ro)
RU (1) RU2155190C2 (ro)
WO (1) WO1995020605A1 (ro)

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MD3972C2 (ro) * 2009-03-11 2010-07-31 Ион МЕРЕУЦЭ Remediu şi metodă de tratament al stărilor precanceroase

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RU2192888C1 (ru) * 2001-02-15 2002-11-20 Эпштейн Олег Ильич Лекарственное средство и способ лечения патологического синдрома
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IL145926A0 (en) 2001-10-15 2002-07-25 Mor Research Applic Ltd Peptide epitopes of mimotopes useful in immunomodulation
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PT2206517T (pt) 2002-07-03 2023-11-07 Tasuku Honjo Composições de imunopotenciação contendo anticorpos anti-pd-l1
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US20090123413A1 (en) * 2004-08-23 2009-05-14 Britta Hardy Use of bat monoclonal antibody for immunotherapy
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PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
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MX2017003227A (es) 2014-09-13 2017-12-04 Novartis Ag Terapias de combinacion de inhibidores de alk.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3972C2 (ro) * 2009-03-11 2010-07-31 Ион МЕРЕУЦЭ Remediu şi metodă de tratament al stărilor precanceroase

Also Published As

Publication number Publication date
CA2182289A1 (en) 1995-08-03
MD1374F2 (ro) 1999-12-31
NO963168D0 (no) 1996-07-29
IL108501A0 (en) 1994-05-30
DE69504955D1 (de) 1998-10-29
RU2155190C2 (ru) 2000-08-27
NO963168L (no) 1996-09-27
JP3478398B2 (ja) 2003-12-15
AU1868695A (en) 1995-08-15
CA2182289C (en) 2003-10-21
LT4225B (en) 1997-10-27
FI963004A7 (fi) 1996-09-27
FI963004L (fi) 1996-09-27
US5897862A (en) 1999-04-27
WO1995020605A1 (en) 1995-08-03
LV11624A (en) 1996-12-20
ATE171461T1 (de) 1998-10-15
FI963004A0 (fi) 1996-07-29
AU693526B2 (en) 1998-07-02
JPH09508390A (ja) 1997-08-26
NO317020B1 (no) 2004-07-26
IL108501A (en) 1998-10-30
EE03285B1 (et) 2000-08-15
CN1145077A (zh) 1997-03-12
LT96115A (en) 1997-05-26
DE69504955T2 (de) 1999-05-27
EP0742795A1 (en) 1996-11-20
ES2124533T3 (es) 1999-02-01
EP0742795B1 (en) 1998-09-23
CN1052733C (zh) 2000-05-24
LV11624B (en) 1997-06-20
DK0742795T3 (da) 1999-06-14
MX9603080A (es) 1998-01-31

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