LT4029B - Alpha-amidating enzyme compositions and process for their production - Google Patents

Alpha-amidating enzyme compositions and process for their production Download PDF

Info

Publication number
LT4029B
LT4029B LTIP1656A LTIP1656A LT4029B LT 4029 B LT4029 B LT 4029B LT IP1656 A LTIP1656 A LT IP1656A LT IP1656 A LTIP1656 A LT IP1656A LT 4029 B LT4029 B LT 4029B
Authority
LT
Lithuania
Prior art keywords
enzyme
alpha
amidating
activity
oligonucleotide probe
Prior art date
Application number
LTIP1656A
Other languages
English (en)
Lithuanian (lt)
Inventor
James P Gilligan
Barry N Jones
Arthur H Bertelsen
Nozer M Mehta
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22196693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4029(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Publication of LTIP1656A publication Critical patent/LTIP1656A/xx
Publication of LT4029B publication Critical patent/LT4029B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003Peptidylglycine monooxygenase (1.14.17.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
LTIP1656A 1987-08-14 1993-12-21 Alpha-amidating enzyme compositions and process for their production LT4029B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/086,161 US6319685B1 (en) 1984-09-27 1987-08-14 Alpha-amidating enzyme compositions and processes for their production and use

Publications (2)

Publication Number Publication Date
LTIP1656A LTIP1656A (en) 1995-07-25
LT4029B true LT4029B (en) 1996-08-26

Family

ID=22196693

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1656A LT4029B (en) 1987-08-14 1993-12-21 Alpha-amidating enzyme compositions and process for their production

Country Status (13)

Country Link
US (1) US6319685B1 (fr)
EP (2) EP0308067A3 (fr)
JP (1) JP2979172B2 (fr)
KR (1) KR0136611B1 (fr)
AT (1) ATE198355T1 (fr)
CA (1) CA1341454C (fr)
DE (1) DE3856446T2 (fr)
DK (1) DK175538B1 (fr)
FI (1) FI883722A (fr)
HU (3) HU213227B (fr)
LT (1) LT4029B (fr)
NO (1) NO883592L (fr)
RU (2) RU2252961C2 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
DK0465404T3 (da) * 1990-06-01 1995-12-18 Ciba Geigy Ag Peptidylhydroxylglycin-N-C-lyase og DNA, som koder derfor
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK67691D0 (da) * 1991-03-01 1991-04-15 Carlbiotech Ltd As Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden
WO1996017941A2 (fr) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production de peptides amides a l'extremite c-terminale a partir de produits de recombinaison proteiques
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
HUP0001272A3 (en) 1997-04-16 2012-12-28 Unigene Lab Inc Direct expression of peptides into culture media
ATE458056T1 (de) 2002-07-26 2010-03-15 Ajinomoto Kk Verfahren zur herstellung eines tripeptids oder höheren peptids
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7531518B2 (en) * 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
US20060293667A1 (en) * 2005-05-19 2006-12-28 Agnes Vignery Bone implant device and methods of using same
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
DK2389388T3 (en) 2009-01-22 2017-05-01 Keybioscience Ag TREATMENT FOR Obesity
EP2504021A4 (fr) 2009-11-23 2013-05-15 Amylin Pharmaceuticals Llc Conjugué de polypeptide
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
CA2813038C (fr) 2010-09-28 2021-12-28 Amylin Pharmaceuticals, Llc Leptines hautement solubles
CA2812951A1 (fr) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Llc Polypeptides genetiquement modifies ayant une duree d'action renforcee
BR112013032088B1 (pt) 2011-06-15 2020-11-24 Resother Pharma Aps produtos farmacêuticos anti-inflamatórios
US9382304B2 (en) 2011-07-08 2016-07-05 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action with reduced immunogenicity
WO2013009539A1 (fr) 2011-07-08 2013-01-17 Amylin Pharmaceuticals, Inc. Polypeptides manipulés présentant une durée d'action accrue et une immunogénicité réduite
RU2616511C2 (ru) 2011-11-02 2017-04-17 Кибайосайнс Аг Пептидные аналоги для лечения заболеваний и расстройств
EP3095484B1 (fr) 2011-11-02 2018-05-02 KeyBioscience AG Mimétiques de calcitonine pour le traitement de maladies et de troubles
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
EP3470422A1 (fr) 2013-11-14 2019-04-17 KeyBioscience AG Mimétiques de calcitonine pour le traitement de maladies et de troubles
CN105939759B (zh) 2013-12-02 2020-01-17 康德生物医疗技术公司 用于治疗白癜风的组合物和方法
WO2015183995A2 (fr) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Compositions thérapeutiques comprenant de la frataxine, de la lactoferrine et des enzymes mitochondriales génératrices d'énergie et leurs utilisations
EP3149035A4 (fr) 2014-05-28 2018-05-16 Stealth BioTherapeutics Corp Compositions thérapeutiques comprenant de petites molécules thérapeutiques et leurs utilisations
CA2952615A1 (fr) 2014-06-17 2015-12-23 Stealth Biotherapeutics Corp Procedes d'identification et de surveillance d'un dysfonctionnement mitochondrial a l'aide d'un criblage des monocytes
GB201500263D0 (en) 2015-01-08 2015-02-25 Keybioscience Ag Calcitonin analogues for treating diseases and disorders
WO2016115082A1 (fr) 2015-01-12 2016-07-21 Enteris Biopharma, Inc. Formes galéniques orales solides
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
GB202001024D0 (en) 2020-01-24 2020-03-11 Key Bioscience Ag Oxyntomodulin mimetics
WO2022266467A2 (fr) 2021-06-17 2022-12-22 Dana-Farber Cancer Institute, Inc. Polypeptide d'histone recombiné et ses utilisations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US655366A (en) 1900-05-16 1900-08-07 Simeon C Lawlor Window-cleaner.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518693A (en) * 1982-11-01 1985-05-21 Research Corporation Immobilized biocatalysts
DE134631T1 (de) 1983-06-15 1985-12-05 Roger Kingdom Craig Peptide, pharmazeutische zusammensetzungen, gene, vektoren, wirtorganismen, verfahren zu deren herstellung und diagnostische reagenzien.
GB2141430B (en) 1983-06-15 1987-01-21 Kingdon Craig R Peptides, pharmaceutical compositions, genes, vectors, host organisms, processes for their production and diagnostic reagents
US4549986A (en) 1983-12-23 1985-10-29 The Salk Institute For Biological Studies Human CGRP
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
JPS6229997A (ja) 1985-04-08 1987-02-07 Sankyo Co Ltd C末端にプロリンアミドを有するペプチドの製法
GB8523156D0 (en) 1985-09-19 1985-10-23 Celltech Ltd Polypeptide production
JPS62177184A (ja) 1986-01-29 1987-08-04 Toyota Motor Corp 鋳鉄製内燃機関用シリンダヘツドおよびその製造方法
JPH0775541B2 (ja) 1986-06-07 1995-08-16 壽之 松尾 C末端アミド化酵素及びその製造方法
EP0249477A3 (fr) 1986-06-12 1988-01-20 Immunex Corporation Polypeptides-analogues fonctionnels recombinants dépourvus d'acides aminés hydrophobes
JP2598050B2 (ja) 1987-07-17 1997-04-09 サントリー株式会社 C−末端α−アミド化酵素
US6255067B1 (en) 1987-09-15 2001-07-03 The Johns Hopkins University cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
JP2845468B2 (ja) 1989-01-17 1999-01-13 サントリー株式会社 ヒト甲状腺由来C―末端α―アミド化酵素

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US655366A (en) 1900-05-16 1900-08-07 Simeon C Lawlor Window-cleaner.

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
B A EIPPER, R E MAINS, AND C C GLEMBOTSKI: "Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid", PROC. NATI. ACAD. SCI. USA, 1983, pages 5144 - 5148
BRADBURY, A.F. ET AL.: "Mechanism of C-terminal amide formation by pituitary enzymes.", NATURE (LOND.), 1982, pages 686 - 688
HUSAIN, I., TATE, S.S.: "Formation of the COOH-terminal amide group of thyrotropin-releasing-factor", FEBS, LETT., 1983, pages 277 - 281, XP025593533, DOI: doi:10.1016/0014-5793(83)80395-0
LATHE R.: "Synthetic oligonucleotide probes deduced from amino acid sequence data. Theoretical and practical considerations", J. MOL. BIOL., 1985, pages 1 - 12, XP024013356, DOI: doi:10.1016/0022-2836(85)90276-1
MAINS RE ET AL.: "Peptide alpha-amidation activity in mouse anterior pituitary AtT-20 cell granules: properties and secretion", ENDOCRINOLOGY, 1984, pages 1522 - 1530
MANIATIS T, ET AL.: "Molecular cloning"

Also Published As

Publication number Publication date
DK175538B1 (da) 2004-11-29
KR0136611B1 (ko) 1998-04-25
RU2080385C1 (ru) 1997-05-27
JP2979172B2 (ja) 1999-11-15
FI883722A (fi) 1989-02-15
DK448988A (da) 1989-02-15
EP0529742A1 (fr) 1993-03-03
HU213227B (en) 1997-07-28
HU212071A9 (en) 1996-02-28
LTIP1656A (en) 1995-07-25
DK448988D0 (da) 1988-08-11
HU00552A9 (en) 1995-10-30
US6319685B1 (en) 2001-11-20
CA1341454C (fr) 2004-04-20
ATE198355T1 (de) 2001-01-15
EP0529742B1 (fr) 2000-12-27
EP0308067A2 (fr) 1989-03-22
NO883592D0 (no) 1988-08-12
AU629795B2 (en) 1992-10-15
JPH02104281A (ja) 1990-04-17
KR890003947A (ko) 1989-04-19
AU2057688A (en) 1989-02-16
DE3856446T2 (de) 2001-07-12
NO883592L (no) 1989-02-15
FI883722A0 (fi) 1988-08-10
RU2252961C2 (ru) 2005-05-27
EP0308067A3 (fr) 1989-07-26
DE3856446D1 (de) 2001-02-01

Similar Documents

Publication Publication Date Title
LT4029B (en) Alpha-amidating enzyme compositions and process for their production
Strydom et al. Amino acid sequence of human tumor derived angiogenin
Smit-McBride et al. Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein
Ishibashi et al. Structures of tremerogens A-9291-I and A-9291-VIII: peptidal sex hormones of Tremella brasiliensis
Miyata et al. Primary structure of hemorrhagic protein, HR2a, isolated from the venom of Trimeresurus flavoviridis
JPH02501112A (ja) 免疫親和性による精製方法
CA2189774A1 (fr) Polypeptide hk2 recombine
US20030017504A1 (en) Antibodies specific for poly(ethylene glycol)
EP0204527A1 (fr) Elimination de la méthionine N-terminal de protéines méthionyliques
US5830860A (en) Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
JP3472587B2 (ja) 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
Gram et al. A novel approach for high level production of a recombinant human parathyroid hormone fragment in Escherichia coli
EP0587541B1 (fr) Procédé de purification de protéine Big-endothéline
Goto et al. Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits. Production, purification and determination of primary structure
NO844123L (no) Fremgangsmaate for fremstilling av nonapeptider og dodekopeptider
US5194592A (en) Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor
EP0816504A2 (fr) Facteur d'activation des plaquettes acétylhydrolase, et gène codant celui-ci
EP0527778A1 (fr) Procede ameliore de purification de proteines de recombinaison et procedes utiles dans ledit procede.
HU197939B (en) Process for producing deoxyribonucleic acid, or its precursor, determining human growth hormone releasing factor
JPH03501205A (ja) ペプチジル‐グリシンアルファ‐アミド化モノオキシゲナーゼ(PAM)をコードするcDNA
FI110433B (fi) Alfa-amidointientsyymiä koodaava DNA-sekvenssi, isäntäsolu ja menetelmä amidoidun peptidien valmistamiseksi
US7365173B2 (en) Method for the production of pure virally inactivated butyrylcholinesterase
HAYASHI et al. Calf Thymus Lysine-and Serine-rich Histone: II. Chymotryptic and Thermolysin Peptides
US5196526A (en) CDNA clone for T-cell suppressor inducer factor
NARITA Amino acid sequence of the C-terminal sixty-six residues of Taka-amylase A

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20111221